CA2715348A1 - Use of picoplatin and bevacizumab to treat colorectal cancer - Google Patents
Use of picoplatin and bevacizumab to treat colorectal cancer Download PDFInfo
- Publication number
- CA2715348A1 CA2715348A1 CA2715348A CA2715348A CA2715348A1 CA 2715348 A1 CA2715348 A1 CA 2715348A1 CA 2715348 A CA2715348 A CA 2715348A CA 2715348 A CA2715348 A CA 2715348A CA 2715348 A1 CA2715348 A1 CA 2715348A1
- Authority
- CA
- Canada
- Prior art keywords
- administered
- picoplatin
- leucovorin
- dose
- bevacizumab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Epidemiology (AREA)
- Organic Chemistry (AREA)
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| US61/027,382 | 2008-02-08 | ||
| US61/027,360 | 2008-02-08 | ||
| US61/027,387 | 2008-02-08 | ||
| PCT/US2009/000770 WO2009099649A1 (en) | 2008-02-08 | 2009-02-06 | Use of picoplatin and bevacizumab to treat colorectal cancer |
Publications (1)
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| CA2715348A1 true CA2715348A1 (en) | 2009-08-13 |
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| CA2715353A Abandoned CA2715353A1 (en) | 2008-02-08 | 2009-02-06 | Use of picoplatin and cetuximab to treat colorectal cancer |
| CA2715329A Abandoned CA2715329A1 (en) | 2008-02-08 | 2009-02-06 | Picoplatin and amrubicin to treat lung cancer |
| CA2715348A Abandoned CA2715348A1 (en) | 2008-02-08 | 2009-02-06 | Use of picoplatin and bevacizumab to treat colorectal cancer |
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| CA2715353A Abandoned CA2715353A1 (en) | 2008-02-08 | 2009-02-06 | Use of picoplatin and cetuximab to treat colorectal cancer |
| CA2715329A Abandoned CA2715329A1 (en) | 2008-02-08 | 2009-02-06 | Picoplatin and amrubicin to treat lung cancer |
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| EP (3) | EP2249644A4 (enExample) |
| JP (3) | JP2011511072A (enExample) |
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| AU (3) | AU2009210656A1 (enExample) |
| CA (3) | CA2715353A1 (enExample) |
| WO (3) | WO2009099634A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) * | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| AU2008214199A1 (en) * | 2007-02-09 | 2008-08-14 | Poniard Pharmaceuticals, Inc. | Encapsulated picoplatin |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| US20100310661A1 (en) * | 2007-07-16 | 2010-12-09 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
| EP2249644A4 (en) * | 2008-02-08 | 2012-05-30 | Poniard Pharmaceuticals Inc | PICOPLATIN AND AMRUBICIN USEFUL IN THE TREATMENT OF LUNG CANCER |
| ES2354922B1 (es) * | 2009-09-02 | 2012-02-07 | Fundacion Institut De Recerca De L'hospital Universitari Vall D'hebron | Marcadores para la selección de terapias personalizadas para el tratamiento del c�?ncer. |
| US9217032B2 (en) * | 2010-01-08 | 2015-12-22 | Les Laboratoires Servier | Methods for treating colorectal cancer |
| WO2011109625A1 (en) * | 2010-03-03 | 2011-09-09 | Targeted Molecular Diagnostics, Llc | Methods for determining responsiveness to a drug based upon determination of ras mutation and/or ras amplification |
| KR20170086706A (ko) * | 2010-03-05 | 2017-07-26 | 포니아드 파머슈티컬즈, 인크. | 소세포 폐암의 치료 방법 |
| AU2011231978B2 (en) | 2010-03-24 | 2014-12-18 | Centre National De La Recherche Scientifique (Cnrs) | Prophylaxis of colorectal and gastrointestinal cancer |
| WO2011133520A1 (en) | 2010-04-19 | 2011-10-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| EP2560641A2 (en) * | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| US8709419B2 (en) * | 2010-08-17 | 2014-04-29 | Hoffmann-La Roche, Inc. | Combination therapy |
| US8962804B2 (en) * | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| CL2011000273A1 (es) | 2011-02-08 | 2011-06-17 | Univ Pontificia Catolica Chile | Uso de un inhibidor de la enzima fosfohidrolasa de acido fosfatidico (pap) o combinacion de inhibidores, en que el inhibidor es d(+) propranolol, y la combinacion es mezcla racemica de propranolol o d(+) propranolol junto con desipramina, para preparar un medicamento util en el tratamiento del cancer. |
| WO2013067162A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| CA2853806C (en) | 2011-11-02 | 2020-07-14 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with platinum-containing agents |
| CA2854188A1 (en) | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| EP2617421A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
| WO2013130625A1 (en) * | 2012-02-27 | 2013-09-06 | Basil Rigas | Phospho-ester derivatives and uses thereof |
| RU2660354C2 (ru) | 2012-04-03 | 2018-07-05 | Новартис Аг | Комбинированные продукты, содержащие ингибиторы тирозинкиназ, и их применение |
| NL2008707C2 (en) * | 2012-04-26 | 2013-10-29 | Stichting Vu Vumc | Biomarkers. |
| ES2942585T3 (es) * | 2012-04-26 | 2023-06-02 | Stichting Vumc | Biomarcadores |
| NL2010276C2 (en) * | 2013-02-08 | 2014-08-11 | Stichting Vu Vumc | Biomarkers. |
| KR20200079568A (ko) * | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
| AU2013334599B2 (en) * | 2012-10-25 | 2016-03-10 | Novartis Ag | Combination |
| US9689874B2 (en) | 2015-04-10 | 2017-06-27 | Applied Proteomics, Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
| US10363226B2 (en) * | 2015-08-12 | 2019-07-30 | North Carolina State University | Platelet membrane-coated drug delivery system |
| US20220249545A1 (en) * | 2019-07-11 | 2022-08-11 | Emory University | Platinum-Based Chemotherapy, Mast Binding Agents, Glucocorticoid Receptor (GR) Binding Agents, and/or HSP90 Binding Agents for Uses in Treating Cancer |
| WO2025217467A1 (en) * | 2024-04-10 | 2025-10-16 | El Capitan Biosciences, Inc. | Occult blood mrna biomarkers paired with dna/rna mutations and dna methylation |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1432562A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum co-ordination compounds |
| US4329299A (en) * | 1979-08-23 | 1982-05-11 | Johnson, Matthey & Co., Limited | Composition of matter containing platinum |
| US4302446A (en) * | 1979-10-02 | 1981-11-24 | Bristol-Myers Company | Pharmaceutical compositions |
| US4533502A (en) * | 1983-02-22 | 1985-08-06 | Rochon Fernande D | Platinum (II) compounds and their preparation |
| DE3582961D1 (de) * | 1984-06-27 | 1991-07-04 | Johnson Matthey Plc | Platinkoordinationsverbindungen. |
| US5082655A (en) * | 1984-07-23 | 1992-01-21 | Zetachron, Inc. | Pharmaceutical composition for drugs subject to supercooling |
| ATE73814T1 (de) * | 1986-12-18 | 1992-04-15 | Shionogi & Co | Ammine-n-heterocyclische platinkomplexe und antitumormittel. |
| MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| GB9105037D0 (en) * | 1991-03-09 | 1991-04-24 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5244991A (en) * | 1991-10-15 | 1993-09-14 | Phillips Petroleum Company | Olefin polymerization process |
| EP1393730A3 (en) * | 1991-11-15 | 2004-03-17 | Smithkline Beecham Corporation | Combination chemotherapy involving topotecan and a platinum coordination compound |
| JP3633932B2 (ja) * | 1992-04-01 | 2005-03-30 | ザ ジョーンズ ホプキンズ ユニバーシティー スクール オブ メディシン | 糞便試料から単離した哺乳類の核酸を検出する方法、およびその検出用試薬 |
| US5624919A (en) * | 1993-09-14 | 1997-04-29 | The University Of Vermont And State Agricultural College | Trans platinum (IV) complexes |
| GB9408218D0 (en) * | 1994-04-26 | 1994-06-15 | Johnson Matthey Plc | Improvements in platinum complexes |
| AU2768295A (en) * | 1994-07-11 | 1996-02-09 | Hoechst Marion Roussel, Inc. | Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5789000A (en) * | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
| US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| PL330747A1 (en) * | 1996-06-25 | 1999-05-24 | Glaxo Group Ltd | Vx478, zidovudin, ftc and/or 3tc containing combinations for use in treating hiv infections |
| DE19847618A1 (de) * | 1998-10-15 | 2000-04-20 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| US6235782B1 (en) * | 1998-11-12 | 2001-05-22 | Rifat Pamukcu | Method for treating a patient with neoplasia by treatment with a platinum coordination complex |
| US6413953B1 (en) * | 1999-04-13 | 2002-07-02 | Anormed Inc. | Pt(IV) antitumor agent |
| CZ303156B6 (cs) * | 1999-04-13 | 2012-05-09 | Anormed Inc. | Komplex cisplatiny a zpusob jeho prípravy |
| GB9925127D0 (en) * | 1999-10-22 | 1999-12-22 | Pharmacia & Upjohn Spa | Oral formulations for anti-tumor compounds |
| US20020102301A1 (en) * | 2000-01-13 | 2002-08-01 | Joseph Schwarz | Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof |
| WO2001060370A1 (en) * | 2000-02-16 | 2001-08-23 | Yamanouchi Pharmaceutical Co., Ltd. | Remedies for endothelin-induced diseases |
| AU2001246477A1 (en) * | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with platinum compounds |
| US20020156033A1 (en) * | 2000-03-03 | 2002-10-24 | Bratzler Robert L. | Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer |
| US6545010B2 (en) * | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
| US20020110601A1 (en) * | 2000-03-31 | 2002-08-15 | Roman Perez-Soler | Antineoplastic platinum therapeutic method and composition |
| EE200200565A (et) * | 2000-03-31 | 2004-06-15 | Angiogene Pharmaceuticals Ltd. | Vaskulaarse kahjustava toimega kombinatsioonravi |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| JP5096657B2 (ja) * | 2000-08-11 | 2012-12-12 | 大日本住友製薬株式会社 | シスプラチン耐性癌治療剤 |
| US6894049B1 (en) * | 2000-10-04 | 2005-05-17 | Anormed, Inc. | Platinum complexes as antitumor agents |
| US6544962B1 (en) * | 2000-11-02 | 2003-04-08 | Matrix Pharmaceutical, Inc. | Methods for treating cellular proliferative disorders |
| SE0004671D0 (sv) * | 2000-12-15 | 2000-12-15 | Amarin Dev Ab | Pharmaceutical formulation |
| CN1309390C (zh) * | 2001-01-30 | 2007-04-11 | 大日本住友制药株式会社 | 治疗肺癌的药物 |
| AR035227A1 (es) * | 2001-02-20 | 2004-05-05 | Oncolytics Biotech Inc | Uso de un agente quimioterapeutico para la manufactura de un medicamento para la sensibilizacion de celulas neoplasicas resistentes a agentes quimioterapeuticos con reovirus |
| US6673370B2 (en) * | 2001-05-15 | 2004-01-06 | Biomedicines, Inc. | Oxidized collagen formulations for use with non-compatible pharmaceutical agents |
| ES2287293T3 (es) * | 2001-08-06 | 2007-12-16 | Astrazeneca Ab | Dispersion acuosa que comprende nanoparticulas estables de trigliceridos de cadena media (mct) activos, insolubles en agua y de tipo excipiente. |
| WO2003015707A2 (en) * | 2001-08-20 | 2003-02-27 | Transave, Inc. | Method for treating lung cancers |
| DE10141528B4 (de) * | 2001-08-24 | 2006-08-10 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Platin(II)- und Platin(IV)-Komplexe und ihre Verwendung |
| US20030144312A1 (en) * | 2001-10-30 | 2003-07-31 | Schoenhard Grant L. | Inhibitors of ABC drug transporters in multidrug resistant cancer cells |
| AU2002353118A1 (en) * | 2001-12-11 | 2003-07-24 | Dor Biopharma, Inc. | Lipid particles and suspensions and uses thereof |
| US20050119238A1 (en) * | 2002-03-01 | 2005-06-02 | Baron John A. | Compositions and methods for preventing sporadic neoplasia in colon |
| ES2381408T3 (es) * | 2002-03-18 | 2012-05-28 | Dainippon Sumitomo Pharma Co., Ltd. | Remedios para el cáncer de pulmón. |
| US20040010553A1 (en) * | 2002-07-15 | 2004-01-15 | International Business Machines Corporation | Peer to peer location based services |
| US7038071B2 (en) * | 2002-07-16 | 2006-05-02 | Sonus Pharmaceuticals, Inc. | Platinum compounds |
| JP2006502233A (ja) * | 2002-08-02 | 2006-01-19 | トランセーブ，インク． | 白金凝集物およびその製造方法 |
| WO2004012680A2 (en) * | 2002-08-06 | 2004-02-12 | Lyotropic Therapeutics, Inc. | Lipid-drug complexes in reversed liquid and liquid crystalline phases |
| AU2002951833A0 (en) * | 2002-10-02 | 2002-10-24 | Novogen Research Pty Ltd | Compositions and therapeutic methods invloving platinum complexes |
| US8217010B2 (en) * | 2002-10-24 | 2012-07-10 | The Board Of Trustees Of The University Of Illinois | Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors |
| TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| DE10256182A1 (de) * | 2002-12-02 | 2004-06-24 | Merck Patent Gmbh | 2-Oxadiazolchromonderivate |
| US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| EP1473293B1 (de) * | 2003-04-30 | 2008-03-19 | MERCK PATENT GmbH | Chromenonderivate |
| US20050020556A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes |
| US20070065522A1 (en) * | 2004-03-18 | 2007-03-22 | Transave, Inc. | Administration of high potency platinum compound formulations by inhalation |
| MXPA06011658A (es) * | 2004-05-14 | 2006-12-14 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| JP2007537238A (ja) * | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療のためのピリミジン誘導体 |
| TW200538149A (en) * | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| TW200600091A (en) * | 2004-05-21 | 2006-01-01 | Telik Inc | Sulfonylethyl phosphorodiamidates |
| US7378423B2 (en) * | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| WO2006002119A2 (en) * | 2004-06-18 | 2006-01-05 | Gpc Biotech, Inc. | Kinase inhibitors for treating cancers |
| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US7485646B2 (en) * | 2004-09-09 | 2009-02-03 | Research Foundation Itsuu Laboratory | Serotonin 5-HT3 receptor agonist |
| BRPI0515567A (pt) * | 2004-09-22 | 2008-07-29 | Pfizer | combinações terapêuticas compreendendo inibidor de poli (adp-ribose) polimerase |
| US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
| WO2006071812A2 (en) * | 2004-12-23 | 2006-07-06 | H. Lee Moffitt Cancer Center And Research Institute | Platinum iv complex inhibitor |
| JP5106098B2 (ja) * | 2005-02-28 | 2012-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の抗癌剤との新規併用 |
| US8106033B2 (en) * | 2005-03-11 | 2012-01-31 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| JP2006319399A (ja) * | 2005-05-10 | 2006-11-24 | Nec Electronics Corp | パルス幅変調回路及び多相クロック生成回路 |
| DK1888550T3 (da) * | 2005-05-12 | 2014-09-29 | Abbvie Bahamas Ltd | Apoptosepromotorer |
| NZ592132A (en) * | 2005-08-31 | 2012-12-21 | Abraxis Bioscience Llc | Composition comprising nanoparticles of docitaxel and a citrate |
| US20070190181A1 (en) * | 2005-11-08 | 2007-08-16 | Pilkiewicz Frank G | Methods of treating cancer with lipid-based platinum compound forumulations administered intravenously |
| US20070190180A1 (en) * | 2005-11-08 | 2007-08-16 | Pilkiewicz Frank G | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intravenously |
| US20070190182A1 (en) * | 2005-11-08 | 2007-08-16 | Pilkiewicz Frank G | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
| EP1792622A1 (en) * | 2005-11-11 | 2007-06-06 | GPC Biotech AG | Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| WO2007064658A2 (en) * | 2005-11-30 | 2007-06-07 | Transave, Inc. | Safe and effective methods of administering therapeutic agents |
| US8143236B2 (en) * | 2005-12-13 | 2012-03-27 | Bionumerik Pharmaceuticals, Inc. | Chemoprotective methods |
| EP2004175A4 (en) * | 2006-03-16 | 2010-12-15 | Bionumerik Pharmaceuticals Inc | COMPOUNDS AND FORMULATIONS FOR INCREASING THE EFFECT OF CANCER AND METHOD FOR THEIR USE |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| AU2008214199A1 (en) * | 2007-02-09 | 2008-08-14 | Poniard Pharmaceuticals, Inc. | Encapsulated picoplatin |
| WO2008150506A1 (en) * | 2007-05-31 | 2008-12-11 | Ascenta Therapeutics, Inc. | Pulsatile dosing of gossypol for treatment of disease |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| US20100310661A1 (en) * | 2007-07-16 | 2010-12-09 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
| ES2647538T3 (es) * | 2007-09-28 | 2017-12-22 | Pfizer Inc. | Direccionamiento a células de cáncer usando nanopartículas |
| EP2249644A4 (en) * | 2008-02-08 | 2012-05-30 | Poniard Pharmaceuticals Inc | PICOPLATIN AND AMRUBICIN USEFUL IN THE TREATMENT OF LUNG CANCER |
| US20110025581A1 (en) * | 2009-07-31 | 2011-02-03 | David John Geer | Antenna assembly |
-
2009
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- 2009-02-06 US US12/866,710 patent/US20110053879A1/en not_active Abandoned
- 2009-02-06 CN CN2009801097586A patent/CN102006875A/zh active Pending
- 2009-02-06 US US12/866,702 patent/US20110052580A1/en not_active Abandoned
- 2009-02-06 EP EP09708387A patent/EP2249827A4/en not_active Withdrawn
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- 2009-02-06 CA CA2715329A patent/CA2715329A1/en not_active Abandoned
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- 2009-02-06 JP JP2010545885A patent/JP2011511074A/ja not_active Withdrawn
- 2009-02-06 WO PCT/US2009/000773 patent/WO2009099651A1/en not_active Ceased
- 2009-02-06 AU AU2009210654A patent/AU2009210654A1/en not_active Abandoned
- 2009-02-06 AU AU2009210734A patent/AU2009210734A1/en not_active Abandoned
- 2009-02-06 WO PCT/US2009/000770 patent/WO2009099649A1/en not_active Ceased
- 2009-02-06 JP JP2010545878A patent/JP2011511071A/ja not_active Withdrawn
- 2009-02-06 CN CN2009801110152A patent/CN101998851A/zh active Pending
- 2009-02-06 CA CA2715348A patent/CA2715348A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110052581A1 (en) | 2011-03-03 |
| JP2011511074A (ja) | 2011-04-07 |
| JP2011511072A (ja) | 2011-04-07 |
| AU2009210654A1 (en) | 2009-08-13 |
| EP2244714A1 (en) | 2010-11-03 |
| CN101998851A (zh) | 2011-03-30 |
| US20110053879A1 (en) | 2011-03-03 |
| WO2009099634A2 (en) | 2009-08-13 |
| WO2009099649A1 (en) | 2009-08-13 |
| JP2011511071A (ja) | 2011-04-07 |
| EP2249644A2 (en) | 2010-11-17 |
| CN102006875A (zh) | 2011-04-06 |
| CA2715329A1 (en) | 2009-08-13 |
| AU2009210656A1 (en) | 2009-08-13 |
| CA2715353A1 (en) | 2009-08-13 |
| CN102014624A (zh) | 2011-04-13 |
| EP2249827A1 (en) | 2010-11-17 |
| US20110052580A1 (en) | 2011-03-03 |
| EP2244714A4 (en) | 2012-06-06 |
| WO2009099634A3 (en) | 2010-01-21 |
| EP2249827A4 (en) | 2012-05-30 |
| AU2009210734A1 (en) | 2009-08-13 |
| WO2009099651A1 (en) | 2009-08-13 |
| EP2249644A4 (en) | 2012-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140206 |