CA2831465C - Procede et systeme pour eliminer l'oxygene et le dioxyde de carbone pendant le traitement d'erythrocytes en utilisant un gaz vecteur inerte et ensemble de collecteur - Google Patents
Procede et systeme pour eliminer l'oxygene et le dioxyde de carbone pendant le traitement d'erythrocytes en utilisant un gaz vecteur inerte et ensemble de collecteur Download PDFInfo
- Publication number
- CA2831465C CA2831465C CA2831465A CA2831465A CA2831465C CA 2831465 C CA2831465 C CA 2831465C CA 2831465 A CA2831465 A CA 2831465A CA 2831465 A CA2831465 A CA 2831465A CA 2831465 C CA2831465 C CA 2831465C
- Authority
- CA
- Canada
- Prior art keywords
- oxygen
- gas
- carbon dioxide
- rbcs
- sensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 title claims abstract description 188
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 131
- 239000001301 oxygen Substances 0.000 title claims abstract description 131
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 131
- 229910002092 carbon dioxide Inorganic materials 0.000 title claims abstract description 94
- 239000001569 carbon dioxide Substances 0.000 title claims abstract description 81
- 239000008280 blood Substances 0.000 title claims abstract description 54
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 238000012545 processing Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 37
- 239000012159 carrier gas Substances 0.000 title description 3
- 239000007789 gas Substances 0.000 claims abstract description 123
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 97
- 238000011010 flushing procedure Methods 0.000 claims abstract description 34
- 238000004891 communication Methods 0.000 claims abstract description 16
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 238000000429 assembly Methods 0.000 claims description 19
- 230000000712 assembly Effects 0.000 claims description 19
- 239000002594 sorbent Substances 0.000 claims description 16
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 15
- 239000000654 additive Substances 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 14
- 239000011261 inert gas Substances 0.000 description 13
- 239000003570 air Substances 0.000 description 12
- 239000012510 hollow fiber Substances 0.000 description 11
- 210000000265 leukocyte Anatomy 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 8
- 239000000835 fiber Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 239000008121 dextrose Substances 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000012080 ambient air Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000004555 blood preservation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000003441 Transfusion reaction Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
La présente invention concerne un ensemble portable pour traiter des érythrocytes RBC comprenant un ensemble de collecte de sang jetable comprenant une poche de sang, une poche de stockage anaérobie et un dispositif de déplétion d'oxygène et/ou d'oxygène et dioxyde de carbone disposé entre la poche de collecte de sang et la poche de stockage anaérobie. L'ensemble portable comprend en outre un dispositif de circulation de gaz en communication fluidique avec le dispositif de déplétion d'oxygène ou d'oxygène et de dioxyde de carbone. Le dispositif de circulation de gaz comprend une source de pression qui est capable de faire circuler du gaz de purge à travers le dispositif de déplétion tandis que les RBC passent de la poche de collecte de sang, à travers le dispositif de déplétion et dans la poche de stockage anaérobie.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161468377P | 2011-03-28 | 2011-03-28 | |
US61/468,377 | 2011-03-28 | ||
PCT/US2012/030930 WO2013022491A1 (fr) | 2011-03-28 | 2012-03-28 | Procédé et système pour éliminer l'oxygène et le dioxyde de carbone pendant le traitement d'érythrocytes en utilisant un gaz vecteur inerte et ensemble de collecteur |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2831465A1 CA2831465A1 (fr) | 2013-02-14 |
CA2831465C true CA2831465C (fr) | 2018-02-27 |
Family
ID=47668769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2831465A Active CA2831465C (fr) | 2011-03-28 | 2012-03-28 | Procede et systeme pour eliminer l'oxygene et le dioxyde de carbone pendant le traitement d'erythrocytes en utilisant un gaz vecteur inerte et ensemble de collecteur |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2691160A4 (fr) |
JP (2) | JP6034362B2 (fr) |
CN (2) | CN107096081B (fr) |
AU (1) | AU2012294890B2 (fr) |
CA (1) | CA2831465C (fr) |
WO (1) | WO2013022491A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
ES2959120T3 (es) | 2010-08-25 | 2024-02-20 | Hemanext Inc | Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento |
EP4218412A1 (fr) | 2010-11-05 | 2023-08-02 | Hemanext Inc. | Irradiation de globules rouges et stockage anaérobie |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
PT3061509T (pt) | 2011-08-10 | 2019-09-10 | New Health Sciences Inc | Depleção de leucócito, oxigénio e/ou co2 integrada e dispositivo de filtro de separação de plasma |
ES2900298T3 (es) | 2013-02-28 | 2022-03-16 | Hemanext Inc | Dispositivo de agotamiento de gas para productos sanguíneos |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
CA2978940C (fr) | 2015-03-10 | 2023-10-17 | New Health Sciences, Inc. | Kits jetables de reduction des niveaux d'oxygene, dispositifs et procedes d'utilisation de ceux-ci |
KR102661405B1 (ko) | 2015-04-23 | 2024-04-25 | 헤마넥스트 인코포레이티드 | 혐기성 혈액 저장 용기 |
BR122021024410B1 (pt) | 2015-05-18 | 2022-05-03 | Hemanext Inc | Métodos para gerenciar um banco de sangue e para prover fornecimento de produtos de sangue total armazenados para medicina de transfusão |
KR20190017747A (ko) | 2016-05-27 | 2019-02-20 | 뉴 헬스 사이언시즈 인코포레이티드 | 혐기성 혈액 저장 및 병원체 불활성화 방법 |
CN108114334B (zh) * | 2016-11-28 | 2024-01-12 | 健帆生物科技集团股份有限公司 | 血液净化器、血液净化系统及其预冲方法 |
CN110982665A (zh) * | 2019-11-22 | 2020-04-10 | 上海理工大学 | 循环肿瘤细胞分选及检测用的多通道进样装置及进样方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4831012A (en) * | 1984-03-23 | 1989-05-16 | Baxter International Inc. | Purified hemoglobin solutions and method for making same |
US4568328A (en) * | 1984-10-29 | 1986-02-04 | Extracorporeal Medical Specialties, Inc. | Automated photophoresis blood portion control methods and apparatus |
US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
US5624794A (en) * | 1995-06-05 | 1997-04-29 | The Regents Of The University Of California | Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas |
US6162396A (en) * | 1997-04-26 | 2000-12-19 | The Regents Of The University Of California | Blood storage device and method for oxygen removal |
WO1998052629A2 (fr) * | 1997-05-20 | 1998-11-26 | Zymequest, Inc. | Appareil et procede de traitement de cellules biologiques |
AU769442B2 (en) * | 1998-10-16 | 2004-01-29 | Terumo Medical Corporation | Blood processing system |
US20080027368A1 (en) * | 2000-09-27 | 2008-01-31 | Sorin Group Usa, Inc. | Disposable cartridge for a blood perfusion system |
AU2002211821A1 (en) * | 2000-09-27 | 2002-04-08 | Cobe Cardiovascular, Inc. | Disposable cartridge for a blood perfusion system |
JP2002173433A (ja) * | 2000-12-04 | 2002-06-21 | Terumo Corp | 白血球除去血液製剤の調製方法および血液セット |
JP4564260B2 (ja) * | 2001-11-16 | 2010-10-20 | ヒーマネクスト・エルエルシー | 血液保存のための添加溶液 |
GB0210022D0 (en) * | 2002-05-01 | 2002-06-12 | Air Prod & Chem | Gas dispenser and recovery apparatus |
US20060081524A1 (en) * | 2004-10-15 | 2006-04-20 | Amitava Sengupta | Membrane contactor and method of making the same |
US20100221697A1 (en) * | 2005-01-12 | 2010-09-02 | BioVec Transfusions, LLC | Composition for preserving platelets and method of using and storing the same |
AU2006236150A1 (en) * | 2005-04-20 | 2006-10-26 | Fred Hutchinson Cancer Research Center | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
JP5770183B2 (ja) * | 2009-07-31 | 2015-08-26 | ユニバーシティ・オブ・ピッツバーグ−オブ・ザ・コモンウェルス・システム・オブ・ハイヤー・エデュケイションUniversity Of Pittsburgh−Of The Commonwealth System Of Higher Education | 生体液からの酸素除去 |
-
2012
- 2012-03-28 JP JP2014502746A patent/JP6034362B2/ja active Active
- 2012-03-28 CN CN201611127102.5A patent/CN107096081B/zh active Active
- 2012-03-28 WO PCT/US2012/030930 patent/WO2013022491A1/fr active Application Filing
- 2012-03-28 AU AU2012294890A patent/AU2012294890B2/en active Active
- 2012-03-28 CN CN201280020712.9A patent/CN103492041B/zh active Active
- 2012-03-28 CA CA2831465A patent/CA2831465C/fr active Active
- 2012-03-28 EP EP12821624.9A patent/EP2691160A4/fr not_active Withdrawn
-
2016
- 2016-10-27 JP JP2016210712A patent/JP2017074381A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN107096081B (zh) | 2019-09-06 |
CN103492041A (zh) | 2014-01-01 |
AU2012294890A1 (en) | 2013-10-31 |
EP2691160A1 (fr) | 2014-02-05 |
JP2017074381A (ja) | 2017-04-20 |
AU2012294890B2 (en) | 2017-05-18 |
CN107096081A (zh) | 2017-08-29 |
CA2831465A1 (fr) | 2013-02-14 |
CN103492041B (zh) | 2017-02-08 |
EP2691160A4 (fr) | 2015-04-08 |
JP6034362B2 (ja) | 2016-11-30 |
JP2014516285A (ja) | 2014-07-10 |
WO2013022491A1 (fr) | 2013-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20170321 |