EA201390866A1 - Филовирусные вакцины на основе аденовирусов серотипа 26 и серотипа 35 - Google Patents

Филовирусные вакцины на основе аденовирусов серотипа 26 и серотипа 35

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Publication number
EA201390866A1
EA201390866A1 EA201390866A EA201390866A EA201390866A1 EA 201390866 A1 EA201390866 A1 EA 201390866A1 EA 201390866 A EA201390866 A EA 201390866A EA 201390866 A EA201390866 A EA 201390866A EA 201390866 A1 EA201390866 A1 EA 201390866A1
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EA
Eurasian Patent Office
Prior art keywords
serotip
philovirus
adenoviruses
vaccines based
serotype
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EA201390866A
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English (en)
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EA029504B1 (ru
Inventor
Нэнси Дж. Салливан
Гари Дж. Нейбел
Клемент Асиеду
Чэн Чэн
Мария Грация Грация Пау
Яап Гоудсмит
Original Assignee
Дзе Гавермент Оф Дзе Юнайтед Стейтс Оф Америка Эз Репрезентед Бай Дзе Секретэри Оф Дзе Департмент Оф Хелт Энд Хьюмэн Сервисиз
Круселл Холланд Б.В.
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Application filed by Дзе Гавермент Оф Дзе Юнайтед Стейтс Оф Америка Эз Репрезентед Бай Дзе Секретэри Оф Дзе Департмент Оф Хелт Энд Хьюмэн Сервисиз, Круселл Холланд Б.В. filed Critical Дзе Гавермент Оф Дзе Юнайтед Стейтс Оф Америка Эз Репрезентед Бай Дзе Секретэри Оф Дзе Департмент Оф Хелт Энд Хьюмэн Сервисиз
Publication of EA201390866A1 publication Critical patent/EA201390866A1/ru
Publication of EA029504B1 publication Critical patent/EA029504B1/ru

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Abstract

Настоящее изобретение относится к рекомбинантным аденовирусным векторам (серотипа 26 и серотипа 35), кодирующим филовирусные антигены. Аденовирусные векторы могут быть использованы для индуцирования протективных иммунных ответов против филовирусной инфекции.
EA201390866A 2010-12-14 2011-12-14 Способ индуцирования иммунного ответа против филовирусного антигена у пациента с использованием аденовирусов серотипа 26 и серотипа 35 EA029504B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42295410P 2010-12-14 2010-12-14
PCT/US2011/064944 WO2012082918A1 (en) 2010-12-14 2011-12-14 Adenovirus serotype 26 and serotype 35 filovirus vaccines

Publications (2)

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EA201390866A1 true EA201390866A1 (ru) 2014-05-30
EA029504B1 EA029504B1 (ru) 2018-04-30

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EA201390866A EA029504B1 (ru) 2010-12-14 2011-12-14 Способ индуцирования иммунного ответа против филовирусного антигена у пациента с использованием аденовирусов серотипа 26 и серотипа 35

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US (1) US9701718B2 (ru)
EP (1) EP2655604B1 (ru)
JP (2) JP6054876B2 (ru)
KR (1) KR101879892B1 (ru)
CN (1) CN103370411B (ru)
AU (1) AU2011343798B2 (ru)
BR (1) BR112013014712B1 (ru)
CA (1) CA2821289C (ru)
DK (1) DK2655604T3 (ru)
EA (1) EA029504B1 (ru)
ES (1) ES2676196T3 (ru)
PL (1) PL2655604T3 (ru)
WO (1) WO2012082918A1 (ru)
ZA (1) ZA201304260B (ru)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013014712B1 (pt) 2010-12-14 2021-03-02 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services primeiro e segundo vetores de adenovírus recombinantes
AU2015279089B2 (en) 2014-06-26 2021-01-28 Janssen Vaccines & Prevention B.V. Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
ZA201608812B (en) 2014-06-26 2019-08-28 Janssen Vaccines & Prevention Bv Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
WO2016036971A1 (en) * 2014-09-03 2016-03-10 Bavarian Nordic A/S Methods and compositions for enhancing immune responses
DK3188753T3 (da) 2014-09-03 2020-03-23 Us Health Fremgangsmåder og sammensætninger til at fremkalde beskyttende immunitet mod filovirusinfektion
EA037583B1 (ru) 2014-09-26 2021-04-16 Бет Изрейэл Диконисс Медикал Сентер, Инк. Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека
DK3271729T3 (da) 2015-03-18 2020-12-14 Janssen Vaccines & Prevention Bv Analyser til rekombinante ekspressionssystemer
US10369214B2 (en) 2015-12-15 2019-08-06 Janssen Vaccines & Prevention B.V. Synthetic human immunodeficiency virus (HIV) envelope antigen, vectors, and compositions thereof
CN115089512B (zh) 2016-02-18 2024-08-27 国际香料和香精公司 聚脲胶囊组合物
CN109070038B (zh) 2016-03-18 2021-08-31 国际香料和香精公司 二氧化硅微胶囊及其制备方法
BR112018075785A2 (pt) 2016-06-16 2019-04-02 Janssen Vaccines & Prevention B.V. formulação de vacina para o hiv
US11540985B2 (en) 2016-07-01 2023-01-03 International Flavors & Fragrances Inc. Stable microcapsule compositions
US10925956B2 (en) 2016-07-15 2021-02-23 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
WO2018011198A1 (en) 2016-07-15 2018-01-18 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
CN109689197B (zh) 2016-09-16 2023-06-23 国际香料和香精公司 用粘度控制剂稳定的微胶囊组合物
US20180085291A1 (en) 2016-09-28 2018-03-29 International Flavors & Fragrances Inc. Microcapsule compositions containing amino silicone
EP3606553A1 (en) 2017-04-06 2020-02-12 Janssen Vaccines & Prevention B.V. Mva-bn and ad26.zebov or ad26.filo prime-boost regimen
US20180346648A1 (en) 2017-05-30 2018-12-06 International Flavors & Fragrances Inc. Branched polyethyleneimine microcapsules
BR112019026126A2 (pt) 2017-06-15 2020-06-30 Janssen Vaccines & Prevention B.V. vetores de poxvírus que codificam antígenos do hiv e métodos de uso dos mesmos
WO2019018724A1 (en) 2017-07-21 2019-01-24 Janssen Vaccines & Prevention B.V. METHODS FOR SAFE INDUCTION OF MULTICLADED CROSS-IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HUMAN BEINGS
MA49693A (fr) 2017-07-28 2020-06-03 Janssen Vaccines & Prevention Bv Méthodes et compositions pour assurer l'immunisation contre l'arnrep hétérologue
WO2019099970A1 (en) 2017-11-20 2019-05-23 Janssen Pharmaceuticals Inc. Method of providing safe administration of adenoviral vectors encoding a zika virus antigen
CN111741766A (zh) 2017-12-19 2020-10-02 杨森科学爱尔兰无限公司 用于诱导针对乙型肝炎病毒(hbv)的免疫应答的方法和组合物
US11713469B2 (en) 2018-07-20 2023-08-01 Janssen Vaccines & Prevention B.V. Recombinant adenoviral vector expressing Zika antigen with improved productivity
EP3856238A1 (en) 2018-09-25 2021-08-04 Janssen Vaccines & Prevention B.V. Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components
US20220071862A1 (en) 2018-12-18 2022-03-10 International Flavors & Fragrances Inc. Microcapsule compositions
KR20220008300A (ko) 2019-05-14 2022-01-20 얀센 바이오테크 인코포레이티드 정용여과 공정을 사용한 효율적인 불순물 제거
US20230075527A1 (en) 2020-01-31 2023-03-09 Janssen Pharmaceuticals, Inc Compositions and Methods for Preventing and Treating Coronavirus Infection - Sars-Cov-2 Vaccines
MX2022014162A (es) 2020-05-11 2023-02-23 Janssen Pharmaceuticals Inc Proteínas de fusión de la proteína de la espícula del coronavirus estabilizadas.
BR112022026408A2 (pt) 2020-06-29 2023-01-17 Janssen Vaccines & Prevention Bv Combinação vacinal contra infecção pelo vírus sincicial respiratório
MX2023000373A (es) 2020-07-06 2023-02-13 Janssen Pharmaceuticals Inc Proteinas de fusion de proteinas de la espicula de coronavirus estabilizadas.
JP2023533528A (ja) 2020-07-08 2023-08-03 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Hbvに対するrnaレプリコンワクチン
WO2022175479A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Vaccine combinations against respiratory syncytial virus strain a and b infections
JP2024509756A (ja) 2021-02-19 2024-03-05 ヤンセン ファッシンズ アンド プリベンション ベーフェー 安定化された融合前rsv fb抗原
US20240197859A1 (en) 2021-04-01 2024-06-20 Janssen Vaccines & Prevention B.V. Stabilized Pre-Fusion PIV3 F Proteins
EP4124383A1 (en) 2021-07-27 2023-02-01 International Flavors & Fragrances Inc. Biodegradable microcapsules
WO2023020939A1 (en) 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023026182A1 (en) 2021-08-24 2023-03-02 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
EP4154974A1 (en) 2021-09-23 2023-03-29 International Flavors & Fragrances Inc. Biodegradable microcapsules
WO2023047348A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized corona virus spike protein fusion proteins
WO2023047349A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
WO2023111725A1 (en) 2021-12-14 2023-06-22 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023110618A1 (en) 2021-12-16 2023-06-22 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
WO2023198815A1 (en) 2022-04-14 2023-10-19 Janssen Vaccines & Prevention B.V. Sequential administration of adenoviruses
WO2024061759A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Stabilized coronavirus s proteins
WO2024061753A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Stabilized trimeric class i fusion proteins
WO2024061757A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Pre-fusion human piv1 f proteins
WO2024074584A1 (en) 2022-10-06 2024-04-11 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion piv3 f proteins
EP4406641A1 (en) 2023-01-26 2024-07-31 International Flavors & Fragrances Inc. Biodegradable microcapsules containing low log p fragrance

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852324B1 (en) * 1997-12-23 2005-02-08 The United States Of America As Represented By The Department Of Health And Human Services Immunization for ebola virus infection
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
WO2003028632A2 (en) 2001-10-01 2003-04-10 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Development of a preventive vaccine for filovirus infection in primates
JP4495588B2 (ja) 2002-04-25 2010-07-07 クルセル ホランド ベー ヴェー 安定なアデノウイルスベクターおよびその増殖方法
SI1497438T1 (sl) 2002-04-25 2010-03-31 Crucell Holland Bv Sredstva in postopki za pripravo adenovirusnih vektorjev
WO2004037294A2 (en) * 2002-10-23 2004-05-06 Crucell Holland B.V. New settings for recombinant adenoviral-based vaccines
WO2005012538A2 (en) * 2003-08-01 2005-02-10 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Accelerated vaccination
US8101739B2 (en) 2004-09-27 2012-01-24 The United States Of America As Represented By The Department Of Health And Human Services Recombinant expression vectors comprising a human codon-optimized marburg virus (MARV) angola glycoprotein gene insert and method of immunization employing said vector
JP4843613B2 (ja) * 2004-10-13 2011-12-21 クルセル ホランド ベー ヴェー 改良されたアデノウイルスベクターおよびその使用方法
MX2007004188A (es) 2004-10-13 2007-10-11 Crucell Holland Bv Vectores adenovirales mejorados y usos de los mismos.
ES2371175T3 (es) * 2004-10-14 2011-12-28 Crucell Holland B.V. Vacunas de sensibilización/refuerzo de malaria.
WO2007104792A2 (en) * 2006-03-16 2007-09-20 Crucell Holland B.V. Recombinant adenoviruses based on serotype 26 and 48, and use thereof
WO2007110409A1 (en) * 2006-03-27 2007-10-04 Crucell Holland B.V. Compositions comprising a recombinant adenovirus and an adjuvant
WO2009092113A2 (en) * 2008-01-19 2009-07-23 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for the delivery of vaccines to disrupted epithelium
BR112013014712B1 (pt) 2010-12-14 2021-03-02 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services primeiro e segundo vetores de adenovírus recombinantes

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EP2655604B1 (en) 2018-05-09
US9701718B2 (en) 2017-07-11
EP2655604A1 (en) 2013-10-30
ES2676196T3 (es) 2018-07-17
JP2017048207A (ja) 2017-03-09
AU2011343798B2 (en) 2016-07-14
KR20140019304A (ko) 2014-02-14
EA029504B1 (ru) 2018-04-30
US20140017278A1 (en) 2014-01-16
CA2821289A1 (en) 2012-06-21
KR101879892B1 (ko) 2018-08-17
CN103370411A (zh) 2013-10-23
CN103370411B (zh) 2016-05-04
PL2655604T3 (pl) 2019-02-28
BR112013014712B1 (pt) 2021-03-02
DK2655604T3 (en) 2018-08-06
AU2011343798A1 (en) 2013-07-11
CA2821289C (en) 2019-05-21
ZA201304260B (en) 2021-05-26
JP6054876B2 (ja) 2016-12-27
EP2655604A4 (en) 2015-01-28
WO2012082918A1 (en) 2012-06-21
JP2014503206A (ja) 2014-02-13
BR112013014712A2 (pt) 2017-06-06
JP6268258B2 (ja) 2018-01-24

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