CA2841757A1 - Modulateurs de gpr 119 - Google Patents

Modulateurs de gpr 119 Download PDF

Info

Publication number
CA2841757A1
CA2841757A1 CA2841757A CA2841757A CA2841757A1 CA 2841757 A1 CA2841757 A1 CA 2841757A1 CA 2841757 A CA2841757 A CA 2841757A CA 2841757 A CA2841757 A CA 2841757A CA 2841757 A1 CA2841757 A1 CA 2841757A1
Authority
CA
Canada
Prior art keywords
diabetes
disease
oxy
carboxylate
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2841757A
Other languages
English (en)
Inventor
Etzer Darout
Cristiano GUIMARAES
Vincent Mascitti
Kim F. Mcclure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2841757A1 publication Critical patent/CA2841757A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2841757A 2011-07-15 2012-07-03 Modulateurs de gpr 119 Abandoned CA2841757A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508250P 2011-07-15 2011-07-15
US61/508,250 2011-07-15
PCT/IB2012/053381 WO2013011402A1 (fr) 2011-07-15 2012-07-03 Modulateurs de gpr 119

Publications (1)

Publication Number Publication Date
CA2841757A1 true CA2841757A1 (fr) 2013-01-24

Family

ID=46579270

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2841757A Abandoned CA2841757A1 (fr) 2011-07-15 2012-07-03 Modulateurs de gpr 119

Country Status (4)

Country Link
EP (1) EP2731944A1 (fr)
JP (1) JP2014520879A (fr)
CA (1) CA2841757A1 (fr)
WO (1) WO2013011402A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
AR091739A1 (es) 2012-07-11 2015-02-25 Elcelyx Therapeutics Inc Composiciones y metodos para reducir el riesgo cardiometabolico
EP2968298B1 (fr) 2013-03-14 2018-01-31 Deuterx, LLC 2,4-thiazolidinediones enrichies en deutérium et méthodes de traitement
CA2934010A1 (fr) 2013-12-20 2015-06-25 Pfizer Limited Inhibiteurs de kinase apparentes a la n-acylpiperidine ether tropomyosine
EP3094328B1 (fr) 2014-01-15 2020-08-19 Poxel SA Méthodes de traitement de troubles neurologiques, métaboliques et autres à l'aide de pioglitazone énantiopure enrichie en deutérium
WO2016153949A1 (fr) * 2015-03-20 2016-09-29 Deuterx, Llc Composés 5-deutéro-thiazolidine-2,4-dione et procédés de traitement de troubles médicaux les utilisant
EP3509588B1 (fr) 2016-09-12 2023-06-07 Integral Health,Inc. Composés bicycliques utiles en tant que modulateurs du gpr120
WO2018049324A1 (fr) * 2016-09-12 2018-03-15 Numerate, Inc. Composés monocycliques utiles comme modulateurs de gpr120
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
CN115385849B (zh) * 2022-09-14 2024-01-26 南通瑞合达医药科技有限公司 一种N-Boc-3-氟-4-哌啶酮提纯的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03007785A (es) 2001-02-28 2003-12-08 Merck & Co Inc Derivados de piperidina acilados como agonistas del receptor de melanocortina 4.
EA200400980A1 (ru) 2002-02-27 2005-02-24 Пфайзер Продактс Инк. Ингибиторы асс
PT1753748E (pt) 2004-05-12 2009-08-28 Pfizer Prod Inc Derivados de prolina e a sua utilização como inibidores de dipeptidil peptidase iv
AU2005247693A1 (en) 2004-05-25 2005-12-08 Pfizer Products Inc. Tetraazabenzo[E]azulene derivatives and analogs thereof
UA92150C2 (ru) 2004-06-04 2010-10-11 Арена Фармасьютикалз, Инк. Замещенные производные арила и гетероарила как модуляторы метаболизма и для профилактики и лечения связанных с ним расстройств
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
EP2463283B1 (fr) 2006-04-20 2014-06-11 Pfizer Products Inc. Composés phényle amido-hétérocycliques fusionnés pour la prévention et le traitement de maladies à médiation par glucokinase
JP2010511035A (ja) 2006-11-29 2010-04-08 ファイザー・プロダクツ・インク スピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
JP2011513233A (ja) 2008-02-22 2011-04-28 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｇｐｒ１１９活性モジュレーターとしての化合物および組成物
EP2297164A1 (fr) 2008-05-28 2011-03-23 Pfizer Inc. Inhibiteurs de la pyrazolospirocétone acétyl-coa carboxylase
ES2545231T3 (es) 2008-05-28 2015-09-09 Pfizer Inc. Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa
CA2729581A1 (fr) 2008-07-29 2010-02-04 Pfizer Inc. Heteroaryles fluores
RS52236B (en) 2008-08-28 2012-10-31 Pfizer Inc. DIOKASA-BICYCLE DERIVATIVES (3.2.1) OCTOBER-2,3,4-TRIOLA
TW201038580A (en) 2009-02-02 2010-11-01 Pfizer 4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl derivatives
WO2010103438A1 (fr) 2009-03-11 2010-09-16 Pfizer Inc. Indazole amides substitués
AU2010222589B2 (en) 2009-03-11 2012-08-16 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
WO2010106457A2 (fr) 2009-03-20 2010-09-23 Pfizer Inc. 3-oxa-7-azabicyclo[3,3.1]nonanes
WO2010128425A1 (fr) 2009-05-08 2010-11-11 Pfizer Inc. Modulateurs de gpr119
EP2427448A1 (fr) 2009-05-08 2012-03-14 Pfizer Inc. Modulateurs du gpr119
CN102459222B (zh) 2009-06-05 2014-06-04 辉瑞大药厂 用作gpr119 调节剂的l-(哌啶-4-基)-吡唑衍生物
WO2011005611A1 (fr) 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Agonistes du récepteur de la neuromédine u et leurs utilisations

Also Published As

Publication number Publication date
EP2731944A1 (fr) 2014-05-21
WO2013011402A1 (fr) 2013-01-24
JP2014520879A (ja) 2014-08-25

Similar Documents

Publication Publication Date Title
US20120095028A1 (en) 3-oxa-7-azabicyclo[3.3.1]nonanes
CA2841757A1 (fr) Modulateurs de gpr 119
US10662171B2 (en) Antidiabetic bicyclic compounds
CA2764021C (fr) Modulateurs du gpr 119
US20120052130A1 (en) Gpr 119 modulators
CA2759843A1 (fr) Modulateurs de gpr119
EP3055300B1 (fr) Antagonistes de récepteur ep3 de prostaglandine
US20100285145A1 (en) Gpr 119 modulators
TWI433843B (zh) Ｇｐｒ１１９調節子
US20120295845A1 (en) Imidazo-pyrazoles as gpr119 inhibitors
US20130072427A1 (en) Gpr 119 modulators

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140103

FZDE Dead

Effective date: 20160610