CA2774952C - Dispositif et systeme de filtration - Google Patents
Dispositif et systeme de filtration Download PDFInfo
- Publication number
- CA2774952C CA2774952C CA2774952A CA2774952A CA2774952C CA 2774952 C CA2774952 C CA 2774952C CA 2774952 A CA2774952 A CA 2774952A CA 2774952 A CA2774952 A CA 2774952A CA 2774952 C CA2774952 C CA 2774952C
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- fluid
- membrane
- filtration
- microchannels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001914 filtration Methods 0.000 title claims abstract description 71
- 239000012530 fluid Substances 0.000 claims abstract description 128
- 239000012528 membrane Substances 0.000 claims abstract description 126
- 230000004087 circulation Effects 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 14
- 230000004888 barrier function Effects 0.000 claims description 7
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 210000004379 membrane Anatomy 0.000 description 105
- 210000004027 cell Anatomy 0.000 description 45
- 238000011161 development Methods 0.000 description 14
- 230000018109 developmental process Effects 0.000 description 14
- 238000004113 cell culture Methods 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 238000009792 diffusion process Methods 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 11
- 235000015097 nutrients Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 241000282414 Homo sapiens Species 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 6
- 210000000056 organ Anatomy 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 230000002349 favourable effect Effects 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000000108 ultra-filtration Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229930003779 Vitamin B12 Natural products 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 239000011715 vitamin B12 Substances 0.000 description 2
- 235000019163 vitamin B12 Nutrition 0.000 description 2
- 235000016626 Agrimonia eupatoria Nutrition 0.000 description 1
- 101710150365 Albumin-1 Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000196323 Marchantiophyta Species 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000007358 intestinal barrier function Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0956568A FR2950359B1 (fr) | 2009-09-23 | 2009-09-23 | Dispositif et systeme de filtration |
| FR0956568 | 2009-09-23 | ||
| PCT/EP2010/064082 WO2011036226A2 (fr) | 2009-09-23 | 2010-09-23 | Dispositif et systeme de filtration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2774952A1 CA2774952A1 (fr) | 2011-03-31 |
| CA2774952C true CA2774952C (fr) | 2018-05-15 |
Family
ID=42211816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2774952A Active CA2774952C (fr) | 2009-09-23 | 2010-09-23 | Dispositif et systeme de filtration |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20130005027A1 (enExample) |
| EP (1) | EP2480654B1 (enExample) |
| JP (1) | JP5956340B2 (enExample) |
| CA (1) | CA2774952C (enExample) |
| FR (1) | FR2950359B1 (enExample) |
| IL (1) | IL218794A (enExample) |
| WO (1) | WO2011036226A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150072413A1 (en) * | 2012-03-29 | 2015-03-12 | Arizona Board Of Regents On Behalf University Of Arizona | Cell culture apparatus and culture methods using same |
| KR101807765B1 (ko) * | 2012-11-16 | 2017-12-11 | 주식회사 케이티 | 모바일 결제 시스템 및 방법 |
| EP3400976A1 (en) * | 2017-05-12 | 2018-11-14 | Universitat Rovira i Virgili | Device and method for the preparation of platelet rich plasma |
| EP3837273B1 (en) | 2018-08-14 | 2025-09-24 | Bristol-Myers Squibb Company | Improved protein recovery |
| US20230113710A1 (en) * | 2021-10-08 | 2023-04-13 | Shanghai Ruiyu Biotech Co., Ltd. | Culture devices |
| EP4633812A2 (en) * | 2022-12-13 | 2025-10-22 | Rapid Micro Biosystems, Inc. | Tube set with dual pressure regulating valve |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763266A (en) * | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| JPH05292990A (ja) * | 1992-04-09 | 1993-11-09 | Tabai Espec Corp | 物質の生産方法および該方法に用いる細胞培養器 |
| US5801055A (en) * | 1997-09-10 | 1998-09-01 | Becton Dickinson And Company | Multi-well culture dish assembly |
| ATE227338T1 (de) * | 1998-03-18 | 2002-11-15 | Massachusetts Inst Technology | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
| US7776021B2 (en) * | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
| SE0004296D0 (sv) * | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
| US20030215941A1 (en) * | 2002-03-12 | 2003-11-20 | Stewart Campbell | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
| US20040018611A1 (en) * | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
| AU2003268202A1 (en) * | 2002-08-27 | 2004-03-19 | Vanderbilt University | Bioreactors with an array of chambers and a common feed line |
| US6878271B2 (en) * | 2002-09-09 | 2005-04-12 | Cytonome, Inc. | Implementation of microfluidic components in a microfluidic system |
| WO2004024300A1 (en) * | 2002-09-11 | 2004-03-25 | The Regents Of The University Of Michigan | Ultrafiltration membrane, device, bioartificial organ and methods |
| US7476326B2 (en) * | 2003-09-26 | 2009-01-13 | Ahn Chong H | On-chip sample preparation for whole blood analysis |
| US8003380B2 (en) * | 2006-01-04 | 2011-08-23 | Agency For Science, Technology And Research | High throughput cell-based assays fabricated with integrated silicon and cell culture technologies |
| EP2169049B1 (en) * | 2007-06-18 | 2018-01-17 | Kuraray Co., Ltd. | Cell culture container and cell culture method |
-
2009
- 2009-09-23 FR FR0956568A patent/FR2950359B1/fr not_active Expired - Fee Related
-
2010
- 2010-09-23 EP EP10757102.8A patent/EP2480654B1/fr active Active
- 2010-09-23 CA CA2774952A patent/CA2774952C/fr active Active
- 2010-09-23 WO PCT/EP2010/064082 patent/WO2011036226A2/fr not_active Ceased
- 2010-09-23 US US13/497,247 patent/US20130005027A1/en not_active Abandoned
- 2010-09-23 JP JP2012530264A patent/JP5956340B2/ja active Active
-
2012
- 2012-03-22 IL IL218794A patent/IL218794A/en active IP Right Grant
-
2016
- 2016-12-16 US US15/382,437 patent/US20170096629A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2480654B1 (fr) | 2015-06-17 |
| IL218794A (en) | 2015-05-31 |
| US20170096629A1 (en) | 2017-04-06 |
| FR2950359A1 (fr) | 2011-03-25 |
| EP2480654A2 (fr) | 2012-08-01 |
| JP2013505029A (ja) | 2013-02-14 |
| CA2774952A1 (fr) | 2011-03-31 |
| JP5956340B2 (ja) | 2016-07-27 |
| IL218794A0 (en) | 2012-06-28 |
| WO2011036226A3 (fr) | 2011-12-29 |
| WO2011036226A2 (fr) | 2011-03-31 |
| FR2950359B1 (fr) | 2011-12-02 |
| US20130005027A1 (en) | 2013-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150930 |