CA2840192A1 - Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof - Google Patents
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof Download PDFInfo
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| PCT/US2012/044096 WO2012178215A1 (en) | 2011-06-23 | 2012-06-25 | Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof |
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| WO (1) | WO2012178215A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113913366A (zh) * | 2013-02-18 | 2022-01-11 | 大学健康网络 | 由多能干细胞生成肝细胞和胆管细胞的方法 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| WO2016061464A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intetine using pluripotent stem cells and methods of making and using same |
| US10627415B2 (en) | 2015-03-12 | 2020-04-21 | Board Of Trustees Of Michigan State University | Compositions and methods for diagnosing, monitoring, and treating an autoimmune disease |
| WO2017192997A1 (en) * | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| CN107099499B (zh) * | 2016-06-03 | 2021-02-02 | 中国人民解放军军事医学科学院野战输血研究所 | 将消化道来源上皮细胞重编程为内胚层干/祖细胞的小分子化合物组合、重编程试剂盒 |
| NZ753051A (en) | 2016-11-04 | 2023-03-31 | Children’S Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| KR102807995B1 (ko) | 2016-12-05 | 2025-05-16 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
| US11530388B2 (en) * | 2017-02-14 | 2022-12-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| EP3694603A4 (en) * | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| IL277806B2 (en) * | 2018-04-23 | 2025-02-01 | Univ Kyoto | Growth inhibitor |
| SG11202100533VA (en) | 2018-07-26 | 2021-02-25 | Childrens Hospital Med Ct | Hepato-biliary-pancreatic tissues and methods of making same |
| SG11202102431YA (en) | 2018-09-12 | 2021-04-29 | Childrens Hospital Med Ct | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| CN111394297A (zh) * | 2018-12-17 | 2020-07-10 | 中国科学院分子细胞科学卓越创新中心 | 内胚层干细胞规模化制备功能性肝母细胞与肝实质细胞的方法及其应用 |
| WO2020227711A1 (en) | 2019-05-09 | 2020-11-12 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of hepatocytes |
| CA3141807A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| EP3980527A4 (en) * | 2019-06-04 | 2023-09-27 | University Health Network | Methods of making and using liver cells |
| CN113265373A (zh) * | 2021-07-19 | 2021-08-17 | 北京明诚创新医学研究院有限责任公司 | 一种人多能干细胞分化为肝祖细胞的培养基、方法及其应用 |
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| SE9700983D0 (sv) * | 1997-03-18 | 1997-03-18 | Ascendia Ab | Stimulering, odling och preservation av pankreas- och andra celler |
| US20060003446A1 (en) * | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2007027156A1 (en) * | 2005-09-02 | 2007-03-08 | Agency For Science, Technology And Research | Method of deriving mesenchymal stem cells |
| JP2009511061A (ja) * | 2005-10-14 | 2009-03-19 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 膵臓表現型を有する細胞への非胚性幹細胞の分化 |
| WO2007127454A2 (en) * | 2006-04-28 | 2007-11-08 | Cythera, Inc. | Hepatocyte lineage cells |
| WO2007143193A1 (en) | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
| US9029147B2 (en) * | 2007-06-15 | 2015-05-12 | Massachusetts Institute Of Technology | Methods and compositions for enhanced differentiation from embryonic stem cells |
| JP5738591B2 (ja) * | 2007-07-18 | 2015-06-24 | ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． | ヒト胚幹細胞の分化 |
| US20100190202A1 (en) * | 2007-07-20 | 2010-07-29 | Cellartis Ab | Novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts stem cells |
| US20090280096A1 (en) * | 2008-05-09 | 2009-11-12 | Atsushi Kubo | Pancreatic endocrine progenitor cells derived from pluripotent stem cells |
| WO2010127367A2 (en) * | 2009-05-01 | 2010-11-04 | Alfagene Bioscience, Inc. | Human gastrointestinal stem cell-derived primary intestinal epithelial cell system and methods of use thereof |
| US9388381B2 (en) | 2009-07-09 | 2016-07-12 | Massachusetts Institute Of Technology | Methods and compositions for increased safety of stem cell-derived populations |
| KR20190065476A (ko) * | 2009-10-30 | 2019-06-11 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 간외 담도계로부터의 다분화능 줄기 세포 및 이의 분리 방법 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113913366A (zh) * | 2013-02-18 | 2022-01-11 | 大学健康网络 | 由多能干细胞生成肝细胞和胆管细胞的方法 |
| CN113913366B (zh) * | 2013-02-18 | 2025-01-10 | 大学健康网络 | 由多能干细胞生成肝细胞和胆管细胞的方法 |
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| Publication number | Publication date |
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| WO2012178215A1 (en) | 2012-12-27 |
| US9476030B2 (en) | 2016-10-25 |
| EP2723851A1 (en) | 2014-04-30 |
| AU2012272586A1 (en) | 2014-01-16 |
| AU2012272586B2 (en) | 2016-07-07 |
| JP2014519854A (ja) | 2014-08-21 |
| EP2723851A4 (en) | 2015-05-20 |
| US20140141509A1 (en) | 2014-05-22 |
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