CA2807993C - Bismuth-thiols as antiseptics for agricultural, industrial and other uses - Google Patents
Bismuth-thiols as antiseptics for agricultural, industrial and other uses Download PDFInfo
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- CA2807993C CA2807993C CA2807993A CA2807993A CA2807993C CA 2807993 C CA2807993 C CA 2807993C CA 2807993 A CA2807993 A CA 2807993A CA 2807993 A CA2807993 A CA 2807993A CA 2807993 C CA2807993 C CA 2807993C
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- wound
- antibiotic
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- microparticulate
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
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US37318810P | 2010-08-12 | 2010-08-12 | |
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PCT/US2011/023549 WO2011097347A2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
USPCT/US2011/023549 | 2011-02-03 | ||
PCT/US2011/047490 WO2012021754A2 (en) | 2010-08-12 | 2011-08-11 | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
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CA2807993C true CA2807993C (en) | 2023-03-14 |
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Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3695835A1 (en) | 2009-02-03 | 2020-08-19 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
US9028878B2 (en) | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
KR101821833B1 (ko) * | 2010-02-03 | 2018-01-25 | 마이크로비온 코포레이션 | 세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올 |
WO2014146644A1 (de) * | 2013-03-18 | 2014-09-25 | Theranovis Gmbh & Co. Kg | Zusammensetzung für die mundpflege |
RU2525200C1 (ru) * | 2013-04-09 | 2014-08-10 | Алексей Георгиевич Бородкин | Средство для защиты и заживления ран деревьев |
KR101703732B1 (ko) * | 2013-11-07 | 2017-02-07 | (주)아모레퍼시픽 | 효소처리 동백나무 씨 오일을 포함하는 항염 조성물 |
WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
BR112020004156A2 (pt) | 2017-08-30 | 2020-09-08 | Nobio Ltd. | partículas antimicrobianas e métodos de aplicação das mesmas |
CN107950536A (zh) * | 2017-12-04 | 2018-04-24 | 刘志伟 | 一种含百菌清的杀菌组合物 |
CN108839186B (zh) * | 2018-05-15 | 2021-02-26 | 阜南县金威工艺品有限公司 | 一种桑枝编织品防霉处理方法 |
SG11202100823RA (en) | 2018-07-31 | 2021-02-25 | Microbion Corp | Bismuth-thiol compositions and methods of use |
IL280413B1 (en) | 2018-07-31 | 2024-10-01 | Microbion Corp | Bismuth-thiol preparations and wound treatment methods |
KR101990253B1 (ko) * | 2018-11-22 | 2019-06-17 | 하봉호 | 컨테이너형 버섯재배장치 |
CN109997856B (zh) * | 2019-04-15 | 2020-11-03 | 广西大学 | 一种小分子化合物的组合物及其应用 |
KR102126721B1 (ko) * | 2019-07-16 | 2020-06-25 | (주)인트론바이오테크놀로지 | 신규한 엔테로박터 애로진스 박테리오파지 Ent-AEP-1 및 이의 엔테로박터 애로진스 균과 엔테로박터 클로아카 균 증식 억제 용도 |
JP7458622B2 (ja) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | 抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法 |
CN110663672B (zh) * | 2019-11-13 | 2024-04-26 | 南京林业大学 | 一种螺纹驱动的根部施药头 |
US11479655B2 (en) * | 2020-01-15 | 2022-10-25 | The Boeing Company | Compositions for use with polysulfide sealants and related methods |
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KR102431000B1 (ko) * | 2021-07-22 | 2022-08-11 | 농업회사법인 주식회사 아그로비즈 | 아스피린과 벤조치아졸이 포함된 식물의 자가면역 증강제 조성물 및 이를 이용한 이용방법 |
EP4310192A1 (en) * | 2022-07-21 | 2024-01-24 | C4Diagnostics | Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents |
CN115323778B (zh) * | 2022-08-16 | 2023-07-18 | 汕头市润丰纺织科技实业有限公司 | 壳聚糖-i型胶原氨基酸复合抗菌整理液及其制备方法和抗菌面料 |
TR2022012983A2 (tr) * | 2022-08-17 | 2022-09-21 | Marmara Ueniv Strateji Gelis Dai Bsk Muhasebe Birimi | Kemi̇k rahatsizliklari ve/veya kirilmalari i̇çi̇n onarici ve tedavi̇ edi̇ci̇ özelli̇kte bi̇youyumlu bi̇r ürün ve söz konusu ürünün eldesi̇ i̇çi̇n bi̇r yöntem |
CN115532295B (zh) * | 2022-09-27 | 2023-07-25 | 苏州大学 | 含有Zn-N-C活性中心的纳米材料在去除细菌生物膜中的应用 |
KR102644907B1 (ko) * | 2023-12-01 | 2024-03-07 | (주)신용이엔씨 | 지반 보강을 위한 친환경 그라우팅용 조성물 및 이의 제조 방법 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2809971A (en) * | 1955-11-22 | 1957-10-15 | Olin Mathieson | Heavy-metal derivatives of 1-hydroxy-2-pyridinethiones and method of preparing same |
JP3813644B2 (ja) * | 1994-08-29 | 2006-08-23 | 英治 安里 | ビスマス錯体およびそれを含有する抗菌剤 |
US5928671A (en) * | 1995-04-25 | 1999-07-27 | Winthrop University Hospital | Method and composition for inhibiting bacteria |
US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
US6017936A (en) * | 1997-03-14 | 2000-01-25 | Arch Chemicals, Inc. | Method for producing particles of pyrithione salts and particles so produced |
US5999828A (en) * | 1997-03-19 | 1999-12-07 | Qualcomm Incorporated | Multi-user wireless telephone having dual echo cancellers |
AU2003204105B2 (en) * | 1997-10-28 | 2005-11-17 | Winthrop-University Hospital | Metal/Thiol Biocides |
AU2656799A (en) * | 1998-02-04 | 1999-08-23 | Winthrop-University Hospital | Metal-thiols as imminomodulating agents |
US6465015B1 (en) * | 1998-02-24 | 2002-10-15 | Arch Chemicals, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
TWI245763B (en) * | 1998-04-02 | 2005-12-21 | Janssen Pharmaceutica Nv | Biocidal benzylbiphenyl derivatives |
EP1115285A1 (en) * | 1998-09-23 | 2001-07-18 | Phycogen, Inc. | Safe and effective biofilm inhibitory compounds and health-related uses thereof |
US6682724B2 (en) * | 1999-02-23 | 2004-01-27 | Arch Chemcials, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
US6630172B2 (en) * | 2001-01-22 | 2003-10-07 | Kareem I. Batarseh | Microbicidal composition containing potassium sodium tartrate |
US6582719B2 (en) * | 2001-02-02 | 2003-06-24 | The Trustees Of Columbia University In The City Of New York | Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms |
JP4357166B2 (ja) * | 2002-10-21 | 2009-11-04 | 日揮触媒化成株式会社 | 抗菌・防黴・防藻性組成物 |
US7381751B2 (en) * | 2003-08-26 | 2008-06-03 | Shantha Sarangapani | Antimicrobial composition for medical articles |
AU2005298344B2 (en) * | 2004-10-25 | 2011-02-10 | Varian Medical Systems, Inc. | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
JP4568232B2 (ja) * | 2006-01-06 | 2010-10-27 | 秀和 西松 | 人工骨頭保持具 |
JP2007332040A (ja) * | 2006-06-12 | 2007-12-27 | Shinshu Univ | カーボンナノチューブを含む抗菌剤とそれを用いた材料及び製剤 |
US20110008402A1 (en) * | 2006-10-13 | 2011-01-13 | Kane Biotech Inc. | Souluble b-n-acetylglucoseaminidase based antibiofilm compositions and uses thereof |
CA2678449C (en) * | 2007-01-24 | 2012-09-18 | Cook Incorporated | Biofilm-inhibiting medical products |
US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
CA2687418A1 (en) * | 2007-05-18 | 2008-11-27 | Agion Technologies, Inc. | Bioactive acid agrichemical compositions and use thereof |
JP5642540B2 (ja) * | 2007-06-01 | 2014-12-17 | アロウ・インターナショナル・インコーポレイテッドArrow International, Inc. | 組み合わされた線維素溶解性および抗菌性のカテーテル、およびその使用 |
EP2545906B1 (en) * | 2007-07-25 | 2017-04-19 | Boston Scientific Limited | Colour-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and colour-coded syringe comprising the same |
EP3695835A1 (en) | 2009-02-03 | 2020-08-19 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
KR101821833B1 (ko) * | 2010-02-03 | 2018-01-25 | 마이크로비온 코포레이션 | 세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올 |
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