CA2782899C - Implants and biodegradable fiducial markers - Google Patents
Implants and biodegradable fiducial markers Download PDFInfo
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- CA2782899C CA2782899C CA2782899A CA2782899A CA2782899C CA 2782899 C CA2782899 C CA 2782899C CA 2782899 A CA2782899 A CA 2782899A CA 2782899 A CA2782899 A CA 2782899A CA 2782899 C CA2782899 C CA 2782899C
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Landscapes
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CA3042067A CA3042067C (en) | 2009-12-15 | 2010-12-15 | Implants and biodegradable fiducial markers |
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| US10675298B2 (en) * | 2006-07-27 | 2020-06-09 | Boston Scientific Scimed Inc. | Particles |
| CN102844054B (zh) | 2009-12-15 | 2016-04-20 | 因赛普特有限责任公司 | 植入物和能生物降解的基准标记物 |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| KR102039468B1 (ko) | 2011-12-05 | 2019-11-01 | 인셉트, 엘엘씨 | 의료용 유기젤 방법 및 조성물 |
| AU2013212592B2 (en) * | 2012-01-24 | 2016-06-30 | Lifecell Corporation | Elongated tissue matrices |
| JP6106259B2 (ja) * | 2012-03-21 | 2017-03-29 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 医用イメージングと生検データとを統合する臨床ワークステーション及びこれを使用する方法 |
| US9226797B2 (en) * | 2012-11-04 | 2016-01-05 | Miba Medical Inc. | Computer aided implantation of body implants |
| WO2014169301A1 (en) * | 2013-04-12 | 2014-10-16 | Bui The Duy | Systems and methods for delivering cross-linked halyuronic acid into a patient |
| EP2968618B1 (en) | 2013-03-15 | 2021-02-17 | Biocompatibles UK Limited | Imageable embolic microsphere |
| WO2014145397A1 (en) * | 2013-03-15 | 2014-09-18 | Herskovic Arnold M | Device and method for delivering medicaments |
| DK3003397T3 (da) | 2013-05-24 | 2020-11-16 | Nanovi Radiotherapy A P S | Gelformuleringer til styring af radioterapi |
| AU2014283217A1 (en) * | 2013-06-20 | 2015-12-24 | Nanobiotix | Compositions and methods for use in medical diagnosis |
| CA2915145C (en) * | 2013-06-20 | 2021-06-08 | Nanobiotix | Compositions and methods for use in oncology |
| US10842969B2 (en) | 2013-10-25 | 2020-11-24 | Mercator Medsystems, Inc. | Systems and methods of treating malacia by local delivery of hydrogel to augment tissue |
| US10743909B2 (en) | 2014-04-03 | 2020-08-18 | Corbin Clinical Resources, Llc | Transperineal prostate biopsy device, systems, and methods of use |
| US12144519B2 (en) * | 2014-04-03 | 2024-11-19 | Corbin Clinical Resources, Llc | Transperineal prostate biopsy and treatment methods |
| US10022475B2 (en) * | 2014-05-01 | 2018-07-17 | Bao Tran | Body augmentation device |
| US9561095B1 (en) * | 2015-10-12 | 2017-02-07 | Phi Nguyen | Body augmentation device |
| US9636210B2 (en) | 2014-05-19 | 2017-05-02 | Mentor Worldwide Llc | Injection zone markers for biomedical implants |
| US9678022B2 (en) * | 2014-09-05 | 2017-06-13 | The Boeing Company | Nonaqueous radiopaque fluid and associated imaging system and method |
| KR101555358B1 (ko) * | 2014-10-21 | 2015-09-24 | 사회복지법인 삼성생명공익재단 | 생분해성 다중블록 공중합체를 이용한 표적 표지자 |
| WO2016065245A1 (en) | 2014-10-24 | 2016-04-28 | Incept, Llc | Extra luminal scaffold |
| CN120501693A (zh) | 2014-12-10 | 2025-08-19 | 因赛普特有限责任公司 | 水凝胶药物递送植入物 |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| US9855317B2 (en) | 2015-04-27 | 2018-01-02 | Reflex Medical, Inc. | Systems and methods for sympathetic cardiopulmonary neuromodulation |
| WO2016183296A1 (en) | 2015-05-12 | 2016-11-17 | Incept, Llc | Drug delivery from hydrogels |
| MA43100A (fr) | 2015-05-28 | 2018-09-05 | Nanobiotix | Nanoparticules à utiliser en tant que vaccin thérapeutique |
| US20170103184A1 (en) * | 2015-10-12 | 2017-04-13 | Phi Nguyen | Injectable filler |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| EP3373870A4 (en) | 2015-11-12 | 2019-07-10 | University Of Virginia Patent Foundation | COMPOSITIONS AND METHODS FOR VAS OCCLUSAL CONSUMER PREVENTION AND THEIR REVERSAL |
| CN108601725B (zh) | 2015-11-25 | 2024-03-08 | 因赛普特有限责任公司 | 形状改变的药物递送装置和方法 |
| WO2017139487A1 (en) | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| WO2018005848A1 (en) | 2016-06-29 | 2018-01-04 | Bright, Corinne | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| US20220249366A1 (en) * | 2016-07-07 | 2022-08-11 | University Of Virginia Patent Foundation | Thiol-michael addition hydrogel-based brachytherapy system and methods comprising the same |
| WO2018009839A1 (en) * | 2016-07-07 | 2018-01-11 | University Of Virginia Patent Foundation | Thiol-michael addition hydrogel-based brachytherapy system and methods comprising the same |
| CN106334213B (zh) * | 2016-08-31 | 2019-07-26 | 安疗生命科学(武汉)有限公司 | 一种血管栓塞材料、其制备方法及在药物制备中的用途 |
| KR102814241B1 (ko) | 2016-09-23 | 2025-05-29 | 인셉트, 엘엘씨 | 전안방내 약물 전달 데포 |
| EP3544540B1 (en) * | 2016-11-23 | 2021-12-08 | Hologic, Inc. | Biopsy site marker |
| US12383421B2 (en) | 2017-01-05 | 2025-08-12 | Contraline, Inc. | Contraceptive devices |
| WO2018129369A1 (en) | 2017-01-05 | 2018-07-12 | Contraline, Inc. | Methods for implanting and reversing stimuli-responsive implants |
| US20180289467A1 (en) * | 2017-04-05 | 2018-10-11 | Ernesto Andrade | Dispensing device, kit, and method for tissue augmentation |
| CA3057875A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| CN107307922A (zh) * | 2017-07-06 | 2017-11-03 | 刘志光 | 一种人体植入填充颗粒的制作方法 |
| EP3648675A1 (en) * | 2017-07-07 | 2020-05-13 | Shadwell Endoscopic, Inc. | System and method for marking and subsequently locating sites of biopsies using rfid technology |
| KR102673196B1 (ko) | 2017-09-05 | 2024-06-10 | 삼성전자주식회사 | 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물 |
| WO2019071245A1 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR REGULATED RELEASE OF ANALGESICS TO TREAT POSTHOPERATIVE PAIN ASSOCIATED WITH ORTHOPEDIC SURGERY, AND RELATED DEVICES, SYSTEMS, AND METHODS |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| EP3737433A1 (en) | 2018-01-08 | 2020-11-18 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| AU2019231330B2 (en) | 2018-03-07 | 2025-01-02 | Margin-Clear Pty Ltd | A topical brachytherapy device and a method of treatment of malignant cancer cells |
| CA3099890A1 (en) | 2018-05-12 | 2019-11-21 | Foundry Therapeutics, Inc. | Implantable polymer depots for the controlled release of therapeutic agents |
| JP2021523794A (ja) | 2018-05-15 | 2021-09-09 | インセプト・リミテッド・ライアビリティ・カンパニーIncept,Llc | 塞栓組成物及び方法 |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| CA3105343A1 (en) | 2018-07-02 | 2020-01-09 | Corinne Bright | Methods and devices for in situ formed nerve cap |
| US12303619B2 (en) | 2018-08-28 | 2025-05-20 | Foundry Therapeutics, Inc. | Polymer implants |
| USD896383S1 (en) | 2018-09-13 | 2020-09-15 | Allergan, Inc. | Tissue expansion device |
| JP7153790B2 (ja) | 2018-09-13 | 2022-10-14 | アラーガン、インコーポレイテッド | 組織伸展装置 |
| JP7582939B2 (ja) | 2018-11-13 | 2024-11-13 | コントラライン,インコーポレイテッド | 生体材料を送達するためのシステムおよび方法 |
| WO2020227107A1 (en) * | 2019-05-03 | 2020-11-12 | Palette Life Sciences, Inc. | Improved tissue spacers |
| EP3983369B1 (en) | 2019-06-12 | 2023-08-02 | Nouryon Chemicals International B.V. | Process for the production of diacyl peroxides |
| JP7355858B2 (ja) * | 2019-06-12 | 2023-10-03 | ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ | 水性側流からカルボン酸を単離するための方法 |
| HUE063796T2 (hu) | 2019-06-12 | 2024-01-28 | Nouryon Chemicals Int Bv | Eljárás diacil-peroxidok elõállítására |
| US11976035B2 (en) | 2019-06-12 | 2024-05-07 | Nouryon Chemicals International B.V. | Process for the production of diacyl peroxides |
| HUE063678T2 (hu) | 2019-06-12 | 2024-01-28 | Nouryon Chemicals Int Bv | Eljárás peroxiészterek elõállítására |
| US11807720B2 (en) | 2019-08-28 | 2023-11-07 | Boston Scientific Scimed, Inc. | Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same |
| EP4021960A1 (en) | 2019-08-28 | 2022-07-06 | Boston Scientific Scimed Inc. | Reactive multi-arm polymers having branched end groups |
| US11878092B2 (en) | 2019-08-28 | 2024-01-23 | Boston Scientific Scimed, Inc. | Medical compositions based on crosslinkable hydrophilic polymers |
| WO2021041227A1 (en) | 2019-08-28 | 2021-03-04 | Boston Scientific Scimed, Inc. | Multifunctional nitroxide-mediated polymerization initiators and products formed therefrom |
| AU2020337329B2 (en) | 2019-08-28 | 2024-07-11 | Boston Scientific Scimed, Inc. | Radiopaque multi-armed polymers and compositions, systems and methods pertaining to the same |
| US11326022B2 (en) | 2019-08-28 | 2022-05-10 | Boston Scientific Scimed, Inc. | Multi-armed polymers comprising free-radical-polymerizable monomers and compositions, systems and methods pertaining to the same |
| JP7667747B2 (ja) * | 2020-01-14 | 2025-04-23 | 持田製薬株式会社 | アルギン酸塩を使用した対象の処置のための組合せ及び方法 |
| CN115052641A (zh) | 2020-02-04 | 2022-09-13 | 波士顿科学国际有限公司 | 用作软组织填充物的可注射体内交联材料 |
| CN111905155B (zh) * | 2020-07-23 | 2021-10-15 | 北京诺康达医药科技股份有限公司 | 一种封闭水凝胶及其制备方法和应用 |
| US12343454B2 (en) | 2020-11-12 | 2025-07-01 | Pramand LLC | Hydrogels formed in situ and composition design for intrauterine use |
| EP4422596A1 (en) | 2021-10-25 | 2024-09-04 | Boston Scientific Scimed Inc. | Iodine labeled hydrogels and precursors thereof with improved radiopacity |
| US20250090693A1 (en) * | 2022-01-13 | 2025-03-20 | National Cancer Center | Biocompatible composition for labeling target lesion, and preparation method therefor |
| KR20240144322A (ko) | 2022-02-02 | 2024-10-02 | 보스톤 싸이엔티픽 싸이메드 인코포레이티드 | 아이오딘화된 화합물 및 이로 형성된 하이드로겔 |
| CN114344554A (zh) * | 2022-02-11 | 2022-04-15 | 上海益思妙医疗器械有限公司 | 一种peg化合物作为制备栓塞剂的应用 |
| US11701451B1 (en) | 2022-03-11 | 2023-07-18 | Carbon Medical Technologies, Inc. | Soft tissue filler and methods |
| US12251466B2 (en) | 2022-04-20 | 2025-03-18 | Pramand LLC | Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels |
| US12440599B2 (en) | 2022-05-06 | 2025-10-14 | Pramand LLC | Water activated hydrogel-based medical patches, and methods of making and using such patches |
| WO2023230267A1 (en) * | 2022-05-25 | 2023-11-30 | Cedars-Sinai Medical Center | Microgel-encapsulated ipsc-derived notochordal cells for treatment of intervertebral disc degeneration and discogenic pain |
| JP2025527540A (ja) | 2022-08-17 | 2025-08-22 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 改善された特性を有するヨウ素標識ヒドロゲル及びその前駆体 |
| EP4623020A1 (en) | 2022-11-21 | 2025-10-01 | Boston Scientific Scimed Inc. | Iodine labeled hydrogels and crosslinking agents for forming the same |
| CN120826240A (zh) | 2023-03-02 | 2025-10-21 | 波士顿科学医学有限公司 | 释放治疗剂的水凝胶及其前体 |
| CN120826427A (zh) | 2023-03-02 | 2025-10-21 | 波士顿科学医学有限公司 | 多氨基碘化化合物和由其形成的不透射线的水凝胶 |
| DE102023108039A1 (de) | 2023-03-29 | 2024-10-02 | Dwi - Leibniz-Institut Für Interaktive Materialien E.V. | Ein System zur Herstellung eines degradierbaren Hydrogels |
| US20240358896A1 (en) * | 2023-04-28 | 2024-10-31 | Boston Scientific Scimed, Inc. | Suspensions of radiopaque crosslinked hydrogel particles in carrier fluids containing biocompatible hydrophilic polymers |
| US20250136760A1 (en) | 2023-11-01 | 2025-05-01 | Boston Scientific Scimed, Inc. | Amino-acid- and amino-alcohol-based polyamine compounds and medical hydrogels formed therefrom |
| WO2025151632A1 (en) * | 2024-01-11 | 2025-07-17 | Boston Scientific Scimed, Inc. | Systems and methods for accelerated hydrolysis of polysaccharide-based hydrogels |
Family Cites Families (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
| US3865108A (en) | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US3872856A (en) | 1971-06-09 | 1975-03-25 | Ralph S Clayton | Apparatus for treating the walls and floor of the pelvic cavity with radiation |
| US4002173A (en) | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
| DE2437629C3 (de) | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen |
| US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| US4193813A (en) | 1976-09-07 | 1980-03-18 | Medi-Coll, Inc. | Method for making collagen sponge |
| US4207893A (en) | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
| CA1295796C (en) | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
| US4697575A (en) | 1984-11-21 | 1987-10-06 | Henry Ford Hospital | Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member |
| US4714074A (en) | 1985-06-28 | 1987-12-22 | Centre National De La Recherche Scientifique | Method for protecting human or animal organs against radiation |
| US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
| US4741872A (en) | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
| IL82834A (en) | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5550187A (en) | 1988-11-21 | 1996-08-27 | Collagen Corporation | Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5306500A (en) | 1988-11-21 | 1994-04-26 | Collagen Corporation | Method of augmenting tissue with collagen-polymer conjugates |
| US5304595A (en) | 1988-11-21 | 1994-04-19 | Collagen Corporation | Collagen-polymer conjugates |
| IL90193A (en) | 1989-05-04 | 1993-02-21 | Biomedical Polymers Int | Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| WO1992010218A1 (en) | 1990-12-06 | 1992-06-25 | W.L. Gore & Associates, Inc. | Implantable bioabsorbable article |
| FR2672713A1 (fr) * | 1991-02-13 | 1992-08-14 | Inst Nat Polytech Grenoble | Composant d'alimentation du type carte de credit. |
| US5629008A (en) | 1992-06-02 | 1997-05-13 | C.R. Bard, Inc. | Method and device for long-term delivery of drugs |
| US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
| US6592859B1 (en) | 1992-08-20 | 2003-07-15 | Ethicon, Inc. | Controlled expansion sphincter augmentation media |
| US5618563A (en) | 1992-09-10 | 1997-04-08 | Children's Medical Center Corporation | Biodegradable polymer matrices for sustained delivery of local anesthetic agents |
| JPH08509642A (ja) | 1993-04-28 | 1996-10-15 | フォーカル,インコーポレイテッド | 管腔内フォトサーモフォーミングの装置およびその方法 |
| US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5499994A (en) | 1993-07-30 | 1996-03-19 | American Medical Systems, Inc. | Dilation device for the urethra |
| CA2188464C (en) | 1994-04-27 | 2006-08-08 | Michael Roreger | Collagen preparation for the controlled release of active substances |
| DE4414755C2 (de) | 1994-04-27 | 2000-11-16 | Lohmann Therapie Syst Lts | Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung |
| US5900245A (en) | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
| ATE369402T1 (de) | 1995-03-23 | 2007-08-15 | Genzyme Corp | Redox und photoinitiatorsystem zur grundierung von verbesserter adhäsion von gelen zu substraten |
| US6214331B1 (en) | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| WO1997002019A1 (en) | 1995-06-30 | 1997-01-23 | Baylor University | Polyester/carboxylic acid composite materials |
| ATE342295T1 (de) | 1995-07-28 | 2006-11-15 | Genzyme Corp | Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen |
| US5759583A (en) | 1995-08-30 | 1998-06-02 | Syntex (U.S.A.) Inc. | Sustained release poly (lactic/glycolic) matrices |
| US5733316A (en) | 1995-10-27 | 1998-03-31 | Dornier Medical Systems, Inc. | Organ separation for thermal therapy |
| US5863984A (en) | 1995-12-01 | 1999-01-26 | Universite Laval, Cite Universitaire | Biostable porous material comprising composite biopolymers |
| US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| PT1704878E (pt) | 1995-12-18 | 2013-07-17 | Angiodevice Internat Gmbh | Composições de polímeros reticulados e métodos para a sua utilização |
| US6060534A (en) * | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
| US7049346B1 (en) | 1996-08-20 | 2006-05-23 | Menlo Care Div Of Ethicon, Inc. | Swollen hydrogel for sphincter augmentation |
| US6063061A (en) | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US20020064546A1 (en) * | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
| ZA978537B (en) | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
| WO1998012274A1 (en) | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US7009034B2 (en) | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| US5932539A (en) | 1996-10-15 | 1999-08-03 | The Board Of Trustees Of The University Of Illinois | Biodegradable polymer matrix for tissue repair |
| JP3092531B2 (ja) | 1996-11-05 | 2000-09-25 | 日本油脂株式会社 | コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法 |
| JP3092530B2 (ja) | 1996-11-05 | 2000-09-25 | 日本油脂株式会社 | コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法 |
| US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
| US6224893B1 (en) | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
| US6271278B1 (en) | 1997-05-13 | 2001-08-07 | Purdue Research Foundation | Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties |
| IL121861A (en) | 1997-09-29 | 2003-07-31 | Moshe Ein Gal | Prostate radiotherapy apparatus |
| US8288745B2 (en) | 1997-10-10 | 2012-10-16 | Senorx, Inc. | Method of utilizing an implant for targeting external beam radiation |
| AU1070899A (en) | 1997-10-10 | 1999-05-03 | Corbitt, John D. Jr. | Breast implant |
| WO1999021512A1 (en) | 1997-10-27 | 1999-05-06 | The Regents Of The University Of California | Methods and pharmaceutical compositions for the closure of retinal breaks |
| EP1036057B1 (en) * | 1997-11-07 | 2005-10-19 | Rutgers, The State University | Radio-opaque polymer biomaterials |
| US6375634B1 (en) | 1997-11-19 | 2002-04-23 | Oncology Innovations, Inc. | Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy |
| US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
| US6428978B1 (en) | 1998-05-08 | 2002-08-06 | Cohesion Technologies, Inc. | Methods for the production of gelatin and full-length triple helical collagen in recombinant cells |
| US6066856A (en) | 1998-05-18 | 2000-05-23 | Children's Medical Center Corporation | Radiation protective device |
| US6280742B1 (en) * | 1998-06-17 | 2001-08-28 | Zonagen, Inc. | Methods and materials for the treatment of prostatic carcinoma |
| US6206930B1 (en) | 1998-08-10 | 2001-03-27 | Charlotte-Mecklenburg Hospital Authority | Absorbable tissue expander |
| US6152943A (en) | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6818018B1 (en) | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| AU5560899A (en) | 1998-08-14 | 2000-03-06 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| US6179862B1 (en) | 1998-08-14 | 2001-01-30 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| AU761158B2 (en) | 1998-10-22 | 2003-05-29 | Bioniche Teoranta | A method for preventing, reducing, and treating radiation cystitis using hyaluronic acid |
| US6899889B1 (en) | 1998-11-06 | 2005-05-31 | Neomend, Inc. | Biocompatible material composition adaptable to diverse therapeutic indications |
| US8802146B2 (en) * | 1998-11-06 | 2014-08-12 | Neomend, Inc. | Systems, methods, and compositions for prevention of tissue adhesion |
| AU1614500A (en) | 1998-11-12 | 2000-06-05 | Canadian Prostate Centre, Inc. | Apparatus and method of separating organs to enable aggressive thermal therapy |
| US6110484A (en) | 1998-11-24 | 2000-08-29 | Cohesion Technologies, Inc. | Collagen-polymer matrices with differential biodegradability |
| WO2000033764A1 (en) | 1998-12-04 | 2000-06-15 | Pathak Chandrashekhar P | Biocompatible crosslinked polymers |
| US20080114092A1 (en) | 1998-12-04 | 2008-05-15 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
| TW392930U (en) * | 1998-12-28 | 2000-06-01 | Hon Hai Prec Ind Co Ltd | Electric connector |
| US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
| PT1146861E (pt) * | 1999-02-03 | 2005-10-31 | Powderject Res Ltd | Formulacoes de particulas de hidrogel |
| US6177514B1 (en) | 1999-04-09 | 2001-01-23 | Sulzer Carbomedics Inc. | Blocked functional reagants for cross-linking biological tissues |
| JP4558213B2 (ja) | 1999-04-12 | 2010-10-06 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 疎水性および親水性の成分を有する水性ゲル形成システム |
| US6268405B1 (en) | 1999-05-04 | 2001-07-31 | Porex Surgical, Inc. | Hydrogels and methods of making and using same |
| US6426145B1 (en) | 1999-05-20 | 2002-07-30 | Scimed Life Systems, Inc. | Radiopaque compositions for visualization of medical devices |
| US6428785B1 (en) | 1999-10-28 | 2002-08-06 | Immunolytics Inc. | Method and composition for treating prostate cancer |
| AU1658601A (en) | 1999-11-15 | 2001-05-30 | The Texas A & M University System | Wound sealant formed in situ |
| US6479079B1 (en) | 1999-12-13 | 2002-11-12 | Sulzer Carbomedics Inc. | Anticalcification treatments for fixed biomaterials |
| US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| US9314339B2 (en) | 2000-03-27 | 2016-04-19 | Formae, Inc. | Implants for replacing cartilage, with negatively-charged hydrogel surfaces and flexible matrix reinforcement |
| US6656200B2 (en) | 2000-04-07 | 2003-12-02 | Collagen Matrix, Inc. | Embolization device |
| US6599448B1 (en) * | 2000-05-10 | 2003-07-29 | Hydromer, Inc. | Radio-opaque polymeric compositions |
| US6383344B1 (en) | 2000-07-19 | 2002-05-07 | Genzyme Corporation | Molecular weight reduction of polymer using irradiation treatment |
| US6545097B2 (en) | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
| US6596471B2 (en) | 2000-12-21 | 2003-07-22 | Carbomedics Inc. | Method of cross-linking tissue with a bis-maleimide compound |
| CA2438193A1 (en) | 2001-02-26 | 2002-09-06 | Duke University | Novel dendritic polymers and their biomedical uses |
| JP4123856B2 (ja) | 2001-07-31 | 2008-07-23 | 日油株式会社 | 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法 |
| CN1277805C (zh) | 2001-10-03 | 2006-10-04 | 大日本除虫菊株式会社 | 炔丙基苄基醇酯衍生物、其制备方法和含有其的杀虫·防虫剂 |
| US20070264227A1 (en) * | 2001-11-07 | 2007-11-15 | Eidgenossische Technische Hochschule Zurich | Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration |
| US20040131582A1 (en) | 2002-02-26 | 2004-07-08 | Grinstaff Mark W. | Novel dendritic polymers and their biomedical uses |
| US7341716B2 (en) * | 2002-04-12 | 2008-03-11 | Boston Scientific Scimed, Inc. | Occlusive composition |
| EP1536746B1 (en) | 2002-06-24 | 2013-05-08 | Incept, LLC | Fillers and methods for displacing tissues to improve radiological outcomes |
| US7351430B2 (en) | 2002-11-06 | 2008-04-01 | Uluru Inc. | Shape-retentive hydrogel particle aggregates and their uses |
| US7129210B2 (en) | 2003-07-23 | 2006-10-31 | Covalent Medical, Inc. | Tissue adhesive sealant |
| US20050033157A1 (en) * | 2003-07-25 | 2005-02-10 | Klein Dean A. | Multi-modality marking material and method |
| US7790141B2 (en) | 2003-08-11 | 2010-09-07 | Pathak Holdings, Llc | Radio-opaque compounds, compositions containing same and methods of their synthesis and use |
| CA2531894C (en) | 2003-09-25 | 2014-02-11 | Rutgers, The State University | Inherently radiopaque polymeric products for embolotherapy |
| CN102499729B (zh) | 2004-06-23 | 2015-07-22 | 直空间有限公司 | 用于组织移除或分离的设备系统和方法 |
| FR2872262B1 (fr) | 2004-06-29 | 2010-11-26 | Air Liquide | Procede et installation de fourniture de secours d'un gaz sous pression |
| WO2006031358A2 (en) | 2004-08-13 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses |
| EP1778761B1 (en) | 2004-08-13 | 2021-09-29 | Reva Medical, Inc. | Inherently radiopaque bioresorbable polymers for multiple uses |
| WO2006031388A2 (en) | 2004-08-20 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dentritic polymers, crosslinked gels, and their uses in orthopedic applications |
| WO2006026325A2 (en) | 2004-08-26 | 2006-03-09 | Pathak Chandrashekhar P | Implantable tissue compositions and method |
| WO2006078770A2 (en) | 2005-01-21 | 2006-07-27 | Civco Medical Instruments Co., Inc. | Creating temporary space between body tissues |
| US7963287B2 (en) * | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
| WO2007005249A2 (en) | 2005-06-29 | 2007-01-11 | Hyperbranch Medical Technology, Inc. | Nanoparticles and dendritic-polymer-based hydrogels comprising them |
| DE102005051366A1 (de) * | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
| US9393344B2 (en) | 2006-01-11 | 2016-07-19 | Hyperbranch Medical Technology, Inc. | Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices |
| US8795709B2 (en) | 2006-03-29 | 2014-08-05 | Incept Llc | Superabsorbent, freeze dried hydrogels for medical applications |
| US7597882B2 (en) | 2006-04-24 | 2009-10-06 | Incept Llc | Protein crosslinkers, crosslinking methods and applications thereof |
| US7872068B2 (en) | 2006-05-30 | 2011-01-18 | Incept Llc | Materials formable in situ within a medical device |
| EP2121057A4 (en) | 2007-02-06 | 2012-10-10 | Incept Llc | POLYMERIZATION WITH PRECIPITATION OF PROTEINS FOR ELUTION IN A PHYSIOLOGICAL SOLUTION |
| WO2008101173A2 (en) | 2007-02-16 | 2008-08-21 | Cornell University | Biodegradable compositions and materials |
| US20080220047A1 (en) * | 2007-03-05 | 2008-09-11 | Sawhney Amarpreet S | Low-swelling biocompatible hydrogels |
| US9987221B2 (en) | 2007-08-23 | 2018-06-05 | Boston Scientific Scimed, Inc. | Injectable hydrogel compositions |
| CA2707649A1 (en) | 2007-11-02 | 2009-05-07 | Genzyme Corporation | Methods of augmenting or repairing soft tissue |
| US8410189B2 (en) * | 2008-02-13 | 2013-04-02 | Hyperbranch Medical Technology, Inc. | Crosslinked polyalkyleneimine hydrogels with tunable degradation rates |
| CN101724144A (zh) | 2008-11-03 | 2010-06-09 | 北京键凯科技有限公司 | 新型的多臂聚乙二醇及其制备方法和应用 |
| WO2010062783A2 (en) | 2008-11-03 | 2010-06-03 | Cornell University | Polymer compositions of dihydroxyacetone and uses thereof |
| CN102844054B (zh) | 2009-12-15 | 2016-04-20 | 因赛普特有限责任公司 | 植入物和能生物降解的基准标记物 |
| US8734930B2 (en) | 2010-05-27 | 2014-05-27 | Covidien Lp | Hydrogel implants with varying degrees of crosslinking |
| EP2953650B1 (en) | 2013-02-08 | 2020-09-30 | Endoshape, Inc. | Radiopaque polymers for medical devices |
| US9789073B2 (en) | 2013-03-14 | 2017-10-17 | Pathak Holdings, Llc | Compositions, methods and devices for local drug delivery |
| CN107759783A (zh) | 2013-12-02 | 2018-03-06 | 北京键凯科技股份有限公司 | 炔基多臂聚乙二醇衍生物 |
| CN106146325B (zh) | 2015-04-24 | 2019-01-29 | 北京键凯科技股份有限公司 | 一种y型多缩乙二醇衍生物及其制备方法 |
| EP3681934A1 (en) * | 2017-09-15 | 2020-07-22 | Université de Strasbourg | Injectable hybrid alginate hydrogels and uses thereof |
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