CA2824331C - Micro-pump or normally-off micro-valve - Google Patents
Micro-pump or normally-off micro-valve Download PDFInfo
- Publication number
- CA2824331C CA2824331C CA2824331A CA2824331A CA2824331C CA 2824331 C CA2824331 C CA 2824331C CA 2824331 A CA2824331 A CA 2824331A CA 2824331 A CA2824331 A CA 2824331A CA 2824331 C CA2824331 C CA 2824331C
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- Prior art keywords
- valve
- membrane
- micro
- cartridge
- membranes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K51/00—Other details not peculiar to particular types of valves or cut-off apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
- F04B53/10—Valves; Arrangement of valves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
- F16K99/0057—Operating means specially adapted for microvalves actuated by fluids the fluid being the circulating fluid itself, e.g. check valves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
- F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0094—Micropumps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/794—With means for separating solid material from the fluid
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reciprocating Pumps (AREA)
- Micromachines (AREA)
- Fluid-Driven Valves (AREA)
- Details Of Reciprocating Pumps (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20110151705 EP2479466A1 (en) | 2011-01-21 | 2011-01-21 | Micro-Pump or normally-off micro-valve |
| EP11151705.8 | 2011-01-21 | ||
| PCT/EP2012/050835 WO2012098214A1 (en) | 2011-01-21 | 2012-01-20 | Micro-pump or normally-off micro-valve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2824331A1 CA2824331A1 (en) | 2012-07-26 |
| CA2824331C true CA2824331C (en) | 2018-11-06 |
Family
ID=44123224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2824331A Expired - Fee Related CA2824331C (en) | 2011-01-21 | 2012-01-20 | Micro-pump or normally-off micro-valve |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9291284B2 (enExample) |
| EP (2) | EP2479466A1 (enExample) |
| JP (1) | JP5967552B2 (enExample) |
| KR (1) | KR20140023889A (enExample) |
| CN (1) | CN103282706B (enExample) |
| AU (1) | AU2012208527B2 (enExample) |
| BR (1) | BR112013018065A2 (enExample) |
| CA (1) | CA2824331C (enExample) |
| RU (1) | RU2588905C2 (enExample) |
| WO (1) | WO2012098214A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| GB2505706A (en) * | 2012-09-10 | 2014-03-12 | Univ Leiden | Apparatus comprising meniscus alignment barriers |
| EP2931427B1 (en) * | 2012-12-13 | 2022-02-09 | Siemens Healthineers Nederland B.V. | Fluidic system with fluidic stop |
| WO2014119497A1 (ja) * | 2013-01-31 | 2014-08-07 | 株式会社 日立ハイテクノロジーズ | 生化学用カートリッジ、生化学用カートリッジ及びカートリッジホルダのセット |
| JP6111161B2 (ja) * | 2013-07-18 | 2017-04-05 | 株式会社エンプラス | 流体取扱装置および流体取扱方法 |
| CN103672016B (zh) * | 2013-09-17 | 2016-01-13 | 中国航天员科研训练中心 | 一种通道型电磁常闭微阀 |
| CN105873681B (zh) | 2013-11-18 | 2019-10-11 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
| EP3142796A4 (en) | 2014-05-16 | 2017-12-20 | Qvella Corporation | Apparatus, system and method for performing automated centrifugal separation |
| US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
| CN104180015B (zh) * | 2014-07-07 | 2016-07-27 | 宁波大学 | 一种微阀及利用该微阀控制微流体输运的方法 |
| WO2016065073A1 (en) | 2014-10-22 | 2016-04-28 | Integenx Inc. | Systems and methods for sample preparation, processing and analysis |
| JP2018516065A (ja) * | 2015-02-04 | 2018-06-21 | ザ チャールズ スターク ドレイパー ラボラトリー インク | マイクロ流体装置用の作動バルブまたはポンプ |
| WO2016174230A1 (en) * | 2015-04-30 | 2016-11-03 | Orphidia Limited | Microfluidic valves and devices |
| CN105372429B (zh) * | 2015-12-21 | 2018-01-12 | 丹娜（天津）生物科技有限公司 | 基于鲎试剂细菌内毒素及(1‑3)‑β‑D葡聚糖检测的微流控芯片 |
| CN106179545B (zh) * | 2016-07-14 | 2018-08-28 | 南京肯辛顿诊断科技有限公司 | 用于生物分析的微流控芯片设备及其制备方法 |
| US10682644B2 (en) * | 2016-10-07 | 2020-06-16 | Boehringer Ingelheim Vetmedica Gmbh | Cartridge, analysis system and method for testing a sample |
| GB2555816A (en) * | 2016-11-10 | 2018-05-16 | Natural Environment Res Council | Analyser |
| CN108217576B (zh) * | 2016-12-21 | 2020-05-22 | 上海傲睿科技有限公司 | 膜片截止阀及其制造方法 |
| DE102017200308B4 (de) | 2017-01-10 | 2021-07-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Mikromechanische Bauelemente mit mechanischen Aktuatoren |
| CN106940351B (zh) * | 2017-03-01 | 2019-09-20 | 浙江大学 | 一种基于微流控芯片的检测中药质量及其生物活性成分的方法 |
| US10921303B1 (en) | 2017-05-31 | 2021-02-16 | Iowa State University Research Foundation, Inc. | Miniature sensors with probe insertable into and for obtaining measurements from plants and a variety of other mediums |
| CN111133195B (zh) * | 2017-08-01 | 2022-06-10 | 惠普发展公司，有限责任合伙企业 | 真空运行泵 |
| CN107569764B (zh) * | 2017-08-24 | 2020-04-21 | 任鹏涛 | 一种基于pdms微电磁肛肠术后给药装置 |
| US10422362B2 (en) | 2017-09-05 | 2019-09-24 | Facebook Technologies, Llc | Fluidic pump and latch gate |
| US10591933B1 (en) | 2017-11-10 | 2020-03-17 | Facebook Technologies, Llc | Composable PFET fluidic device |
| CA3091580A1 (en) | 2018-03-02 | 2019-09-06 | National Research Council Of Canada | Polymeric microfluidic valve |
| DE102018204633A1 (de) * | 2018-03-27 | 2019-10-02 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung und Verfahren zum Prozessieren einer Flüssigkeit |
| US11071530B2 (en) | 2018-03-27 | 2021-07-27 | Gyrus Acmi, Inc. | Needle system restrictor |
| WO2020033307A1 (en) * | 2018-08-06 | 2020-02-13 | Signal Biosystems Llc | Microfluidic devices and uses thereof |
| CN109185554B (zh) * | 2018-09-30 | 2019-10-18 | 浙江大学 | 一种音圈驱动的微型柔性阀 |
| DE102018124467A1 (de) * | 2018-10-04 | 2020-04-09 | Mst Innovation Gmbh | Hydraulisches Mikroventil |
| KR102151648B1 (ko) * | 2018-12-03 | 2020-09-03 | 광운대학교 산학협력단 | 미세유체 접속 장치 |
| WO2020179053A1 (ja) * | 2019-03-07 | 2020-09-10 | 株式会社日立ハイテク | 温度制御装置用送液カートリッジ |
| EP3763439A1 (en) * | 2019-07-12 | 2021-01-13 | Curiosity Diagnostics sp. z o.o | Microfluidic chip and valve, production process and uses |
| CN110410575A (zh) * | 2019-08-16 | 2019-11-05 | 郑州轻工业学院 | 一种面向微流控芯片的移动式电磁驱动微阀 |
| CN114728281B (zh) | 2019-10-18 | 2023-11-03 | 瞬知（广州）健康科技有限公司 | 用于输注流体的系统和方法 |
| TWI713142B (zh) | 2019-11-18 | 2020-12-11 | 研能科技股份有限公司 | 微流體致動器之製造方法 |
| CN112808330B (zh) * | 2019-11-18 | 2022-06-24 | 研能科技股份有限公司 | 微流体致动器的制造方法 |
| KR20220060258A (ko) * | 2020-11-04 | 2022-05-11 | 한양대학교 에리카산학협력단 | 마이크로 채널을 갖는 필름 구조체 및 그 제조 방법 |
| CN114768894B (zh) * | 2021-01-22 | 2023-08-11 | 中国科学院上海微系统与信息技术研究所 | 一种检测芯片及检测方法 |
| KR102515586B1 (ko) * | 2021-03-25 | 2023-03-29 | 주식회사 바이오스페로 | 세포의 멀티 배양, 대량 배양 및 실시간 모니터링이 가능한 미세 생리학적 시스템 |
| AU2022267355A1 (en) | 2021-04-30 | 2023-10-19 | Root Applied Sciences Inc. | Device for collecting material from air |
| CN113251208B (zh) * | 2021-05-13 | 2022-09-23 | 哈尔滨工业大学 | 一种气控两位三通阀 |
| CN113280187A (zh) * | 2021-05-19 | 2021-08-20 | 哈尔滨工业大学 | 一种基于pdms材料的常闭式气动压力开关 |
| CN113769798B (zh) * | 2021-09-03 | 2023-04-25 | 北京京东方技术开发有限公司 | 微流控芯片 |
| CN118574674A (zh) * | 2022-01-23 | 2024-08-30 | 新发病毒诊断(香港)有限公司 | 微流体阀 |
| CN115948236A (zh) * | 2022-11-26 | 2023-04-11 | 杭州迪安医学检验中心有限公司 | 一种基于旋转式储液仓的集成式多重核酸检测卡盒 |
| WO2025171198A1 (en) * | 2024-02-09 | 2025-08-14 | Nutcracker Therapeutics, Inc. | Apparatus and method for treating rna with beads |
| CN119267172B (zh) * | 2024-09-29 | 2025-09-05 | 华中科技大学 | 按压泵和微流控芯片 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1255014B (it) * | 1992-03-27 | 1995-10-13 | Instrumentation Lab Spa | Dispositivi di movimentazione ed intercettazione di fluidi |
| DE4402119C2 (de) * | 1994-01-25 | 1998-07-23 | Karlsruhe Forschzent | Verfahren zur Herstellung von Mikromembranpumpen |
| DE19526897A1 (de) * | 1995-07-22 | 1997-01-23 | Bosch Gmbh Robert | Mikroventil mit verbundenen Schichten und Verfahren zur Herstellung eines Mikroventils |
| DE19546570C1 (de) * | 1995-12-13 | 1997-03-27 | Inst Mikro Und Informationstec | Fluidpumpe |
| DE19719862A1 (de) * | 1997-05-12 | 1998-11-19 | Fraunhofer Ges Forschung | Mikromembranpumpe |
| KR20010043451A (ko) * | 1998-05-08 | 2001-05-25 | 인피니언 테크놀로지스 아게 | 마이크로밸브 |
| GB0028647D0 (en) * | 2000-11-24 | 2001-01-10 | Nextgen Sciences Ltd | Apparatus for chemical assays |
| RU2275541C2 (ru) * | 2004-07-05 | 2006-04-27 | Владимир Анатольевич Васин | Клапан (варианты) |
| US8703476B2 (en) | 2005-06-30 | 2014-04-22 | Biocartis Sa | Cartridge for automated medical diagnostics |
| US9416883B2 (en) | 2005-06-30 | 2016-08-16 | Koninklijke Philips N.V. | Valve device |
| US8257964B2 (en) | 2006-01-04 | 2012-09-04 | Cell ASIC | Microwell cell-culture device and fabrication method |
| JP2007040322A (ja) * | 2005-07-29 | 2007-02-15 | Canon Inc | リリーフバルブ、その製造方法および燃料電池 |
| JP2007170469A (ja) * | 2005-12-20 | 2007-07-05 | Kawamura Inst Of Chem Res | 温度応答性バルブおよびその製造方法 |
| WO2007080850A1 (ja) * | 2006-01-12 | 2007-07-19 | Sumitomo Bakelite Co., Ltd. | 受動型一方弁及びマイクロ流体デバイス |
| JP2009526969A (ja) * | 2006-02-13 | 2009-07-23 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 分子診断アプリケーションのための微小流体装置 |
| EP1998891B1 (en) * | 2006-03-20 | 2016-08-31 | Koninklijke Philips N.V. | A system-in-package platform for electronic-microfluidic devices |
| US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
| GB2443260C (en) | 2006-10-26 | 2017-11-29 | Cellnovo Ltd | Micro-valve |
| US20100171054A1 (en) | 2006-11-28 | 2010-07-08 | Astc Aerospace Ab | Micromechanical slow acting valve system |
| CN101520034A (zh) | 2008-02-29 | 2009-09-02 | 中国科学院大连化学物理研究所 | 集成常闭pdms微阀及制备工艺和含有该微阀的微泵 |
| DE102008002336A1 (de) * | 2008-06-10 | 2009-12-24 | Robert Bosch Gmbh | Quetschventil und Verfahren zu dessen Herstellung |
| RU2380418C1 (ru) * | 2008-10-01 | 2010-01-27 | Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН | Сменный микрофлюидный модуль для автоматизированного выделения и очистки нуклеиновых кислот из биологических образцов и способ выделения и очистки нуклеиновых кислот с его использованием |
| US8556373B2 (en) * | 2009-06-19 | 2013-10-15 | Burkhard Buestgens | Multichannel-printhead or dosing head |
-
2011
- 2011-01-21 EP EP20110151705 patent/EP2479466A1/en not_active Withdrawn
-
2012
- 2012-01-20 JP JP2013549822A patent/JP5967552B2/ja active Active
- 2012-01-20 CN CN201280004320.3A patent/CN103282706B/zh active Active
- 2012-01-20 AU AU2012208527A patent/AU2012208527B2/en not_active Ceased
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- 2012-01-20 RU RU2013134957/06A patent/RU2588905C2/ru not_active IP Right Cessation
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- 2012-01-20 CA CA2824331A patent/CA2824331C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20130299015A1 (en) | 2013-11-14 |
| CA2824331A1 (en) | 2012-07-26 |
| EP2665956B1 (en) | 2018-08-15 |
| EP2479466A1 (en) | 2012-07-25 |
| BR112013018065A2 (pt) | 2020-10-27 |
| EP2665956A1 (en) | 2013-11-27 |
| AU2012208527B2 (en) | 2016-11-17 |
| RU2588905C2 (ru) | 2016-07-10 |
| KR20140023889A (ko) | 2014-02-27 |
| US9291284B2 (en) | 2016-03-22 |
| CN103282706B (zh) | 2016-01-20 |
| JP5967552B2 (ja) | 2016-08-10 |
| WO2012098214A1 (en) | 2012-07-26 |
| JP2014510878A (ja) | 2014-05-01 |
| CN103282706A (zh) | 2013-09-04 |
| RU2013134957A (ru) | 2015-02-27 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20161027 |
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| MKLA | Lapsed |
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| MKLA | Lapsed |
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