JP2014503593A - 閉塞性睡眠時無呼吸を処置するための方法 - Google Patents
閉塞性睡眠時無呼吸を処置するための方法 Download PDFInfo
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- JP2014503593A JP2014503593A JP2013551354A JP2013551354A JP2014503593A JP 2014503593 A JP2014503593 A JP 2014503593A JP 2013551354 A JP2013551354 A JP 2013551354A JP 2013551354 A JP2013551354 A JP 2013551354A JP 2014503593 A JP2014503593 A JP 2014503593A
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- Prior art keywords
- sleep
- osa
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- apnea
- pyridostigmine
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Links
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Images
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/56—Devices for preventing snoring
- A61F5/566—Intra-oral devices
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437272P | 2011-01-28 | 2011-01-28 | |
| US61/437,272 | 2011-01-28 | ||
| PCT/US2012/022825 WO2012103398A2 (en) | 2011-01-28 | 2012-01-27 | Methods for treating obstructive sleep apnea |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000145A Division JP6342525B2 (ja) | 2011-01-28 | 2017-01-04 | 閉塞性睡眠時無呼吸を処置するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503593A true JP2014503593A (ja) | 2014-02-13 |
| JP2014503593A5 JP2014503593A5 (enExample) | 2015-03-19 |
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| JP2013551354A Pending JP2014503593A (ja) | 2011-01-28 | 2012-01-27 | 閉塞性睡眠時無呼吸を処置するための方法 |
| JP2017000145A Active JP6342525B2 (ja) | 2011-01-28 | 2017-01-04 | 閉塞性睡眠時無呼吸を処置するための方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000145A Active JP6342525B2 (ja) | 2011-01-28 | 2017-01-04 | 閉塞性睡眠時無呼吸を処置するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8753327B2 (enExample) |
| EP (1) | EP2672972B1 (enExample) |
| JP (2) | JP2014503593A (enExample) |
| CN (2) | CN103458899A (enExample) |
| CA (1) | CA2825309C (enExample) |
| WO (1) | WO2012103398A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024143302A1 (ja) * | 2022-12-28 | 2024-07-04 | 西川株式会社 | 健康リスク判定システム、自律神経判定システム、生活改善システム、寝姿勢判定システム、寝姿勢判定プログラム、歯ぎしり検出システム、および歯ぎしり検出プログラム |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2672972B1 (en) * | 2011-01-28 | 2020-11-04 | Pfantastic Medical Research Institute, LLC | Methods for treating obstructive sleep apnea |
| EP3446663A1 (en) * | 2014-03-03 | 2019-02-27 | Sleep Innovations Pty Ltd | Device and method for sleep apnoea treatment |
| WO2016014229A1 (en) | 2014-07-25 | 2016-01-28 | Mendelowitz David | Oxytocin improves treatment of obstructive sleep apnea |
| AU2016243801B2 (en) | 2015-04-02 | 2020-05-21 | Hill-Rom Services Pte. Ltd. | Manifold for respiratory device |
| WO2018115351A1 (en) * | 2016-12-23 | 2018-06-28 | Koninklijke Philips N.V. | System for treating snoring among at least two users |
| GEP20227387B (en) * | 2017-04-28 | 2022-06-10 | Brigham & Womens Hospital Inc | Methods and compositions for treating sleep apnea |
| BR112020015316A2 (pt) | 2018-01-30 | 2020-12-08 | Apnimed, Inc. (Delaware) | Métodos e composições para o tratamento da apneia do sono |
| EP3824881B1 (en) * | 2018-06-18 | 2022-02-16 | Amneal Complex Products Research LLC | Extended release compositions comprising pyridostigmine |
| EP3840806B1 (en) * | 2018-08-24 | 2023-10-11 | Koninklijke Philips N.V. | Providing sleep therapy with a pressure therapy system |
| US20200281522A1 (en) | 2019-03-06 | 2020-09-10 | Medtronic Xomed, LLC | System and method for improved obstructive sleep apnea diagnostic for implantable devices |
| CN114504643B (zh) * | 2021-12-24 | 2024-03-26 | 北京大学第一医院 | 抗IgE抗体在用于治疗OSAS中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000511873A (ja) * | 1995-12-19 | 2000-09-12 | エー プラス サイエンス インヴエスト アクチエボラグ | 睡眠時呼吸障害を治療および診断する方法、並びにこの方法を実施する手段 |
| JP2007502297A (ja) * | 2003-08-13 | 2007-02-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | コリンエステラーゼ阻害剤を用いる睡眠障害の処置 |
| WO2008042707A2 (en) * | 2006-09-29 | 2008-04-10 | Nellcor Puritan Bennett Llc | Device for managing obstructive sleep apnea and snoring |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2247662B (en) | 1990-08-31 | 1994-11-02 | Instance Ltd David J | Labels and manufacture thereof |
| CA2622721A1 (en) * | 2005-09-16 | 2007-03-22 | Cereuscience Ab | Method and means of preventing and treating sleep disordered breathing |
| US20080066739A1 (en) * | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| EP2672972B1 (en) * | 2011-01-28 | 2020-11-04 | Pfantastic Medical Research Institute, LLC | Methods for treating obstructive sleep apnea |
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2012
- 2012-01-27 EP EP12739245.4A patent/EP2672972B1/en active Active
- 2012-01-27 WO PCT/US2012/022825 patent/WO2012103398A2/en not_active Ceased
- 2012-01-27 CA CA2825309A patent/CA2825309C/en active Active
- 2012-01-27 JP JP2013551354A patent/JP2014503593A/ja active Pending
- 2012-01-27 US US13/359,692 patent/US8753327B2/en active Active
- 2012-01-27 CN CN2012800065522A patent/CN103458899A/zh active Pending
- 2012-01-27 CN CN201610821591.8A patent/CN107007602A/zh active Pending
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2014
- 2014-05-05 US US14/269,326 patent/US9295670B2/en active Active
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2017
- 2017-01-04 JP JP2017000145A patent/JP6342525B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000511873A (ja) * | 1995-12-19 | 2000-09-12 | エー プラス サイエンス インヴエスト アクチエボラグ | 睡眠時呼吸障害を治療および診断する方法、並びにこの方法を実施する手段 |
| JP2007502297A (ja) * | 2003-08-13 | 2007-02-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | コリンエステラーゼ阻害剤を用いる睡眠障害の処置 |
| WO2008042707A2 (en) * | 2006-09-29 | 2008-04-10 | Nellcor Puritan Bennett Llc | Device for managing obstructive sleep apnea and snoring |
Non-Patent Citations (1)
| Title |
|---|
| JPN6016034591; NEW薬理学(改訂第3版) , 19970801, p.234-241 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024143302A1 (ja) * | 2022-12-28 | 2024-07-04 | 西川株式会社 | 健康リスク判定システム、自律神経判定システム、生活改善システム、寝姿勢判定システム、寝姿勢判定プログラム、歯ぎしり検出システム、および歯ぎしり検出プログラム |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2672972B1 (en) | 2020-11-04 |
| WO2012103398A2 (en) | 2012-08-02 |
| US20140238412A1 (en) | 2014-08-28 |
| CA2825309A1 (en) | 2012-08-02 |
| US8753327B2 (en) | 2014-06-17 |
| CN107007602A (zh) | 2017-08-04 |
| CN103458899A (zh) | 2013-12-18 |
| JP6342525B2 (ja) | 2018-06-13 |
| EP2672972A4 (en) | 2014-09-10 |
| WO2012103398A9 (en) | 2012-09-27 |
| CA2825309C (en) | 2019-10-01 |
| EP2672972A2 (en) | 2013-12-18 |
| US9295670B2 (en) | 2016-03-29 |
| JP2017095485A (ja) | 2017-06-01 |
| US20120197235A1 (en) | 2012-08-02 |
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