CA2830432C - Integrated catalytic protection of oxidation sensitive materials - Google Patents

Integrated catalytic protection of oxidation sensitive materials Download PDF

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Publication number
CA2830432C
CA2830432C CA2830432A CA2830432A CA2830432C CA 2830432 C CA2830432 C CA 2830432C CA 2830432 A CA2830432 A CA 2830432A CA 2830432 A CA2830432 A CA 2830432A CA 2830432 C CA2830432 C CA 2830432C
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CA
Canada
Prior art keywords
sensor
graft
porous
protective coating
hydrogen peroxide
Prior art date
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Active
Application number
CA2830432A
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English (en)
French (fr)
Other versions
CA2830432A1 (en
Inventor
Arthur E. Colvin, Jr.
Hui Jiang
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Senseonics Inc
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Senseonics Inc
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Filing date
Publication date
Application filed by Senseonics Inc filed Critical Senseonics Inc
Publication of CA2830432A1 publication Critical patent/CA2830432A1/en
Application granted granted Critical
Publication of CA2830432C publication Critical patent/CA2830432C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/076—Permanent implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/162—Capsule shaped sensor housings, e.g. for swallowing or implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/18—Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2830432A 2011-03-15 2012-03-15 Integrated catalytic protection of oxidation sensitive materials Active CA2830432C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161452893P 2011-03-15 2011-03-15
US61/452,893 2011-03-15
US201161527368P 2011-08-25 2011-08-25
US61/527,368 2011-08-25
PCT/US2012/029209 WO2012125814A2 (en) 2011-03-15 2012-03-15 Integrated catalytic protection of oxidation sensitive materials

Publications (2)

Publication Number Publication Date
CA2830432A1 CA2830432A1 (en) 2012-09-20
CA2830432C true CA2830432C (en) 2022-04-26

Family

ID=46828999

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2830432A Active CA2830432C (en) 2011-03-15 2012-03-15 Integrated catalytic protection of oxidation sensitive materials

Country Status (10)

Country Link
US (2) US9681824B2 (https=)
EP (1) EP2685884B1 (https=)
JP (1) JP6084172B2 (https=)
KR (1) KR101959067B1 (https=)
CN (1) CN103533884B (https=)
AU (1) AU2012229109A1 (https=)
CA (1) CA2830432C (https=)
SG (1) SG193496A1 (https=)
TW (1) TWI592663B (https=)
WO (1) WO2012125814A2 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150366367A1 (en) 2007-03-19 2015-12-24 Augustine Temperature Management LLC Electric heating pad with electrosurgical grounding
US20150289817A1 (en) * 2014-04-10 2015-10-15 Augustine Biomedical And Design, Llc Medical apparatus including hydrogen peroxide protection
US8283602B2 (en) 2007-03-19 2012-10-09 Augustine Temperature Management LLC Heating blanket
US10201935B2 (en) 2007-03-19 2019-02-12 Augustine Temperature Management LLC Electric heating pad
EP2685884B1 (en) 2011-03-15 2020-09-23 Senseonics, Incorporated Integrated catalytic protection of oxidation sensitive materials
US20140088383A1 (en) * 2012-09-14 2014-03-27 Senseonics, Incorporated Integrated catalytic protection of oxidation sensitive materials
MX2015008531A (es) 2012-12-28 2016-02-10 Senseonics Inc Sistema de membrana permeable a analito para estabilidad oxidativa y óptica.
US11109779B2 (en) 2012-12-28 2021-09-07 Senseonics, Incorporated Chemical modification of analyte permeable membrane for enhanced oxidative stability
DK3035849T3 (da) * 2013-08-21 2019-09-30 Senseonics Inc Lægemiddeleluering til beskyttelse in vivo af biosensor-analysander
US9963556B2 (en) * 2013-09-18 2018-05-08 Senseonics, Incorporated Critical point drying of hydrogels in analyte sensors
BR112016018076B1 (pt) * 2014-02-19 2022-03-15 Mallinckrodt Hospital Products IP Limited Métodos para compensar a longo prazo a sensibilidade do sentido de sensores de gases eletroquímicos expostos a óxido nítrico
WO2016077742A1 (en) 2014-11-13 2016-05-19 Augustine Temperature Management, Llc Heated underbody warming systems with electrosurgical grounding
KR102764897B1 (ko) 2015-11-16 2025-02-07 에이치헬리, 엘엘씨 에너지 저장 용도, 촉매 용도, 광전지 용도 및 센서 용도를 위한 합성된 표면-관능화된, 산성화 금속 산화물 재료
US20180000997A1 (en) * 2016-06-29 2018-01-04 Berlock Aps Implantable Device Having an Outer Surface Comprising Gold and Its Use as an Anti-Migration Device
US10869624B2 (en) 2016-10-18 2020-12-22 Senseonics, Incorporated Real time assessement of sensor performance and prediction of the end of the functional life of an implanted sensor
WO2018093945A1 (en) 2016-11-15 2018-05-24 Hheli, Llc. A surface-functionalized, acidified metal oxide material in an acidified electrolyte system or an acidified electrode system
CN117727928A (zh) * 2017-04-10 2024-03-19 氢氦锂有限公司 具有新型组分的电池
US12369824B2 (en) 2017-04-19 2025-07-29 Senseonics, Incorporated Detecting and correcting for interference in an analyte monitoring system
PL4014864T3 (pl) 2017-04-19 2024-10-21 Senseonics, Incorporated Wykrywanie i korygowanie zmian wskaźnika analitu
CA3062617C (en) 2017-05-17 2023-09-19 HHeLI, LLC A high capacity battery cell with low active material loading
JP7309619B2 (ja) 2017-05-17 2023-07-18 ヒーリー，エルエルシー 酸性化カソードおよびリチウムアノードを有する電池
US10978731B2 (en) 2017-06-21 2021-04-13 HHeLI, LLC Ultra high capacity performance battery cell
WO2019060773A1 (en) 2017-09-22 2019-03-28 HHeLI, LLC CONSTRUCTION OF VERY HIGH CAPACITY PERFORMANCE BATTERY ELEMENTS
US20190159708A1 (en) * 2017-11-28 2019-05-30 Senseonics, Incorporated Analyte indicator integrated with a catalytically active material
KR102098078B1 (ko) * 2018-07-13 2020-04-08 주식회사 엔게인 수화겔 및 이를 포함하는 글루코스 센서
JP7410934B2 (ja) 2018-09-10 2024-01-10 ヒーリー、エルエルシー 超大容量高性能電池セルの使用方法
WO2020092897A1 (en) * 2018-11-02 2020-05-07 Senseonics, Incorporated Drug eluting matrix on analyte indicator
EP3891498B1 (en) * 2018-12-05 2025-04-30 Senseonics, Incorporated Reduction of in vivo analyte signal degradation using multiple metals
US10765580B1 (en) 2019-03-27 2020-09-08 Augustine Biomedical And Design, Llc Patient securement system for the surgical trendelenburg position
CA3137757A1 (en) 2019-05-08 2020-11-12 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
US11963761B2 (en) * 2019-05-16 2024-04-23 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
US12278342B2 (en) 2019-06-12 2025-04-15 HHeLI, LLC Alkaline and acidified metal oxide blended active materials
US12401018B2 (en) 2019-06-12 2025-08-26 HHeLI, LLC Blended active materials for battery cells
CA3157995A1 (en) 2019-10-25 2021-04-29 Cercacor Laboratories, Inc. Indicator compounds, devices comprising indicator compounds, and methods of making and using the same
IL273038B (en) 2020-03-03 2022-02-01 Ben Zion Karmon bone graft
EP4543392A1 (en) 2022-06-23 2025-04-30 Augustine Biomedical and Design, LLC Patient securement system for the surgical trendelenburg position
US11844733B1 (en) 2022-06-23 2023-12-19 Augustine Biomedical And Design, Llc Patient securement system for the surgical Trendelenburg position
US20240260861A1 (en) * 2023-02-06 2024-08-08 Senseonics, Incorporated Reduction of in vivo analyte signal degradation using multiple metals
CN116392648B (zh) * 2023-04-14 2024-08-23 中国科学院长春应用化学研究所 一种温度、炎症双响应性的抗凝复合涂层及其制备方法、应用
WO2025217563A1 (en) 2024-04-12 2025-10-16 Glucotrack, Inc. Low power implantable glucose sensors and methods of glucose measurement
US20250387054A1 (en) * 2024-06-25 2025-12-25 Senseonics, Incorporated Preventing yellowing and fluorescence in epoxide diamine networks

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63291595A (ja) 1987-05-22 1988-11-29 Meidensha Electric Mfg Co Ltd 生体試料中のグルコ−スの測定方法
US5517313A (en) 1995-02-21 1996-05-14 Colvin, Jr.; Arthur E. Fluorescent optical sensor
US5772864A (en) 1996-02-23 1998-06-30 Meadox Medicals, Inc. Method for manufacturing implantable medical devices
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US5917605A (en) 1997-05-13 1999-06-29 Colvin, Jr.; Arthur E. Fluorescence sensing device
US5894351A (en) 1997-05-13 1999-04-13 Colvin, Jr.; Arthur E. Fluorescence sensing device
US5910661A (en) 1997-05-13 1999-06-08 Colvin, Jr.; Arthur E. Flourescence sensing device
US5922183A (en) 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors
WO1999007277A1 (de) * 1997-08-09 1999-02-18 Roche Diagnostics Gmbh Analysevorrichtung zur in-vivo-analyse im körper eines patienten
KR100718953B1 (ko) 1998-03-11 2007-05-16 센서즈 포 메드슨 앤드 사이언스 인코포레이티드 형광성 란타니드 킬레이트에 의한 검체의 분석
JP4689825B2 (ja) 1998-08-26 2011-05-25 センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド 光学式検知装置
US6304766B1 (en) 1998-08-26 2001-10-16 Sensors For Medicine And Science Optical-based sensing devices, especially for in-situ sensing in humans
DE19855421C2 (de) * 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6189536B1 (en) * 1999-04-15 2001-02-20 Medtronic Inc. Method for protecting implantable devices
US7553280B2 (en) 2000-06-29 2009-06-30 Sensors For Medicine And Science, Inc. Implanted sensor processing system and method
US6400974B1 (en) 2000-06-29 2002-06-04 Sensors For Medicine And Science, Inc. Implanted sensor processing system and method for processing implanted sensor output
WO2002012251A1 (en) 2000-08-04 2002-02-14 Sensors For Medicine And Science, Inc. Detection of analytes in aqueous environments
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6800451B2 (en) 2001-01-05 2004-10-05 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
JP2004529352A (ja) 2001-05-04 2004-09-24 センサーズ・フォー・メディシン・アンド・サイエンス インコーポレーテッド 参照通路を備えたエレクトロオプティカルセンサ装置
TWI293363B (en) 2001-12-11 2008-02-11 Sensors For Med & Science Inc High performance fluorescent optical sensor
KR20030055609A (ko) 2001-12-27 2003-07-04 김재열 꼬임 방지형 원주 자동 용접장치
SE0200269D0 (sv) * 2002-01-31 2002-01-31 Ellem Bioteknik Ab Material for implantation
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US20040063167A1 (en) 2002-07-12 2004-04-01 Peter Kaastrup Minimising calibration problems of in vivo glucose sensors
DK1618768T3 (da) 2003-04-15 2013-09-08 Senseonics Inc Implanterbar sensorbearbejdningssystem med integreret printkort-antenne
US7467003B2 (en) * 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20050095174A1 (en) * 2003-10-31 2005-05-05 Wolf David E. Semipermeable sensors for detecting analyte
EP1694200B1 (en) * 2003-11-03 2010-09-29 MicroCHIPS, Inc. Medical device for sensing glucose
WO2005051170A2 (en) * 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
EP2329763B1 (en) 2003-12-09 2017-06-21 DexCom, Inc. Signal processing for continuous analyte sensor
US8165651B2 (en) * 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7450980B2 (en) 2004-03-31 2008-11-11 Terumo Kabushiki Kaisha Intracorporeal substance measuring assembly
JP2005315871A (ja) * 2004-03-31 2005-11-10 Terumo Corp 体内物質測定用構成物、体内物質測定用構成物の製造方法、および埋込型物質センサー
US7713745B2 (en) 2004-04-13 2010-05-11 Sensors For Medicine And Science, Inc. Non-covalent immobilization of indicator molecules
US20050234316A1 (en) 2004-04-16 2005-10-20 Sensors For Medicine And Science, Inc. Housing for a circuit that is to be implanted in-vivo and process of making the same
US7375347B2 (en) 2004-04-26 2008-05-20 Sensors For Medicine And Science, Inc. Systems and methods for extending the useful life of optical sensors
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8073548B2 (en) 2004-08-24 2011-12-06 Sensors For Medicine And Science, Inc. Wristband or other type of band having an adjustable antenna for use with a sensor reader
US8308794B2 (en) 2004-11-15 2012-11-13 IZEK Technologies, Inc. Instrumented implantable stents, vascular grafts and other medical devices
US7308292B2 (en) 2005-04-15 2007-12-11 Sensors For Medicine And Science, Inc. Optical-based sensing devices
US20060282042A1 (en) 2005-06-08 2006-12-14 Sensors For Medicine And Science, Inc. Insertion device and method
US20070014726A1 (en) 2005-07-18 2007-01-18 Sensors For Medicine And Science Oxidation-resistant indicator macromolecule
EP1790977A1 (en) 2005-11-23 2007-05-30 SONY DEUTSCHLAND GmbH Nanoparticle/nanofiber based chemical sensor, arrays of such sensors, uses and method of fabrication thereof, and method of detecting an analyte
US20100202966A1 (en) 2006-03-28 2010-08-12 Yossi Gross Implantable Sensor
US20080125838A1 (en) 2006-08-10 2008-05-29 Medtronic, Inc. Implantable Devices With Photocatalytic Surfaces
WO2008066921A2 (en) 2006-11-30 2008-06-05 Sensors For Medicine And Science, Inc. Oxidation resistant indicator molecules
US8738107B2 (en) * 2007-05-10 2014-05-27 Medtronic Minimed, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
CA2680194A1 (en) 2007-03-08 2008-09-18 Jason D. Colvin Light emitting diode for harsh environments
CA2732040A1 (en) 2008-07-28 2010-02-04 Sensors For Medicine & Science, Inc. Systems and methods for optical measurement of analyte concentration
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
AU2010233152B2 (en) 2009-04-09 2014-12-04 The Children's Hospital Of Philadelphia Ligand-specific inhibition of attachment of immune cells to implantable biomaterials
US20100298674A1 (en) 2009-04-21 2010-11-25 Sensors For Medicine & Science, Inc. Protective shell for an in vivo sensor made from resorbable polymer
JP2013519101A (ja) * 2010-02-08 2013-05-23 グルメトリクス， インコーポレイテッド 化学センサーの抗酸化剤保護
US9151764B2 (en) 2010-02-16 2015-10-06 Lightship Medical Limited Barrier layer for glucose sensor
JP5101659B2 (ja) * 2010-05-25 2012-12-19 株式会社東芝 血圧センサ
US20120053427A1 (en) 2010-08-31 2012-03-01 Glumetrics, Inc. Optical sensor configuration and methods for monitoring glucose activity in interstitial fluid
EP4449978B1 (en) 2010-10-06 2026-03-18 Profusa, Inc. Tissue-integrating sensors
EP2685884B1 (en) 2011-03-15 2020-09-23 Senseonics, Incorporated Integrated catalytic protection of oxidation sensitive materials
EP2744909B1 (en) 2011-08-17 2021-09-22 Baxter International Inc. Method for preparing a barrier layer for a glucose sensor
IN2014DN07535A (https=) 2012-03-15 2015-04-24 Lightship Medical Ltd

Also Published As

Publication number Publication date
KR20140035892A (ko) 2014-03-24
EP2685884A4 (en) 2015-04-15
SG193496A1 (en) 2013-10-30
JP2014514033A (ja) 2014-06-19
US9681824B2 (en) 2017-06-20
CA2830432A1 (en) 2012-09-20
CN103533884B (zh) 2016-06-01
EP2685884B1 (en) 2020-09-23
JP6084172B2 (ja) 2017-02-22
EP2685884A2 (en) 2014-01-22
US10674937B2 (en) 2020-06-09
TW201243332A (en) 2012-11-01
WO2012125814A2 (en) 2012-09-20
WO2012125814A3 (en) 2013-12-27
TWI592663B (zh) 2017-07-21
CN103533884A (zh) 2014-01-22
US20120238842A1 (en) 2012-09-20
AU2012229109A1 (en) 2013-10-10
KR101959067B1 (ko) 2019-03-15
US20180146885A1 (en) 2018-05-31

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