CA2766483C - Pharmaceutical composition with glycosaminoglycans and use thereof in the treatment of chronic ulcers - Google Patents
Pharmaceutical composition with glycosaminoglycans and use thereof in the treatment of chronic ulcers Download PDFInfo
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- CA2766483C CA2766483C CA2766483A CA2766483A CA2766483C CA 2766483 C CA2766483 C CA 2766483C CA 2766483 A CA2766483 A CA 2766483A CA 2766483 A CA2766483 A CA 2766483A CA 2766483 C CA2766483 C CA 2766483C
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- Prior art keywords
- diabetic
- heparin
- healing
- ulcers
- day
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 238000007631 vascular surgery Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP200802002 | 2008-07-01 | ||
| ES200802002A ES2340902B1 (es) | 2008-07-01 | 2008-07-01 | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
| PCT/ES2009/070264 WO2010000904A1 (es) | 2008-07-01 | 2009-06-30 | Composición farmacéutica con glicosaminoglicanos y su uso en tratamiento de úlceras crónicas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2766483A1 CA2766483A1 (en) | 2010-01-07 |
| CA2766483C true CA2766483C (en) | 2017-01-17 |
Family
ID=41319881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2766483A Expired - Fee Related CA2766483C (en) | 2008-07-01 | 2009-06-30 | Pharmaceutical composition with glycosaminoglycans and use thereof in the treatment of chronic ulcers |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20110201572A1 (enExample) |
| EP (1) | EP2308497B1 (enExample) |
| JP (1) | JP2011526608A (enExample) |
| CN (1) | CN102176915A (enExample) |
| AU (1) | AU2009265623B2 (enExample) |
| BR (1) | BRPI0913839A2 (enExample) |
| CA (1) | CA2766483C (enExample) |
| CY (1) | CY1115780T1 (enExample) |
| DK (1) | DK2308497T3 (enExample) |
| ES (2) | ES2340902B1 (enExample) |
| MX (1) | MX2010014552A (enExample) |
| PL (1) | PL2308497T3 (enExample) |
| PT (1) | PT2308497E (enExample) |
| RU (1) | RU2011103459A (enExample) |
| WO (3) | WO2010000905A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2357601B1 (es) * | 2011-01-26 | 2012-03-21 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas. |
| JP2012245943A (ja) * | 2011-05-31 | 2012-12-13 | Hitachi Automotive Systems Ltd | 制御装置 |
| JP5942133B2 (ja) * | 2012-09-11 | 2016-06-29 | 学校法人関西文理総合学園 | 蛍光プローブ及びこれを用いた酵素活性検出方法 |
| AU2016235662B2 (en) * | 2015-03-20 | 2020-07-30 | Aarhus Universitet | Inhibitors of PCSK9 for treatment of lipoprotein metabolism disorders |
| EP3273239A1 (en) * | 2016-07-19 | 2018-01-24 | Laboratorios Farmacéuticos Rovi, S.A. | Procedure of analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance |
| CN111194220B (zh) * | 2017-09-05 | 2024-06-18 | 黄玲惠 | 用于治疗缺血的肝素组合物 |
| CN114072430B (zh) * | 2020-04-27 | 2023-07-28 | 罗威制药股份有限公司 | 低分子量肝素获取程序以及由此获得的低分子量肝素 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004A (en) * | 1849-01-09 | chinnqck | ||
| CH636888A5 (fr) * | 1977-08-08 | 1983-06-30 | Choay Sa | Heparines purifiees et leur preparation. |
| CA1136620A (en) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
| FR2482611B1 (fr) * | 1980-05-14 | 1986-03-07 | Pharmindustrie | Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments |
| IT1245907B (it) * | 1991-05-17 | 1994-10-25 | Alfa Wassermann Spa | Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. |
| AU1173599A (en) * | 1997-11-20 | 1999-06-15 | Ikuo Yamashina | Low-molecular heparin modification and remedy for skin ulcer |
| ES2161615B1 (es) * | 1999-07-23 | 2003-03-16 | Rovi Lab Farmaceut Sa | Composiciones de heparinas de muy bajo peso molecular. |
| EP1357931A2 (en) | 2001-01-08 | 2003-11-05 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| CU23043A1 (es) | 2001-12-20 | 2005-05-20 | Ct Ingenieria Genetica Biotech | Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico. |
| BR0309707A (pt) | 2002-05-02 | 2005-02-09 | Pfizer Prod Inc | Tratamento de diabetes e complicações diabéticas com inibidores nhe-1 |
| US20060040896A1 (en) * | 2004-08-18 | 2006-02-23 | Paringenix, Inc. | Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity |
| CU23388B6 (es) | 2006-01-31 | 2009-07-16 | Ct Ingenieria Genetica Biotech | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
-
2008
- 2008-07-01 ES ES200802002A patent/ES2340902B1/es not_active Expired - Fee Related
-
2009
- 2009-06-30 WO PCT/ES2009/070265 patent/WO2010000905A1/es not_active Ceased
- 2009-06-30 EP EP09772593.1A patent/EP2308497B1/en active Active
- 2009-06-30 US US13/001,895 patent/US20110201572A1/en not_active Abandoned
- 2009-06-30 CN CN2009801338633A patent/CN102176915A/zh active Pending
- 2009-06-30 ES ES09772593.1T patent/ES2476966T3/es active Active
- 2009-06-30 BR BRPI0913839A patent/BRPI0913839A2/pt not_active Application Discontinuation
- 2009-06-30 DK DK09772593.1T patent/DK2308497T3/da active
- 2009-06-30 CA CA2766483A patent/CA2766483C/en not_active Expired - Fee Related
- 2009-06-30 PL PL09772593T patent/PL2308497T3/pl unknown
- 2009-06-30 PT PT97725931T patent/PT2308497E/pt unknown
- 2009-06-30 JP JP2011515493A patent/JP2011526608A/ja active Pending
- 2009-06-30 WO PCT/ES2009/070264 patent/WO2010000904A1/es not_active Ceased
- 2009-06-30 AU AU2009265623A patent/AU2009265623B2/en not_active Ceased
- 2009-06-30 RU RU2011103459/15A patent/RU2011103459A/ru unknown
- 2009-06-30 MX MX2010014552A patent/MX2010014552A/es active IP Right Grant
- 2009-06-30 WO PCT/ES2009/070266 patent/WO2010000906A1/es not_active Ceased
-
2013
- 2013-09-05 US US14/018,840 patent/US9211305B2/en not_active Expired - Fee Related
-
2014
- 2014-07-14 CY CY20141100529T patent/CY1115780T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010000906A1 (es) | 2010-01-07 |
| DK2308497T3 (da) | 2014-07-14 |
| CN102176915A (zh) | 2011-09-07 |
| ES2476966T3 (es) | 2014-07-15 |
| CA2766483A1 (en) | 2010-01-07 |
| JP2011526608A (ja) | 2011-10-13 |
| RU2011103459A (ru) | 2012-08-10 |
| US9211305B2 (en) | 2015-12-15 |
| EP2308497A1 (en) | 2011-04-13 |
| WO2010000905A1 (es) | 2010-01-07 |
| AU2009265623B2 (en) | 2014-11-20 |
| EP2308497B1 (en) | 2014-04-16 |
| WO2010000904A1 (es) | 2010-01-07 |
| MX2010014552A (es) | 2011-04-26 |
| ES2340902B1 (es) | 2011-05-03 |
| PL2308497T3 (pl) | 2014-10-31 |
| US20110201572A1 (en) | 2011-08-18 |
| ES2340902A1 (es) | 2010-06-10 |
| BRPI0913839A2 (pt) | 2015-10-20 |
| CY1115780T1 (el) | 2017-01-25 |
| AU2009265623A1 (en) | 2010-01-07 |
| US20140066402A1 (en) | 2014-03-06 |
| PT2308497E (pt) | 2014-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140612 |
|
| MKLA | Lapsed |
Effective date: 20220301 |
|
| MKLA | Lapsed |
Effective date: 20200831 |