CA2756873C - Imidazo [2,1-b] [1,3,4] thiadiazole derivatives - Google Patents

Imidazo [2,1-b] [1,3,4] thiadiazole derivatives Download PDF

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Publication number
CA2756873C
CA2756873C CA2756873A CA2756873A CA2756873C CA 2756873 C CA2756873 C CA 2756873C CA 2756873 A CA2756873 A CA 2756873A CA 2756873 A CA2756873 A CA 2756873A CA 2756873 C CA2756873 C CA 2756873C
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Prior art keywords
imidazo
pyridin
optionally substituted
thiadiazol
phenyl
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CA2756873A
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English (en)
French (fr)
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CA2756873A1 (en
Inventor
Joaquin Pastor Fernandez
Guido Kurz
Sonia Martinez Gonzalez
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Centro Nacional de Investigaciones Oncologicas CNIO
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Centro Nacional de Investigaciones Oncologicas CNIO
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
CA2756873A 2009-04-02 2010-04-01 Imidazo [2,1-b] [1,3,4] thiadiazole derivatives Active CA2756873C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09380069.6 2009-04-02
EP09380069 2009-04-02
PCT/GB2010/000674 WO2010112874A1 (en) 2009-04-02 2010-04-01 Imidazo [2, 1-b] [ 1, 3, 4 ] thiadiazole derivatives

Publications (2)

Publication Number Publication Date
CA2756873A1 CA2756873A1 (en) 2010-10-07
CA2756873C true CA2756873C (en) 2018-01-09

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CA2756873A Active CA2756873C (en) 2009-04-02 2010-04-01 Imidazo [2,1-b] [1,3,4] thiadiazole derivatives

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US (1) US8815918B2 (OSRAM)
EP (1) EP2414369B1 (OSRAM)
JP (1) JP5615902B2 (OSRAM)
KR (1) KR101727264B1 (OSRAM)
CN (1) CN102388055B (OSRAM)
AU (1) AU2010231162B2 (OSRAM)
BR (1) BRPI1015367B8 (OSRAM)
CA (1) CA2756873C (OSRAM)
CY (1) CY1116880T1 (OSRAM)
DK (1) DK2414369T3 (OSRAM)
EA (1) EA022753B1 (OSRAM)
ES (1) ES2548571T3 (OSRAM)
HR (1) HRP20151126T1 (OSRAM)
HU (1) HUE027964T2 (OSRAM)
IL (1) IL215158A (OSRAM)
MX (1) MX2011010372A (OSRAM)
NZ (1) NZ595674A (OSRAM)
PL (1) PL2414369T3 (OSRAM)
PT (1) PT2414369E (OSRAM)
SG (1) SG175001A1 (OSRAM)
SI (1) SI2414369T1 (OSRAM)
WO (1) WO2010112874A1 (OSRAM)
ZA (1) ZA201107350B (OSRAM)

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DK2414369T3 (en) 2015-09-21
EA201101435A1 (ru) 2012-04-30
ZA201107350B (en) 2015-06-24
JP2012522759A (ja) 2012-09-27
AU2010231162B2 (en) 2014-12-11
US8815918B2 (en) 2014-08-26
IL215158A0 (en) 2011-12-29
CN102388055B (zh) 2015-07-29
EP2414369B1 (en) 2015-08-12
WO2010112874A1 (en) 2010-10-07
HRP20151126T1 (hr) 2015-11-20
IL215158A (en) 2015-07-30
PT2414369E (pt) 2015-10-22
EP2414369A1 (en) 2012-02-08
BRPI1015367B8 (pt) 2021-05-25
BRPI1015367A2 (pt) 2018-02-20
KR20120034607A (ko) 2012-04-12
CY1116880T1 (el) 2017-04-05
BRPI1015367B1 (pt) 2021-05-11
CA2756873A1 (en) 2010-10-07
MX2011010372A (es) 2012-01-12
HUE027964T2 (en) 2016-11-28
ES2548571T3 (es) 2015-10-19
SG175001A1 (en) 2011-11-28
EA022753B1 (ru) 2016-02-29
AU2010231162A1 (en) 2011-11-03
US20120094996A1 (en) 2012-04-19
HK1166979A1 (zh) 2012-11-16
NZ595674A (en) 2012-12-21
PL2414369T3 (pl) 2016-04-29
SI2414369T1 (sl) 2015-12-31
KR101727264B1 (ko) 2017-04-14
CN102388055A (zh) 2012-03-21
JP5615902B2 (ja) 2014-10-29

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