WO2013011402A1 - Modulateurs de gpr 119 - Google Patents

Modulateurs de gpr 119 Download PDF

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Publication number
WO2013011402A1
WO2013011402A1 PCT/IB2012/053381 IB2012053381W WO2013011402A1 WO 2013011402 A1 WO2013011402 A1 WO 2013011402A1 IB 2012053381 W IB2012053381 W IB 2012053381W WO 2013011402 A1 WO2013011402 A1 WO 2013011402A1
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
oxy
disease
carboxylate
composition
Prior art date
Application number
PCT/IB2012/053381
Other languages
English (en)
Inventor
Etzer Darout
Cristiano GUIMARAES
Vincent Mascitti
Kim F. Mcclure
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Priority to EP12738619.1A priority Critical patent/EP2731944A1/fr
Priority to JP2014520751A priority patent/JP2014520879A/ja
Priority to CA2841757A priority patent/CA2841757A1/fr
Publication of WO2013011402A1 publication Critical patent/WO2013011402A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • Such acids are for example, acetic, glycolic, lactic, pyruvic, malonic, succinic, glutaric, fumaric, malic, tartaric, citric, ascorbic, maleic, hydroxymaleic, benzoic, hydroxy-benzoic, phenylacetic, cinnamic, salicylic, 2-phenoxybenzoic, p-toluenesulfonic acid, and sulfonic acids such as methane sulfonic acid and 2-hydroxyethane sulfonic acid.
  • Such salts can exist in either a hydrated or substantially anhydrous form. In general, the acid addition salts of these compounds are soluble in water and various hydrophilic organic solvents.
  • the composition further includes at least one additional pharmaceutical agent selected from the group consisting of an anti-obesity agent and an anti-diabetic agent.
  • Example anti-obesity agents include dirlotapide, mitratapide, implitapide, R56918 (CAS No. 403987), CAS No. 913541-47-6, lorcaserin, cetilistat, PYY3-36, naltrexone, oleoyl-estrone, obinepitide, pramlintide, tesofensine, leptin, liraglutide, bromocriptine, orlistat, exenatide, AOD-9604 (CAS No.
  • the compounds may be used to treat neurological disorders such as Alzheimer's disease, schizophrenia, and impaired cognition.
  • the compounds will also be beneficial in gastrointestinal illnesses such as inflammatory bowel disease, ulcerative colitis, Crohn's disease, irritable bowel syndrome, etc.
  • the compounds may also be used to stimulate weight loss in obese patients, especially those afflicted with diabetes.
  • the present invention further provides a method for preventing or ameliorating the symptoms of any of the diseases or disorders described above in a subject in need thereof, which method comprises administering to a subject a therapeutically effective amount of a compound of the present invention.
  • Further aspects of the invention include the preparation of medicaments for the treating diabetes and its related co-morbidities.
  • the compounds need to be administered in a quantity sufficient to modulate activation of the G-protein- coupled receptor GPR1 19. This amount can vary depending upon the particular disease/condition being treated, the severity of the patient's disease/condition, the patient, the particular compound being administered, the route of administration, and the presence of other underlying disease states within the patient, etc.
  • the compounds When administered systemically, the compounds typically exhibit their effect at a dosage range of from about 0.1 mg/kg/day to about 100 mg/kg/day for any of the diseases or conditions listed above. Repetitive daily administration may be desirable and will vary according to the conditions outlined above.
  • a 1 L flask was charged with titanium methoxide (100 g), cyclohexanol (232 g), and toluene (461 ml_). The flask was equipped with a Dean-Stark trap and condenser. The mixture was heated at 140 degrees Celsius until the methanol was removed. The toluene was removed at 180 degrees Celsius. More toluene was added and this process was repeated twice. After all the toluene was removed the flask was dried under high vacuum. Diethyl ether (580 mL) was added to the flask to prepare a 1 M solution in diethyl ether.
  • the aqueous layer was extracted twice with ethyl acetate, and all the organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate and brine and then dried over magnesium sulfate. The mixture was filtered, and the filtrate was

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des composés qui modulent l'activité du récepteur couplé à la protéine G GPR119 et leurs utilisations dans le traitement de maladies liées à la modulation du récepteur couplé à la protéine G GPR119 chez des animaux.
PCT/IB2012/053381 2011-07-15 2012-07-03 Modulateurs de gpr 119 WO2013011402A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP12738619.1A EP2731944A1 (fr) 2011-07-15 2012-07-03 Modulateurs de gpr 119
JP2014520751A JP2014520879A (ja) 2011-07-15 2012-07-03 Ｇｐｒ１１９調節因子
CA2841757A CA2841757A1 (fr) 2011-07-15 2012-07-03 Modulateurs de gpr 119

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161508250P 2011-07-15 2011-07-15
US61/508,250 2011-07-15

Publications (1)

Publication Number Publication Date
WO2013011402A1 true WO2013011402A1 (fr) 2013-01-24

Family

ID=46579270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/053381 WO2013011402A1 (fr) 2011-07-15 2012-07-03 Modulateurs de gpr 119

Country Status (4)

Country Link
EP (1) EP2731944A1 (fr)
JP (1) JP2014520879A (fr)
CA (1) CA2841757A1 (fr)
WO (1) WO2013011402A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014011926A1 (fr) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comportant des statines, des biguanides et d'autres agents pour réduire un risque cardiométabolique
WO2015092610A1 (fr) 2013-12-20 2015-06-25 Pfizer Limited Inhibiteurs de kinase apparentés à la n-acylpipéridine éther tropomyosine
WO2016153949A1 (fr) * 2015-03-20 2016-09-29 Deuterx, Llc Composés 5-deutéro-thiazolidine-2,4-dione et procédés de traitement de troubles médicaux les utilisant
US9833445B2 (en) 2013-03-14 2017-12-05 Deuterx, Llc 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
WO2018049324A1 (fr) * 2016-09-12 2018-03-15 Numerate, Inc. Composés monocycliques utiles comme modulateurs de gpr120
US10188639B2 (en) 2014-01-15 2019-01-29 Deuterx, Llc Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
US10576071B2 (en) 2007-09-26 2020-03-03 Poxel Sa Deuterium-enriched pioglitazone
US10865201B2 (en) 2016-09-12 2020-12-15 Valo Health, Inc. Bicyclic compounds useful as GPR120 modulators
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
CN115385849A (zh) * 2022-09-14 2022-11-25 南通瑞合达医药科技有限公司 一种N-Boc-3-氟-4-哌啶酮提纯的方法
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone

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WO2011005611A1 (fr) 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Agonistes du récepteur de la neuromédine u et leurs utilisations

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10940143B2 (en) 2007-09-26 2021-03-09 Poxel Sa Deuterium-enriched pioglitazone
US11918567B2 (en) 2007-09-26 2024-03-05 Poxel Sa Deuterium-enriched pioglitazone
US10576071B2 (en) 2007-09-26 2020-03-03 Poxel Sa Deuterium-enriched pioglitazone
WO2014011926A1 (fr) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comportant des statines, des biguanides et d'autres agents pour réduire un risque cardiométabolique
US11918569B2 (en) 2013-03-14 2024-03-05 Poxel Sa 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
US9833445B2 (en) 2013-03-14 2017-12-05 Deuterx, Llc 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
US10265305B2 (en) 2013-03-14 2019-04-23 Poxel Sa 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
US11123336B2 (en) 2013-03-14 2021-09-21 Poxel Sa 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
WO2015092610A1 (fr) 2013-12-20 2015-06-25 Pfizer Limited Inhibiteurs de kinase apparentés à la n-acylpipéridine éther tropomyosine
US10188639B2 (en) 2014-01-15 2019-01-29 Deuterx, Llc Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
US11141411B2 (en) 2014-01-15 2021-10-12 Poxel Sa Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
WO2016153949A1 (fr) * 2015-03-20 2016-09-29 Deuterx, Llc Composés 5-deutéro-thiazolidine-2,4-dione et procédés de traitement de troubles médicaux les utilisant
US10865201B2 (en) 2016-09-12 2020-12-15 Valo Health, Inc. Bicyclic compounds useful as GPR120 modulators
US10800773B2 (en) 2016-09-12 2020-10-13 Integral Health, Inc. Monocyclic compounds useful as GPR120 modulators
US11548886B2 (en) 2016-09-12 2023-01-10 Valo Health, Inc. Monocyclic compounds useful as GPR120 modulators
US11919891B2 (en) 2016-09-12 2024-03-05 Valo Health, Inc. Bicyclic compounds useful as GPR120 modulators
WO2018049324A1 (fr) * 2016-09-12 2018-03-15 Numerate, Inc. Composés monocycliques utiles comme modulateurs de gpr120
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
CN115385849A (zh) * 2022-09-14 2022-11-25 南通瑞合达医药科技有限公司 一种N-Boc-3-氟-4-哌啶酮提纯的方法
CN115385849B (zh) * 2022-09-14 2024-01-26 南通瑞合达医药科技有限公司 一种N-Boc-3-氟-4-哌啶酮提纯的方法

Also Published As

Publication number Publication date
CA2841757A1 (fr) 2013-01-24
EP2731944A1 (fr) 2014-05-21
JP2014520879A (ja) 2014-08-25

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