CA2743553C - Dimeric 1-arylpyrazole derivatives - Google Patents

Dimeric 1-arylpyrazole derivatives Download PDF

Info

Publication number
CA2743553C
CA2743553C CA2743553A CA2743553A CA2743553C CA 2743553 C CA2743553 C CA 2743553C CA 2743553 A CA2743553 A CA 2743553A CA 2743553 A CA2743553 A CA 2743553A CA 2743553 C CA2743553 C CA 2743553C
Authority
CA
Canada
Prior art keywords
group
alkyl
spp
independently selected
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2743553A
Other languages
English (en)
French (fr)
Other versions
CA2743553A1 (en
Inventor
Charles Q. Meng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Priority to CA2952443A priority Critical patent/CA2952443C/en
Publication of CA2743553A1 publication Critical patent/CA2743553A1/en
Application granted granted Critical
Publication of CA2743553C publication Critical patent/CA2743553C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2743553A 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives Active CA2743553C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2952443A CA2952443C (en) 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11602108P 2008-11-19 2008-11-19
US61/116,021 2008-11-19
PCT/US2009/064981 WO2010059719A2 (en) 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2952443A Division CA2952443C (en) 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives

Publications (2)

Publication Number Publication Date
CA2743553A1 CA2743553A1 (en) 2010-05-27
CA2743553C true CA2743553C (en) 2017-03-14

Family

ID=42034586

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2743553A Active CA2743553C (en) 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives
CA2952443A Active CA2952443C (en) 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2952443A Active CA2952443C (en) 2008-11-19 2009-11-18 Dimeric 1-arylpyrazole derivatives

Country Status (12)

Country Link
US (1) US8642636B2 (enExample)
EP (1) EP2364300B1 (enExample)
JP (1) JP2012509338A (enExample)
CN (1) CN102264706A (enExample)
AU (1) AU2009316710B2 (enExample)
BR (1) BRPI0922042B1 (enExample)
CA (2) CA2743553C (enExample)
EA (1) EA020923B1 (enExample)
ES (1) ES2605811T3 (enExample)
MX (1) MX2011005214A (enExample)
NZ (1) NZ592985A (enExample)
WO (1) WO2010059719A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102001364B1 (ko) 2011-05-13 2019-07-22 어레이 바이오파마 인크. Trka 키나제 저해제로서의 피롤리디닐 유레아 및 피롤리디닐 티오유레아 화합물
WO2014078378A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078328A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078331A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9809578B2 (en) 2012-11-13 2017-11-07 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
RU2664541C2 (ru) 2012-11-13 2018-08-20 Эррэй Биофарма Инк. Бициклические соединения мочевины, тиомочевины, гуанидина и цианогуанидина, пригодные для лечения боли
WO2014078325A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
UA116455C2 (uk) 2012-11-13 2018-03-26 Еррей Біофарма Інк. Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka
US9981959B2 (en) 2012-11-13 2018-05-29 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
JP2016164125A (ja) * 2013-07-02 2016-09-08 国立大学法人帯広畜産大学 バベシア症の治療剤及び予防剤
MY191956A (en) 2014-05-15 2022-07-20 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
WO2017195173A1 (en) 2016-05-12 2017-11-16 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
KR102480799B1 (ko) 2017-03-28 2022-12-22 베르데시안 라이프 사이언시스 유.에스., 엘엘씨 효소-유도된 우레아 분해를 조절하기 위한 트리아릴메탄 화합물
PL3876722T3 (pl) 2018-11-06 2026-02-23 Corteva Agriscience Llc Zabezpieczone kompozycje zawierające herbicydy pirydynokarboksylanowe i klokwintocet
DK3876726T3 (da) * 2018-11-06 2025-03-03 Corteva Agriscience Llc Sammensætninger, som omfatter pyridincarboxylat-herbicider og azolcarboxylat-safeners
EP3876730B1 (en) 2018-11-07 2025-07-02 Corteva Agriscience LLC Compositions comprising pyridine carboxylate herbicides and 4-hydroxyphenyl-pyruvate dioxygenase (hppd) inhibitor herbicides
EA202191264A1 (ru) 2018-11-07 2021-07-27 КОРТЕВА АГРИСАЙЕНС ЭлЭлСи Композиции, содержащие гербициды на основе пиридинкарбоксилата с гербицидами, представляющими собой ингибиторы фотосистемы ii и необязательно hppd
HUE072472T2 (hu) 2018-11-07 2025-11-28 Corteva Agriscience Llc Piridin-karboxilát herbicideket acetolaktát-szintáz (ALS) gátló herbicidekkel tartalmazó készítmények
EA202191265A1 (ru) 2018-11-07 2021-07-27 КОРТЕВА АГРИСАЙЕНС ЭлЭлСи Композиции, содержащие гербицид на основе пиридинкарбоксилата и гербициды, представляющие собой ингибиторы протопорфириногеноксидазы (protox)
KR102860839B1 (ko) 2018-11-07 2025-09-17 코르테바 애그리사이언스 엘엘씨 피리딘 카르복실레이트 제초제를 합성 옥신 제초제 또는 옥신 수송 억제제와 함께 포함하는 조성물
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
JP7724845B2 (ja) 2020-07-24 2025-08-18 エランコ・ユーエス・インコーポレイテッド イソオキサゾリン化合物及びその中間体を作製するための方法
KR20230061465A (ko) 2020-09-04 2023-05-08 엘랑코 유에스 인코포레이티드 기호성 제형

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966900A (en) * 1969-03-12 1976-06-29 Airwick Industries, Inc. Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator
MY129771A (en) * 1999-12-02 2007-04-30 Merial Ltd Control of arthropods in animals
US7262214B2 (en) * 2003-02-26 2007-08-28 Merial Limited 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases
ES2444015T3 (es) 2004-06-26 2014-02-21 Merial Limited Derivados de N-fenilpirazol como plaguicidas

Also Published As

Publication number Publication date
CA2952443A1 (en) 2010-05-27
HK1160852A1 (en) 2012-08-17
EA201100800A1 (ru) 2011-12-30
AU2009316710A1 (en) 2010-05-27
JP2012509338A (ja) 2012-04-19
EP2364300B1 (en) 2016-10-19
MX2011005214A (es) 2011-06-01
ES2605811T3 (es) 2017-03-16
AU2009316710B2 (en) 2015-08-06
BRPI0922042B1 (pt) 2020-01-28
CA2952443C (en) 2019-04-02
US20110245157A1 (en) 2011-10-06
US8642636B2 (en) 2014-02-04
EP2364300A2 (en) 2011-09-14
CA2743553A1 (en) 2010-05-27
WO2010059719A3 (en) 2010-11-18
NZ592985A (en) 2013-04-26
WO2010059719A2 (en) 2010-05-27
CN102264706A (zh) 2011-11-30
EA020923B1 (ru) 2015-02-27
BRPI0922042A2 (pt) 2016-11-01

Similar Documents

Publication Publication Date Title
US8642636B2 (en) Dimeric 1-arylpyrazole derivatives for use against ectoparasites, agricultural pests, and household pests
AU2014342241B2 (en) Antiparasitic and pesticidal isoxazoline compounds
KR102785432B1 (ko) 구충성 헤테로시클릭 화합물
TWI457347B (zh) 二聚合的阿佛菌素（ａｖｅｒｍｅｃｔｉｎ）及密倍脈心（ｍｉｌｂｅｍｙｃｉｎ）衍生物
US10653144B2 (en) Pesticidal and parasiticidal vinyl isoxazoline compounds
EP3668866B1 (en) Pesticidal and parasiticidal pyrazole-isoxazoline compounds
HK1160852B (en) Dimeric 1-arylpyrazole derivatives
HK1157790B (en) Dimeric avermectin and milbemycin derivatives

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20141017

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 16TH ANNIV.) - STANDARD

Year of fee payment: 16

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251110

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251110