CA2732229C - Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand - Google Patents
Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand Download PDFInfo
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- CA2732229C CA2732229C CA2732229A CA2732229A CA2732229C CA 2732229 C CA2732229 C CA 2732229C CA 2732229 A CA2732229 A CA 2732229A CA 2732229 A CA2732229 A CA 2732229A CA 2732229 C CA2732229 C CA 2732229C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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| US8376308P | 2008-07-25 | 2008-07-25 | |
| US61/083,763 | 2008-07-25 | ||
| PCT/US2009/051648 WO2010011895A1 (en) | 2008-07-25 | 2009-07-24 | Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand |
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| CA2732229A Active CA2732229C (en) | 2008-07-25 | 2009-07-24 | Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand |
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| EP1913011B1 (en) * | 2004-08-04 | 2016-11-02 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
| US20060089324A1 (en) * | 2004-10-22 | 2006-04-27 | Sailen Barik | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| US20070197460A1 (en) * | 2005-11-01 | 2007-08-23 | Alnylam Pharmaceuticals, Inc. | Rnai inhibition of influenza virus replication |
| WO2009120878A2 (en) * | 2008-03-26 | 2009-10-01 | Alnylam Pharmaceuticals, Inc. | Non-natural ribonucleotides, and methods of use thereof |
| JP2012147677A (ja) * | 2009-05-14 | 2012-08-09 | Nippon Shinyaku Co Ltd | 二本鎖修飾ｒｎａ |
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2009
- 2009-07-24 EP EP09790796.8A patent/EP2321414B1/en active Active
- 2009-07-24 WO PCT/US2009/051648 patent/WO2010011895A1/en not_active Ceased
- 2009-07-24 CA CA2732229A patent/CA2732229C/en active Active
- 2009-07-24 AU AU2009273878A patent/AU2009273878A1/en not_active Abandoned
- 2009-07-24 JP JP2011520219A patent/JP2011528910A/ja active Pending
- 2009-07-24 US US13/055,894 patent/US20110223665A1/en not_active Abandoned
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2013
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2016
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- 2016-09-28 JP JP2016189465A patent/JP6476155B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2321414B1 (en) | 2018-01-10 |
| WO2010011895A1 (en) | 2010-01-28 |
| JP6476155B2 (ja) | 2019-02-27 |
| JP2017002079A (ja) | 2017-01-05 |
| AU2016202344A1 (en) | 2016-05-05 |
| CA2732229A1 (en) | 2010-01-28 |
| US20130196434A1 (en) | 2013-08-01 |
| AU2016202344B2 (en) | 2017-11-30 |
| EP2321414A1 (en) | 2011-05-18 |
| JP2011528910A (ja) | 2011-12-01 |
| AU2009273878A1 (en) | 2010-01-28 |
| US20110223665A1 (en) | 2011-09-15 |
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