CA2774692C - Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes - Google Patents
Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes Download PDFInfo
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- CA2774692C CA2774692C CA2774692A CA2774692A CA2774692C CA 2774692 C CA2774692 C CA 2774692C CA 2774692 A CA2774692 A CA 2774692A CA 2774692 A CA2774692 A CA 2774692A CA 2774692 C CA2774692 C CA 2774692C
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C07K2317/55—Fab or Fab'
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- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
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GBGB0916822.0A GB0916822D0 (en) | 2009-09-24 | 2009-09-24 | Bacterial host strain |
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GB0916821A GB0916821D0 (en) | 2009-09-24 | 2009-09-24 | Bacterial host strain |
GB0916821.2 | 2009-09-24 | ||
PCT/GB2010/001790 WO2011036454A1 (en) | 2009-09-24 | 2010-09-23 | Bacterial host strain |
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CA2774692A1 CA2774692A1 (en) | 2011-03-31 |
CA2774692C true CA2774692C (en) | 2017-12-19 |
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CA2774692A Active CA2774692C (en) | 2009-09-24 | 2010-09-23 | Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes |
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HR (1) | HRP20181482T1 (forum.php) |
HU (1) | HUE040306T2 (forum.php) |
IN (1) | IN2012DN02401A (forum.php) |
LT (1) | LT2993231T (forum.php) |
PL (1) | PL2993231T3 (forum.php) |
PT (1) | PT2993231T (forum.php) |
SG (1) | SG10201606462WA (forum.php) |
SI (1) | SI2993231T1 (forum.php) |
SM (1) | SMT201800549T1 (forum.php) |
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IN2012DN02401A (forum.php) | 2009-09-24 | 2015-08-21 | Ucb Pharma Sa | |
GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
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GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
ES2659155T3 (es) * | 2011-07-13 | 2018-03-14 | Ucb Biopharma Sprl | Cepa hospedante bacteriana que expresa DSBC recombinante |
GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
EP3774926A1 (en) | 2018-04-05 | 2021-02-17 | Bio-Rad ABD Serotec GmbH | Display systems for proteins of interest |
WO2020188350A1 (en) | 2019-03-18 | 2020-09-24 | Bio-Rad Abd Serotec Gmbh | Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation |
CN110616181A (zh) * | 2019-09-27 | 2019-12-27 | 北京理工大学 | 一株基于大肠杆菌改造的工程菌株 |
CN117965503B (zh) * | 2024-02-02 | 2024-08-09 | 南京迪诺薇华生物科技有限公司 | 一种蛋白酶突变体及其在洗护肤品、化妆品中的应用 |
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GB201001791D0 (en) | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
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ES2659155T3 (es) | 2011-07-13 | 2018-03-14 | Ucb Biopharma Sprl | Cepa hospedante bacteriana que expresa DSBC recombinante |
EP2546267A1 (en) | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
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