JP2014500307A5 - - Google Patents
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- Publication number
- JP2014500307A5 JP2014500307A5 JP2013545584A JP2013545584A JP2014500307A5 JP 2014500307 A5 JP2014500307 A5 JP 2014500307A5 JP 2013545584 A JP2013545584 A JP 2013545584A JP 2013545584 A JP2013545584 A JP 2013545584A JP 2014500307 A5 JP2014500307 A5 JP 2014500307A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- group
- independently
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(NC)N**N(C=N)N(C)* Chemical compound C*(NC)N**N(C=N)N(C)* 0.000 description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10196092.0 | 2010-12-21 | ||
| EP10196092 | 2010-12-21 | ||
| PCT/IB2011/055730 WO2012085789A1 (en) | 2010-12-21 | 2011-12-16 | Agents for clearing biomolecules from circulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500307A JP2014500307A (ja) | 2014-01-09 |
| JP2014500307A5 true JP2014500307A5 (enExample) | 2015-10-29 |
| JP5992435B2 JP5992435B2 (ja) | 2016-09-14 |
Family
ID=43530614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545584A Active JP5992435B2 (ja) | 2010-12-21 | 2011-12-16 | 循環からの生体分子の除去剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9427482B2 (enExample) |
| EP (1) | EP2654796A1 (enExample) |
| JP (1) | JP5992435B2 (enExample) |
| CN (1) | CN103328008B (enExample) |
| RU (1) | RU2013133813A (enExample) |
| WO (1) | WO2012085789A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6215194B2 (ja) * | 2011-05-16 | 2017-10-18 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 生体直交型薬物活性化 |
| WO2014081299A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Activatable liposomes |
| WO2014081301A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Bio-orthogonal drug activation |
| WO2014081300A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Channel protein activatable liposomes |
| DK2922574T3 (da) * | 2012-11-22 | 2023-08-21 | Tagworks Pharmaceuticals B V | Kemisk spaltbar gruppe |
| ES2966631T3 (es) | 2013-06-19 | 2024-04-23 | Univ California | Estructuras químicas para el suministro localizado de agentes terapéuticos |
| JP6625550B2 (ja) | 2014-03-14 | 2019-12-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Tco複合体および治療薬の送達のための方法 |
| WO2016025480A1 (en) | 2014-08-11 | 2016-02-18 | The General Hospital Corporation | Cyclooctenes for bioorthogonol reactions |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| ES2899906T3 (es) | 2015-07-06 | 2022-03-15 | Alkermes Inc | Inhibidores bicíclicos de histona desacetilasa |
| WO2017044983A1 (en) | 2015-09-10 | 2017-03-16 | Shasqi, Inc. | Bioorthogonal compositions |
| US11617799B2 (en) * | 2016-06-27 | 2023-04-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| US10222346B2 (en) * | 2017-01-09 | 2019-03-05 | National Research Council Of Canada | Decomposable S-tetrazine based polymers for single walled carbon nanotube applications |
| ES2875562T3 (es) | 2017-01-11 | 2021-11-10 | Alkermes Inc | Inhibidores bicíclicos de histona desacetilasa |
| ES2983582T3 (es) | 2017-04-07 | 2024-10-23 | Tambo Inc | Composiciones bioortogonales |
| AU2018297272B2 (en) | 2017-07-06 | 2022-10-27 | Memorial Sloan Kettering Cancer Center | DOTA-hapten compositions for anti-DOTA/anti-tumor antigen bispecific antibody pretargeted radioimmunotherapy |
| US11559494B2 (en) | 2017-07-14 | 2023-01-24 | The Penn State Research Foundation | Compositions and methods for targeted delivery of therapeutic and/or diagnostic species |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| CN112088169A (zh) | 2018-03-12 | 2020-12-15 | 纪念斯隆凯特琳癌症中心 | 双特异性结合剂及其用途 |
| AU2019344897B2 (en) | 2018-09-18 | 2024-01-18 | Nikang Therapeutics, Inc. | Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors |
| IL289095A (en) | 2019-06-17 | 2022-02-01 | Tagworks Pharmaceuticals B V | Activating components to cleave labels from biomolecules in vivo |
| EP4382129A3 (en) | 2019-06-17 | 2024-07-03 | Tagworks Pharmaceuticals B.V. | Compounds for fast and efficient click release |
| KR20250141267A (ko) * | 2023-02-15 | 2025-09-26 | 태그웍스 파마슈티컬스 비.브이. | 개선된 특성을 가지는 테트라진 |
| WO2025166289A1 (en) * | 2024-01-31 | 2025-08-07 | Oregon State University | Tunable tetrazine amino acids for encodable protein labeling |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6075010A (en) | 1992-06-09 | 2000-06-13 | Neorx Corporation | Small molecular weight ligand-hexose containing clearing agents |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US5326856A (en) | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US5616690A (en) | 1992-06-09 | 1997-04-01 | Neorx Corporation | Hexose derivatized human serum albumin clearing agents |
| US5624896A (en) | 1992-06-09 | 1997-04-29 | Neorx Corporation | Clearing agents useful in pretargeting methods |
| US20030129191A1 (en) | 1992-12-23 | 2003-07-10 | Neorx Corporation | Pretargeting methods and compounds |
| WO1995015978A1 (en) | 1993-12-07 | 1995-06-15 | Neorx Corporation | Pretargeting methods and compounds |
| DE69433343D1 (de) | 1993-12-07 | 2003-12-24 | Neorx Corp | Pretargeting verfahren und mitteln |
| US6172045B1 (en) | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
| US6908903B1 (en) | 1994-12-07 | 2005-06-21 | Aletheon Pharmaceuticals, Inc. | Cluster clearing agents |
| US5886143A (en) | 1994-12-07 | 1999-03-23 | Neorx Corporation | Hepatic-directed compounds and reagents for preparation thereof |
| WO1996040245A1 (en) | 1995-06-07 | 1996-12-19 | Immunomedics, Inc. | Improved delivery of diagnostic and therapeutic agents to a target site |
| US7052872B1 (en) | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
| EP1799273A2 (en) | 2004-10-07 | 2007-06-27 | Koninklijke Philips Electronics N.V. | Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy |
| CN101511389A (zh) | 2005-10-04 | 2009-08-19 | 皇家飞利浦电子股份有限公司 | 使用[3+2]叠氮化物-炔环加成的靶向成像和/或治疗 |
| EP2361098B1 (en) | 2008-10-31 | 2019-08-28 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
| EP2419141A1 (en) * | 2009-04-16 | 2012-02-22 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| US20120034161A1 (en) | 2009-04-16 | 2012-02-09 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| WO2012082773A1 (en) | 2010-12-13 | 2012-06-21 | Biomimetic Therapeutics, Inc. | Compositions and methods for spine fusion procedures |
-
2011
- 2011-12-16 RU RU2013133813/15A patent/RU2013133813A/ru not_active Application Discontinuation
- 2011-12-16 US US13/994,783 patent/US9427482B2/en active Active
- 2011-12-16 EP EP11807788.2A patent/EP2654796A1/en not_active Withdrawn
- 2011-12-16 WO PCT/IB2011/055730 patent/WO2012085789A1/en not_active Ceased
- 2011-12-16 JP JP2013545584A patent/JP5992435B2/ja active Active
- 2011-12-16 CN CN201180061889.9A patent/CN103328008B/zh active Active
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