CA2817713C - Intravaginal devices for controlled delivery of lubricants - Google Patents
Intravaginal devices for controlled delivery of lubricants Download PDFInfo
- Publication number
- CA2817713C CA2817713C CA2817713A CA2817713A CA2817713C CA 2817713 C CA2817713 C CA 2817713C CA 2817713 A CA2817713 A CA 2817713A CA 2817713 A CA2817713 A CA 2817713A CA 2817713 C CA2817713 C CA 2817713C
- Authority
- CA
- Canada
- Prior art keywords
- segment
- intravaginal device
- lubricant
- water
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 339
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 170
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- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 1
- MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/02—Enemata; Irrigators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Nanotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Lubricants (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41323810P | 2010-11-12 | 2010-11-12 | |
| US61/413,238 | 2010-11-12 | ||
| US201161516582P | 2011-04-05 | 2011-04-05 | |
| US61/516,582 | 2011-04-05 | ||
| US201161542552P | 2011-10-03 | 2011-10-03 | |
| US61/542,552 | 2011-10-03 | ||
| PCT/US2011/060389 WO2012065073A2 (en) | 2010-11-12 | 2011-11-11 | Intravaginal devices for controlled delivery of lubricants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2817713A1 CA2817713A1 (en) | 2012-05-18 |
| CA2817713C true CA2817713C (en) | 2018-12-04 |
Family
ID=46051587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2817713A Active CA2817713C (en) | 2010-11-12 | 2011-11-11 | Intravaginal devices for controlled delivery of lubricants |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9078813B2 (enExample) |
| EP (1) | EP2637730B1 (enExample) |
| JP (1) | JP6139408B2 (enExample) |
| KR (1) | KR101993786B1 (enExample) |
| CN (1) | CN103298519B (enExample) |
| AU (1) | AU2011325975B2 (enExample) |
| BR (1) | BR112013011744B1 (enExample) |
| CA (1) | CA2817713C (enExample) |
| ES (1) | ES2896968T3 (enExample) |
| IL (1) | IL226298A (enExample) |
| MX (1) | MX339735B (enExample) |
| RU (1) | RU2591786C2 (enExample) |
| WO (1) | WO2012065073A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9078813B2 (en) * | 2010-11-12 | 2015-07-14 | The University Of Utah Research Foundation | Intravaginal devices for controlled delivery of lubricants |
| CN103648482B (zh) * | 2011-07-15 | 2018-01-02 | 根特大学 | 阴道内递送系统 |
| WO2014123880A1 (en) * | 2013-02-05 | 2014-08-14 | The Population Council, Inc. | Intravaginal ring for the delivery of unique combinations of antimicrobial compositions |
| US9962324B2 (en) | 2013-05-30 | 2018-05-08 | Sca Hygiene Products Ab | Composition comprising a buffered lactic acid |
| KR101470282B1 (ko) * | 2013-10-01 | 2014-12-05 | 최원석 | 소금 및 당의 조합물을 유효성분으로 함유하는 질이완증 또는 질건조증 예방 및 치료용 약학 조성물 및 이의 용도 |
| EP3277241B1 (en) | 2015-03-31 | 2023-12-20 | Merck Sharp & Dohme B.V. | Vaginal ring applicator |
| US20170119937A1 (en) * | 2015-10-29 | 2017-05-04 | Zohny Zohny | Surgical suction device |
| EP3468530A4 (en) | 2016-06-10 | 2020-03-11 | Clarity Cosmetics Inc. | NON-COMEDOGEN FORMULA FOR HAIR AND SCALP CARE AND METHOD FOR USE |
| CA3080325A1 (en) | 2017-10-27 | 2019-05-02 | Renovia Inc. | Devices, systems, and methods for training pelvic floor muscles |
| WO2019147877A1 (en) * | 2018-01-26 | 2019-08-01 | The Procter & Gamble Company | Methods and compositions for reducing the feeling of vaginal dryness |
| US20210121396A1 (en) * | 2018-04-18 | 2021-04-29 | Amy M. Spring | Personal Lubricant Disk |
| US10918593B2 (en) * | 2018-04-18 | 2021-02-16 | Amy M. Spring | Personal lubricant disk |
| US20190382578A1 (en) * | 2018-06-18 | 2019-12-19 | GM Global Technology Operations LLC | Fluorine-containing additives for non-fluoro thermoplastic polymers |
| US10570292B1 (en) | 2018-10-09 | 2020-02-25 | GM Global Technology Operations LLC | Water-borne precursors for forming heterophasic anti-fouling, polymeric coatings having a fluorinated continuous phase with non-fluorinated domains |
| CA3135163A1 (en) * | 2019-03-29 | 2020-10-08 | Bridget MARTELL | Segmented eva intravaginal rings |
| WO2021099504A1 (en) * | 2019-11-20 | 2021-05-27 | Bayer Animal Health Gmbh | An intravaginal device for a cow |
| US11421114B2 (en) | 2020-01-29 | 2022-08-23 | GM Global Technology Operations LLC | Precursors for forming heterophasic anti-fouling polymeric coatings |
| US11590073B2 (en) | 2020-06-09 | 2023-02-28 | The Procter & Gamble Company | Methods and compositions for reducing the feeling of vaginal dryness |
| CN112137789A (zh) * | 2020-09-25 | 2020-12-29 | 郑闪 | 一种锁精环 |
| US11746253B2 (en) * | 2021-03-08 | 2023-09-05 | Hoi Ming Michael HO | Sprayable conductive agent capable of forming conductive portion and manufacturing method and use thereof |
| US11820890B2 (en) | 2021-04-01 | 2023-11-21 | Stratasys Inc | Pulverulent thermoplastic polymer blends |
| US20230404910A1 (en) * | 2022-06-16 | 2023-12-21 | Stephanie Gore | Implantable cannabis transdermal |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| FR2273021B1 (enExample) | 1974-05-31 | 1977-03-11 | Ato Chimie | |
| DE2616064A1 (de) * | 1976-04-09 | 1977-10-20 | Schering Ag | Vaginalring iii |
| CA1146828A (en) * | 1977-04-29 | 1983-05-24 | Roger E. Homm | Vaginal diaphragm and method |
| FR2466478B2 (fr) | 1979-10-02 | 1986-03-14 | Ato Chimie | Procede de preparation de copolyetheresteramides aliphatiques elastomeres |
| FR2497518A1 (fr) | 1981-01-05 | 1982-07-09 | Ato Chimie | Compositions adhesives thermofusibles a base de copolyetheramides sequences |
| US4629449A (en) | 1982-07-29 | 1986-12-16 | Alza Corporation | Vaginal dispenser for dispensing beneficial hormone |
| US4663148A (en) * | 1984-03-21 | 1987-05-05 | Alza Corporation | Dispenser comprising telescopically engaging members |
| US4743673A (en) | 1986-12-19 | 1988-05-10 | Tyndale Plains-Hunter, Ltd. | Hydrophilic carboxy polyurethanes |
| CA1338678C (en) | 1987-12-02 | 1996-10-22 | Tyndale Plains-Hunter Ltd. | Hydrophilic polyurethanes of improved strength |
| NO178843C (no) | 1988-07-11 | 1996-06-19 | Sspl Sa Safe Sex Prod Licens | Fremgangsmåte for fremstilling av et farmasöytisk preparat for å forhindre seksuelt overförbare sykdommer |
| US5589563A (en) | 1992-04-24 | 1996-12-31 | The Polymer Technology Group | Surface-modifying endgroups for biomedical polymers |
| DE69320470T2 (de) | 1992-04-24 | 1999-04-29 | The Polymer Technology Group, Inc., Emeryville, Calif. | Copolymere, sowie daraus hergestellte nichtporöse halbdurchlässige membranen und ihre verwendung zum filtern von molekülen in einem vorgegebenen molekulargewichtbereich |
| US5592949A (en) * | 1994-06-29 | 1997-01-14 | Moench; Thomas R. | Device for acidic buffering and method for inactivation of pathogens |
| US6251436B1 (en) * | 1995-09-29 | 2001-06-26 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
| US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| US6197327B1 (en) | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| USD442688S1 (en) | 1998-01-28 | 2001-05-22 | N.V. Organon | Vaginal ring applicator |
| NL1008170C1 (nl) | 1998-01-30 | 1999-08-02 | Akzo Nobel Nv | Applicator voor een vaginale ring. |
| US6448276B1 (en) * | 2000-05-17 | 2002-09-10 | Inspire Pharmaceuticals, Inc. | Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists |
| JP4898431B2 (ja) | 2003-04-29 | 2012-03-14 | ザ ジェネラル ホスピタル コーポレイション | 複数薬物の持続放出のための方法およびデバイス |
| ES2442675T3 (es) * | 2003-07-10 | 2014-02-12 | Warner Chilcott (Ireland) Limited | Dispositivos intravaginales de suministro de fármacos |
| US20080140185A1 (en) | 2004-04-15 | 2008-06-12 | University Of Utah Research Foundation | Biodegradable and Biocompatible Peg-Based Poly(Ester-Urethanes) |
| US8062658B2 (en) | 2004-12-14 | 2011-11-22 | Poly-Med, Inc. | Multicomponent bioactive intravaginal ring |
| EP1853221A2 (en) * | 2005-02-03 | 2007-11-14 | Duramed Pharmaceuticals, Inc. | Devices for delivering agents to a vaginal tract |
| JP2009521533A (ja) * | 2005-12-27 | 2009-06-04 | デュラメド ファーマシューティカルズ インコーポレーティッド | 結合型エストロゲン組成物、アプリケーター、キット、ならびにそれらの作製および使用の方法 |
| CN101448452B (zh) | 2006-03-20 | 2012-07-18 | 特卫华妇女健康有限公司 | 挠性压缩的阴道内环、其制备和使用方法及其生产设备 |
| GB0613638D0 (en) * | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| US20100316691A2 (en) | 2007-01-19 | 2010-12-16 | University Of Utah Research Foundation | Biodegradable intravaginal medical device for delivery of therapeutics |
| SG195525A1 (en) | 2007-06-26 | 2013-12-30 | Warner Chilcott Co Llc | Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs |
| TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| KR20100120665A (ko) | 2008-01-25 | 2010-11-16 | 더 유니버시티 오브 유타 리서치 파운데이션 | 일차 방출 중합체 |
| US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
| US9078813B2 (en) * | 2010-11-12 | 2015-07-14 | The University Of Utah Research Foundation | Intravaginal devices for controlled delivery of lubricants |
| WO2013013172A1 (en) | 2011-07-20 | 2013-01-24 | The University Of Utah Research Foundation | Intravaginal devices for drug delivery |
-
2011
- 2011-11-11 US US13/884,936 patent/US9078813B2/en active Active
- 2011-11-11 RU RU2013126633/14A patent/RU2591786C2/ru active
- 2011-11-11 CN CN201180064772.6A patent/CN103298519B/zh active Active
- 2011-11-11 EP EP11839939.3A patent/EP2637730B1/en active Active
- 2011-11-11 WO PCT/US2011/060389 patent/WO2012065073A2/en not_active Ceased
- 2011-11-11 ES ES11839939T patent/ES2896968T3/es active Active
- 2011-11-11 BR BR112013011744-3A patent/BR112013011744B1/pt active IP Right Grant
- 2011-11-11 JP JP2013538936A patent/JP6139408B2/ja active Active
- 2011-11-11 CA CA2817713A patent/CA2817713C/en active Active
- 2011-11-11 AU AU2011325975A patent/AU2011325975B2/en active Active
- 2011-11-11 KR KR1020137014655A patent/KR101993786B1/ko active Active
- 2011-11-11 MX MX2013005354A patent/MX339735B/es active IP Right Grant
-
2013
- 2013-05-12 IL IL226298A patent/IL226298A/en active IP Right Grant
-
2015
- 2015-05-11 US US14/709,138 patent/US9226894B2/en active Active
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2016
- 2016-01-04 US US14/987,306 patent/US9642795B2/en active Active
-
2017
- 2017-04-18 US US15/490,628 patent/US20170273899A1/en not_active Abandoned
- 2017-10-27 US US15/796,335 patent/US10350160B2/en active Active
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| EEER | Examination request |
Effective date: 20161109 |