CA2740559C - Improved process - Google Patents

Improved process Download PDF

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Publication number
CA2740559C
CA2740559C CA2740559A CA2740559A CA2740559C CA 2740559 C CA2740559 C CA 2740559C CA 2740559 A CA2740559 A CA 2740559A CA 2740559 A CA2740559 A CA 2740559A CA 2740559 C CA2740559 C CA 2740559C
Authority
CA
Canada
Prior art keywords
process according
coupling agent
mixture
carried out
dcc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2740559A
Other languages
English (en)
French (fr)
Other versions
CA2740559A1 (en
Inventor
Vinayak G. Gore
Madhukar S. Patil
Rahul A. Bhalerao
Hemant M. Mande
Sandeep G. Mekde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Generics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Publication of CA2740559A1 publication Critical patent/CA2740559A1/en
Application granted granted Critical
Publication of CA2740559C publication Critical patent/CA2740559C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2740559A 2008-10-15 2009-10-14 Improved process Expired - Fee Related CA2740559C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1746KO2008 2008-10-15
IN1746/KOL/2008 2008-10-15
PCT/GB2009/051376 WO2010043904A2 (en) 2008-10-15 2009-10-14 Improved process

Publications (2)

Publication Number Publication Date
CA2740559A1 CA2740559A1 (en) 2010-04-22
CA2740559C true CA2740559C (en) 2016-02-16

Family

ID=41822438

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2740559A Expired - Fee Related CA2740559C (en) 2008-10-15 2009-10-14 Improved process

Country Status (8)

Country Link
US (2) US8883851B2 (https=)
EP (1) EP2349985A2 (https=)
JP (1) JP5769627B2 (https=)
CN (1) CN102264694B (https=)
AU (1) AU2009305214B2 (https=)
CA (1) CA2740559C (https=)
NZ (1) NZ592686A (https=)
WO (1) WO2010043904A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1391812B1 (it) * 2008-07-29 2012-01-27 Maria Grazia Rimoli Profarmaco galattosilato del ketorolac ad uso analgesico e antinfiammatorio con migliori caratteristiche farmacocinetiche e profilo tossicologico del farmaco di partenza
JP2012509929A (ja) * 2008-11-26 2012-04-26 ジェネリクス・（ユーケー）・リミテッド 多型
WO2011061545A1 (en) 2009-11-23 2011-05-26 Generics [Uk] Limited Hplc method for analyzing vorinostat
US20110313044A1 (en) * 2010-06-18 2011-12-22 Urquima S.A. Polymorphs of Suberoylanilide Hydroxamic Acid
CN103018346A (zh) * 2011-09-20 2013-04-03 北京本草天源药物研究院 伏立诺他及其药物组合物中的杂质的高效液相色谱分析方法
CN104693071A (zh) * 2013-12-04 2015-06-10 山东新时代药业有限公司 一种n- 羟基-n’- 苯基辛二酰胺制备方法
CN103922967B (zh) * 2014-04-15 2016-06-01 北京化工大学 一种异羟肟酸类化合物及其在制备抑制癌细胞增殖和/或治疗癌症的药物中的应用
CN104292133B (zh) * 2014-09-29 2016-06-01 烟台市华文欣欣医药科技有限公司 一种抗癌药物伏立诺他的合成方法
CN104649925A (zh) * 2015-02-13 2015-05-27 山东新时代药业有限公司 一种伏立诺他中间体的制备方法
CN105259261A (zh) * 2015-10-09 2016-01-20 扬子江药业集团江苏海慈生物药业有限公司 一种药物中苯胺含量的测定方法
CN106008267B (zh) * 2016-06-27 2018-04-06 马腾 一种抗癌药物伏立诺他的制备方法
CN106187818B (zh) * 2016-06-27 2017-12-08 刘美新 一种制备抗癌药物伏立诺他的方法
US11554123B2 (en) * 2017-03-01 2023-01-17 Saint Joseph's University Compositions and methods for reactivating latent HIV-1 infections
TWI650139B (zh) 2017-10-11 2019-02-11 行政院原子能委員會核能硏究所 含有放射性同位素氟的異羥肟酸類造影劑、其製備方法及其用途
CN109134313B (zh) * 2018-10-16 2021-05-25 新昌县勤勉生物医药科技有限公司 一种利用改性介孔材料催化制备伏立诺他的方法
CN110283102B (zh) * 2019-05-31 2022-09-27 宿州亿帆药业有限公司 一种伏林司他ⅰ晶型的制备方法
CN113943232A (zh) * 2021-11-25 2022-01-18 汤斌 一种从大鲵肽中提取伏立诺他的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
GB9504084D0 (en) * 1995-03-01 1995-04-19 British Biotech Pharm Synthesis of carboxylic and hydroxamic acid derivatives
IT1283637B1 (it) * 1996-05-14 1998-04-23 Italfarmaco Spa Composti ad attivita' antinfiammatoria ed immunosoppressiva
US6497820B1 (en) 1998-02-03 2002-12-24 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
KR20020070285A (ko) 1999-11-23 2002-09-05 메틸진, 인크. 히스톤 디아세틸라제의 억제제
WO2003075839A2 (en) 2002-03-04 2003-09-18 Aton Pharma, Inc. Methods of inducing terminal differentiation
US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
KR100924737B1 (ko) 2003-08-26 2009-11-04 슬로안-케테링인스티튜트퍼캔서리서치 Ｈｄａｃ 억제제를 이용한 암의 치료 방법
CN1870985B (zh) * 2003-08-26 2011-11-30 默克Hdac研究有限责任公司 用hdac抑制剂治疗癌症的方法
EP1541549A1 (en) 2003-12-12 2005-06-15 Exonhit Therapeutics S.A. Tricyclic hydroxamate and benzaminde derivatives, compositions and methods
TWI365068B (en) 2005-05-20 2012-06-01 Merck Sharp & Dohme Formulations of suberoylanilide hydroxamic acid and methods for producing same
EP2229941A1 (en) 2005-05-20 2010-09-22 Merck Sharp & Dohme Corp. Formulations of suberoylanilide hydroxamic acid and methods for producing same
WO2008039421A2 (en) 2006-09-28 2008-04-03 Merck & Co., Inc. Pharmaceutical compositions of hdac inhibitors and chelatable metal compounds, and metal-hdac inhibitor chelate complexes
WO2008042146A1 (en) 2006-09-28 2008-04-10 Merck & Co., Inc. Amine base salts of saha and polymorphs thereof
CA2709262A1 (en) 2007-12-14 2009-06-25 Generics [Uk] Limited New hplc method
US20110039937A1 (en) 2008-02-07 2011-02-17 Abhay Gaitonde Novel process for the preparation of vorinostat
US20090223286A1 (en) 2008-02-13 2009-09-10 Vandana Singh Analytical method for determination of related substances of imipenem and cilastatin
CZ2008167A3 (cs) 2008-03-14 2010-02-24 Zentiva, A. S. Specifické necistoty montelukastu
JP2012509929A (ja) 2008-11-26 2012-04-26 ジェネリクス・（ユーケー）・リミテッド 多型
CA2744458A1 (en) 2008-11-26 2010-06-03 Generics [Uk] Limited Novel processes and pure polymorphs

Also Published As

Publication number Publication date
EP2349985A2 (en) 2011-08-03
JP5769627B2 (ja) 2015-08-26
JP2012505872A (ja) 2012-03-08
US9162974B2 (en) 2015-10-20
US8883851B2 (en) 2014-11-11
CA2740559A1 (en) 2010-04-22
US20150018424A1 (en) 2015-01-15
WO2010043904A3 (en) 2010-09-16
CN102264694B (zh) 2015-11-25
US20110263712A1 (en) 2011-10-27
WO2010043904A2 (en) 2010-04-22
CN102264694A (zh) 2011-11-30
AU2009305214A1 (en) 2010-04-22
NZ592686A (en) 2012-12-21
AU2009305214B2 (en) 2015-06-25

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Effective date: 20201014