CA2821289C - Adenovirus serotype 26 and serotype 35 filovirus vaccines - Google Patents

Adenovirus serotype 26 and serotype 35 filovirus vaccines Download PDF

Info

Publication number
CA2821289C
CA2821289C CA2821289A CA2821289A CA2821289C CA 2821289 C CA2821289 C CA 2821289C CA 2821289 A CA2821289 A CA 2821289A CA 2821289 A CA2821289 A CA 2821289A CA 2821289 C CA2821289 C CA 2821289C
Authority
CA
Canada
Prior art keywords
adenovirus
vectors
vector
rad35
filovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2821289A
Other languages
English (en)
French (fr)
Other versions
CA2821289A1 (en
Inventor
Nancy J. Sullivan
Gary J. Nabel
Clement Asiedu
Cheng Cheng
Maria Grazia Pau
Jaap Goudsmit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
US Department of Health and Human Services
Original Assignee
Crucell Holand BV
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holand BV, US Department of Health and Human Services filed Critical Crucell Holand BV
Publication of CA2821289A1 publication Critical patent/CA2821289A1/en
Application granted granted Critical
Publication of CA2821289C publication Critical patent/CA2821289C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • C12N15/861Adenoviral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/235Adenoviridae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10041Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/14011Filoviridae
    • C12N2760/14034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/14011Filoviridae
    • C12N2760/14111Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2821289A 2010-12-14 2011-12-14 Adenovirus serotype 26 and serotype 35 filovirus vaccines Active CA2821289C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42295410P 2010-12-14 2010-12-14
US61/422,954 2010-12-14
PCT/US2011/064944 WO2012082918A1 (en) 2010-12-14 2011-12-14 Adenovirus serotype 26 and serotype 35 filovirus vaccines

Publications (2)

Publication Number Publication Date
CA2821289A1 CA2821289A1 (en) 2012-06-21
CA2821289C true CA2821289C (en) 2019-05-21

Family

ID=46245095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2821289A Active CA2821289C (en) 2010-12-14 2011-12-14 Adenovirus serotype 26 and serotype 35 filovirus vaccines

Country Status (14)

Country Link
US (1) US9701718B2 (cg-RX-API-DMAC7.html)
EP (1) EP2655604B1 (cg-RX-API-DMAC7.html)
JP (2) JP6054876B2 (cg-RX-API-DMAC7.html)
KR (1) KR101879892B1 (cg-RX-API-DMAC7.html)
CN (1) CN103370411B (cg-RX-API-DMAC7.html)
AU (1) AU2011343798B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013014712B1 (cg-RX-API-DMAC7.html)
CA (1) CA2821289C (cg-RX-API-DMAC7.html)
DK (1) DK2655604T3 (cg-RX-API-DMAC7.html)
EA (1) EA029504B1 (cg-RX-API-DMAC7.html)
ES (1) ES2676196T3 (cg-RX-API-DMAC7.html)
PL (1) PL2655604T3 (cg-RX-API-DMAC7.html)
WO (1) WO2012082918A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201304260B (cg-RX-API-DMAC7.html)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013014712B1 (pt) 2010-12-14 2021-03-02 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services primeiro e segundo vetores de adenovírus recombinantes
ZA201608812B (en) 2014-06-26 2019-08-28 Janssen Vaccines & Prevention Bv Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
AU2015279089B2 (en) 2014-06-26 2021-01-28 Janssen Vaccines & Prevention B.V. Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
CA2960092C (en) * 2014-09-03 2021-05-04 Bavarian Nordic A/S Vaccine combination including vectors comprising nucleic acid encoding antigens from filovirus subtypes
KR20190062617A (ko) 2014-09-03 2019-06-05 버베리안 노딕 에이/에스 면역 반응을 증대시키기 위한 방법 및 조성물
LT3197489T (lt) 2014-09-26 2021-07-26 Beth Israel Deaconess Medical Center, Inc. Būdai ir kompozicijos, skirti indukuoti apsauginį imunitetą prieš žmogaus imunodeficito viruso infekciją
WO2016146844A1 (en) 2015-03-18 2016-09-22 Janssen Vaccines & Prevention B.V. Assays for recombinant expression systems
RS62360B1 (sr) 2015-12-15 2021-10-29 Janssen Vaccines & Prevention Bv Antigeni, vektori i sastavi virusa humane imunodeficijencije, i postupci njihove primene
MX2018009997A (es) 2016-02-18 2019-02-07 Int Flavors & Fragrances Inc Composiciones de cápsulas de poliurea.
CN109070038B (zh) 2016-03-18 2021-08-31 国际香料和香精公司 二氧化硅微胶囊及其制备方法
EP3471765B1 (en) 2016-06-16 2024-04-24 Janssen Vaccines & Prevention B.V. Hiv vaccine formulation
BR112018076803B1 (pt) 2016-07-01 2022-05-03 International Flavors & Fragrances Inc Composição estável de microcápsula, e, produto de consumo
US10925955B2 (en) 2016-07-15 2021-02-23 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a Marburg virus infection
EP3484507A1 (en) 2016-07-15 2019-05-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
EP3512625B1 (en) 2016-09-16 2023-04-26 International Flavors & Fragrances Inc. Microcapsule compositions stabilized with viscosity control agents
US20180085291A1 (en) 2016-09-28 2018-03-29 International Flavors & Fragrances Inc. Microcapsule compositions containing amino silicone
US11173204B2 (en) 2017-04-06 2021-11-16 Janssen Vaccines & Prevention B.V. MVA-BN and Ad26.ZEBOV or Ad26.filo prime-boost regimen
US20180346648A1 (en) 2017-05-30 2018-12-06 International Flavors & Fragrances Inc. Branched polyethyleneimine microcapsules
ES2976495T3 (es) 2017-06-15 2024-08-02 Janssen Vaccines & Prevention Bv Vectores poxvirus que codifican antígenos del VIH y métodos de uso de los mismos
WO2019018724A1 (en) 2017-07-21 2019-01-24 Janssen Vaccines & Prevention B.V. METHODS FOR SAFE INDUCTION OF MULTICLADED CROSS-IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HUMAN BEINGS
CN111163799A (zh) 2017-07-28 2020-05-15 扬森疫苗与预防公司 用于异源repRNA免疫接种的方法和组合物
BR112020007884A2 (pt) 2017-11-20 2020-11-03 Janssen Pharmaceuticals, Inc. método de proporcionar uma administração segura de vetores adenovirais que codificam um antígeno de vírus zika
MX2020006471A (es) 2017-12-19 2020-09-22 Janssen Sciences Ireland Unlimited Co Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv).
MX2020011366A (es) 2018-04-27 2020-11-24 Int Flavors & Fragrances Inc Composiciones estables de microcapsulas de poliurea.
WO2020016394A1 (en) 2018-07-20 2020-01-23 Janssen Vaccines & Prevention B.V. Recombinant adenoviral vector expressing zika antigen with improved productivity
AU2019345942A1 (en) 2018-09-25 2021-03-18 Janssen Vaccines & Prevention B.V. Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components
US12303856B2 (en) 2018-12-18 2025-05-20 International Flavors & Fragrances Inc. Hydroxyethyl cellulose microcapsules
PH12021552797A1 (en) 2019-05-14 2022-09-19 Janssen Biotech Inc Ultrafiltration/diafiltration (uf/df) process
JP2023512519A (ja) 2020-01-31 2023-03-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド コロナウイルス感染症を予防および処置するための組成物および方法-sars-cov-2ワクチン
WO2021228842A1 (en) 2020-05-11 2021-11-18 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
IL299515A (en) 2020-06-29 2023-02-01 Janssen Vaccines & Prevention Bv Vaccine combination against respiratory syncytial virus infection
WO2022008438A1 (en) 2020-07-06 2022-01-13 Janssen Pharmaceuticals, Inc. Stabilized corona virus spike protein fusion proteins
WO2022008613A1 (en) 2020-07-08 2022-01-13 Janssen Sciences Ireland Unlimited Company Rna replicon vaccines against hbv
MX2022002609A (es) * 2020-08-22 2022-06-08 Federal State Budgetary Institution National Res Centre For Epidemiology And Microbiology Named Afte Vector de expresion para el desarrollo de un agente inmunobiologico para inducir inmunidad especifica contra el virus de sindrome respiratorio agudo grave sars-cov-2 (variantes).
WO2022175479A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Vaccine combinations against respiratory syncytial virus strain a and b infections
AU2022221983A1 (en) 2021-02-19 2023-08-17 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv fb antigens
EP4314019A2 (en) 2021-04-01 2024-02-07 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion piv3 f proteins
EP4124383A1 (en) 2021-07-27 2023-02-01 International Flavors & Fragrances Inc. Biodegradable microcapsules
WO2023020939A1 (en) 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023026182A1 (en) 2021-08-24 2023-03-02 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
EP4154974A1 (en) 2021-09-23 2023-03-29 International Flavors & Fragrances Inc. Biodegradable microcapsules
WO2023047348A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized corona virus spike protein fusion proteins
WO2023047349A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
WO2023111725A1 (en) 2021-12-14 2023-06-22 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
EP4448802A1 (en) 2021-12-16 2024-10-23 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
WO2023198815A1 (en) 2022-04-14 2023-10-19 Janssen Vaccines & Prevention B.V. Sequential administration of adenoviruses
EP4590690A1 (en) 2022-09-23 2025-07-30 Janssen Vaccines & Prevention B.V. Pre-fusion human piv1 f proteins
EP4590689A1 (en) 2022-09-23 2025-07-30 Janssen Vaccines & Prevention B.V. Stabilized trimeric class i fusion proteins
WO2024061759A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Stabilized coronavirus s proteins
AU2023355822A1 (en) 2022-10-06 2025-04-17 Msd International Business Gmbh Stabilized pre-fusion piv3 f proteins
EP4406641A1 (en) 2023-01-26 2024-07-31 International Flavors & Fragrances Inc. Biodegradable microcapsules containing low log p fragrance

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852324B1 (en) * 1997-12-23 2005-02-08 The United States Of America As Represented By The Department Of Health And Human Services Immunization for ebola virus infection
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
ES2307093T3 (es) * 2001-10-01 2008-11-16 THE GOVERNMENT OF THE USA, AS REPR. BY SECRETARY, DEPT. HEALTH & HUMAN SERVICES, NAT. INST OF HEALTH Desarrollo de un vacuna preventiva para la infeccion por filovirus en primates.
WO2004001032A2 (en) 2002-04-25 2003-12-31 Crucell Holland B.V. Stable adenoviral vectors and methods for propagation thereof
BR0308783A (pt) 2002-04-25 2005-01-04 Crucell Holland Bv Vetor de adenovìrus recombinante, método para produzir um vetor de adenovìrus recombinante, composição farmacêutica, método para tratar um corpo humano, e, kit de partes
AU2003288273A1 (en) * 2002-10-23 2004-05-13 Crucell Holland B.V. New settings for recombinant adenoviral-based vaccines
WO2005012538A2 (en) * 2003-08-01 2005-02-10 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Accelerated vaccination
CA2581840C (en) 2004-09-27 2014-08-05 Crucell Holland B.V. Optimized vaccines to provide protection against ebola and other viruses
JP4843613B2 (ja) * 2004-10-13 2011-12-21 クルセル ホランド ベー ヴェー 改良されたアデノウイルスベクターおよびその使用方法
BRPI0516048A (pt) 2004-10-13 2008-08-19 Crucell Holland B V E Beth Isr batelada de um adenovìrus recombinante defectivo em replicação baseado em um sorotipo do subgrupo c
MX2007004031A (es) * 2004-10-14 2007-11-08 Crucell Holland Bv Vacunas de cebado/refuerzo contra el paludismo.
US20100143302A1 (en) 2006-03-16 2010-06-10 Crucell Holland B.V. Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof
WO2007110409A1 (en) * 2006-03-27 2007-10-04 Crucell Holland B.V. Compositions comprising a recombinant adenovirus and an adjuvant
US20110091496A1 (en) * 2008-01-19 2011-04-21 Graham Barney S Methods and compositions for the delivery of vaccines to disrupted epithelium
BR112013014712B1 (pt) 2010-12-14 2021-03-02 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services primeiro e segundo vetores de adenovírus recombinantes

Also Published As

Publication number Publication date
PL2655604T3 (pl) 2019-02-28
ZA201304260B (en) 2021-05-26
EP2655604A4 (en) 2015-01-28
JP6054876B2 (ja) 2016-12-27
EA201390866A1 (ru) 2014-05-30
US20140017278A1 (en) 2014-01-16
KR20140019304A (ko) 2014-02-14
AU2011343798B2 (en) 2016-07-14
JP6268258B2 (ja) 2018-01-24
BR112013014712B1 (pt) 2021-03-02
EP2655604A1 (en) 2013-10-30
EP2655604B1 (en) 2018-05-09
WO2012082918A1 (en) 2012-06-21
JP2017048207A (ja) 2017-03-09
ES2676196T3 (es) 2018-07-17
CN103370411A (zh) 2013-10-23
CN103370411B (zh) 2016-05-04
CA2821289A1 (en) 2012-06-21
AU2011343798A1 (en) 2013-07-11
EA029504B1 (ru) 2018-04-30
DK2655604T3 (en) 2018-08-06
KR101879892B1 (ko) 2018-08-17
US9701718B2 (en) 2017-07-11
BR112013014712A2 (pt) 2017-06-06
JP2014503206A (ja) 2014-02-13

Similar Documents

Publication Publication Date Title
CA2821289C (en) Adenovirus serotype 26 and serotype 35 filovirus vaccines
US11913013B2 (en) Chimpanzee adenoviral vector-based filovirus vaccines
AU2015311868B2 (en) Methods and compositions for enhancing immune responses
AU2015311852B2 (en) Methods and compositions for inducing protective immunity against filovirus infection
WO2016187613A1 (en) Methods and compositions for inducing protective immunity against filovirus infection and/or disease
US10925955B2 (en) Methods and compositions for inducing protective immunity against a Marburg virus infection
OA19216A (en) Methods and compositions for inducing protective immunity against a Marburg virus infection.
HK1239544A1 (en) Methods and compositions for inducing protective immunity against filovirus infection
HK1239544B (en) Methods and compositions for inducing protective immunity against filovirus infection

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20161213