CA2845651A1 - Improved modifiable occlusion device - Google Patents
Improved modifiable occlusion device Download PDFInfo
- Publication number
- CA2845651A1 CA2845651A1 CA2845651A CA2845651A CA2845651A1 CA 2845651 A1 CA2845651 A1 CA 2845651A1 CA 2845651 A CA2845651 A CA 2845651A CA 2845651 A CA2845651 A CA 2845651A CA 2845651 A1 CA2845651 A1 CA 2845651A1
- Authority
- CA
- Canada
- Prior art keywords
- occlusive device
- pore features
- aneurysm
- patient
- vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000463 material Substances 0.000 claims abstract description 78
- 239000011148 porous material Substances 0.000 claims abstract description 78
- 206010002329 Aneurysm Diseases 0.000 claims abstract description 72
- 230000003628 erosive effect Effects 0.000 claims abstract description 22
- 230000001154 acute effect Effects 0.000 claims abstract description 14
- 208000028867 ischemia Diseases 0.000 claims abstract description 12
- 230000004888 barrier function Effects 0.000 claims abstract description 11
- 210000005166 vasculature Anatomy 0.000 claims abstract description 11
- 238000003780 insertion Methods 0.000 claims abstract description 7
- 230000037431 insertion Effects 0.000 claims abstract description 7
- 238000012276 Endovascular treatment Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 25
- 239000010408 film Substances 0.000 claims description 15
- 239000006260 foam Substances 0.000 claims description 15
- 238000002513 implantation Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 229920001610 polycaprolactone Polymers 0.000 claims description 7
- 239000004632 polycaprolactone Substances 0.000 claims description 7
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004633 polyglycolic acid Substances 0.000 claims description 5
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- 229940072056 alginate Drugs 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 238000010276 construction Methods 0.000 description 27
- 239000000835 fiber Substances 0.000 description 18
- 239000012530 fluid Substances 0.000 description 13
- 239000000126 substance Substances 0.000 description 11
- 230000017531 blood circulation Effects 0.000 description 10
- 210000001367 artery Anatomy 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 230000003073 embolic effect Effects 0.000 description 7
- 230000036772 blood pressure Effects 0.000 description 5
- 230000002085 persistent effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000000149 penetrating effect Effects 0.000 description 4
- 229950008885 polyglycolic acid Drugs 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000001523 electrospinning Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000001732 thrombotic effect Effects 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000005744 arteriovenous malformation Effects 0.000 description 2
- 210000001841 basilar artery Anatomy 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000013590 bulk material Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000002631 hypothermal effect Effects 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 2
- 229910001000 nickel titanium Inorganic materials 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008321 arterial blood flow Effects 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012148 non-surgical treatment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/12031—Type of occlusion complete occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/03—Automatic limiting or abutting means, e.g. for safety
- A61B2090/037—Automatic limiting or abutting means, e.g. for safety with a frangible part, e.g. by reduced diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
- A61F2250/0024—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity made from both porous and non-porous parts, e.g. adjacent parts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,818 US20130204288A1 (en) | 2011-03-31 | 2013-03-13 | Modifiable occlusion device |
| US13/798,818 | 2013-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2845651A1 true CA2845651A1 (en) | 2014-09-13 |
Family
ID=50342162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2845651A Abandoned CA2845651A1 (en) | 2013-03-13 | 2014-03-11 | Improved modifiable occlusion device |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2777544B1 (enExample) |
| JP (2) | JP6388775B2 (enExample) |
| KR (1) | KR102232440B1 (enExample) |
| CN (1) | CN104042356B (enExample) |
| AU (1) | AU2014201229B2 (enExample) |
| BR (1) | BR102014005930A2 (enExample) |
| CA (1) | CA2845651A1 (enExample) |
| DK (1) | DK2777544T3 (enExample) |
| IN (1) | IN2014DE00518A (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456345B (zh) * | 2014-06-12 | 2021-11-23 | 国立研究开发法人国立循环器病研究中心 | 支架 |
| CN104758086B (zh) * | 2015-04-20 | 2016-08-17 | 湖南埃普特医疗器械有限公司 | 脑动脉瘤腔内血管重建装置 |
| US10893869B2 (en) * | 2016-03-24 | 2021-01-19 | Covidien Lp | Thin wall constructions for vascular flow diversion |
| CN108210134B (zh) * | 2018-02-27 | 2024-05-10 | 北京航空航天大学 | 一种血管支架 |
| US20240197331A1 (en) * | 2022-12-15 | 2024-06-20 | Coherex Medical, Inc. | Medical device and system with enhanced echogenicity and method thereof |
| CN119908792A (zh) * | 2024-12-31 | 2025-05-02 | 上海形状记忆合金材料有限公司 | 泡沫血管塞及其制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US692631A (en) | 1899-10-06 | 1902-02-04 | Charles S Farquhar | Apparatus for electrically dispersing fluids. |
| US705691A (en) | 1900-02-20 | 1902-07-29 | William James Morton | Method of dispersing fluids. |
| US1975504A (en) | 1929-12-07 | 1934-10-02 | Richard Schreiber Gastell | Process and apparatus for preparing artificial threads |
| US2048651A (en) | 1933-06-23 | 1936-07-21 | Massachusetts Inst Technology | Method of and apparatus for producing fibrous or filamentary material |
| US2349950A (en) | 1937-08-18 | 1944-05-30 | Formhals Anton | Method and apparatus for spinning |
| US6187036B1 (en) | 1998-12-11 | 2001-02-13 | Endologix, Inc. | Endoluminal vascular prosthesis |
| US6613074B1 (en) * | 1999-03-10 | 2003-09-02 | Cordis Corporation | Endovascular aneurysm embolization device |
| US8313504B2 (en) * | 2000-09-18 | 2012-11-20 | Cordis Corporation | Foam matrix embolization device |
| AU2002351311A1 (en) * | 2001-12-06 | 2003-06-23 | Thomas J. Clement | Medical device |
| US7156871B2 (en) | 2004-10-28 | 2007-01-02 | Cordis Neurovascular, Inc. | Expandable stent having a stabilized portion |
| WO2007117645A2 (en) | 2006-04-07 | 2007-10-18 | Penumbra, Inc. | Aneurysm occlusion system and method |
| US8100960B2 (en) * | 2008-03-20 | 2012-01-24 | Medtronic Vascular, Inc. | Bloused stent-graft and fenestration method |
| JP5824794B2 (ja) | 2010-09-03 | 2015-12-02 | 国立研究開発法人国立循環器病研究センター | 動脈瘤治療用ステント |
| US20120253377A1 (en) * | 2011-03-31 | 2012-10-04 | Codman & Shurtleff, Inc. | Modifiable occlusion device |
| IN2014DE00464A (enExample) * | 2013-03-12 | 2015-06-12 | Depuy Synthes Products Llc |
-
2014
- 2014-02-25 IN IN518DE2014 patent/IN2014DE00518A/en unknown
- 2014-03-05 AU AU2014201229A patent/AU2014201229B2/en not_active Ceased
- 2014-03-07 KR KR1020140026876A patent/KR102232440B1/ko active Active
- 2014-03-11 CA CA2845651A patent/CA2845651A1/en not_active Abandoned
- 2014-03-12 DK DK14159102.4T patent/DK2777544T3/da active
- 2014-03-12 JP JP2014048669A patent/JP6388775B2/ja active Active
- 2014-03-12 EP EP14159102.4A patent/EP2777544B1/en active Active
- 2014-03-13 CN CN201410092514.4A patent/CN104042356B/zh active Active
- 2014-03-13 BR BRBR102014005930-0A patent/BR102014005930A2/pt active Search and Examination
-
2018
- 2018-03-15 JP JP2018047591A patent/JP6657281B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140112409A (ko) | 2014-09-23 |
| JP2014176659A (ja) | 2014-09-25 |
| AU2014201229A1 (en) | 2014-10-02 |
| EP2777544A3 (en) | 2015-03-18 |
| EP2777544A2 (en) | 2014-09-17 |
| AU2014201229B2 (en) | 2018-11-08 |
| BR102014005930A2 (pt) | 2014-12-30 |
| JP6657281B2 (ja) | 2020-03-04 |
| CN104042356A (zh) | 2014-09-17 |
| EP2777544B1 (en) | 2019-04-24 |
| CN104042356B (zh) | 2018-03-09 |
| JP2018110910A (ja) | 2018-07-19 |
| KR102232440B1 (ko) | 2021-03-26 |
| IN2014DE00518A (enExample) | 2015-06-12 |
| JP6388775B2 (ja) | 2018-09-12 |
| DK2777544T3 (da) | 2019-07-08 |
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| Publication | Publication Date | Title |
|---|---|---|
| CA2773163C (en) | Modifiable occlusion device | |
| US20130204288A1 (en) | Modifiable occlusion device | |
| JP6657281B2 (ja) | 改善された変化可能な閉塞装置 | |
| US8357180B2 (en) | Thin film metallic device for plugging aneurysms or vessels | |
| EP2777640B1 (en) | Variable porosity intravascular implant and manufacturing method | |
| AU2014201043B2 (en) | Method of fabricating modifiable occlusion device | |
| JP2018536505A (ja) | インプラント | |
| US20130190805A1 (en) | Method of fabricating modifiable occlusion device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190308 |
|
| FZDE | Discontinued |
Effective date: 20221024 |