JP2006505290A5 - - Google Patents

Info

Publication number

JP2006505290A5

JP2006505290A5 JP2005506685A JP2005506685A JP2006505290A5 JP 2006505290 A5 JP2006505290 A5 JP 2006505290A5 JP 2005506685 A JP2005506685 A JP 2005506685A JP 2005506685 A JP2005506685 A JP 2005506685A JP 2006505290 A5 JP2006505290 A5 JP 2006505290A5

Authority

JP

Japan

Prior art keywords

peroxiredoxin

fragment

pharmaceutical composition

vihum

prx

Prior art date

2003-11-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims 16
• 102000007456 Peroxiredoxin Human genes 0.000 claims 15
• 108030002458 peroxiredoxin Proteins 0.000 claims 15
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 238000000034 method Methods 0.000 claims 10
• 102000039446 nucleic acids Human genes 0.000 claims 9
• 108020004707 nucleic acids Proteins 0.000 claims 9
• 150000007523 nucleic acids Chemical class 0.000 claims 9
• 239000013612 plasmid Substances 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 6
• IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 239000004480 active ingredient Substances 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 239000000654 additive Substances 0.000 claims 2
• 230000000996 additive effect Effects 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 230000003078 antioxidant effect Effects 0.000 claims 2
• 210000001723 extracellular space Anatomy 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 210000000056 organ Anatomy 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 230000001105 regulatory effect Effects 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 230000000843 anti-fungal effect Effects 0.000 claims 1
• 230000001387 anti-histamine Effects 0.000 claims 1
• 230000000840 anti-viral effect Effects 0.000 claims 1
• 229940121375 antifungal agent Drugs 0.000 claims 1
• 239000000739 antihistaminic agent Substances 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000009792 diffusion process Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 125000000864 peroxy group Chemical group O(O*)* 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1
• 210000001215 vagina Anatomy 0.000 claims 1
• 239000011782 vitamin Substances 0.000 claims 1
• 229940088594 vitamin Drugs 0.000 claims 1
• 229930003231 vitamin Natural products 0.000 claims 1
• 235000013343 vitamin Nutrition 0.000 claims 1