CA2835298C - Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene - Google Patents
Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene Download PDFInfo
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- CA2835298C CA2835298C CA2835298A CA2835298A CA2835298C CA 2835298 C CA2835298 C CA 2835298C CA 2835298 A CA2835298 A CA 2835298A CA 2835298 A CA2835298 A CA 2835298A CA 2835298 C CA2835298 C CA 2835298C
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- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 1
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
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- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
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- XRYCYKGEIYZQGE-UHFFFAOYSA-N tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate Chemical compound CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN XRYCYKGEIYZQGE-UHFFFAOYSA-N 0.000 description 1
- CKYOADUULAMWKP-UHFFFAOYSA-N tert-butyl n-[6-[(6-cyanopyridin-3-yl)amino]-6-oxohexyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCCCC(=O)NC1=CC=C(C#N)N=C1 CKYOADUULAMWKP-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0495—Pretargeting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nuclear Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11165267.3 | 2011-05-09 | ||
| EP11165267A EP2522369A1 (en) | 2011-05-09 | 2011-05-09 | Pretargeting kit, method and agents used therein |
| PCT/IB2012/052260 WO2012153254A1 (en) | 2011-05-09 | 2012-05-07 | Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2835298A1 CA2835298A1 (en) | 2012-11-15 |
| CA2835298C true CA2835298C (en) | 2019-06-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2835298A Active CA2835298C (en) | 2011-05-09 | 2012-05-07 | Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9913921B2 (enExample) |
| EP (2) | EP2522369A1 (enExample) |
| JP (1) | JP6223962B2 (enExample) |
| CN (1) | CN103648533B (enExample) |
| AU (1) | AU2012252024B2 (enExample) |
| CA (1) | CA2835298C (enExample) |
| WO (1) | WO2012153254A1 (enExample) |
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| DK2709667T3 (da) * | 2011-05-16 | 2022-07-04 | Tagworks Pharmaceuticals B V | Bio-orthogonal lægemiddelaktivering |
| EP2948186A4 (en) * | 2013-01-25 | 2016-10-05 | Sloan Kettering Inst Cancer | TETRAZINE / TRANSCYCLOOKTENE IN SOLID PHASE SYNTHESIS MARKED PEPTIDE |
| CN105611914B (zh) * | 2013-06-19 | 2020-09-08 | 加利福尼亚大学董事会 | 局部递送治疗剂的化学构造物 |
| CA2939265A1 (en) * | 2014-02-10 | 2015-08-13 | Mcmaster University | Targeted molecular imaging contrast agents |
| AU2015229014B2 (en) * | 2014-03-14 | 2019-07-25 | The Regents Of The University Of California | TCO conjugates and methods for delivery of therapeutic agents |
| WO2015154082A1 (en) * | 2014-04-04 | 2015-10-08 | President And Fellows Of Harvard College | Refillable drug delivery devices and methods of use thereof |
| WO2016025480A1 (en) | 2014-08-11 | 2016-02-18 | The General Hospital Corporation | Cyclooctenes for bioorthogonol reactions |
| WO2016164565A1 (en) * | 2015-04-08 | 2016-10-13 | University Of Delaware | Trans-cycloheptenes and hetero-trans-cycloheptenes for bioorthogonal coupling |
| US11135309B2 (en) | 2015-08-14 | 2021-10-05 | The Regents Of The University Of California | Poly(vinyl alcohol) nanocarriers |
| CN117567535A (zh) * | 2015-09-10 | 2024-02-20 | 坦伯公司 | 生物正交组合物 |
| US11690825B2 (en) | 2016-03-09 | 2023-07-04 | Board Of Regents, The University Of Texas System | 20-HETE receptor (GPR75) antagonists and methods of use |
| WO2018004338A1 (en) | 2016-06-27 | 2018-01-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| WO2018187740A1 (en) | 2017-04-07 | 2018-10-11 | Shasqi, Inc. | Bioorthogonal compositions |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| CN107746367B (zh) * | 2017-11-07 | 2020-05-26 | 清华大学 | β-石竹烯衍生物及其制备方法与应用 |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| EP3826673A4 (en) * | 2018-07-26 | 2022-03-09 | Tayu Huaxia Biotech Medical Group Co., Ltd. | COMPOSITIONS AND METHODS FOR IMAGING |
| US20200115389A1 (en) | 2018-09-18 | 2020-04-16 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
| CN113473975B (zh) | 2018-10-10 | 2025-01-21 | 坦博公司 | 制备官能化环辛烯的工艺 |
| IL289095A (en) | 2019-06-17 | 2022-02-01 | Tagworks Pharmaceuticals B V | Activating components to cleave labels from biomolecules in vivo |
| CN110954514B (zh) * | 2019-12-02 | 2022-06-21 | 上海交通大学 | 适用于研究脂质体体内外分布的荧光示踪系统和方法 |
| US20230310643A1 (en) | 2020-08-18 | 2023-10-05 | Rigshospitalet | Extracorporeal clearing traps based on inverse electron demand diels-alder cycloaddition for (pre)-targeted therapy and diagnostics |
| US20250135011A1 (en) * | 2021-12-08 | 2025-05-01 | European Molecular Biology Laboratory | Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates |
| WO2024172652A1 (en) * | 2023-02-15 | 2024-08-22 | Tagworks Pharmaceuticals B.V. | Tetrazines with improved properties |
| CN118546131B (zh) * | 2024-05-10 | 2025-02-28 | 四川大学华西医院 | 四嗪聚集诱导发光探针前体、探针及其制备方法、应用 |
| CN119746111A (zh) * | 2024-12-04 | 2025-04-04 | 苏州大学 | 一种体内放射性标记降低肝脏辐射剂量的试剂及其应用 |
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| US3143578A (en) * | 1962-12-28 | 1964-08-04 | Union Carbide Corp | Preparation of tricyclo [8.2.1.02.9] trideca-5, 11-diene |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US5326856A (en) | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US20030129191A1 (en) | 1992-12-23 | 2003-07-10 | Neorx Corporation | Pretargeting methods and compounds |
| WO2003047740A2 (en) * | 2001-12-05 | 2003-06-12 | California Institute Of Technology | ENANTIOSELECTIVE TRANSFORMATION OF α,β-UNSATURATED KETONES USING CHIRAL ORGANIC CATALYSTS |
| US8236949B2 (en) * | 2007-07-17 | 2012-08-07 | University Of Delaware | Tetrazine-based bio-orthogonal coupling reagents and methods |
| CN102271712B (zh) | 2008-10-31 | 2015-11-25 | 通用医疗公司 | 用于将物质递送至生物靶标的组合物和方法 |
| EP2419142B1 (en) * | 2009-04-16 | 2020-01-15 | Tagworks Pharmaceuticals B.V. | Pretargeting kit, method and agents used therein |
| CN102438656B (zh) | 2009-04-16 | 2014-11-12 | 皇家飞利浦电子股份有限公司 | 预靶向试剂盒、方法和其中使用的试剂 |
| EP2360167A1 (en) * | 2010-02-03 | 2011-08-24 | Deutsches Krebsforschungszentrum | Post-synthetic modification of nucleic acids by inverse Diels-Alder reaction |
| US10434197B2 (en) * | 2010-07-23 | 2019-10-08 | University Of Delaware | Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes |
| US9463256B2 (en) * | 2010-10-14 | 2016-10-11 | Koninklijke Philips N.V. | Pretargeting kit, method and agents used therein |
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- 2011-05-09 EP EP11165267A patent/EP2522369A1/en not_active Withdrawn
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2012
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Also Published As
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|---|---|
| US20140093450A1 (en) | 2014-04-03 |
| WO2012153254A1 (en) | 2012-11-15 |
| CN103648533B (zh) | 2017-09-08 |
| EP2707035A1 (en) | 2014-03-19 |
| JP6223962B2 (ja) | 2017-11-01 |
| AU2012252024B2 (en) | 2017-06-29 |
| AU2012252024A1 (en) | 2014-01-09 |
| CN103648533A (zh) | 2014-03-19 |
| US9913921B2 (en) | 2018-03-13 |
| CA2835298A1 (en) | 2012-11-15 |
| EP2707035B1 (en) | 2020-04-01 |
| JP2014518861A (ja) | 2014-08-07 |
| EP2522369A1 (en) | 2012-11-14 |
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