CA2741186C - Thioamide compounds, method of making and method of using thereof - Google Patents
Thioamide compounds, method of making and method of using thereof Download PDFInfo
- Publication number
- CA2741186C CA2741186C CA2741186A CA2741186A CA2741186C CA 2741186 C CA2741186 C CA 2741186C CA 2741186 A CA2741186 A CA 2741186A CA 2741186 A CA2741186 A CA 2741186A CA 2741186 C CA2741186 C CA 2741186C
- Authority
- CA
- Canada
- Prior art keywords
- halo
- alkyl
- alkoxy
- alkylthio
- alkylcarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10711408P | 2008-10-21 | 2008-10-21 | |
| US61/107,114 | 2008-10-21 | ||
| PCT/US2009/061337 WO2010048191A1 (en) | 2008-10-21 | 2009-10-20 | Thioamide compounds, method of making and method of using thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2741186A1 CA2741186A1 (en) | 2010-04-29 |
| CA2741186C true CA2741186C (en) | 2016-07-19 |
Family
ID=41404569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2741186A Active CA2741186C (en) | 2008-10-21 | 2009-10-20 | Thioamide compounds, method of making and method of using thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7964621B2 (https=) |
| EP (1) | EP2358687B9 (https=) |
| JP (1) | JP5614853B2 (https=) |
| KR (2) | KR101782308B1 (https=) |
| CN (1) | CN102239151B (https=) |
| AU (1) | AU2009307736B2 (https=) |
| BR (1) | BRPI0920145B8 (https=) |
| CA (1) | CA2741186C (https=) |
| CL (1) | CL2011000917A1 (https=) |
| EA (1) | EA026649B1 (https=) |
| ES (1) | ES2393965T3 (https=) |
| MX (1) | MX2011004217A (https=) |
| NZ (1) | NZ592382A (https=) |
| WO (1) | WO2010048191A1 (https=) |
| ZA (1) | ZA201103033B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH669977A5 (https=) | 1986-02-27 | 1989-04-28 | Bbc Brown Boveri & Cie | |
| EP2604506A4 (en) * | 2010-08-10 | 2014-01-08 | Kawasaki Heavy Ind Ltd | MOTOR SYSTEM AND SHIP THEREOF |
| RS58417B1 (sr) | 2011-09-12 | 2019-04-30 | Merial Inc | Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima |
| EP3216448B8 (en) | 2012-02-06 | 2019-06-05 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| NZ723198A (en) | 2012-11-20 | 2018-11-30 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic compounds and compositions and methods of using thereof |
| CN103073487B (zh) * | 2013-01-15 | 2014-11-19 | 西华大学 | N-双取代硫代乙酰胺类化合物的合成方法 |
| AR094961A1 (es) | 2013-03-15 | 2015-09-09 | Lilly Co Eli | 1-hidroxi-benzooxaboroles como agentes antiparasitarios |
| WO2015066277A1 (en) | 2013-11-01 | 2015-05-07 | Merial Limited | Antiparisitic and pesticidal isoxazoline compounds |
| CN104610110A (zh) * | 2014-03-12 | 2015-05-13 | 广东东阳光药业有限公司 | 一种制备4-取代硫代苯甲酰胺衍生物的方法 |
| EP3131398B1 (en) | 2014-04-17 | 2019-10-23 | Boehringer Ingelheim Animal Health USA Inc. | Use of malononitrile compounds for protecting animals from parasites |
| ES2842592T3 (es) | 2014-05-19 | 2021-07-14 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelmínticos |
| US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| LT3298027T (lt) | 2015-05-20 | 2021-08-10 | Boehringer Ingelheim Animal Health USA Inc. | Antihelmintiniai depsipeptido junginiai |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| CN113260419A (zh) | 2018-11-20 | 2021-08-13 | 勃林格殷格翰动物保健美国公司 | 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法 |
| KR102281492B1 (ko) * | 2018-12-24 | 2021-07-26 | 동인당제약 주식회사 | 세벨라머 함유 경구투여용 현탁제 조성물 및 그 제조방법 |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| CN111781291A (zh) * | 2020-06-23 | 2020-10-16 | 广西壮族自治区水产科学研究院 | 一种水中13种大环内酯类抗生素的高分辨质谱检测方法 |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
| JP2025507585A (ja) | 2022-02-17 | 2025-03-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
| CN117837424A (zh) * | 2024-02-04 | 2024-04-09 | 黄淮学院 | 一种控制农作物灰飞虱的方法 |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6289076B1 (en) | 1997-05-06 | 2001-09-11 | Sumitomo Heavy Industries, Ltd. | Transmission system for synchrotron radiation light |
| US6239077B1 (en) | 1998-05-01 | 2001-05-29 | Nihon Nohyaku Co., Ltd. | Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof |
| TWI292712B (en) * | 2000-12-20 | 2008-01-21 | Novartis Ag | Aminoacetonitrile compounds for use in the control of endoparasites |
| WO2002050052A1 (en) | 2000-12-20 | 2002-06-27 | Syngenta Participations Ag | N-acyl aminoacetonitriles having pesticidal properties |
| AR035531A1 (es) | 2001-01-22 | 2004-06-02 | Novartis Ag | Composicion para el control de plagas endoparasiticas en ganados y animales domesticos, un metodo para su control y el uso de dicha composicion para la preparacion de medicamentos |
| CA2447084A1 (en) | 2001-05-15 | 2002-11-21 | Novartis Ag | Benzamidoacetonitriles and their use as antiparasitics |
| AR036054A1 (es) | 2001-06-15 | 2004-08-04 | Novartis Ag | Uso de compuestos de aminoacetonitrilo para el control de plagas, una composicion y un proceso para dicho control y una composicion farmaceutica contra parasitos |
| KR20050033043A (ko) | 2001-10-04 | 2005-04-08 | 노파르티스 아게 | 유기 화합물 |
| KR100650458B1 (ko) | 2001-10-04 | 2006-11-29 | 노파르티스 아게 | 항기생충제로서의 카르보닐옥시-시아노메틸 화합물 |
| TW200300140A (en) | 2001-11-14 | 2003-05-16 | Novartis Ag | Organic compounds |
| AR037746A1 (es) | 2001-12-06 | 2004-12-01 | Novartis Ag | Compuestos derivados de amidoacetonitrilo, un procedimiento para su preparacion, un procedimiento para la preparacion de compuestos intermediarios, una composicion para combatir parasitos, un procedimiento para combatir dichos parasitos, y el empleo de dichos derivados para la preparacion de una com |
| AR038156A1 (es) | 2002-01-21 | 2004-12-29 | Novartis Ag | Compuestos de amidoacetonitrilo, proceso para su preparacion, composicion para controlar los parasitos, y uso de estos compuestos para preparar una composicion farmaceutica |
| TW200305556A (en) | 2002-03-21 | 2003-11-01 | Novartis Ag | Organic compounds |
| TW200400004A (en) | 2002-05-22 | 2004-01-01 | Novartis Ag | Organic compounds |
| TW200400931A (en) | 2002-05-22 | 2004-01-16 | Novartis Ag | Organic compounds |
| AR039961A1 (es) | 2002-06-06 | 2005-03-09 | Novartis Ag | Derivados de amidoacetonitrilo y su uso como pesticida |
| TW200406386A (en) | 2002-06-07 | 2004-05-01 | Novartis Ag | Organic compounds |
| GB0214117D0 (en) | 2002-06-19 | 2002-07-31 | Syngenta Participations Ag | N-sulphonylaminoacetonitriles having pesticidal properties |
| TW200400932A (en) | 2002-06-19 | 2004-01-16 | Novartis Ag | Organic compounds |
| AR042420A1 (es) * | 2002-09-11 | 2005-06-22 | Novartis Ag | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica |
| GB0402677D0 (en) | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
| AR046757A1 (es) | 2003-12-10 | 2005-12-21 | Novartis Ag | Amidoacetonitrilos utiles como pesticidas |
| AR049391A1 (es) | 2004-06-10 | 2006-07-26 | Novartis Ag | Derivados de aminoacetonitrilo y su uso para controlar parasitos en animales de sangre caliente |
| WO2006043654A1 (ja) | 2004-10-22 | 2006-04-27 | Nihon Nohyaku Co., Ltd. | アセトニトリル誘導体及び有害生物防除剤並びにその使用方法 |
| AU2005303993B2 (en) * | 2004-11-09 | 2009-10-29 | Elanco Tiergesundheit Ag | Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates |
| US20080227863A1 (en) | 2005-07-25 | 2008-09-18 | Novartis Ag | Organic Compounds |
| WO2008062005A1 (en) | 2006-11-24 | 2008-05-29 | Novartis Ag | The use of aminoacetonitril compounds in the control of endoparasites in warm- blood animals. |
| WO2008064891A1 (en) | 2006-12-01 | 2008-06-05 | Syngenta Participations Ag | N-cyanoalkylanthranilamides as insecticides |
| US20100027495A1 (en) | 2007-02-05 | 2010-02-04 | Nokia Corporation | Method and Apparatus for Providing Acknowledgment Signaling |
| KR20110098012A (ko) | 2007-02-09 | 2011-08-31 | 화이자 리미티드 | 구충제 |
| RS55271B1 (sr) * | 2007-05-15 | 2017-02-28 | Merial Sas | Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene |
-
2009
- 2009-10-20 MX MX2011004217A patent/MX2011004217A/es active IP Right Grant
- 2009-10-20 JP JP2011533272A patent/JP5614853B2/ja active Active
- 2009-10-20 EP EP09744007.7A patent/EP2358687B9/en active Active
- 2009-10-20 KR KR1020167036242A patent/KR101782308B1/ko active Active
- 2009-10-20 EA EA201100666A patent/EA026649B1/ru not_active IP Right Cessation
- 2009-10-20 ES ES09744007T patent/ES2393965T3/es active Active
- 2009-10-20 WO PCT/US2009/061337 patent/WO2010048191A1/en not_active Ceased
- 2009-10-20 CA CA2741186A patent/CA2741186C/en active Active
- 2009-10-20 NZ NZ592382A patent/NZ592382A/xx unknown
- 2009-10-20 BR BRPI0920145A patent/BRPI0920145B8/pt active IP Right Grant
- 2009-10-20 AU AU2009307736A patent/AU2009307736B2/en active Active
- 2009-10-20 US US12/582,486 patent/US7964621B2/en active Active
- 2009-10-20 CN CN200980148694.0A patent/CN102239151B/zh active Active
- 2009-10-20 KR KR1020117011425A patent/KR101782311B1/ko active Active
-
2011
- 2011-04-13 US US13/086,161 patent/US8314146B2/en active Active
- 2011-04-21 ZA ZA2011/03033A patent/ZA201103033B/en unknown
- 2011-04-21 CL CL2011000917A patent/CL2011000917A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009307736A1 (en) | 2010-04-29 |
| KR20110071140A (ko) | 2011-06-28 |
| US8314146B2 (en) | 2012-11-20 |
| CN102239151B (zh) | 2014-07-02 |
| KR101782308B1 (ko) | 2017-09-27 |
| NZ592382A (en) | 2013-03-28 |
| US7964621B2 (en) | 2011-06-21 |
| CL2011000917A1 (es) | 2011-09-16 |
| CA2741186A1 (en) | 2010-04-29 |
| US20110190231A1 (en) | 2011-08-04 |
| BRPI0920145B8 (pt) | 2021-05-25 |
| EP2358687B1 (en) | 2012-09-19 |
| CN102239151A (zh) | 2011-11-09 |
| EA026649B1 (ru) | 2017-05-31 |
| ES2393965T3 (es) | 2013-01-03 |
| ES2393965T9 (es) | 2013-07-19 |
| EP2358687B9 (en) | 2013-04-17 |
| BRPI0920145A2 (pt) | 2017-06-06 |
| BRPI0920145B1 (pt) | 2021-03-30 |
| AU2009307736B2 (en) | 2015-02-05 |
| JP5614853B2 (ja) | 2014-10-29 |
| EA201100666A1 (ru) | 2011-12-30 |
| JP2012506441A (ja) | 2012-03-15 |
| KR20170003704A (ko) | 2017-01-09 |
| WO2010048191A1 (en) | 2010-04-29 |
| US20100130565A1 (en) | 2010-05-27 |
| MX2011004217A (es) | 2011-06-20 |
| ZA201103033B (en) | 2012-02-29 |
| EP2358687A1 (en) | 2011-08-24 |
| KR101782311B1 (ko) | 2017-09-27 |
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Legal Events
| Date | Code | Title | Description |
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