CA2776498A1 - Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells - Google Patents

Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells Download PDF

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Publication number
CA2776498A1
CA2776498A1 CA2776498A CA2776498A CA2776498A1 CA 2776498 A1 CA2776498 A1 CA 2776498A1 CA 2776498 A CA2776498 A CA 2776498A CA 2776498 A CA2776498 A CA 2776498A CA 2776498 A1 CA2776498 A1 CA 2776498A1
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CA
Canada
Prior art keywords
pkc
cells
isozyme
index
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2776498A
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English (en)
French (fr)
Inventor
Tapan Kumar Khan
Daniel L. Alkon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
West Virginia University
Original Assignee
Blanchette Rockefeller Neurosciences Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blanchette Rockefeller Neurosciences Institute filed Critical Blanchette Rockefeller Neurosciences Institute
Publication of CA2776498A1 publication Critical patent/CA2776498A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2776498A 2009-10-02 2010-10-01 Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells Abandoned CA2776498A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24836109P 2009-10-02 2009-10-02
US61/248,361 2009-10-02
PCT/US2010/051112 WO2011041670A2 (en) 2009-10-02 2010-10-01 Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells

Publications (1)

Publication Number Publication Date
CA2776498A1 true CA2776498A1 (en) 2011-04-07

Family

ID=43302691

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2776498A Abandoned CA2776498A1 (en) 2009-10-02 2010-10-01 Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells

Country Status (7)

Country Link
US (1) US20110212474A1 (cg-RX-API-DMAC10.html)
EP (1) EP2483695A2 (cg-RX-API-DMAC10.html)
JP (2) JP6013184B2 (cg-RX-API-DMAC10.html)
CN (1) CN102741696A (cg-RX-API-DMAC10.html)
BR (1) BR112012007557A2 (cg-RX-API-DMAC10.html)
CA (1) CA2776498A1 (cg-RX-API-DMAC10.html)
WO (1) WO2011041670A2 (cg-RX-API-DMAC10.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014145316A1 (en) * 2013-03-15 2014-09-18 Alkon Daniel L Methods for identifying neuroprotective pkc activators
EP3265810A1 (en) 2015-03-06 2018-01-10 Blanchette Rockefeller Neurosciences, Institute Methods for classifying populations including alzheimer's disease populations
US20190041404A1 (en) * 2016-02-22 2019-02-07 The West Virginia University Board Of Governors On Behalf Of West Virginia University Diagnosing mild cognitive impairment (mci), predicting alzheimer's disease (ad) dementia onset, and screening and monitoring agents for treating mci or preventing dementia onset
US20180282784A1 (en) * 2017-03-31 2018-10-04 NeuroDiagnostics LLC LYMPHOCYTE-BASED PKCe TEST FOR ALZHEIMER'S DISEASE
CN115078570B (zh) * 2022-05-30 2024-05-28 郑州大学第一附属医院 Tau蛋白639位硫氰酸氨基酸修饰在快速质谱法检测阿尔茨海默症中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080784A (en) * 1986-06-11 2000-06-27 Procyon Pharmaceuticals, Inc. Protein kinase C modulators N
US5385915A (en) * 1990-05-16 1995-01-31 The Rockefeller University Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
US5242932A (en) * 1991-12-17 1993-09-07 The Rockefeller University Treatment of amyloidosis associated with alzheimer disease
US20030108956A1 (en) * 1993-05-03 2003-06-12 Alkon Daniel L. Cell tests for Alzheimer's disease
US6107050A (en) 1993-05-03 2000-08-22 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic test for alzheimers disease
US5976816A (en) * 1993-05-03 1999-11-02 The United States Of America As Represented By The Department Of Health And Human Services Cell tests for alzheimer's disease
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
AU2316797A (en) * 1996-02-29 1997-09-16 Mount Sinai Hospital Corporation Shc proteins
AU1630501A (en) * 1999-10-08 2001-04-23 Superarray, Inc. Compositions and methods for detecting protein modification and enzymatic activity
AUPR215700A0 (en) * 2000-12-19 2001-01-25 Fujisawa Pharmaceutical Co., Ltd. Carboxylic acid compound having cyclopropane ring
WO2002063005A2 (en) * 2001-02-06 2002-08-15 Incyte Genomics, Inc. Lipid-associated molecules
ES2305234T3 (es) * 2001-02-27 2008-11-01 Blanchette Rockefeller Neurosciences Institute Diagnostico de la enfermedad de alzheimer basado en la fosforilacion de una proteina quinosa activada por mitogeno.
US20040014678A1 (en) * 2001-08-08 2004-01-22 Antonella Favit Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytoc pathway
US7608406B2 (en) * 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US6897014B2 (en) 2002-02-15 2005-05-24 Fuji Photo Film Co., Ltd. Silver halide photographic light-sensitive material, photographic emulsion, and mercapto group-containing polymer compound used for them
ITMI20031098A1 (it) * 2003-05-30 2004-11-30 Indena Spa Composti utili nella terapia del morbo di alzheimer e formulazioni che li contengono
KR100574017B1 (ko) 2003-08-11 2006-04-26 삼성전자주식회사 잉크젯 프린터의 잉크 카트리지
KR101332540B1 (ko) 2005-05-27 2013-11-22 칼 짜이스 에스엠테 게엠베하 광산란 디스크, 그 사용 및 파면 측정 장치
US20070054890A1 (en) * 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
WO2007044094A1 (en) * 2005-10-11 2007-04-19 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)
US7595167B2 (en) * 2005-10-11 2009-09-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio
US20090029873A1 (en) * 2005-10-11 2009-01-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb)
CN101848726A (zh) 2007-02-09 2010-09-29 布朗歇特洛克菲勒神经科学研究所 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效

Also Published As

Publication number Publication date
WO2011041670A2 (en) 2011-04-07
EP2483695A2 (en) 2012-08-08
JP2016197112A (ja) 2016-11-24
JP6013184B2 (ja) 2016-10-25
CN102741696A (zh) 2012-10-17
WO2011041670A3 (en) 2011-06-30
JP2013506844A (ja) 2013-02-28
US20110212474A1 (en) 2011-09-01
BR112012007557A2 (pt) 2017-05-02

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EEER Examination request

Effective date: 20150910

FZDE Discontinued

Effective date: 20190716