CA2824776A1 - Purification of triglyceride oil from microbial sources using short path distillation - Google Patents
Purification of triglyceride oil from microbial sources using short path distillation Download PDFInfo
- Publication number
- CA2824776A1 CA2824776A1 CA2824776A CA2824776A CA2824776A1 CA 2824776 A1 CA2824776 A1 CA 2824776A1 CA 2824776 A CA2824776 A CA 2824776A CA 2824776 A CA2824776 A CA 2824776A CA 2824776 A1 CA2824776 A1 CA 2824776A1
- Authority
- CA
- Canada
- Prior art keywords
- sterol
- oil
- acid
- fraction
- microbial oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000000526 short-path distillation Methods 0.000 title claims abstract description 54
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- 238000012261 overproduction Methods 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000008103 phosphatidic acids Chemical class 0.000 description 1
- 229940067626 phosphatidylinositols Drugs 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 description 1
- 150000003019 phosphosphingolipids Chemical class 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 150000003096 polyprenols Chemical class 0.000 description 1
- 150000003135 prenol lipids Chemical class 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003313 saccharo lipids Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 150000003338 secosteroids Chemical class 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 239000012130 whole-cell lysate Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/12—Molecular distillation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
- C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/12—Refining fats or fatty oils by distillation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161441842P | 2011-02-11 | 2011-02-11 | |
| US61/441,842 | 2011-02-11 | ||
| PCT/US2012/024687 WO2012109563A1 (en) | 2011-02-11 | 2012-02-10 | Purification of triglyceride oil from microbial sources using short path distillation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2824776A1 true CA2824776A1 (en) | 2012-08-16 |
Family
ID=46638975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2824776A Abandoned CA2824776A1 (en) | 2011-02-11 | 2012-02-10 | Purification of triglyceride oil from microbial sources using short path distillation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9040730B2 (enExample) |
| EP (1) | EP2673063A1 (enExample) |
| JP (1) | JP2014510166A (enExample) |
| CN (1) | CN103379946A (enExample) |
| AU (1) | AU2012214285A1 (enExample) |
| CA (1) | CA2824776A1 (enExample) |
| WO (1) | WO2012109563A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6061866B2 (ja) | 2011-02-11 | 2017-01-18 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 微生物バイオマスから脂質含有組成物を得る方法 |
| US9074160B2 (en) * | 2013-03-07 | 2015-07-07 | Algisys, Llc | Production of omega-3 fatty acids from pythium species |
| JP6824038B2 (ja) | 2013-12-04 | 2021-02-03 | 日本水産株式会社 | ジホモ−γ−リノレン酸含有微生物油及びジホモ−γ−リノレン酸含有微生物菌体 |
| FR3025216A1 (fr) * | 2014-09-03 | 2016-03-04 | Univ Toulouse 3 Paul Sabatier | Procede d'extraction de lipide par electropulsation |
| CN106318984B (zh) * | 2015-06-30 | 2020-11-17 | 中国科学院大连化学物理研究所 | 一种产油微生物制脂肪酸甘油脂的方法及其甘油脂和应用 |
| US10751638B2 (en) | 2017-03-03 | 2020-08-25 | Lab Society Llc | High efficiency distillation head and methods of use |
| US10406451B2 (en) | 2017-08-24 | 2019-09-10 | Lab Society Llc | High efficiency distillation head and methods of use |
| WO2019206443A1 (en) | 2018-04-25 | 2019-10-31 | Nuseed Pty Ltd. | Dha enriched polyunsaturated fatty acid compositions |
| EP3560342B1 (en) | 2018-04-25 | 2020-06-03 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586643A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586641A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586642A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala enriched polyunsaturated fatty acid compositions |
| LV15474B (lv) * | 2018-06-29 | 2020-07-20 | Rīgas Tehniskā Universitāte | Vienšūņu eļļas iegūšanas paņēmiens no biodegradējamiem ražošanas atkritumiem |
| MX2022009806A (es) * | 2020-02-10 | 2022-10-03 | C16 Biosciences Inc | Sustitutos de aceite de palma producidos microbialmente. |
| EP4243627A4 (en) * | 2020-11-12 | 2024-10-16 | C16 Biosciences, Inc. | Edible microbial oil |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2874171A (en) * | 1957-02-20 | 1959-02-17 | Upjohn Co | Recovery of ergosterol |
| US4293220A (en) | 1979-07-02 | 1981-10-06 | The United States Of America As Represented By The Secretary Of The Navy | Application of inductively coupled plasma emission spectrometry to the elemental analysis of organic compounds and to the determination of the empirical formulas for these and other compounds |
| ES2052564T3 (es) * | 1986-07-08 | 1994-07-16 | Suntory Ltd | Procedimiento para la produccion de acido bishomo-gamma-linolenico y acido eicosapanteonico. |
| EP0442184A1 (en) | 1990-02-15 | 1991-08-21 | Campbell Soup Company | Production of low cholesterol animal fat by short path distillation |
| JP2000510513A (ja) * | 1996-05-15 | 2000-08-15 | ヒスト―ブロカデス・ベスローテン・フェンノートシャップ | 低ステロール且つ高トリグリセライドの微生物性油を得るための極性溶媒によるステロール抽出 |
| US20020016317A1 (en) * | 2000-03-27 | 2002-02-07 | Schul David Allen | Sterol ester compositions |
| EP2261312A1 (en) | 2001-12-12 | 2010-12-15 | Martek Biosciences Corporation | Extraction and Winterization of Lipids from Oilseed and Microbial Sources |
| EP2295529B2 (en) * | 2002-07-11 | 2022-05-18 | Basf As | Use of a volatile environmental pollutants-decreasing working fluid for decreasing the amount of pollutants in a fat for alimentary or cosmetic use |
| US7550651B2 (en) * | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| AU2005275741A1 (en) * | 2004-08-24 | 2006-03-02 | Suntory Holdings Limited | Process for producing microorganism fat containing diacylglycerol in any amount and the fat |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US8034391B2 (en) | 2005-07-01 | 2011-10-11 | Martek Biosciences Corporation | Polyunsaturated fatty acid-containing oil product and uses and production thereof |
| MY139389A (en) * | 2005-07-20 | 2009-09-30 | Malaysian Palm Oil Board Mpob | Production of edible oil with high diglyceride content |
| EP2074214A2 (en) | 2006-09-28 | 2009-07-01 | Microbia, Inc. | Production of sterols in oleaginous yeast and fungi |
| CN103282474A (zh) * | 2010-04-22 | 2013-09-04 | 纳幕尔杜邦公司 | 从微生物生物质中获得包含多不饱和脂肪酸的组合物的方法 |
| CN101851561A (zh) * | 2010-06-04 | 2010-10-06 | 江南大学 | 一种利用油脂脱臭馏出物联产生物柴油、植物甾醇和生育酚的方法 |
-
2012
- 2012-02-10 JP JP2013553603A patent/JP2014510166A/ja not_active Abandoned
- 2012-02-10 AU AU2012214285A patent/AU2012214285A1/en not_active Abandoned
- 2012-02-10 CA CA2824776A patent/CA2824776A1/en not_active Abandoned
- 2012-02-10 WO PCT/US2012/024687 patent/WO2012109563A1/en not_active Ceased
- 2012-02-10 US US13/370,785 patent/US9040730B2/en not_active Expired - Fee Related
- 2012-02-10 CN CN2012800078429A patent/CN103379946A/zh active Pending
- 2012-02-10 EP EP12744290.3A patent/EP2673063A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014510166A (ja) | 2014-04-24 |
| AU2012214285A1 (en) | 2013-07-18 |
| US20130046106A1 (en) | 2013-02-21 |
| US9040730B2 (en) | 2015-05-26 |
| WO2012109563A1 (en) | 2012-08-16 |
| EP2673063A1 (en) | 2013-12-18 |
| CN103379946A (zh) | 2013-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20170210 |