CA2728453A1 - Method and apparatus for retaining and recirculating cells - Google Patents

Method and apparatus for retaining and recirculating cells Download PDF

Info

Publication number
CA2728453A1
CA2728453A1 CA2728453A CA2728453A CA2728453A1 CA 2728453 A1 CA2728453 A1 CA 2728453A1 CA 2728453 A CA2728453 A CA 2728453A CA 2728453 A CA2728453 A CA 2728453A CA 2728453 A1 CA2728453 A1 CA 2728453A1
Authority
CA
Canada
Prior art keywords
channels
cells
hollow cylinder
bioreactor
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2728453A
Other languages
English (en)
French (fr)
Inventor
Joerg Kauling
Bjoern Frahm
Marc Jenne
Helmut Brod
Stephan Kirchner
Arndt Braun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Bayer Technology Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Technology Services GmbH filed Critical Bayer Technology Services GmbH
Publication of CA2728453A1 publication Critical patent/CA2728453A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C12M29/08—Air lift
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/22—Settling tanks; Sedimentation by gravity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2728453A 2008-06-20 2009-06-10 Method and apparatus for retaining and recirculating cells Abandoned CA2728453A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008029307A DE102008029307A1 (de) 2008-06-20 2008-06-20 Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen
DE102008029307.5 2008-06-20
PCT/EP2009/004200 WO2009152990A2 (de) 2008-06-20 2009-06-10 Verfahren und vorrichtung zur rückhaltung und rückführung von zellen

Publications (1)

Publication Number Publication Date
CA2728453A1 true CA2728453A1 (en) 2009-12-23

Family

ID=41334928

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2728453A Abandoned CA2728453A1 (en) 2008-06-20 2009-06-10 Method and apparatus for retaining and recirculating cells

Country Status (10)

Country Link
US (1) US20110097800A1 (https=)
EP (1) EP2304017A2 (https=)
JP (1) JP2011529331A (https=)
KR (1) KR20110027696A (https=)
CN (1) CN102239244B (https=)
AU (1) AU2009259664A1 (https=)
CA (1) CA2728453A1 (https=)
DE (1) DE102008029307A1 (https=)
IL (1) IL209232A0 (https=)
WO (1) WO2009152990A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5820802B2 (ja) * 2009-04-03 2015-11-24 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 組織及び臓器移植片のためのバイオリアクター並びに操作方法
PL2665806T3 (pl) * 2011-01-17 2021-12-27 F.Hoffmann-La Roche Ag Urządzenie rozdzielające
BR112014020120B1 (pt) * 2012-02-20 2020-09-15 Bayer Aktiengesellschaft Separador de sólidos de canais inclinados para reter e recircular sólidos de uma mistura de um reator e unidade biorreatora
JP2015519922A (ja) * 2012-06-21 2015-07-16 ネオステム オンコロジー リミテッド ライビリティ カンパニー バイオリアクタのカートリッジ及びシステム
JP2015077119A (ja) * 2013-10-15 2015-04-23 カンウォン ナショナル ユニバーシティ， ユニバーシティ−インダストリー コーペレーション ファンデーション アクチノバシラススクシノゲネスを用いたコハク酸連続生産工程
US10596492B2 (en) 2014-07-09 2020-03-24 Sudhin Biopharma Particle settling devices
WO2016089874A1 (en) * 2014-12-01 2016-06-09 Sudhin Biopharma Particle settling device with annular ramps
AU2019257236B2 (en) 2018-04-18 2022-09-01 Sudhin Biopharma Particle settling devices
EP4121214A4 (en) 2020-03-19 2024-07-10 Sudhin Biopharma Particle settling devices
WO2021199529A1 (ja) * 2020-03-31 2021-10-07 昭和電工マテリアルズ株式会社 細胞培養装置及び培養方法
DE102020118668A1 (de) * 2020-07-15 2022-01-20 Hochschule Anhalt (FH) , Körperschaft des öffentlichen Rechts Fermentationsverfahren und Bioreaktor zur Durchführung von anaeroben, aeroben und mikro-aerophilen Fermentationen umfassend einen Airlift-Schachtüberfall
TWI751073B (zh) * 2021-04-15 2021-12-21 蘇碩彥 交叉複合式傾斜管之製造方法與生產線
WO2025027938A1 (ja) * 2023-07-31 2025-02-06 エイブル株式会社 培養装置及び細胞分離方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76003A (en) 1984-08-03 1988-12-30 Biotechnolog Forschung Gmbh Process and apparatus for the bubble-free gassing of liquids
US4814278A (en) * 1985-02-05 1989-03-21 Teijin Limited Culture apparatus and method
GB8515636D0 (en) * 1985-06-20 1985-07-24 Celltech Ltd Fermenter
DE3535183A1 (de) 1985-10-02 1987-04-16 Biotechnolog Forschung Gmbh Vorrichtung und verfahren zur blasenfreien begasung von fluessigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen
US5320963A (en) * 1992-11-25 1994-06-14 National Research Council Of Canada Bioreactor for the perfusion culture of cells
GB9309429D0 (en) 1993-05-07 1993-06-23 Bioscot Ltd Fermenter accessory
KR100909316B1 (ko) 2001-08-31 2009-07-24 바이엘 헬스케어 아게 고세포밀도 발효를 수행하기 위한 유닛 및 방법
CN1286966C (zh) * 2003-12-10 2006-11-29 上海伯瑞生物技术发展有限公司 造血细胞连续灌注悬浮培养过程细胞沉降截留装置

Also Published As

Publication number Publication date
WO2009152990A2 (de) 2009-12-23
CN102239244B (zh) 2014-10-29
CN102239244A (zh) 2011-11-09
US20110097800A1 (en) 2011-04-28
DE102008029307A1 (de) 2009-12-24
JP2011529331A (ja) 2011-12-08
WO2009152990A3 (de) 2011-11-24
EP2304017A2 (de) 2011-04-06
KR20110027696A (ko) 2011-03-16
IL209232A0 (en) 2011-01-31
AU2009259664A1 (en) 2009-12-23

Similar Documents

Publication Publication Date Title
US20110097800A1 (en) Method and apparatus for retaining and recirculating cells
CN100443581C (zh) 实现高细胞密度发酵的装置和方法
CN112020385B (zh) 颗粒沉降装置
US5320963A (en) Bioreactor for the perfusion culture of cells
AU2002333739A1 (en) A unit and a process for carrying out high cell density fermentation
JPH0276569A (ja) 細胞培養装置
AU664596B2 (en) Method and apparatus for growing biomass particles
CN101316925A (zh) 细胞培养方法以及进行该方法的设备
CN104126001A (zh) 用于阻留和回流细胞的单向分离器
US11679345B2 (en) Particle settling devices
JP2003529362A (ja) 植物又は動物の組織培養の培養装置
JP2023503590A (ja) 積層固定床バイオリアクターおよびその使用方法
JPS63500008A (ja) 発酵装置
Kompala et al. Optimization of high cell density perfusion bioreactors
AU2006310795B2 (en) Module for membrane gas treatment
JPH09504946A (ja) 連続式沈降装置
TW202327712A (zh) 生物反應器內的粒子沉降裝置
Vallez-Chetreanu Characterization of the mechanism of action of spin-filters for animal cell perfusion cultures
WO2025049667A1 (en) Perfusion bioreactors and systems for large scale cell culture
HK1073668B (en) A unit and a process for carrying out high cell density fermentation
HK40043575B (en) Particle settling devices
JPS62289169A (ja) 細胞培養装置

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140116

FZDE Discontinued

Effective date: 20160610