CA2743057C - Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling - Google Patents
Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling Download PDFInfo
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- CA2743057C CA2743057C CA2743057A CA2743057A CA2743057C CA 2743057 C CA2743057 C CA 2743057C CA 2743057 A CA2743057 A CA 2743057A CA 2743057 A CA2743057 A CA 2743057A CA 2743057 C CA2743057 C CA 2743057C
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US11257908P | 2008-11-07 | 2008-11-07 | |
| US61/112,579 | 2008-11-07 | ||
| PCT/US2009/063748 WO2010054328A2 (en) | 2008-11-07 | 2009-11-09 | Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling |
Publications (2)
| Publication Number | Publication Date |
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| CA2743057A1 CA2743057A1 (en) | 2010-05-14 |
| CA2743057C true CA2743057C (en) | 2019-11-26 |
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| CA2743057A Expired - Fee Related CA2743057C (en) | 2008-11-07 | 2009-11-09 | Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling |
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| AU (1) | AU2009313255B2 (enExample) |
| CA (1) | CA2743057C (enExample) |
| WO (1) | WO2010054328A2 (enExample) |
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| CN102692505A (zh) * | 2011-03-21 | 2012-09-26 | 中国医学科学院肿瘤研究所 | 一种改进的免疫共沉淀技术方法 |
| EP2970443A4 (en) | 2013-03-14 | 2017-01-11 | Parkash S. Gill | Cancer treatment using antibodies that bind cell surface grp78 |
| US10117908B2 (en) | 2013-10-17 | 2018-11-06 | Grant Labs, Inc. | Suppression of cellular transformation and dysplasia by topical application of lefty |
| EP4614154A3 (en) | 2017-10-13 | 2025-11-26 | Nibec Co., Ltd. | Grp78-derived peptide for identifying high-efficiency stem cells |
| US20210009946A1 (en) * | 2017-10-13 | 2021-01-14 | Nibec Co., Ltd. | Method for selecting highly efficient stem cell, using protein marker grp78 |
| US12060410B2 (en) * | 2020-04-20 | 2024-08-13 | Creative Bio Therapeutics LLC | Antivirus proteins having a Kringle 5 subunit |
| CN116041477B (zh) * | 2022-10-13 | 2023-08-08 | 呈诺再生医学科技(北京)有限公司 | Tdgf1基因在制备治疗衰老相关疾病或逆转细胞衰老的药物中的应用 |
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| AU2009313255A1 (en) | 2010-05-14 |
| CA2743057A1 (en) | 2010-05-14 |
| CN102272157A (zh) | 2011-12-07 |
| CN102272157B (zh) | 2015-11-25 |
| JP2015133984A (ja) | 2015-07-27 |
| WO2010054328A3 (en) | 2010-09-10 |
| WO2010054328A2 (en) | 2010-05-14 |
| EP2350131A4 (en) | 2013-01-16 |
| EP2350131A2 (en) | 2011-08-03 |
| EP2350131B1 (en) | 2017-06-07 |
| JP5805538B2 (ja) | 2015-11-04 |
| JP2012508025A (ja) | 2012-04-05 |
| US20100135904A1 (en) | 2010-06-03 |
| AU2009313255B2 (en) | 2014-08-07 |
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