FR2977800B1 - Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium - Google Patents

Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium

Info

Publication number
FR2977800B1
FR2977800B1 FR1156398A FR1156398A FR2977800B1 FR 2977800 B1 FR2977800 B1 FR 2977800B1 FR 1156398 A FR1156398 A FR 1156398A FR 1156398 A FR1156398 A FR 1156398A FR 2977800 B1 FR2977800 B1 FR 2977800B1
Authority
FR
France
Prior art keywords
aluminum hydroxide
vaccine composition
hydroxide nanoparticles
nanoparticles
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1156398A
Other languages
English (en)
French (fr)
Other versions
FR2977800A1 (fr
Inventor
Yannick Mathieu
Benedicte Lebeau
Valentin Valtech
Joel Patarin
Marie Garinot
Jean Haensler
Elisabeth Sauzeat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Inc
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1156398A priority Critical patent/FR2977800B1/fr
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Priority to ES12744086.5T priority patent/ES2650740T3/es
Priority to EP12744086.5A priority patent/EP2731622B1/fr
Priority to US14/131,616 priority patent/US9770505B2/en
Priority to PCT/FR2012/051648 priority patent/WO2013007956A1/fr
Priority to NO12744086A priority patent/NO2731622T3/no
Priority to JP2014519611A priority patent/JP6111245B2/ja
Priority to CA2838817A priority patent/CA2838817A1/fr
Priority to CN201280034602.8A priority patent/CN103826658A/zh
Publication of FR2977800A1 publication Critical patent/FR2977800A1/fr
Application granted granted Critical
Publication of FR2977800B1 publication Critical patent/FR2977800B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FR1156398A 2011-07-13 2011-07-13 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium Expired - Fee Related FR2977800B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR1156398A FR2977800B1 (fr) 2011-07-13 2011-07-13 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
EP12744086.5A EP2731622B1 (fr) 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
US14/131,616 US9770505B2 (en) 2011-07-13 2012-07-12 Vaccine composition with aluminium hydroxide nanoparticles
PCT/FR2012/051648 WO2013007956A1 (fr) 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
ES12744086.5T ES2650740T3 (es) 2011-07-13 2012-07-12 Composición de vacuna con unas nanopartículas de hidróxido de aluminio
NO12744086A NO2731622T3 (enExample) 2011-07-13 2012-07-12
JP2014519611A JP6111245B2 (ja) 2011-07-13 2012-07-12 水酸化アルミニウムナノ粒子を含むワクチン組成物
CA2838817A CA2838817A1 (fr) 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
CN201280034602.8A CN103826658A (zh) 2011-07-13 2012-07-12 具有氢氧化铝纳米颗粒的疫苗组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1156398A FR2977800B1 (fr) 2011-07-13 2011-07-13 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium

Publications (2)

Publication Number Publication Date
FR2977800A1 FR2977800A1 (fr) 2013-01-18
FR2977800B1 true FR2977800B1 (fr) 2014-03-14

Family

ID=46639612

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1156398A Expired - Fee Related FR2977800B1 (fr) 2011-07-13 2011-07-13 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium

Country Status (9)

Country Link
US (1) US9770505B2 (enExample)
EP (1) EP2731622B1 (enExample)
JP (1) JP6111245B2 (enExample)
CN (1) CN103826658A (enExample)
CA (1) CA2838817A1 (enExample)
ES (1) ES2650740T3 (enExample)
FR (1) FR2977800B1 (enExample)
NO (1) NO2731622T3 (enExample)
WO (1) WO2013007956A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107496915B (zh) * 2015-01-23 2025-02-25 四川大学 一种基于氢氧化铝纳米粒的疫苗载体
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106421775B (zh) * 2015-08-12 2020-12-01 普莱柯生物工程股份有限公司 一种疫苗用佐剂及含该佐剂的疫苗组合物和其应用
WO2017053594A1 (en) * 2015-09-23 2017-03-30 The Regents Of The University Of California Compositions and methods of using the same for decontamination of skin
CN107041952B (zh) * 2016-02-05 2020-11-10 中国人民解放军军事医学科学院微生物流行病研究所 表面修饰有氧化铝的疫苗及其制备方法和疫苗组合物
CA3023271A1 (en) * 2016-06-01 2017-12-07 Infectious Disease Research Institute Nanoalum particles containing a sizing agent
CN113666404B (zh) * 2021-09-23 2023-07-28 北京智飞绿竹生物制药有限公司 一种适合规模化生产的高浓度纳米级氢氧化铝佐剂配制方法
CN118846101A (zh) * 2022-02-18 2024-10-29 广州瑞贝斯药业有限公司 一种铝纳米晶复合免疫药物及其制备方法和应用
GB202215072D0 (en) * 2022-10-13 2022-11-30 Glaxosmithkline Biologicals Sa Process for production of aluminium hydroxide particles
CN115944723A (zh) * 2022-12-22 2023-04-11 中国人民解放军陆军军医大学 基于纳米铝盐与纳米乳的复合物在制备疫苗佐剂中的应用及其产品

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4836948A (en) * 1987-12-30 1989-06-06 Lever Brothers Company Viscoelastic gel detergent compositions
DE69332031T2 (de) * 1993-01-08 2002-12-19 Csl Ltd., Parkville Impfstoffpräparate
CA2773698C (en) * 1998-10-16 2015-05-19 Glaxosmithkline Biologicals S.A. Adjuvant systems comprising an immunostimulant adsorbed to a metallic salt particle and vaccines thereof
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
ES2377884T3 (es) * 2005-11-04 2012-04-02 Novartis Vaccines And Diagnostics S.R.L. Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores
ES2367194T3 (es) * 2005-11-04 2011-10-31 Novartis Vaccines And Diagnostics S.R.L. Cambio del equilibrio th1/th2 en vacunas contra la gripe fraccionadas con adyuvantes.
DK2131856T3 (da) * 2007-03-07 2014-12-15 Uti Limited Partnership Sammensætninger og fremgangsmåder til forebyggelsen og behandlingen af autoimmune tilstande
CN101801343A (zh) * 2007-07-26 2010-08-11 圣诺菲·帕斯图尔有限公司 抗原佐剂组合物及其方法
CA3154626A1 (en) * 2009-04-14 2010-10-21 Glaxosmithkline Biologicals S.A. Compositions for immunising against staphylococcus aureus

Also Published As

Publication number Publication date
FR2977800A1 (fr) 2013-01-18
JP6111245B2 (ja) 2017-04-05
EP2731622A1 (fr) 2014-05-21
NO2731622T3 (enExample) 2018-03-10
JP2014520836A (ja) 2014-08-25
US20140234422A1 (en) 2014-08-21
CA2838817A1 (fr) 2013-01-17
CN103826658A (zh) 2014-05-28
ES2650740T3 (es) 2018-01-22
WO2013007956A1 (fr) 2013-01-17
US9770505B2 (en) 2017-09-26
EP2731622B1 (fr) 2017-10-11

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