AU2009240481B2 - Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs - Google Patents

Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs Download PDF

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Publication number
AU2009240481B2
AU2009240481B2 AU2009240481A AU2009240481A AU2009240481B2 AU 2009240481 B2 AU2009240481 B2 AU 2009240481B2 AU 2009240481 A AU2009240481 A AU 2009240481A AU 2009240481 A AU2009240481 A AU 2009240481A AU 2009240481 B2 AU2009240481 B2 AU 2009240481B2
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seq
cdr3
residue
ratio
library
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AU2009240481A1 (en
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Robert C. Ladner
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2009240481A 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs Active AU2009240481B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4752908P 2008-04-24 2008-04-24
US61/047,529 2008-04-24
PCT/US2009/041688 WO2009132287A2 (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Publications (2)

Publication Number Publication Date
AU2009240481A1 AU2009240481A1 (en) 2009-10-29
AU2009240481B2 true AU2009240481B2 (en) 2015-07-30

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AU2009240481A Active AU2009240481B2 (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs

Country Status (10)

Country Link
US (4) US9388510B2 (https=)
EP (1) EP2281078B1 (https=)
JP (1) JP5780951B2 (https=)
AU (1) AU2009240481B2 (https=)
CA (3) CA3049612C (https=)
CY (1) CY1116306T1 (https=)
DK (1) DK2281078T3 (https=)
ES (1) ES2528963T3 (https=)
PT (1) PT2281078E (https=)
WO (1) WO2009132287A2 (https=)

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US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
US9873957B2 (en) 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
ES2528963T3 (es) 2008-04-24 2015-02-13 Dyax Corp. Bibliotecas de paquetes genéticos que comprenden nuevos diseños de CDR1, CDR2, y CDR3 de HC y nuevos diseños de CDR1, CDR2, y CDR3 de LC
SG184345A1 (en) * 2010-03-31 2012-11-29 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US9687591B2 (en) 2010-03-31 2017-06-27 Agency For Science, Technology And Research Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes
US8999916B2 (en) 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
DK2593594T3 (en) 2010-07-16 2017-12-11 Adimab Llc ANTIBODY LIBRARIES
EP3663314A1 (en) * 2012-01-09 2020-06-10 The Scripps Research Institute Humanized antibodies with ultralong cdr3s
US10774132B2 (en) 2012-01-09 2020-09-15 The Scripps Research Instittue Ultralong complementarity determining regions and uses thereof
US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
CN105073781A (zh) 2013-01-11 2015-11-18 加州生物医学研究所 牛融合抗体
EP3019531A4 (en) * 2013-07-11 2017-03-15 The California Institute for Biomedical Research Immunoglobulin fusion proteins and compositions thereof
AU2014290361B2 (en) 2013-07-18 2019-04-18 Taurus Biosciences, Llc Humanized antibodies with ultralong complementarity determining regions
EP3293293A1 (en) * 2016-09-08 2018-03-14 Italfarmaco SpA Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution
SG11201913137VA (en) 2017-07-11 2020-01-30 Compass Therapeutics Llc Agonist antibodies that bind human cd137 and uses thereof
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
WO2019099454A2 (en) * 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
US11046769B2 (en) 2018-11-13 2021-06-29 Compass Therapeutics Llc Multispecific binding constructs against checkpoint molecules and uses thereof
CN113912675B (zh) * 2021-09-23 2023-04-11 中国药科大学 一种具有镇痛活性的蜈蚣多肽及其应用

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Also Published As

Publication number Publication date
ES2528963T3 (es) 2015-02-13
US20200347117A1 (en) 2020-11-05
JP5780951B2 (ja) 2015-09-16
US20110172125A1 (en) 2011-07-14
US11598024B2 (en) 2023-03-07
EP2281078B1 (en) 2014-10-22
EP2281078A4 (en) 2011-07-20
US20230340697A1 (en) 2023-10-26
CA2722409C (en) 2017-12-12
US20160355571A1 (en) 2016-12-08
US9388510B2 (en) 2016-07-12
CA2722409A1 (en) 2009-10-29
JP2011518565A (ja) 2011-06-30
AU2009240481A1 (en) 2009-10-29
CA2968164C (en) 2019-08-20
WO2009132287A3 (en) 2010-01-28
HK1151323A1 (en) 2012-01-27
EP2281078A2 (en) 2011-02-09
US10683342B2 (en) 2020-06-16
CA2968164A1 (en) 2009-10-29
CY1116306T1 (el) 2017-02-08
CA3049612A1 (en) 2009-10-29
WO2009132287A2 (en) 2009-10-29
DK2281078T3 (en) 2015-02-02
CA3049612C (en) 2023-01-10
PT2281078E (pt) 2015-02-05

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Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED

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