CA2748392C - Use of interleukin-22 for the prevention and/or treatment of multiple organ dysfunction syndrome (mods) - Google Patents
Use of interleukin-22 for the prevention and/or treatment of multiple organ dysfunction syndrome (mods) Download PDFInfo
- Publication number
- CA2748392C CA2748392C CA2748392A CA2748392A CA2748392C CA 2748392 C CA2748392 C CA 2748392C CA 2748392 A CA2748392 A CA 2748392A CA 2748392 A CA2748392 A CA 2748392A CA 2748392 C CA2748392 C CA 2748392C
- Authority
- CA
- Canada
- Prior art keywords
- multiple organ
- treatment
- organ dysfunction
- mods
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010074109 interleukin-22 Proteins 0.000 title claims abstract description 48
- 102100030703 Interleukin-22 Human genes 0.000 title claims abstract description 40
- 208000010718 Multiple Organ Failure Diseases 0.000 title claims abstract description 37
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 title claims abstract description 37
- 230000002265 prevention Effects 0.000 title claims abstract description 7
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- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 1
- 101150092328 22 gene Proteins 0.000 description 1
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- 206010058558 Hypoperfusion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 241000607662 Salmonella enterica subsp. enterica serovar Abortusequi Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
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- 210000004027 cell Anatomy 0.000 description 1
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- 238000004440 column chromatography Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012215 gene cloning Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000004768 organ dysfunction Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14413409P | 2009-01-12 | 2009-01-12 | |
| US61/144,134 | 2009-01-12 | ||
| PCT/US2010/020673 WO2010081112A1 (en) | 2009-01-12 | 2010-01-11 | Prevention and/or treatment of multiple organ dysfunction syndrome with interleukin-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2748392A1 CA2748392A1 (en) | 2010-07-15 |
| CA2748392C true CA2748392C (en) | 2017-06-27 |
Family
ID=42316862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2748392A Active CA2748392C (en) | 2009-01-12 | 2010-01-11 | Use of interleukin-22 for the prevention and/or treatment of multiple organ dysfunction syndrome (mods) |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8956605B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2385841B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5981141B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102348463B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010203446B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2748392C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010081112A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361968B (zh) | 2007-08-06 | 2011-08-03 | 健能隆医药技术（上海）有限公司 | 白介素-22在治疗脂肪肝中的应用 |
| LT2970422T (lt) | 2013-03-15 | 2018-06-25 | F. Hoffmann-La Roche Ag | Il-22 polipeptidai ir il-22 su fc sulieti baltymai bei panaudojimo būdai |
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术（上海）有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| WO2017181143A1 (en) | 2016-04-15 | 2017-10-19 | Generon (Shanghai) Corporation, Ltd. | Use of il-22 in treating necrotizing enterocolitis |
| CN112007146A (zh) * | 2020-09-03 | 2020-12-01 | 上海市儿童医院 | Il-22在治疗和/或预防脓毒症诱发的肝脏损伤的药物中的用途 |
| WO2022191828A1 (en) * | 2021-03-10 | 2022-09-15 | Wen Tan | NEW USE OF (R)-β2-AGONISTS IN TREATMENT OF SEPSIS AND ACUTE RESPIRATORY DISTRESS SYNDROME |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010023070A1 (en) * | 1998-05-29 | 2001-09-20 | Reinhard Ebner | Interleukins-21 and 22 |
| EP1082433A4 (en) * | 1998-05-29 | 2003-01-02 | Human Genome Sciences Inc | Interleukins 21 and 22 |
| US7226591B2 (en) * | 2000-05-22 | 2007-06-05 | Genentech, Inc. | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
| US20050148029A1 (en) * | 2003-09-29 | 2005-07-07 | Biosite, Inc. | Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes |
| CN100515491C (zh) * | 2005-01-04 | 2009-07-22 | 健能隆医药技术（上海）有限公司 | 白介素-22的医药用途 |
| CN101219208B (zh) * | 2005-01-04 | 2010-08-11 | 健能隆医药技术（上海）有限公司 | 白介素-22的医药用途 |
| JP2009541338A (ja) * | 2006-06-19 | 2009-11-26 | ワイス | Ｉｌ−２２およびｉｌ−１７の調節方法 |
| WO2008085229A2 (en) * | 2006-11-15 | 2008-07-17 | Arteriocyte Inc. | Cell-based therapies for treating liver disease |
| CN101168049A (zh) * | 2007-10-23 | 2008-04-30 | 中国人民解放军军事医学科学院基础医学研究所 | 白介素-22在制备治疗肝病药物中的应用及其制备方法 |
-
2010
- 2010-01-11 CN CN201080010768.7A patent/CN102348463B/zh active Active
- 2010-01-11 US US13/142,423 patent/US8956605B2/en active Active
- 2010-01-11 JP JP2011545498A patent/JP5981141B2/ja active Active
- 2010-01-11 AU AU2010203446A patent/AU2010203446B2/en not_active Ceased
- 2010-01-11 WO PCT/US2010/020673 patent/WO2010081112A1/en not_active Ceased
- 2010-01-11 EP EP10729641.0A patent/EP2385841B1/en active Active
- 2010-01-11 CA CA2748392A patent/CA2748392C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8956605B2 (en) | 2015-02-17 |
| EP2385841A4 (en) | 2012-12-19 |
| JP5981141B2 (ja) | 2016-08-31 |
| CA2748392A1 (en) | 2010-07-15 |
| CN102348463A (zh) | 2012-02-08 |
| JP2012515165A (ja) | 2012-07-05 |
| EP2385841B1 (en) | 2016-11-16 |
| AU2010203446B2 (en) | 2015-12-17 |
| EP2385841A1 (en) | 2011-11-16 |
| CN102348463B (zh) | 2014-05-07 |
| US20110268696A1 (en) | 2011-11-03 |
| AU2010203446A1 (en) | 2011-07-14 |
| WO2010081112A1 (en) | 2010-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20141002 |