CA2824073A1 - Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same - Google Patents
Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same Download PDFInfo
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- CA2824073A1 CA2824073A1 CA2824073A CA2824073A CA2824073A1 CA 2824073 A1 CA2824073 A1 CA 2824073A1 CA 2824073 A CA2824073 A CA 2824073A CA 2824073 A CA2824073 A CA 2824073A CA 2824073 A1 CA2824073 A1 CA 2824073A1
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- nucleic acid
- acid molecule
- reference nucleic
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C12N2330/31—Libraries, arrays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
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- Biophysics (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11000117.9 | 2011-01-10 | ||
| EP11000117 | 2011-01-10 | ||
| EPPCT/EP2011/002068 | 2011-04-21 | ||
| PCT/EP2011/002068 WO2011131371A1 (en) | 2010-04-21 | 2011-04-21 | Lipid binding nucleic acids |
| EP11008467 | 2011-10-21 | ||
| EP11008467.0 | 2011-10-21 | ||
| PCT/EP2012/000089 WO2012095303A1 (en) | 2011-01-10 | 2012-01-10 | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
Publications (1)
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| CA2824073A1 true CA2824073A1 (en) | 2012-07-19 |
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| CA2824073A Abandoned CA2824073A1 (en) | 2011-01-10 | 2012-01-10 | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
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| KR (2) | KR102080142B1 (enExample) |
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| AU (1) | AU2012206750A1 (enExample) |
| CA (1) | CA2824073A1 (enExample) |
| WO (1) | WO2012095303A1 (enExample) |
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| US20150232852A1 (en) * | 2011-10-21 | 2015-08-20 | Noxxon Pharma Ag | Glucagon Binding Nucleic Acids |
| CA2860809A1 (en) * | 2012-01-10 | 2013-07-18 | Noxxon Pharma Ag | Nucleic acids specifically binding cgrp |
| MX362061B (es) * | 2012-01-10 | 2019-01-07 | Noxxon Pharma Ag | Ácidos nucleicos de enlace c5a nuevos. |
| US11172873B2 (en) | 2018-05-17 | 2021-11-16 | The Procter & Gamble Company | Systems and methods for hair analysis |
| CN112188861B (zh) | 2018-05-17 | 2025-01-28 | 宝洁公司 | 用于毛发覆盖分析的系统和方法 |
| CN112771164A (zh) | 2018-06-29 | 2021-05-07 | 宝洁公司 | 用于个人护理应用的适配体 |
| EP3956451A1 (en) | 2019-04-16 | 2022-02-23 | The Procter & Gamble Company | Aptamers for odor control applications |
| US12039732B2 (en) | 2021-04-14 | 2024-07-16 | The Procter & Gamble Company | Digital imaging and learning systems and methods for analyzing pixel data of a scalp region of a users scalp to generate one or more user-specific scalp classifications |
| EP4306640A1 (en) | 2022-06-21 | 2024-01-17 | TME Pharma AG | Method for treating a tumor in a subject |
| CN119654415A (zh) | 2022-06-21 | 2025-03-18 | Tme制药股份公司 | 治疗受试者中肿瘤的方法 |
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| EP1695978A1 (en) | 1990-06-11 | 2006-08-30 | Gilead Sciences, Inc. | Nucleic acid ligands |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| DE59708838D1 (de) | 1996-08-30 | 2003-01-09 | Jens Peter Fuerste | Spiegelselektion und spiegelevolution von nucleinsäuren |
| US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| EP1264603B8 (en) | 2001-06-10 | 2010-03-03 | Noxxon Pharma AG | Use of L-polynucleotides for in vivo imaging |
| DK2431377T3 (en) | 2001-10-26 | 2017-08-14 | Noxxon Pharma Ag | Modified L-nucleic acids |
| EP1306382A1 (de) | 2001-10-26 | 2003-05-02 | Noxxon Pharma AG | Modifizierte L-Nukleinsäure |
| DE60329126D1 (de) | 2002-02-20 | 2009-10-15 | Beth Israel Hospital | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| FI20051017A7 (fi) | 2003-04-13 | 2005-11-28 | Enzon Pharmaceutivals Inc | Polymeeriset oligonukleotidiaihiolääkkeet |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| WO2005049828A1 (en) | 2003-11-10 | 2005-06-02 | Noxxon Pharma Ag | Nucleic acids specifically binding bioactive ghrelin |
| CN1917905B (zh) | 2004-02-09 | 2012-01-04 | 诺松制药股份公司 | 从多糖和多核苷酸生产缀合物的方法 |
| MXPA06010782A (es) | 2004-03-23 | 2007-03-28 | Complex Biosystems Gmbh | Ligador de profarmaco. |
| US7579450B2 (en) | 2004-04-26 | 2009-08-25 | Archemix Corp. | Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics |
| CA2585664C (en) | 2004-11-05 | 2014-05-20 | The Children's Hospital Of Philadelphia | Biodegradable linkers for molecular therapies |
| EP2385141B1 (en) * | 2005-10-07 | 2013-08-07 | SpeeDx Pty Ltd | Multicomponent nucleic acid enzymes and methods for their use |
| US20120101267A1 (en) | 2005-10-07 | 2012-04-26 | Alison Velyian Todd | Multicomponent nucleic acid enzymes with cleavage, ligase or other activity and methods for their use |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| NZ580129A (en) | 2007-04-05 | 2012-05-25 | Johnson & Johnson Res Pty Ltd | Nucleic acid enzymes and complexes and methods for their use |
| WO2008134077A1 (en) * | 2007-04-30 | 2008-11-06 | Archemix Corp. | Metabolic profile directed aptamer medicinal chemistry |
| US20100035967A1 (en) * | 2008-07-28 | 2010-02-11 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 9 expression by antisense oligonucleotides |
| CN102906265B (zh) | 2010-04-21 | 2016-08-24 | 诺松制药股份公司 | 脂质结合核酸 |
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Also Published As
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| EP2663640A1 (en) | 2013-11-20 |
| EP2663640B1 (en) | 2020-11-04 |
| US20190367921A1 (en) | 2019-12-05 |
| KR20140026357A (ko) | 2014-03-05 |
| JP2017148055A (ja) | 2017-08-31 |
| US20140350088A1 (en) | 2014-11-27 |
| WO2012095303A1 (en) | 2012-07-19 |
| AU2012206750A1 (en) | 2013-07-18 |
| KR102080142B1 (ko) | 2020-02-21 |
| KR20190067260A (ko) | 2019-06-14 |
| CN103339258A (zh) | 2013-10-02 |
| JP2014504865A (ja) | 2014-02-27 |
| US9976145B2 (en) | 2018-05-22 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20171222 |
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| FZDE | Discontinued |
Effective date: 20210831 |
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| FZDE | Discontinued |
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