CA2838817A1 - Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium - Google Patents

Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium Download PDF

Info

Publication number
CA2838817A1
CA2838817A1 CA2838817A CA2838817A CA2838817A1 CA 2838817 A1 CA2838817 A1 CA 2838817A1 CA 2838817 A CA2838817 A CA 2838817A CA 2838817 A CA2838817 A CA 2838817A CA 2838817 A1 CA2838817 A1 CA 2838817A1
Authority
CA
Canada
Prior art keywords
nanoparticles
vaccine composition
boehmite
polyacrylate
pseudo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2838817A
Other languages
English (en)
French (fr)
Inventor
Yannick Mathieu
Benedicte Lebeau
Valentin Valtchev
Joel Patarin
Marie GARINOT
Jean Haensler
Elisabeth Sauzeat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Sanofi Pasteur SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur SA filed Critical Sanofi Pasteur SA
Publication of CA2838817A1 publication Critical patent/CA2838817A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2838817A 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium Abandoned CA2838817A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1156398A FR2977800B1 (fr) 2011-07-13 2011-07-13 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
FR1156398 2011-07-13
PCT/FR2012/051648 WO2013007956A1 (fr) 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium

Publications (1)

Publication Number Publication Date
CA2838817A1 true CA2838817A1 (fr) 2013-01-17

Family

ID=46639612

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2838817A Abandoned CA2838817A1 (fr) 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium

Country Status (9)

Country Link
US (1) US9770505B2 (enExample)
EP (1) EP2731622B1 (enExample)
JP (1) JP6111245B2 (enExample)
CN (1) CN103826658A (enExample)
CA (1) CA2838817A1 (enExample)
ES (1) ES2650740T3 (enExample)
FR (1) FR2977800B1 (enExample)
NO (1) NO2731622T3 (enExample)
WO (1) WO2013007956A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107496915B (zh) * 2015-01-23 2025-02-25 四川大学 一种基于氢氧化铝纳米粒的疫苗载体
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106421775B (zh) * 2015-08-12 2020-12-01 普莱柯生物工程股份有限公司 一种疫苗用佐剂及含该佐剂的疫苗组合物和其应用
WO2017053594A1 (en) * 2015-09-23 2017-03-30 The Regents Of The University Of California Compositions and methods of using the same for decontamination of skin
CN107041952B (zh) * 2016-02-05 2020-11-10 中国人民解放军军事医学科学院微生物流行病研究所 表面修饰有氧化铝的疫苗及其制备方法和疫苗组合物
EP3463300A1 (en) * 2016-06-01 2019-04-10 Infectious Disease Research Institute Nanoalum particles containing a sizing agent
CN113666404B (zh) * 2021-09-23 2023-07-28 北京智飞绿竹生物制药有限公司 一种适合规模化生产的高浓度纳米级氢氧化铝佐剂配制方法
CN118846101A (zh) * 2022-02-18 2024-10-29 广州瑞贝斯药业有限公司 一种铝纳米晶复合免疫药物及其制备方法和应用
GB202215072D0 (en) * 2022-10-13 2022-11-30 Glaxosmithkline Biologicals Sa Process for production of aluminium hydroxide particles
CN115944723A (zh) * 2022-12-22 2023-04-11 中国人民解放军陆军军医大学 基于纳米铝盐与纳米乳的复合物在制备疫苗佐剂中的应用及其产品

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4836948A (en) * 1987-12-30 1989-06-06 Lever Brothers Company Viscoelastic gel detergent compositions
DE69332031T2 (de) * 1993-01-08 2002-12-19 Csl Ltd., Parkville Impfstoffpräparate
ES2284287T3 (es) * 1998-10-16 2007-11-01 Glaxosmithkline Biologicals S.A. Sistemas adyuvantes y vacunas.
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
CN101325967A (zh) * 2005-11-04 2008-12-17 诺华疫苗和诊断有限公司 水包油乳液佐剂含量降低的流感疫苗
ES2377884T3 (es) * 2005-11-04 2012-04-02 Novartis Vaccines And Diagnostics S.R.L. Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores
JP5650406B2 (ja) * 2007-03-07 2015-01-07 ユーティーアイ リミテッド パートナーシップ 自己免疫状態の予防および治療のための組成物および方法
JP2010534622A (ja) * 2007-07-26 2010-11-11 サノフィ パストゥール リミテッド 抗原−アジュバント組成物および方法
EP2419129A2 (en) * 2009-04-14 2012-02-22 Novartis AG Compositions for immunising against staphylococcus aerus

Also Published As

Publication number Publication date
EP2731622A1 (fr) 2014-05-21
FR2977800A1 (fr) 2013-01-18
FR2977800B1 (fr) 2014-03-14
JP2014520836A (ja) 2014-08-25
WO2013007956A1 (fr) 2013-01-17
JP6111245B2 (ja) 2017-04-05
NO2731622T3 (enExample) 2018-03-10
US20140234422A1 (en) 2014-08-21
US9770505B2 (en) 2017-09-26
EP2731622B1 (fr) 2017-10-11
ES2650740T3 (es) 2018-01-22
CN103826658A (zh) 2014-05-28

Similar Documents

Publication Publication Date Title
EP2731622B1 (fr) Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
CN101287491B (zh) 由使用纳米结构的中孔二氧化硅包囊的疫苗抗原形成的免疫原性复合物
Gregory et al. Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity
Camacho et al. Mucosal immunization with Shigella flexneri outer membrane vesicles induced protection in mice
JP2018008964A (ja) Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用
US10245319B2 (en) Lymph node-targeting nanoparticles
EP2763695A1 (en) Adjuvanted formulations of staphylococcus aureus antigens
EP1753411A2 (en) Methods of manufacture and use of calcium phosphate particles containing allergens
BE1022857A1 (fr) Immunisation contre staphylococcus aureus
Yu et al. The pH-responsive zeolitic imidazolate framework nanoparticle as a promising immune-enhancing adjuvant for anti-caries vaccine
Martin-Bertelsen et al. Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: supramolecular structure and adjuvant efficacy
CN106572978A (zh) 涂覆方法和材料
FR2985430A1 (fr) Composition vaccinale comprenant des nanoparticules hybrides d'aluminium et de copolymere hydrosoluble
WO2012038801A1 (en) A spray dried powder formulation for vaccines entrapping alum and the antigen in biodegradable polymer particles
Salomon Polysaccharide based nanocarriers for the delivery of antigens
이혜선 Development of adjuvants using cytokine and polymeric particles for efficient mucosal immunization
Li Vaccine formulation development: towards addressing major limitations of vaccines that are adjuvanted with aluminum salts
Sharma Development and evaluation of novel biodegradable nanoparticles for vaccine delivery
Liao et al. Carbopol Dispersed U@ PAA with High Colloidal Stability as a Combination Nano-Adjuvant Boosts Immune Responses and Protection Against Pseudorabies Virus in Mice and Pigs
HK1124791B (en) Immunogenic complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica
BRPI0503817B1 (pt) Immunogenic complex formed by vacinal antigens encapsulated by nanoestrutured mesophorus soil

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20200831