CA2722409C - Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs - Google Patents

Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs Download PDF

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Publication number
CA2722409C
CA2722409C CA2722409A CA2722409A CA2722409C CA 2722409 C CA2722409 C CA 2722409C CA 2722409 A CA2722409 A CA 2722409A CA 2722409 A CA2722409 A CA 2722409A CA 2722409 C CA2722409 C CA 2722409C
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Prior art keywords
seq
cdr3
residue
ratio
varies
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CA2722409A
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English (en)
French (fr)
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CA2722409A1 (en
Inventor
Robert C. Ladner
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Takeda Pharmaceutical Co Ltd
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Dyax Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2722409A 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs Active CA2722409C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2968164A CA2968164C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4752908P 2008-04-24 2008-04-24
US61/047,529 2008-04-24
PCT/US2009/041688 WO2009132287A2 (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2968164A Division CA2968164C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Publications (2)

Publication Number Publication Date
CA2722409A1 CA2722409A1 (en) 2009-10-29
CA2722409C true CA2722409C (en) 2017-12-12

Family

ID=41217437

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2722409A Active CA2722409C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
CA2968164A Active CA2968164C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
CA3049612A Active CA3049612C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2968164A Active CA2968164C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
CA3049612A Active CA3049612C (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Country Status (10)

Country Link
US (4) US9388510B2 (https=)
EP (1) EP2281078B1 (https=)
JP (1) JP5780951B2 (https=)
AU (1) AU2009240481B2 (https=)
CA (3) CA2722409C (https=)
CY (1) CY1116306T1 (https=)
DK (1) DK2281078T3 (https=)
ES (1) ES2528963T3 (https=)
PT (1) PT2281078E (https=)
WO (1) WO2009132287A2 (https=)

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JP5780951B2 (ja) 2008-04-24 2015-09-16 ダイアックス コーポレーション 新規のｈｃｃｄｒ１、ｃｄｒ２、およびｃｄｒ３設計、ならびに新規のｌｃｃｄｒ１、ｃｄｒ２、およびｃｄｒ３設計を含む、遺伝子パッケージのライブラリ
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AU2018301393B2 (en) 2017-07-11 2025-02-27 Compass Therapeutics Llc Agonist antibodies that bind human CD137 and uses thereof
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
WO2019099454A2 (en) * 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
EP3713961A2 (en) 2017-11-20 2020-09-30 Compass Therapeutics LLC Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
US11046769B2 (en) 2018-11-13 2021-06-29 Compass Therapeutics Llc Multispecific binding constructs against checkpoint molecules and uses thereof
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Also Published As

Publication number Publication date
CA2968164C (en) 2019-08-20
AU2009240481B2 (en) 2015-07-30
JP2011518565A (ja) 2011-06-30
AU2009240481A1 (en) 2009-10-29
DK2281078T3 (en) 2015-02-02
US20200347117A1 (en) 2020-11-05
EP2281078A4 (en) 2011-07-20
EP2281078A2 (en) 2011-02-09
PT2281078E (pt) 2015-02-05
CA2722409A1 (en) 2009-10-29
WO2009132287A3 (en) 2010-01-28
HK1151323A1 (en) 2012-01-27
US20110172125A1 (en) 2011-07-14
CA3049612C (en) 2023-01-10
US10683342B2 (en) 2020-06-16
JP5780951B2 (ja) 2015-09-16
ES2528963T3 (es) 2015-02-13
US11598024B2 (en) 2023-03-07
US20160355571A1 (en) 2016-12-08
US9388510B2 (en) 2016-07-12
WO2009132287A2 (en) 2009-10-29
EP2281078B1 (en) 2014-10-22
CY1116306T1 (el) 2017-02-08
CA3049612A1 (en) 2009-10-29
CA2968164A1 (en) 2009-10-29
US20230340697A1 (en) 2023-10-26

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