CA2825309C - Pyridostigmine for the treatment of obstructive sleep apnea - Google Patents

Pyridostigmine for the treatment of obstructive sleep apnea Download PDF

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Publication number
CA2825309C
CA2825309C CA2825309A CA2825309A CA2825309C CA 2825309 C CA2825309 C CA 2825309C CA 2825309 A CA2825309 A CA 2825309A CA 2825309 A CA2825309 A CA 2825309A CA 2825309 C CA2825309 C CA 2825309C
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CA
Canada
Prior art keywords
pharmaceutical composition
sleep
pyridostigmine
subject
osa
Prior art date
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CA2825309A
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English (en)
French (fr)
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CA2825309A1 (en
Inventor
Jian-Qiang Fan
Original Assignee
PFANTASTIC MEDICAL RESEARCH INSTITUTE LLC
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Publication of CA2825309A1 publication Critical patent/CA2825309A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/56—Devices for preventing snoring
    • A61F5/566—Intra-oral devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Nursing (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2825309A 2011-01-28 2012-01-27 Pyridostigmine for the treatment of obstructive sleep apnea Active CA2825309C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437272P 2011-01-28 2011-01-28
US61/437,272 2011-01-28
PCT/US2012/022825 WO2012103398A2 (en) 2011-01-28 2012-01-27 Methods for treating obstructive sleep apnea

Publications (2)

Publication Number Publication Date
CA2825309A1 CA2825309A1 (en) 2012-08-02
CA2825309C true CA2825309C (en) 2019-10-01

Family

ID=46577943

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2825309A Active CA2825309C (en) 2011-01-28 2012-01-27 Pyridostigmine for the treatment of obstructive sleep apnea

Country Status (6)

Country Link
US (2) US8753327B2 (enExample)
EP (1) EP2672972B1 (enExample)
JP (2) JP2014503593A (enExample)
CN (2) CN103458899A (enExample)
CA (1) CA2825309C (enExample)
WO (1) WO2012103398A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014503593A (ja) * 2011-01-28 2014-02-13 ファンタスティック・メディカル・リサーチ・インスティテュート・エルエルシー 閉塞性睡眠時無呼吸を処置するための方法
US20160361192A1 (en) * 2014-03-03 2016-12-15 Sleep Innovations Pty Ltd Device and method for sleep apnoea treatment
US10166268B2 (en) 2014-07-25 2019-01-01 The George Washington University Oxytocin improves treatment of obstructive sleep apnea
AU2016243801B2 (en) 2015-04-02 2020-05-21 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
CN110198688B (zh) * 2016-12-23 2022-06-24 皇家飞利浦有限公司 用于处置至少两个用户间的打鼾的系统
GEAP202416602A (en) * 2017-04-28 2024-10-10 Brigham & Womens Hospital Inc Methods and compositions for treating sleep apnea
KR102874891B1 (ko) 2018-01-30 2025-10-21 애프니메드, 인코포레이티드 (델라웨어) 수면 무호흡증을 치료하기 위한 방법 및 조성물
EP3824881B1 (en) * 2018-06-18 2022-02-16 Amneal Complex Products Research LLC Extended release compositions comprising pyridostigmine
CN112601568B (zh) * 2018-08-24 2024-07-26 皇家飞利浦有限公司 利用压力治疗系统提供睡眠治疗
CN118557736A (zh) 2019-02-08 2024-08-30 布里格姆妇女医院 用于治疗睡眠呼吸暂停的方法和组合物
US20200282215A1 (en) 2019-03-06 2020-09-10 Medtronic Xomed, LLC Evaluating stimulation eficacy for treating sleep apnea and lingual muscle tone sensing system for improved osa therapy
CN114504643B (zh) * 2021-12-24 2024-03-26 北京大学第一医院 抗IgE抗体在用于治疗OSAS中的应用
EP4620390A1 (en) * 2022-12-28 2025-09-24 Nishikawa Co., Ltd. Health risk determination system, autonomic nerve determination system, life improvement system, sleeping posture determination system, sleeping posture determination program, bruxism detection system, and bruxism detection program
CN117402958A (zh) * 2023-10-26 2024-01-16 天津医科大学总医院 Claudin3及家族相关分子对阻塞性睡眠呼吸暂停低通气综合征的诊断价值

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2247662B (en) 1990-08-31 1994-11-02 Instance Ltd David J Labels and manufacture thereof
SE9504537D0 (sv) * 1995-12-19 1995-12-19 Jan Hedner Sätt att behandla och diagnosticera andningsstörningar under sömn och medel för utförande av sättet
US7297691B2 (en) * 2003-08-13 2007-11-20 Janssen Pharmaceutica N.V. Treatment of sleep disorders with cholinesterase inhibitors
CN101291663A (zh) * 2005-09-16 2008-10-22 赛诺科学股份公司 预防和治疗睡眠呼吸障碍的方法和工具
US20080066739A1 (en) * 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US7984714B2 (en) * 2006-09-29 2011-07-26 Nellcor Puritan Bennett Llc Managing obstructive sleep apnea and/or snoring using local time released agents
JP2014503593A (ja) * 2011-01-28 2014-02-13 ファンタスティック・メディカル・リサーチ・インスティテュート・エルエルシー 閉塞性睡眠時無呼吸を処置するための方法

Also Published As

Publication number Publication date
JP2014503593A (ja) 2014-02-13
CA2825309A1 (en) 2012-08-02
WO2012103398A9 (en) 2012-09-27
JP2017095485A (ja) 2017-06-01
EP2672972A4 (en) 2014-09-10
WO2012103398A2 (en) 2012-08-02
EP2672972A2 (en) 2013-12-18
JP6342525B2 (ja) 2018-06-13
US8753327B2 (en) 2014-06-17
US9295670B2 (en) 2016-03-29
EP2672972B1 (en) 2020-11-04
US20120197235A1 (en) 2012-08-02
US20140238412A1 (en) 2014-08-28
CN107007602A (zh) 2017-08-04
CN103458899A (zh) 2013-12-18

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