CA2779460A1 - Method for producing butanol using extractive fermentation with osmolyte addition - Google Patents
Method for producing butanol using extractive fermentation with osmolyte addition Download PDFInfo
- Publication number
- CA2779460A1 CA2779460A1 CA2779460A CA2779460A CA2779460A1 CA 2779460 A1 CA2779460 A1 CA 2779460A1 CA 2779460 A CA2779460 A CA 2779460A CA 2779460 A CA2779460 A CA 2779460A CA 2779460 A1 CA2779460 A1 CA 2779460A1
- Authority
- CA
- Canada
- Prior art keywords
- butanol
- fermentation medium
- osmolyte
- extractant
- phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 title claims abstract description 704
- 238000000855 fermentation Methods 0.000 title claims abstract description 352
- 230000004151 fermentation Effects 0.000 title claims abstract description 352
- 230000000065 osmolyte Effects 0.000 title claims abstract description 209
- 238000004519 manufacturing process Methods 0.000 title claims description 50
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- 229910052799 carbon Inorganic materials 0.000 claims abstract description 88
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- RWVGQQGBQSJDQV-UHFFFAOYSA-M sodium;3-[[4-[(e)-[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]-2-methylcyclohexa-2,5-dien-1-ylidene]methyl]-n-ethyl-3-methylanilino]methyl]benzenesulfonate Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C(=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=2C(=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=C1 RWVGQQGBQSJDQV-UHFFFAOYSA-M 0.000 description 1
- PZDOWFGHCNHPQD-VNNZMYODSA-N sophorose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PZDOWFGHCNHPQD-VNNZMYODSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/26—Processes using, or culture media containing, hydrocarbons
- C12N1/28—Processes using, or culture media containing, hydrocarbons aliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26352209P | 2009-11-23 | 2009-11-23 | |
| US61/263,522 | 2009-11-23 | ||
| PCT/US2010/057846 WO2011063402A2 (en) | 2009-11-23 | 2010-11-23 | Method for producing butanol using extractive fermentation with osmolyte addition |
Publications (1)
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|---|---|
| CA2779460A1 true CA2779460A1 (en) | 2011-05-26 |
Family
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Family Applications (1)
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| CA2779460A Abandoned CA2779460A1 (en) | 2009-11-23 | 2010-11-23 | Method for producing butanol using extractive fermentation with osmolyte addition |
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| EP (1) | EP2504447A2 (enExample) |
| JP (1) | JP2013511284A (enExample) |
| KR (1) | KR20120117990A (enExample) |
| CN (1) | CN102666867A (enExample) |
| AU (1) | AU2010321575A1 (enExample) |
| BR (1) | BR112012012211A2 (enExample) |
| CA (1) | CA2779460A1 (enExample) |
| IN (1) | IN2012DN03327A (enExample) |
| MX (1) | MX2012005910A (enExample) |
| NZ (1) | NZ599415A (enExample) |
| WO (1) | WO2011063402A2 (enExample) |
| ZA (1) | ZA201203652B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| BRPI0913682A2 (pt) * | 2008-09-29 | 2020-08-11 | Butamax Advanced Biofuels Llc | método para identificar enzimas dihidróxi-ácido desidratase (dhad) [2fe-2s], célula hospedeira microbiana recombinante, método para a produção de isobutanol e método para a conversão de 2,3-dihidróxiisovalerato |
| JP5804946B2 (ja) | 2008-09-29 | 2015-11-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 酵母における異種性Ｆｅ−Ｓ酵素活性の増大 |
| AU2011218090B2 (en) | 2010-02-17 | 2016-06-23 | Butamax(Tm) Advanced Biofuels Llc | Improving activity of Fe-S cluster requiring proteins |
| AU2011268215B2 (en) * | 2010-06-18 | 2014-10-23 | Butamax(Tm) Advanced Biofuels Llc | Supplementation of fatty acids for improving alcohol productivity |
| AU2011268220B2 (en) | 2010-06-18 | 2015-01-29 | Butamax(Tm) Advanced Biofuels Llc | Extraction solvents derived from oil for alcohol removal in extractive fermentation |
| US8765425B2 (en) * | 2011-03-23 | 2014-07-01 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| JP2014509869A (ja) * | 2011-03-23 | 2014-04-24 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 発酵におけるアルコールエステルの酵素的生産のためのリパーゼの原位置発現 |
| US8759044B2 (en) | 2011-03-23 | 2014-06-24 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| CN102356899B (zh) * | 2011-09-07 | 2012-11-28 | 中国食品发酵工业研究院 | 一种天然果蔬酵素饮料及其制备方法 |
| US9962623B2 (en) | 2011-12-09 | 2018-05-08 | Butamax Advanced Biofuels Llc | Process to remove product alcohols from fermentation broth |
| AU2012362274A1 (en) | 2011-12-30 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Fermentative production of alcohols |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013148289A1 (en) * | 2012-03-30 | 2013-10-03 | Hydration Systems, Llc | Use of novel draw solutes and combinations in forward osmosis system |
| KR20150007329A (ko) | 2012-05-04 | 2015-01-20 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 알코올 생산 및 회수를 위한 공정 및 시스템 |
| US9605281B2 (en) | 2012-09-12 | 2017-03-28 | Butamax Advanced Biofuels Llc | Processes and systems for the fermentative production of alcohols |
| WO2014018837A1 (en) | 2012-07-26 | 2014-01-30 | Cheng Cecilia | Butanol purification |
| CN102787144B (zh) * | 2012-07-27 | 2013-10-16 | 中国科学院过程工程研究所 | 一种生物质发酵-渗透汽化膜耦合生产丙酮丁醇的工艺 |
| US9109196B2 (en) | 2012-09-12 | 2015-08-18 | Butamax Advanced Biofuels Llc | Processes and systems for the production of fermentation products |
| CA2885427A1 (en) | 2012-09-21 | 2014-03-27 | Butamax Advanced Biofuels Llc | A method for producing butanol using two-phase extractive fermentation and recyclable extractant compositions |
| US20140093931A1 (en) | 2012-09-28 | 2014-04-03 | Butamax Advanced Biofuels Llc | Production of fermentation products |
| US9650624B2 (en) | 2012-12-28 | 2017-05-16 | Butamax Advanced Biofuels Llc | DHAD variants for butanol production |
| WO2014105840A1 (en) | 2012-12-31 | 2014-07-03 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| US9523104B2 (en) | 2013-03-12 | 2016-12-20 | Butamax Advanced Biofuels Llc | Processes and systems for the production of alcohols |
| US9469584B2 (en) | 2013-03-15 | 2016-10-18 | Butamax Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
| WO2014144728A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for production of butanol using extractive fermentation |
| WO2014151190A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
| US9771602B2 (en) | 2013-03-15 | 2017-09-26 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| EP3114103A4 (en) * | 2014-03-04 | 2018-01-17 | White Dog Labs, Inc. | Energy efficient batch recycle method for the production of biomolecules |
| EP3129116A4 (en) | 2014-04-11 | 2018-02-14 | Butamax Advanced Biofuels LLC | Contamination mitigation |
| EP3277652A4 (en) * | 2015-03-31 | 2018-11-07 | White Dog Labs, Inc. | Method of producing bioproducts |
| WO2016160817A1 (en) * | 2015-03-31 | 2016-10-06 | White Dog Labs, Inc. | Method of producing bioproducts |
| CN105713823A (zh) * | 2016-03-25 | 2016-06-29 | 华南理工大学 | 一种萃取发酵生产异丙醇和丁醇的装置和方法 |
| CN109536397B (zh) * | 2018-12-03 | 2021-11-05 | 上海交通大学 | 一种基因工程酿酒酵母及其制备方法和应用 |
| JP7738417B2 (ja) * | 2021-07-08 | 2025-09-12 | 日鉄エンジニアリング株式会社 | 連続抽出発酵装置及び連続抽出発酵方法 |
| EP4536615A1 (en) * | 2022-06-10 | 2025-04-16 | Amyris, Inc. | Compositions and methods for improved cell culture efficiency |
| CN116590209A (zh) * | 2023-06-13 | 2023-08-15 | 浙江工业大学 | 一种产d-泛酸的基因工程菌、构建方法及应用 |
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| CA1280705C (en) * | 1985-09-13 | 1991-02-26 | Finn Kollerup | Solvents and process for extractive fermentation |
| US4865973A (en) * | 1985-09-13 | 1989-09-12 | Queen's University At Kingston | Process for extractive fermentation |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| CN101297042A (zh) * | 2005-10-26 | 2008-10-29 | 纳幕尔杜邦公司 | 四碳醇的发酵生产 |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| US20110009773A1 (en) * | 2006-02-04 | 2011-01-13 | Evigia Systems, Inc. | Implantable sensing modules and methods of using |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| US7541173B2 (en) * | 2006-06-15 | 2009-06-02 | E.I. Du Pont De Nemours And Company | Solvent tolerant microorganisms and methods of isolation |
| WO2008130995A2 (en) * | 2007-04-18 | 2008-10-30 | E. I. Du Pont De Nemours And Company | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| EP2677028B1 (en) * | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| BRPI0821519A2 (pt) * | 2007-12-27 | 2015-06-16 | Gevo Inc | Recuperação de alcoois superiores a partir de soluções aquosas diluída |
| US8188250B2 (en) * | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| WO2009149240A1 (en) * | 2008-06-04 | 2009-12-10 | E. I. Du Pont De Nemours And Company | Deletion mutants for the production of isobutanol |
| WO2009149270A2 (en) * | 2008-06-04 | 2009-12-10 | E. I. Du Pont De Nemours And Company | A method for producing butanol using two-phase extractive fermentation |
| BRPI0909989A2 (pt) * | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| JP5804946B2 (ja) * | 2008-09-29 | 2015-11-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 酵母における異種性Ｆｅ−Ｓ酵素活性の増大 |
| BRPI0913682A2 (pt) | 2008-09-29 | 2020-08-11 | Butamax Advanced Biofuels Llc | método para identificar enzimas dihidróxi-ácido desidratase (dhad) [2fe-2s], célula hospedeira microbiana recombinante, método para a produção de isobutanol e método para a conversão de 2,3-dihidróxiisovalerato |
| BRPI0914521A2 (pt) | 2008-10-27 | 2016-07-26 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol |
| EP2483401B1 (en) * | 2009-09-29 | 2017-06-21 | Butamax (TM) Advanced Biofuels LLC | Improved yeast production host cells |
-
2010
- 2010-11-23 IN IN3327DEN2012 patent/IN2012DN03327A/en unknown
- 2010-11-23 BR BR112012012211A patent/BR112012012211A2/pt not_active IP Right Cessation
- 2010-11-23 JP JP2012540155A patent/JP2013511284A/ja active Pending
- 2010-11-23 CN CN201080052282XA patent/CN102666867A/zh active Pending
- 2010-11-23 CA CA2779460A patent/CA2779460A1/en not_active Abandoned
- 2010-11-23 MX MX2012005910A patent/MX2012005910A/es not_active Application Discontinuation
- 2010-11-23 AU AU2010321575A patent/AU2010321575A1/en not_active Abandoned
- 2010-11-23 US US12/952,549 patent/US20110136193A1/en not_active Abandoned
- 2010-11-23 NZ NZ599415A patent/NZ599415A/en not_active IP Right Cessation
- 2010-11-23 EP EP10784647A patent/EP2504447A2/en not_active Withdrawn
- 2010-11-23 WO PCT/US2010/057846 patent/WO2011063402A2/en not_active Ceased
- 2010-11-23 KR KR1020127016238A patent/KR20120117990A/ko not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA201203652B (en) | 2013-08-28 |
| MX2012005910A (es) | 2012-06-19 |
| NZ599415A (en) | 2014-06-27 |
| IN2012DN03327A (enExample) | 2015-10-23 |
| WO2011063402A2 (en) | 2011-05-26 |
| KR20120117990A (ko) | 2012-10-25 |
| WO2011063402A3 (en) | 2011-10-13 |
| JP2013511284A (ja) | 2013-04-04 |
| US20110136193A1 (en) | 2011-06-09 |
| BR112012012211A2 (pt) | 2017-05-09 |
| CN102666867A (zh) | 2012-09-12 |
| EP2504447A2 (en) | 2012-10-03 |
| AU2010321575A1 (en) | 2012-05-10 |
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| FZDE | Discontinued |
Effective date: 20161123 |