CA2719805A1 - Multifactorial methods for detecting lung disorders - Google Patents
Multifactorial methods for detecting lung disorders Download PDFInfo
- Publication number
- CA2719805A1 CA2719805A1 CA2719805A CA2719805A CA2719805A1 CA 2719805 A1 CA2719805 A1 CA 2719805A1 CA 2719805 A CA2719805 A CA 2719805A CA 2719805 A CA2719805 A CA 2719805A CA 2719805 A1 CA2719805 A1 CA 2719805A1
- Authority
- CA
- Canada
- Prior art keywords
- lung cancer
- relevant
- patient
- cancer
- analyzing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 48
- 208000019693 Lung disease Diseases 0.000 title claims abstract description 27
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims abstract description 175
- 201000005202 lung cancer Diseases 0.000 claims abstract description 175
- 208000020816 lung neoplasm Diseases 0.000 claims abstract description 175
- 230000014509 gene expression Effects 0.000 claims abstract description 95
- 238000003745 diagnosis Methods 0.000 claims abstract description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 63
- 201000011510 cancer Diseases 0.000 claims description 59
- 238000012360 testing method Methods 0.000 claims description 57
- 108090000623 proteins and genes Proteins 0.000 claims description 56
- 238000013276 bronchoscopy Methods 0.000 claims description 35
- 239000008280 blood Substances 0.000 claims description 24
- 210000004369 blood Anatomy 0.000 claims description 24
- 239000000523 sample Substances 0.000 claims description 17
- 108700011259 MicroRNAs Proteins 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 238000004458 analytical method Methods 0.000 claims description 6
- 230000002159 abnormal effect Effects 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 4
- 238000011285 therapeutic regimen Methods 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 3
- 238000011269 treatment regimen Methods 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 abstract description 54
- 230000035945 sensitivity Effects 0.000 abstract description 19
- 238000012549 training Methods 0.000 description 27
- 238000007477 logistic regression Methods 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 9
- 230000000391 smoking effect Effects 0.000 description 9
- 238000002405 diagnostic procedure Methods 0.000 description 8
- 210000000038 chest Anatomy 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 238000002600 positron emission tomography Methods 0.000 description 5
- 208000008771 Lymphadenopathy Diseases 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000018555 lymphatic system disease Diseases 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 210000001552 airway epithelial cell Anatomy 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- -1 miR-189 Proteins 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 description 2
- 241000208125 Nicotiana Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 102100030728 Protein disulfide-thiol oxidoreductase Human genes 0.000 description 2
- 238000001793 Wilcoxon signed-rank test Methods 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 238000007435 diagnostic evaluation Methods 0.000 description 2
- 230000001667 episodic effect Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 208000037841 lung tumor Diseases 0.000 description 2
- 108091071817 miR-128b stem-loop Proteins 0.000 description 2
- 108091073628 miR-181d stem-loop Proteins 0.000 description 2
- 108091040176 miR-218 stem-loop Proteins 0.000 description 2
- 108091087529 miR-500 stem-loop Proteins 0.000 description 2
- 108091036496 miR-500-2 stem-loop Proteins 0.000 description 2
- 102000029752 retinol binding Human genes 0.000 description 2
- 108091000053 retinol binding Proteins 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 108010066066 tumor-associated NADH oxidase Proteins 0.000 description 2
- AOYNUTHNTBLRMT-SLPGGIOYSA-N 2-deoxy-2-fluoro-aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](F)C=O AOYNUTHNTBLRMT-SLPGGIOYSA-N 0.000 description 1
- 241001598984 Bromius obscurus Species 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010063599 Exposure to chemical pollution Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108091046841 MiR-150 Proteins 0.000 description 1
- 108091093085 MiR-338 Proteins 0.000 description 1
- 108091062140 Mir-223 Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102000054727 Serum Amyloid A Human genes 0.000 description 1
- 108700028909 Serum Amyloid A Proteins 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 108010025220 aspartic acid 2-oxoglutarate-dependent dioxygenase Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000002113 chemopreventative effect Effects 0.000 description 1
- 235000019506 cigar Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000013211 curve analysis Methods 0.000 description 1
- 238000009110 definitive therapy Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 108091064157 miR-106a stem-loop Proteins 0.000 description 1
- 108091045790 miR-106b stem-loop Proteins 0.000 description 1
- 108091064399 miR-10b stem-loop Proteins 0.000 description 1
- 108091091360 miR-125b stem-loop Proteins 0.000 description 1
- 108091077112 miR-128a stem-loop Proteins 0.000 description 1
- 108091032320 miR-146 stem-loop Proteins 0.000 description 1
- 108091024530 miR-146a stem-loop Proteins 0.000 description 1
- 108091091751 miR-17 stem-loop Proteins 0.000 description 1
- 108091041042 miR-18 stem-loop Proteins 0.000 description 1
- 108091062221 miR-18a stem-loop Proteins 0.000 description 1
- 108091092012 miR-199b stem-loop Proteins 0.000 description 1
- 108091037787 miR-19b stem-loop Proteins 0.000 description 1
- 108091043187 miR-30a stem-loop Proteins 0.000 description 1
- 108091029750 miR-30a-1 stem-loop Proteins 0.000 description 1
- 108091030035 miR-30a-2 stem-loop Proteins 0.000 description 1
- 108091090692 miR-337 stem-loop Proteins 0.000 description 1
- 108091068952 miR-362 stem-loop Proteins 0.000 description 1
- 108091039521 miR-363 stem-loop Proteins 0.000 description 1
- 108091056495 miR-363-1 stem-loop Proteins 0.000 description 1
- 108091025820 miR-363-2 stem-loop Proteins 0.000 description 1
- 108091030670 miR-365 stem-loop Proteins 0.000 description 1
- 108091036688 miR-365-3 stem-loop Proteins 0.000 description 1
- 108091056454 miR-625 stem-loop Proteins 0.000 description 1
- 108091050734 miR-652 stem-loop Proteins 0.000 description 1
- 108091076732 miR-99a stem-loop Proteins 0.000 description 1
- 108091064318 miR-99a-1 stem-loop Proteins 0.000 description 1
- 108091086202 miR-99a-2 stem-loop Proteins 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 238000013125 spirometry Methods 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 231100000606 suspected carcinogen Toxicity 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4043408P | 2008-03-28 | 2008-03-28 | |
| US61/040,434 | 2008-03-28 | ||
| PCT/US2009/038836 WO2009121070A1 (en) | 2008-03-28 | 2009-03-30 | Multifactorial methods for detecting lung disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2719805A1 true CA2719805A1 (en) | 2009-10-01 |
Family
ID=41114359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2719805A Abandoned CA2719805A1 (en) | 2008-03-28 | 2009-03-30 | Multifactorial methods for detecting lung disorders |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100055689A1 (https=) |
| EP (1) | EP2268836A4 (https=) |
| JP (1) | JP2011516046A (https=) |
| CA (1) | CA2719805A1 (https=) |
| WO (1) | WO2009121070A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3211093A1 (en) | 2005-04-14 | 2017-08-30 | The Trustees of Boston University | Diagnostic for lung disorders using class prediction |
| WO2007103541A2 (en) * | 2006-03-09 | 2007-09-13 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| CN101990577A (zh) * | 2007-09-19 | 2011-03-23 | 波士顿大学理事会 | 鉴定肺病药物开发的新途径 |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3360978A3 (en) | 2009-05-07 | 2018-09-26 | Veracyte, Inc. | Methods for diagnosis of thyroid conditions |
| CN102892897B (zh) * | 2009-12-24 | 2016-08-03 | 复旦大学 | 用于肺癌的微rna表达谱分析的组合物和方法 |
| JP6581502B2 (ja) * | 2012-08-20 | 2019-09-25 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 初期段階の肺がんにおける予後指標としてのタンパク質コーディング遺伝子及び非コーディング遺伝子の発現 |
| EP2968988A4 (en) | 2013-03-14 | 2016-11-16 | Allegro Diagnostics Corp | METHOD FOR EVALUATING A COPD STATUS |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| WO2016011068A1 (en) | 2014-07-14 | 2016-01-21 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| US20170335396A1 (en) | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| MX2017014859A (es) * | 2015-05-19 | 2018-07-06 | Wistar Inst | Metodos y composiciones para diagnosticar o detectar canceres de pulmon. |
| CN110114680A (zh) * | 2016-05-05 | 2019-08-09 | 佰欧迪塞克斯公司 | 用于诊断肺癌的组合物、方法和试剂盒 |
| WO2017197335A1 (en) | 2016-05-12 | 2017-11-16 | Trustees Of Boston University | Nasal epithelium gene expression signature and classifier for the prediction of lung cancer |
| US9612243B1 (en) * | 2016-05-31 | 2017-04-04 | Mor-Nuco Enterprises, Inc. | Methods and compositions for targeted two-dimensional western blot analysis for early cancer detection and cancer diagnosis up to ten years in advance of clinical symptoms of malignant disease |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| US10677800B2 (en) * | 2016-09-14 | 2020-06-09 | University Of Maryland, Baltimore | Biomarkers for diagnosis and prognosis of lung cancer |
| KR102685289B1 (ko) * | 2016-09-14 | 2024-07-16 | 필립모리스 프로덕츠 에스.에이. | 개인의 생물학적 상태를 예측하기 위한 시스템, 방법 및 유전자 시그니처 |
| CN116269239B (zh) * | 2023-04-06 | 2025-12-02 | 上海交通大学医学院附属瑞金医院 | 一种双模态复合肿瘤治疗系统 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3640268A (en) * | 1965-10-23 | 1972-02-08 | Hugh J Davis | Method and device for biopsy specimen collecting and handling |
| US4641662A (en) * | 1984-09-28 | 1987-02-10 | Jaicks John R | Endocervical curette system |
| US4800896A (en) * | 1985-11-08 | 1989-01-31 | Jalowayski Alfredo A | Cell sample collector probe |
| US5422273A (en) * | 1993-03-23 | 1995-06-06 | Baal Medical Products, Inc. | Cell collection apparatus |
| US5477863A (en) * | 1993-04-14 | 1995-12-26 | Grant; Michael A. | Collection kit with a sample collector |
| US5440942A (en) * | 1994-02-02 | 1995-08-15 | Hubbard; Stephen H. | Biological sample collecting and holding device |
| US6085907A (en) * | 1998-05-08 | 2000-07-11 | Institute Of Legal Medicine, University Of Bern | Foldable cardboard box for contact-free drying and long-term storage of biological evidence recovered on cotton swabs and forensic evidence collection kit including same |
| US6746846B1 (en) * | 1999-06-30 | 2004-06-08 | Corixa Corporation | Methods for diagnosing lung cancer |
| KR20030094281A (ko) * | 2001-03-12 | 2003-12-11 | 모노젠, 인크. | 세포에 기초한 질병상태의 검출 및 질병상태의 구별 |
| US20040197785A1 (en) * | 2001-03-14 | 2004-10-07 | Willey James C. | Method for quantitative measurement of gene expression for indentifying individuals at risk for bronchogenic carcinoma |
| US20040009489A1 (en) * | 2001-09-28 | 2004-01-15 | Golub Todd R. | Classification of lung carcinomas using gene expression analysis |
| US20040005294A1 (en) * | 2002-02-25 | 2004-01-08 | Ho-Young Lee | IGFBP-3 in the diagnosis and treatment of cancer |
| JP2006506945A (ja) * | 2002-03-28 | 2006-03-02 | メディカル・カレッジ・オブ・オハイオ | 遺伝子発現プロフィールを使用する非小細胞肺癌の診断および処置のための方法および組成物 |
| AU2003253860A1 (en) * | 2002-07-10 | 2004-01-23 | The Regents Of The University Of Michigan | Expression profile of lung cancer |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| US20040241725A1 (en) * | 2003-03-25 | 2004-12-02 | Wenming Xiao | Lung cancer detection |
| EP2327795B1 (en) * | 2003-06-10 | 2017-08-09 | The Trustees Of Boston University | Detection methods for disorders of the lung |
| WO2005047451A2 (en) * | 2003-11-12 | 2005-05-26 | Trustees Of Boston University | Isolation of nucleic acid from mouth epithelial cells |
| WO2005086679A2 (en) * | 2004-03-05 | 2005-09-22 | Medical College Of Ohio | Methods and compositions for assessing nucleic acids and alleles |
| US7862995B2 (en) * | 2004-12-10 | 2011-01-04 | Targeted Molecular Diagnostics | Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor |
| WO2006079048A2 (en) * | 2005-01-21 | 2006-07-27 | Gene Express, Inc. | Databases for assessing nucleic acids |
| EP3211093A1 (en) * | 2005-04-14 | 2017-08-30 | The Trustees of Boston University | Diagnostic for lung disorders using class prediction |
| ATE548467T1 (de) * | 2005-09-02 | 2012-03-15 | Univ Toledo | Verfahren zur identifizierung von biomarkern mit eignung bei der diagnose biologischer zustände |
| WO2007103541A2 (en) * | 2006-03-09 | 2007-09-13 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| CN101990577A (zh) * | 2007-09-19 | 2011-03-23 | 波士顿大学理事会 | 鉴定肺病药物开发的新途径 |
-
2009
- 2009-03-30 US US12/414,555 patent/US20100055689A1/en not_active Abandoned
- 2009-03-30 CA CA2719805A patent/CA2719805A1/en not_active Abandoned
- 2009-03-30 JP JP2011502136A patent/JP2011516046A/ja not_active Withdrawn
- 2009-03-30 EP EP09724548A patent/EP2268836A4/en not_active Withdrawn
- 2009-03-30 WO PCT/US2009/038836 patent/WO2009121070A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20100055689A1 (en) | 2010-03-04 |
| EP2268836A4 (en) | 2011-08-03 |
| JP2011516046A (ja) | 2011-05-26 |
| EP2268836A1 (en) | 2011-01-05 |
| WO2009121070A1 (en) | 2009-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20100055689A1 (en) | Multifactorial methods for detecting lung disorders | |
| KR102930361B1 (ko) | 암의 평가 및/또는 치료를 위한 무 세포 dna | |
| Beane et al. | A prediction model for lung cancer diagnosis that integrates genomic and clinical features | |
| EP3169814B1 (en) | Methods for evaluating lung cancer status | |
| US20170314081A1 (en) | Methods of detecting cancer | |
| US20150080243A1 (en) | Methods and compositions for detecting cancer based on mirna expression profiles | |
| US20150088430A1 (en) | Methods for evaluating lung cancer status | |
| US12297505B2 (en) | Algorithms for disease diagnostics | |
| WO2013049152A2 (en) | Methods for evaluating lung cancer status | |
| CN116287355A (zh) | 上消化道肿瘤化疗疗效及不良反应的肠道菌群预测模型 | |
| CN107435062B (zh) | 甄别肺部微小结节良恶性的外周血基因标志物及其用途 | |
| CN114807377B (zh) | 膀胱癌预后生存期标志物的应用、评估装置以及计算机可读取介质 | |
| EP3953492A1 (en) | Method for determining rcc subtypes | |
| EP4303323B1 (en) | A method differentiating benign and malignant tyroid nodules | |
| CN109182520B (zh) | 一种宫颈癌及其癌前病变检测试剂盒及其应用 | |
| WO2017221744A1 (ja) | 肺がん検査用の情報を提供する方法、肺がんの検査方法、肺がんの検査装置、肺がんの検査装置のプログラム及び記録媒体、並びに肺がん検査用のｍｉＲＮＡ測定用キット | |
| TWI626314B (zh) | 評估罹患大腸直腸癌風險的方法 | |
| US20250305051A1 (en) | Systems and methods of diagnosing idiopathic pulmonary fibrosis | |
| EP3717660B1 (en) | Methods for evaluating head and neck cancers | |
| JP2014054198A (ja) | 大腸ガン検出方法、診断用キット及びｄｎａチップ | |
| US20220243276A1 (en) | Methods of detecting cancer | |
| CN121496057A (zh) | 一种用于辅助食管鳞状细胞癌早期诊断的甲基化位点标志物及其应用 | |
| TW201412989A (zh) | 一種以糞便中細胞基因套組偵測大腸直腸癌的方法 | |
| WO2018061143A1 (ja) | 孤発性大腸癌発症可能性の判定方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140402 |