WO2011014855A3 - Removal of oxygen from biological fluids - Google Patents

Removal of oxygen from biological fluids Download PDF

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Publication number
WO2011014855A3
WO2011014855A3 PCT/US2010/044045 US2010044045W WO2011014855A3 WO 2011014855 A3 WO2011014855 A3 WO 2011014855A3 US 2010044045 W US2010044045 W US 2010044045W WO 2011014855 A3 WO2011014855 A3 WO 2011014855A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxygen
tubes
removal
biological fluids
concentration
Prior art date
Application number
PCT/US2010/044045
Other languages
French (fr)
Other versions
WO2011014855A2 (en
Inventor
William J. Federspiel
Tatsuro Yoshida
Paul J. Vernucci
Brian Joseph Frankowski
Laura Wheeler Lund
Original Assignee
University Of Pittsburgh -Of The Commonwealth System Of Higher Education
New Health Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Pittsburgh -Of The Commonwealth System Of Higher Education, New Health Sciences, Inc. filed Critical University Of Pittsburgh -Of The Commonwealth System Of Higher Education
Priority to US13/387,528 priority Critical patent/US20120129149A1/en
Priority to EP10805155.8A priority patent/EP2459247A4/en
Priority to AU2010278768A priority patent/AU2010278768A1/en
Priority to NZ598410A priority patent/NZ598410A/en
Priority to JP2012523121A priority patent/JP5770183B2/en
Priority to CA2772320A priority patent/CA2772320A1/en
Publication of WO2011014855A2 publication Critical patent/WO2011014855A2/en
Publication of WO2011014855A3 publication Critical patent/WO2011014855A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/022—Encapsulating hollow fibres
    • B01D63/0221—Encapsulating hollow fibres using a mould
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/13—Use of sweep gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2626—Absorption or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/40—Adsorbents within the flow path

Abstract

A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces the concentration of oxygen at an exterior surface of the tubes to facilitate transport of oxygen from the fluid flowing through the tubes to an exterior of the tubes.
PCT/US2010/044045 2009-07-31 2010-07-31 Removal of oxygen from biological fluids WO2011014855A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US13/387,528 US20120129149A1 (en) 2009-07-31 2010-07-31 Removal of oxygen from biological fluids
EP10805155.8A EP2459247A4 (en) 2009-07-31 2010-07-31 Removal of oxygen from biological fluids
AU2010278768A AU2010278768A1 (en) 2009-07-31 2010-07-31 Removal of oxygen from biological fluids
NZ598410A NZ598410A (en) 2009-07-31 2010-07-31 Removal of oxygen from biological fluids
JP2012523121A JP5770183B2 (en) 2009-07-31 2010-07-31 Oxygen removal from biological fluids
CA2772320A CA2772320A1 (en) 2009-07-31 2010-07-31 Removal of oxygen from biological fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23057509P 2009-07-31 2009-07-31
US61/230,575 2009-07-31

Publications (2)

Publication Number Publication Date
WO2011014855A2 WO2011014855A2 (en) 2011-02-03
WO2011014855A3 true WO2011014855A3 (en) 2011-06-16

Family

ID=43529974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/044045 WO2011014855A2 (en) 2009-07-31 2010-07-31 Removal of oxygen from biological fluids

Country Status (7)

Country Link
US (1) US20120129149A1 (en)
EP (1) EP2459247A4 (en)
JP (1) JP5770183B2 (en)
AU (1) AU2010278768A1 (en)
CA (1) CA2772320A1 (en)
NZ (1) NZ598410A (en)
WO (1) WO2011014855A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
WO2011046841A1 (en) * 2009-10-12 2011-04-21 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
NZ599890A (en) 2009-10-12 2014-03-28 Univ Pittsburgh Oxygen depletion devices and methods for removing oxygen from red blood cells
JP5930483B2 (en) 2010-08-25 2016-06-08 ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． Methods for enhancing red blood cell quality and survival during storage
CA2817106C (en) 2010-11-05 2020-08-25 Paul Vernucci Irradiation of red blood cells and anaerobic storage
WO2012125955A2 (en) 2011-03-16 2012-09-20 Mayo Foundation For Medical Education And Research Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations
EP2691160A4 (en) * 2011-03-28 2015-04-08 New Health Sciences Inc Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
US9067004B2 (en) * 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
DE102011052187A1 (en) * 2011-07-27 2013-01-31 Maquet Vertrieb Und Service Deutschland Gmbh Arrangement for removing carbon dioxide from an extracorporeal blood stream by means of inert gases
WO2013023156A1 (en) 2011-08-10 2013-02-14 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
GB201207543D0 (en) * 2012-05-01 2012-06-13 Haemair Ltd Treatment of transfusion blood
EP2961269B1 (en) * 2013-02-28 2021-09-15 Hemanext Inc. Gas depletion device for blood products
CA2978940C (en) 2015-03-10 2023-10-17 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
BR122022005103B1 (en) 2015-04-23 2023-03-14 Hemanext Inc BLOOD STORAGE DEVICE FOR STORING OXYGEN DEPLETED BLOOD AND METHOD FOR STORING OXYGEN DEPLETED BLOOD
KR20180010206A (en) 2015-05-18 2018-01-30 뉴 헬스 사이언시즈 인코포레이티드 Method for storing whole blood, and composition thereof
BR112018073923A2 (en) 2016-05-27 2019-02-26 New Health Sciences, Inc. anaerobic blood storage and pathogen inactivation method

Citations (4)

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US4749551A (en) * 1985-09-24 1988-06-07 Sorin Biomedica S.P.A. Hollow-fiber oxygenators for blood
US5192320A (en) * 1987-07-11 1993-03-09 Dainippon Ink And Chemicals Inc. Artificial lung and method of using it
US6162396A (en) * 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
WO2006057473A1 (en) * 2004-11-23 2006-06-01 Newheart Bio Co., Ltd. Filter module with multi-function parts for a blood purification and/or oxygenation using thereof and method for a blood purification and oxygenation and purification device comprising thereof

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Publication number Priority date Publication date Assignee Title
US4749551A (en) * 1985-09-24 1988-06-07 Sorin Biomedica S.P.A. Hollow-fiber oxygenators for blood
US5192320A (en) * 1987-07-11 1993-03-09 Dainippon Ink And Chemicals Inc. Artificial lung and method of using it
US6162396A (en) * 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
WO2006057473A1 (en) * 2004-11-23 2006-06-01 Newheart Bio Co., Ltd. Filter module with multi-function parts for a blood purification and/or oxygenation using thereof and method for a blood purification and oxygenation and purification device comprising thereof

Also Published As

Publication number Publication date
WO2011014855A2 (en) 2011-02-03
EP2459247A2 (en) 2012-06-06
JP2013500794A (en) 2013-01-10
NZ598410A (en) 2014-04-30
AU2010278768A1 (en) 2012-03-15
US20120129149A1 (en) 2012-05-24
JP5770183B2 (en) 2015-08-26
EP2459247A4 (en) 2013-08-28
CA2772320A1 (en) 2011-02-03

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