CA2822994C - Intermediaires pour la preparation d'analogues d'halichondrine b - Google Patents

Intermediaires pour la preparation d'analogues d'halichondrine b Download PDF

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Publication number
CA2822994C
CA2822994C CA2822994A CA2822994A CA2822994C CA 2822994 C CA2822994 C CA 2822994C CA 2822994 A CA2822994 A CA 2822994A CA 2822994 A CA2822994 A CA 2822994A CA 2822994 C CA2822994 C CA 2822994C
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Prior art keywords
vol
added
reaction
stirred
mixture
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CA2822994A
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CA2822994A1 (fr
Inventor
Charles E. Chase
Francis G. Fang
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Priority to CA2935786A priority Critical patent/CA2935786C/fr
Priority claimed from CA2567984A external-priority patent/CA2567984C/fr
Publication of CA2822994A1 publication Critical patent/CA2822994A1/fr
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Abstract

La présente invention a trait à des composés macrocycliques, la synthèse de ceux-ci et leurs intermédiaires. De tels composés, et leurs compositions, servent à traiter ou éviter les troubles prolifératifs de formule F4.
CA2822994A 2004-06-03 2005-06-03 Intermediaires pour la preparation d'analogues d'halichondrine b Active CA2822994C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2935786A CA2935786C (fr) 2004-06-03 2005-06-03 Intermediaires pour la preparation d'analogues d'halichondrine b

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US57664204P 2004-06-03 2004-06-03
US60/576,642 2004-06-03
US62676904P 2004-11-10 2004-11-10
US60/626,769 2004-11-10
US66330005P 2005-03-18 2005-03-18
US60/663,300 2005-03-18
CA2567984A CA2567984C (fr) 2004-06-03 2005-06-03 Intermediaires pour la preparation d'analogues d'halichondrine b

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2567984A Division CA2567984C (fr) 2004-06-03 2005-06-03 Intermediaires pour la preparation d'analogues d'halichondrine b

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2935786A Division CA2935786C (fr) 2004-06-03 2005-06-03 Intermediaires pour la preparation d'analogues d'halichondrine b

Publications (2)

Publication Number Publication Date
CA2822994A1 CA2822994A1 (fr) 2005-12-15
CA2822994C true CA2822994C (fr) 2016-09-27

Family

ID=38214909

Family Applications (1)

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CA2822994A Active CA2822994C (fr) 2004-06-03 2005-06-03 Intermediaires pour la preparation d'analogues d'halichondrine b

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CN (3) CN109180615A (fr)
CA (1) CA2822994C (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5735277B2 (ja) * 2007-10-03 2015-06-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂ類似体の合成のための中間体および方法
MX2012008510A (es) * 2010-01-26 2012-11-21 Eisai R&D Man Co Ltd Derivados de furo [3, 2-b] pirano utiles en la sintesis de analogos de halicondrina b.
US9062020B2 (en) * 2011-12-29 2015-06-23 Alphora Research Inc. 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
US9783549B2 (en) 2013-11-04 2017-10-10 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
RU2676486C1 (ru) * 2013-12-06 2018-12-29 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способы, предназначенные для синтеза аналогов галихондрина b
CN105713031B (zh) * 2014-12-05 2021-05-07 正大天晴药业集团股份有限公司 一种用于制备艾日布林的中间体及其制备方法
CN108658956B (zh) * 2017-03-28 2021-02-02 上海时莱生物技术有限公司 艾日布林中间体及其制备方法
CN108948064B (zh) * 2017-05-17 2021-02-02 上海时莱生物技术有限公司 一种艾日布林中间体及其制备方法
CN109694379B (zh) * 2017-10-24 2020-09-11 江苏恒瑞医药股份有限公司 用于制备艾日布林的中间体及其制备方法
US11396515B2 (en) 2018-03-02 2022-07-26 Beijing Tienyi Lufu Pharmatech Co. Ltd. Pyran fused ring compound, preparation method therefor and use thereof
CN111689982B (zh) * 2019-03-15 2023-04-07 博瑞生物医药（苏州）股份有限公司 艾日布林中间体及其制备方法
CN110684036B (zh) * 2019-11-22 2022-04-12 江苏慧聚药业股份有限公司 一条制备甲磺酸艾日布林的方法
CN113121555B (zh) * 2020-01-16 2024-03-08 南通诺泰生物医药技术有限公司 通过微通道反应器制备艾日布林中间体的方法
CN113354659B (zh) * 2021-06-08 2022-04-08 江苏慧聚药业股份有限公司 甲磺酸艾日布林的合成

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436238A (en) * 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
PT1087960E (pt) * 1998-06-17 2011-06-17 Eisai R&D Man Co Ltd Análogos macrocíclicos e métodos de sua utilização e preparação

Also Published As

Publication number Publication date
CA2822994A1 (fr) 2005-12-15
CN109180615A (zh) 2019-01-11
CN1993342A (zh) 2007-07-04
CN108997267A (zh) 2018-12-14

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