CA2775328A1 - Pyrido[4,3-b]indoles and methods of use - Google Patents

Info

Publication number

CA2775328A1

CA2775328A1 CA2775328A CA2775328A CA2775328A1 CA 2775328 A1 CA2775328 A1 CA 2775328A1 CA 2775328 A CA2775328 A CA 2775328A CA 2775328 A CA2775328 A CA 2775328A CA 2775328 A1 CA2775328 A1 CA 2775328A1

Authority

CA

Canada

Prior art keywords

substituted

moiety

unsubstituted

taken together

alkyl

Prior art date

2009-09-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 77
• RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 title abstract description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 495
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• 230000001404 mediated effect Effects 0.000 claims abstract description 37
• 238000011282 treatment Methods 0.000 claims abstract description 29
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• -1 perhaloalkyl Chemical group 0.000 claims description 132
• 125000003118 aryl group Chemical group 0.000 claims description 111
• 125000001072 heteroaryl group Chemical group 0.000 claims description 105
• 125000003545 alkoxy group Chemical group 0.000 claims description 98
• 125000000623 heterocyclic group Chemical group 0.000 claims description 94
• QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 86
• 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 86
• 125000000217 alkyl group Chemical group 0.000 claims description 77
• 150000003839 salts Chemical class 0.000 claims description 74
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• 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 59
• 125000005102 carbonylalkoxy group Chemical group 0.000 claims description 58
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 54
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 54
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• 125000004442 acylamino group Chemical group 0.000 claims description 52
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 51
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• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 32
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