JP5770183B2 - 生体液からの酸素除去 - Google Patents
生体液からの酸素除去 Download PDFInfo
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- JP5770183B2 JP5770183B2 JP2012523121A JP2012523121A JP5770183B2 JP 5770183 B2 JP5770183 B2 JP 5770183B2 JP 2012523121 A JP2012523121 A JP 2012523121A JP 2012523121 A JP2012523121 A JP 2012523121A JP 5770183 B2 JP5770183 B2 JP 5770183B2
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims description 153
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Description
本願は、2009年7月31日付で出願された米国仮特許出願第61/230,575号の権利を主張し、この特許出願の開示が参照によって本明細書に組み込まれる。
本発明は、米国国立衛生研究所の米国心肺血液研究所によってNew Health Sciences社に授与された助成金番号R44HL088848−01に基づいて政府支援で行われた。政府は、本発明にある種の権利を有している。
・R(ファイバ内径)と、
・pO2in(入口酸素分圧)と、
・▲D▼(血液中の酸素の拡散率)と、
・Vmax(ファイバ中の血液の速度)と、
・f(p*)=(BCHb/σ)dSO2/dpO2(CHbは、ヘモグロビンの濃度であり、Bは、ヘモグロビンの酸素容量であり、σは、血液中の酸素の溶解度であり、dSO2/dpO2は、オキシヘモグロビン解離曲線の勾配である)と、
を含む。
Claims (20)
- 赤血球を含む流体中の酸素の濃度を低減する装置であって、
ハウジングと、
流体入口と、
流体出口と、
前記ハウジングの内部に延在し、前記流体の流れに適合する、前記流体入口及び前記流体出口と流体接続している、複数の微小孔性で疎水性の中空管と、
前記複数の微小孔性で疎水性の中空管の中を流れる前記流体から酸素の輸送を容易化するために前記複数の微小孔性で疎水性の中空管の外面で酸素の濃度を低減する運搬システムと、を備え、
前記複数の微小孔性で疎水性の中空管は、0.01μmから0.5μmまでの範囲の細孔径を有する、装置。 - 前記ハウジングは、さらに、運搬入口と、運搬出口と、を備える、請求項1記載の装置。
- 前記運搬システムは、酸素以外のガスを含む流体である、請求項1記載の装置。
- 前記複数の微小孔性で疎水性の中空管は、150μmから200μmまでの範囲の管外径を有する、請求項1記載の装置。
- 前記複数の微小孔性で疎水性の中空管は、0.1μmから0.4μmの範囲の細孔径を有する、請求項1記載の装置。
- 前記複数の微小孔性で疎水性の中空管は、5000本から8000本までの数の範囲に及ぶ、請求項1記載の装置。
- 前記複数の微小孔性で疎水性の中空管は、10cmから50cmまでの長さの範囲に及ぶ、請求項1記載の装置。
- 前記運搬システムは、ポンプによって供給される酸素以外のガス、及び、加圧容器によって供給される酸素以外のガスからなる群から選択される流体又は真空源を含む、請求項3記載の装置。
- 前記運搬システムは、酸素吸収材を含む、請求項1記載の装置。
- 前記酸素吸収材は、前記複数の微小孔性で疎水性の中空管の少なくとも一部分の外面に固定化されている、請求項9記載の装置。
- 前記酸素吸収材は、前記複数の微小孔性で疎水性の中空管の外部にある前記ハウジングの容積内に位置付けられている、請求項9記載の装置。
- 複数の前記複数の微小孔性で疎水性の中空管が一つ以上の群として配置され、前記酸素吸収材は、前記一つ以上の群の長さの少なくとも一部分を囲む、請求項9記載の装置。
- 複数の管が前記複数の微小孔性で疎水性の中空管の長さの少なくとも一部分に亘って前記酸素吸収材の周囲の周りに配置されている、請求項9記載の装置。
- 前記運搬システムは、流体処理システムの流体経路の内部に接続可能である、請求項1記載の装置。
- 前記流体は、赤血球懸濁液を含む、請求項1記載の装置。
- 赤血球を含む流体中の酸素の濃度を低減する方法であって、
ハウジングの内部に延在する複数の微小孔性で疎水性の中空管内に前記流体を流し、
前記複数の微小孔性で疎水性の中空管は、0.01μmから0.5μmまでの範囲の細孔径を有し、
前記複数の微小孔性で疎水性の中空管の外面が、酸素の拡散を促進するように濃度勾配を保つことによって、前記流体より酸素の濃度を低く保つ運搬システムに流体接続されている、方法。 - 前記流体は、赤血球懸濁液を含む、請求項16記載の方法。
- 赤血球を含む流体中の酸素の濃度を低減する装置であって、
ハウジングと、
前記ハウジングの内部に延在し、複数の微小孔性で疎水性の中空管のルーメン内部にある酸素吸収材を有する、前記複数の微小孔性で疎水性の中空管と、
前記複数の微小孔性で疎水性の中空管の外部にある前記ハウジングの容積と流体接続している流体入口と、
前記容積と流体接続している流体出口と、
を備え、
前記複数の微小孔性で疎水性の中空管は、0.01μmから0.5μmまでの範囲の細孔径を有する、装置。 - 前記複数の微小孔性で疎水性の中空管は、ポンプ、加圧容器、及び真空源からなる群から選択されるデバイスと流体接続する、請求項1記載の装置。
- 前記複数の微小孔性で疎水性の中空管は、ポリプロピレンからなる、請求項1又は18記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23057509P | 2009-07-31 | 2009-07-31 | |
US61/230,575 | 2009-07-31 | ||
PCT/US2010/044045 WO2011014855A2 (en) | 2009-07-31 | 2010-07-31 | Removal of oxygen from biological fluids |
Publications (2)
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JP2013500794A JP2013500794A (ja) | 2013-01-10 |
JP5770183B2 true JP5770183B2 (ja) | 2015-08-26 |
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JP2012523121A Expired - Fee Related JP5770183B2 (ja) | 2009-07-31 | 2010-07-31 | 生体液からの酸素除去 |
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US (1) | US20120129149A1 (ja) |
EP (1) | EP2459247A4 (ja) |
JP (1) | JP5770183B2 (ja) |
AU (1) | AU2010278768A1 (ja) |
CA (1) | CA2772320A1 (ja) |
NZ (1) | NZ598410A (ja) |
WO (1) | WO2011014855A2 (ja) |
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US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
BR112012008683B8 (pt) | 2009-10-12 | 2022-11-08 | Hemanext Inc | dispositivo de armazenagem de sangue para armazenar sangue depletado de oxigênio e dióxido de carbono, dispositivo de depleção de oxigênio e dióxido de carbono, método para remover oxigênio e dióxido de carbono de hemácias, sistema de armazenagem de sangue, dispositivo de armazenagem de sangue, método para remover oxigênio de hemácias e método para aumentar os níveis de adenosina trifosfato (atp) nas hemácias |
WO2011046963A1 (en) | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Oxygen depletion devices and methods for removing oxygen from red blood cells |
WO2012027582A1 (en) | 2010-08-25 | 2012-03-01 | New Health Sciences | Method for enhancing red blood cell quality and survival during storage |
PT2635114T (pt) | 2010-11-05 | 2020-06-16 | New Health Sciences Inc | Irradiação de glóbulos vermelhos e armazenamento anaeróbico |
JP2014510731A (ja) | 2011-03-16 | 2014-05-01 | メイヨー ファンデーション フォー メディカル エデュケーション アンド リサーチ | 赤血球製剤および血小板製剤の有効貯蔵を延ばすための方法および材料 |
US9067004B2 (en) * | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
CN103492041B (zh) * | 2011-03-28 | 2017-02-08 | 新健康科学股份有限公司 | 用于在红细胞血液处理过程中使用惰性载气和歧管组件去除氧和二氧化碳的方法和系统 |
DE102011052187A1 (de) * | 2011-07-27 | 2013-01-31 | Maquet Vertrieb Und Service Deutschland Gmbh | Anordnung zum Entfernen von Kohlenstoffdioxid aus einem exkorporalen Blutstrom mittels Inertgasen |
ES2923571T3 (es) | 2011-08-10 | 2022-09-28 | Hemanext Inc | Dispositivo integrado de filtrado de leucocitos, oxígeno y/o CO2 y separación de plasma |
GB201207543D0 (en) * | 2012-05-01 | 2012-06-13 | Haemair Ltd | Treatment of transfusion blood |
AU2014223165B2 (en) * | 2013-02-28 | 2017-04-13 | Hemanext Inc. | Gas depletion and gas addition devices for blood treatment |
KR20180012242A (ko) | 2015-03-10 | 2018-02-05 | 뉴 헬스 사이언시즈 인코포레이티드 | 산소 감소 1회용 키트, 장치 및 이의 사용 방법 |
IL285359B2 (en) | 2015-04-23 | 2024-01-01 | Hemanext Inc | Anaerobic blood storage containers |
CA2985799A1 (en) | 2015-05-18 | 2016-11-24 | New Health Sciences, Inc. | Methods for the storage of whole blood, and compositions thereof |
EP3463466B1 (en) | 2016-05-27 | 2022-02-16 | Hemanext Inc. | Anaerobic blood storage and pathogen inactivation method |
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US4629544A (en) * | 1984-09-24 | 1986-12-16 | Aquanautics Corporation | Apparatus and method for reversibly removing ligands from carriers |
IT1218450B (it) * | 1985-09-24 | 1990-04-19 | Teresa Borgione | Perfezionamenti agli ossigenatori per il sangue, a fibre cave |
US5192320A (en) * | 1987-07-11 | 1993-03-09 | Dainippon Ink And Chemicals Inc. | Artificial lung and method of using it |
JP2700170B2 (ja) * | 1987-07-11 | 1998-01-19 | 大日本インキ化学工業株式会社 | 膜型人工肺 |
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US6162396A (en) * | 1997-04-26 | 2000-12-19 | The Regents Of The University Of California | Blood storage device and method for oxygen removal |
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TW531428B (en) * | 1999-01-29 | 2003-05-11 | Mykrolis Corp | Fluid-fluid phase contactors and methods of using and making the same |
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JP3772909B1 (ja) * | 2005-04-04 | 2006-05-10 | 東洋紡績株式会社 | 血液浄化器 |
-
2010
- 2010-07-31 CA CA2772320A patent/CA2772320A1/en not_active Abandoned
- 2010-07-31 EP EP10805155.8A patent/EP2459247A4/en not_active Withdrawn
- 2010-07-31 NZ NZ598410A patent/NZ598410A/en not_active IP Right Cessation
- 2010-07-31 WO PCT/US2010/044045 patent/WO2011014855A2/en active Application Filing
- 2010-07-31 US US13/387,528 patent/US20120129149A1/en not_active Abandoned
- 2010-07-31 JP JP2012523121A patent/JP5770183B2/ja not_active Expired - Fee Related
- 2010-07-31 AU AU2010278768A patent/AU2010278768A1/en not_active Abandoned
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NZ598410A (en) | 2014-04-30 |
WO2011014855A2 (en) | 2011-02-03 |
AU2010278768A1 (en) | 2012-03-15 |
JP2013500794A (ja) | 2013-01-10 |
US20120129149A1 (en) | 2012-05-24 |
WO2011014855A3 (en) | 2011-06-16 |
EP2459247A4 (en) | 2013-08-28 |
CA2772320A1 (en) | 2011-02-03 |
EP2459247A2 (en) | 2012-06-06 |
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