DE102008029307A1 - Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen - Google Patents
Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen Download PDFInfo
- Publication number
- DE102008029307A1 DE102008029307A1 DE102008029307A DE102008029307A DE102008029307A1 DE 102008029307 A1 DE102008029307 A1 DE 102008029307A1 DE 102008029307 A DE102008029307 A DE 102008029307A DE 102008029307 A DE102008029307 A DE 102008029307A DE 102008029307 A1 DE102008029307 A1 DE 102008029307A1
- Authority
- DE
- Germany
- Prior art keywords
- channels
- cells
- hollow cylinder
- bioreactor
- retention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 210000004027 cell Anatomy 0.000 description 138
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- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
- C12M29/08—Air lift
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/22—Settling tanks; Sedimentation by gravity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008029307A DE102008029307A1 (de) | 2008-06-20 | 2008-06-20 | Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen |
| US12/997,281 US20110097800A1 (en) | 2008-06-20 | 2009-06-10 | Method and apparatus for retaining and recirculating cells |
| CA2728453A CA2728453A1 (en) | 2008-06-20 | 2009-06-10 | Method and apparatus for retaining and recirculating cells |
| EP09765570A EP2304017A2 (de) | 2008-06-20 | 2009-06-10 | Verfahren und vorrichtung zur rückhaltung und rückführung von zellen |
| KR1020107028446A KR20110027696A (ko) | 2008-06-20 | 2009-06-10 | 세포를 보호유지하고 재순환시키는 방법 및 장치 |
| AU2009259664A AU2009259664A1 (en) | 2008-06-20 | 2009-06-10 | Method and apparatus for retaining and recirculating cells |
| PCT/EP2009/004200 WO2009152990A2 (de) | 2008-06-20 | 2009-06-10 | Verfahren und vorrichtung zur rückhaltung und rückführung von zellen |
| CN200980123039.XA CN102239244B (zh) | 2008-06-20 | 2009-06-10 | 用于截留和返回细胞的方法和装置 |
| JP2011513926A JP2011529331A (ja) | 2008-06-20 | 2009-06-10 | 細胞を保持し再循環させるための方法及び装置 |
| IL209232A IL209232A0 (en) | 2008-06-20 | 2010-11-10 | Method and apparatus for retaining and recirculating cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008029307A DE102008029307A1 (de) | 2008-06-20 | 2008-06-20 | Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102008029307A1 true DE102008029307A1 (de) | 2009-12-24 |
Family
ID=41334928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102008029307A Withdrawn DE102008029307A1 (de) | 2008-06-20 | 2008-06-20 | Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110097800A1 (https=) |
| EP (1) | EP2304017A2 (https=) |
| JP (1) | JP2011529331A (https=) |
| KR (1) | KR20110027696A (https=) |
| CN (1) | CN102239244B (https=) |
| AU (1) | AU2009259664A1 (https=) |
| CA (1) | CA2728453A1 (https=) |
| DE (1) | DE102008029307A1 (https=) |
| IL (1) | IL209232A0 (https=) |
| WO (1) | WO2009152990A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022012843A1 (de) * | 2020-07-15 | 2022-01-20 | Hochschule Anhalt | Fermentationsverfahren und bioreaktor zur durchführung von anaeroben, aeroben und mikro-aerophilen fermentationen umfassend einen airlift-schachtüberfall |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5820802B2 (ja) * | 2009-04-03 | 2015-11-24 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 組織及び臓器移植片のためのバイオリアクター並びに操作方法 |
| PL2665806T3 (pl) * | 2011-01-17 | 2021-12-27 | F.Hoffmann-La Roche Ag | Urządzenie rozdzielające |
| BR112014020120B1 (pt) * | 2012-02-20 | 2020-09-15 | Bayer Aktiengesellschaft | Separador de sólidos de canais inclinados para reter e recircular sólidos de uma mistura de um reator e unidade biorreatora |
| JP2015519922A (ja) * | 2012-06-21 | 2015-07-16 | ネオステム オンコロジー リミテッド ライビリティ カンパニー | バイオリアクタのカートリッジ及びシステム |
| JP2015077119A (ja) * | 2013-10-15 | 2015-04-23 | カンウォン ナショナル ユニバーシティ， ユニバーシティ−インダストリー コーペレーション ファンデーション | アクチノバシラススクシノゲネスを用いたコハク酸連続生産工程 |
| US10596492B2 (en) | 2014-07-09 | 2020-03-24 | Sudhin Biopharma | Particle settling devices |
| WO2016089874A1 (en) * | 2014-12-01 | 2016-06-09 | Sudhin Biopharma | Particle settling device with annular ramps |
| AU2019257236B2 (en) | 2018-04-18 | 2022-09-01 | Sudhin Biopharma | Particle settling devices |
| EP4121214A4 (en) | 2020-03-19 | 2024-07-10 | Sudhin Biopharma | Particle settling devices |
| WO2021199529A1 (ja) * | 2020-03-31 | 2021-10-07 | 昭和電工マテリアルズ株式会社 | 細胞培養装置及び培養方法 |
| TWI751073B (zh) * | 2021-04-15 | 2021-12-21 | 蘇碩彥 | 交叉複合式傾斜管之製造方法與生產線 |
| WO2025027938A1 (ja) * | 2023-07-31 | 2025-02-06 | エイブル株式会社 | 培養装置及び細胞分離方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172478A1 (de) | 1984-08-03 | 1986-02-26 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Verfahren und Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere von Kulturmedien zur Vermehrung von Gewebekulturen |
| EP0240560A1 (de) | 1985-10-02 | 1987-10-14 | Biotechnolog Forschung Gmbh | Vorrichtung und verfahren zur blasenfreien begasung von flüssigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen. |
| EP0227774B1 (en) | 1985-06-20 | 1990-09-05 | Celltech Limited | Fermenter |
| US5817505A (en) | 1993-05-07 | 1998-10-06 | Bioscot Limited | Particle settler for use in cell culture |
| WO2003020919A2 (en) | 2001-08-31 | 2003-03-13 | Bayer Healthcare Ag | A unit and a process for carrying out high cell density fermentation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814278A (en) * | 1985-02-05 | 1989-03-21 | Teijin Limited | Culture apparatus and method |
| US5320963A (en) * | 1992-11-25 | 1994-06-14 | National Research Council Of Canada | Bioreactor for the perfusion culture of cells |
| CN1286966C (zh) * | 2003-12-10 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 造血细胞连续灌注悬浮培养过程细胞沉降截留装置 |
-
2008
- 2008-06-20 DE DE102008029307A patent/DE102008029307A1/de not_active Withdrawn
-
2009
- 2009-06-10 CN CN200980123039.XA patent/CN102239244B/zh not_active Expired - Fee Related
- 2009-06-10 JP JP2011513926A patent/JP2011529331A/ja not_active Withdrawn
- 2009-06-10 CA CA2728453A patent/CA2728453A1/en not_active Abandoned
- 2009-06-10 AU AU2009259664A patent/AU2009259664A1/en not_active Abandoned
- 2009-06-10 KR KR1020107028446A patent/KR20110027696A/ko not_active Withdrawn
- 2009-06-10 WO PCT/EP2009/004200 patent/WO2009152990A2/de not_active Ceased
- 2009-06-10 US US12/997,281 patent/US20110097800A1/en not_active Abandoned
- 2009-06-10 EP EP09765570A patent/EP2304017A2/de not_active Withdrawn
-
2010
- 2010-11-10 IL IL209232A patent/IL209232A0/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172478A1 (de) | 1984-08-03 | 1986-02-26 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Verfahren und Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere von Kulturmedien zur Vermehrung von Gewebekulturen |
| EP0227774B1 (en) | 1985-06-20 | 1990-09-05 | Celltech Limited | Fermenter |
| EP0240560A1 (de) | 1985-10-02 | 1987-10-14 | Biotechnolog Forschung Gmbh | Vorrichtung und verfahren zur blasenfreien begasung von flüssigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen. |
| US5817505A (en) | 1993-05-07 | 1998-10-06 | Bioscot Limited | Particle settler for use in cell culture |
| EP0699101B1 (en) | 1993-05-07 | 2004-10-06 | Serologicals Limited | Particle settler for use in mammalian cell culture |
| WO2003020919A2 (en) | 2001-08-31 | 2003-03-13 | Bayer Healthcare Ag | A unit and a process for carrying out high cell density fermentation |
Non-Patent Citations (5)
| Title |
|---|
| H.-J. Binder, Sedimentation aus Ein- und Mehrkornsuspensionen in schr�g stehenden, laminar durchstr�mten Kreis- und Rechteckrohren, Dissertation Berlin, 1980 |
| Henzler, H.-J., Chemie-Technik, 1, 1992, 3 |
| Henzler, H.-J., Kauling, J., Oxygenation of cell cultures, Bioprocess Engineering, 9, 1993, 61-75 |
| Nienow, A. W., Reactor Engineering in Large Scale Animal Cell Culture, Cytotechnology, 50, 1-3, 2006, 9-33 |
| Varley, J., Birch, J., Reactor design for large scale suspension animal cell culture, Cytotechnology, 29, 3, 2004, 177-205 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022012843A1 (de) * | 2020-07-15 | 2022-01-20 | Hochschule Anhalt | Fermentationsverfahren und bioreaktor zur durchführung von anaeroben, aeroben und mikro-aerophilen fermentationen umfassend einen airlift-schachtüberfall |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009152990A2 (de) | 2009-12-23 |
| CN102239244B (zh) | 2014-10-29 |
| CN102239244A (zh) | 2011-11-09 |
| US20110097800A1 (en) | 2011-04-28 |
| JP2011529331A (ja) | 2011-12-08 |
| WO2009152990A3 (de) | 2011-11-24 |
| EP2304017A2 (de) | 2011-04-06 |
| KR20110027696A (ko) | 2011-03-16 |
| IL209232A0 (en) | 2011-01-31 |
| CA2728453A1 (en) | 2009-12-23 |
| AU2009259664A1 (en) | 2009-12-23 |
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| Date | Code | Title | Description |
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| R120 | Application withdrawn or ip right abandoned |
Effective date: 20110923 |