CA2819013C - Apparatus and methods for aliquotting frozen samples - Google Patents
Apparatus and methods for aliquotting frozen samples Download PDFInfo
- Publication number
- CA2819013C CA2819013C CA2819013A CA2819013A CA2819013C CA 2819013 C CA2819013 C CA 2819013C CA 2819013 A CA2819013 A CA 2819013A CA 2819013 A CA2819013 A CA 2819013A CA 2819013 C CA2819013 C CA 2819013C
- Authority
- CA
- Canada
- Prior art keywords
- sample
- frozen
- location
- aliquot
- samples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012520 frozen sample Substances 0.000 title claims abstract description 192
- 238000000034 method Methods 0.000 title claims abstract description 38
- 239000000523 sample Substances 0.000 claims abstract description 227
- 239000000126 substance Substances 0.000 claims abstract description 33
- 239000012530 fluid Substances 0.000 claims description 50
- 238000007689 inspection Methods 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 12
- -1 cell homogenates Substances 0.000 claims description 9
- 210000002381 plasma Anatomy 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 5
- 230000002538 fungal effect Effects 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 206010003445 Ascites Diseases 0.000 claims description 3
- 210000004381 amniotic fluid Anatomy 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 239000013592 cell lysate Substances 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 claims description 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 3
- 210000004700 fetal blood Anatomy 0.000 claims description 3
- 210000001589 microsome Anatomy 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 210000003097 mucus Anatomy 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 210000003463 organelle Anatomy 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 210000004243 sweat Anatomy 0.000 claims description 3
- 210000001138 tear Anatomy 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- 210000004102 animal cell Anatomy 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 238000004140 cleaning Methods 0.000 description 71
- 230000007246 mechanism Effects 0.000 description 33
- 230000020347 spindle assembly Effects 0.000 description 21
- 239000012472 biological sample Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- 230000008569 process Effects 0.000 description 12
- 239000007789 gas Substances 0.000 description 11
- 238000001035 drying Methods 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 230000005670 electromagnetic radiation Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 238000005553 drilling Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108020005196 Mitochondrial DNA Proteins 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000013611 chromosomal DNA Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
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- 244000052769 pathogen Species 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
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- 210000002345 respiratory system Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 244000078885 bloodborne pathogen Species 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010226 confocal imaging Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002592 echocardiography Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
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- 230000036316 preload Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41868810P | 2010-12-01 | 2010-12-01 | |
| US61/418,688 | 2010-12-01 | ||
| PCT/US2011/061214 WO2012074771A2 (en) | 2010-12-01 | 2011-11-17 | Apparatus and methods for aliquotting frozen samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2819013A1 CA2819013A1 (en) | 2012-06-07 |
| CA2819013C true CA2819013C (en) | 2020-04-14 |
Family
ID=45044753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2819013A Expired - Fee Related CA2819013C (en) | 2010-12-01 | 2011-11-17 | Apparatus and methods for aliquotting frozen samples |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140335554A1 (enExample) |
| EP (1) | EP2646792B1 (enExample) |
| JP (2) | JP2013545105A (enExample) |
| CN (1) | CN103370610B (enExample) |
| AU (1) | AU2011337043A1 (enExample) |
| BR (1) | BR112013013505A2 (enExample) |
| CA (1) | CA2819013C (enExample) |
| WO (1) | WO2012074771A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9032854B2 (en) | 2011-12-21 | 2015-05-19 | Sakura Finetek U.S.A., Inc. | Reciprocating microtome drive system |
| US9134202B2 (en) | 2012-01-26 | 2015-09-15 | Cryoxtract Instruments, Llc | Robotic end effector for frozen aliquotter and methods of taking a frozen aliquot from biological samples |
| US20140267713A1 (en) * | 2013-03-15 | 2014-09-18 | Cryoxtract Instruments, Llc | Machine Vision System for Frozen Aliquotter for Biological Samples |
| US20130286192A1 (en) * | 2012-04-30 | 2013-10-31 | Cryoxtract Instruments, Llc | Machine Vision System for Frozen Aliquotter for Biological Samples |
| US12157595B2 (en) * | 2012-05-03 | 2024-12-03 | Vanrx Pharmasystems Inc. | Cover removal system for use in controlled environment enclosures |
| US12065347B2 (en) * | 2012-05-03 | 2024-08-20 | Vanrx Pharmasystems Inc. | Cover removal system for use in controlled environment enclosures |
| EP2877827A2 (en) * | 2012-07-24 | 2015-06-03 | CryoXtract Instruments, LLC | Apparatus and methods for aliquotting frozen samples |
| FI10181U1 (fi) * | 2013-04-17 | 2013-08-14 | Konecranes Oyj | Tarttuja kuormankäsittelylaitetta varten ja nosturi |
| AU2014262888A1 (en) * | 2013-05-04 | 2015-11-19 | Cryoxtract Instruments, Llc | Targeting systems and methods for frozen aliquotter for biological samples |
| CN103636737B (zh) * | 2013-10-24 | 2016-05-11 | 杨公明 | 一种羊胎盘及羊水现场收集与保鲜的方法 |
| US12392692B2 (en) | 2017-03-09 | 2025-08-19 | Hologic, Inc. | Systems for automated preparation of biological specimens |
| TWI755498B (zh) * | 2017-03-09 | 2022-02-21 | 美商好樂杰公司 | 自動化製備生物樣本之系統及方法 |
| CN107843453B (zh) * | 2017-12-21 | 2024-01-23 | 上海泽泉科技股份有限公司 | 可调速手持低温样本分装仪 |
| WO2019245906A1 (en) * | 2018-06-20 | 2019-12-26 | Gen-Probe Incorporated | Method and apparatus for freezing dispensed droplets of liquid |
| EP3924675B1 (en) * | 2019-02-17 | 2023-07-05 | National Scientific And Technical Research Council - Argentina (Conicet) | System for accessing biological samples in a cryogenic dewar vessel |
| CN113533762B (zh) * | 2020-04-22 | 2025-10-24 | 深圳迎凯生物科技有限公司 | 试剂存储装置 |
| CN111504691B (zh) * | 2020-05-10 | 2023-03-10 | 淮阴师范学院 | 一种便携式地理信息采集装置 |
| US11981473B2 (en) * | 2020-09-27 | 2024-05-14 | V Anrx Pharmasystems Inc. | Cover removal system for use in controlled environment enclosures |
| CN116643025B (zh) * | 2023-05-06 | 2024-04-02 | 中国地质大学（北京） | 一种用于环境地质土壤检测的检测装置 |
| WO2025111515A1 (en) * | 2023-11-22 | 2025-05-30 | Mitegen, Llc | Systems, methods, and devices for cryopreservation and recovery of cells and other biological materials |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6166944A (ja) * | 1984-09-11 | 1986-04-05 | Nitsuteku Eng:Kk | 血清試料の秤取方法及びその装置 |
| US6117130A (en) * | 1998-09-24 | 2000-09-12 | Abiomed, Inc. | Coring device for myocardial revascularization |
| TW388790B (en) * | 1999-04-13 | 2000-05-01 | Inst Of Unclear Energy Res Roc | An automatic sampling method and facility for the heterogeneous materials |
| US20040085443A1 (en) * | 2000-12-13 | 2004-05-06 | Kallioniemi Olli P | Method and system for processing regions of interest for objects comprising biological material |
| US20020129975A1 (en) * | 2001-01-17 | 2002-09-19 | Barta Ernest G. | Ice auger system |
| US6635414B2 (en) * | 2001-05-22 | 2003-10-21 | Integrated Biosystems, Inc. | Cryopreservation system with controlled dendritic freezing front velocity |
| GB0325483D0 (en) * | 2003-10-31 | 2003-12-03 | Plasmacute As | Assay |
| JP4451263B2 (ja) * | 2004-10-13 | 2010-04-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 試料摘出装置 |
| US8448456B2 (en) | 2006-01-13 | 2013-05-28 | President And Fellows Of Harvard College | Systems, methods and devices for frozen sample distribution |
| US7823818B2 (en) * | 2007-10-17 | 2010-11-02 | Max-Planck-Gessellschaft zur Foerderung der Wissenschafter E.V. | System and method for producing weighed portions of powder from at least one biological material at cryotemperatures |
| CN105181407B (zh) * | 2008-03-31 | 2020-06-30 | 希森美康株式会社 | 制样装置与制样方法以及细胞分析装置与细胞分析方法 |
| JP5530613B2 (ja) * | 2008-10-06 | 2014-06-25 | シスメックス株式会社 | 検体処理システム及び検体搬送システム |
| JP5203889B2 (ja) * | 2008-10-28 | 2013-06-05 | シスメックス株式会社 | 検体分析装置及び検体分析方法 |
-
2011
- 2011-11-17 JP JP2013542034A patent/JP2013545105A/ja active Pending
- 2011-11-17 US US13/991,103 patent/US20140335554A1/en not_active Abandoned
- 2011-11-17 WO PCT/US2011/061214 patent/WO2012074771A2/en not_active Ceased
- 2011-11-17 AU AU2011337043A patent/AU2011337043A1/en not_active Abandoned
- 2011-11-17 CN CN201180057843.XA patent/CN103370610B/zh not_active Expired - Fee Related
- 2011-11-17 CA CA2819013A patent/CA2819013C/en not_active Expired - Fee Related
- 2011-11-17 EP EP11788311.6A patent/EP2646792B1/en not_active Not-in-force
- 2011-11-17 BR BR112013013505A patent/BR112013013505A2/pt not_active Application Discontinuation
-
2016
- 2016-03-31 JP JP2016071584A patent/JP2016122018A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013013505A2 (pt) | 2016-09-06 |
| US20140335554A1 (en) | 2014-11-13 |
| CN103370610B (zh) | 2016-08-10 |
| WO2012074771A3 (en) | 2012-08-16 |
| JP2013545105A (ja) | 2013-12-19 |
| CN103370610A (zh) | 2013-10-23 |
| JP2016122018A (ja) | 2016-07-07 |
| CA2819013A1 (en) | 2012-06-07 |
| EP2646792A2 (en) | 2013-10-09 |
| AU2011337043A1 (en) | 2013-06-13 |
| WO2012074771A2 (en) | 2012-06-07 |
| EP2646792B1 (en) | 2019-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20171107 |
|
| MKLA | Lapsed |
Effective date: 20201117 |