CA2710680C - Anti-c35 antibody combination therapies and methods - Google Patents

Anti-c35 antibody combination therapies and methods Download PDF

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Publication number
CA2710680C
CA2710680C CA2710680A CA2710680A CA2710680C CA 2710680 C CA2710680 C CA 2710680C CA 2710680 A CA2710680 A CA 2710680A CA 2710680 A CA2710680 A CA 2710680A CA 2710680 C CA2710680 C CA 2710680C
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Canada
Prior art keywords
antibody
antigen
use according
seq
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2710680A
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English (en)
French (fr)
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CA2710680A1 (en
Inventor
Maurice Zauderer
Elizabeth E. Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaccinex Inc
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Vaccinex Inc
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Publication of CA2710680A1 publication Critical patent/CA2710680A1/en
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Publication of CA2710680C publication Critical patent/CA2710680C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2710680A 2007-12-26 2008-12-23 Anti-c35 antibody combination therapies and methods Expired - Fee Related CA2710680C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1676307P 2007-12-26 2007-12-26
US61/016,763 2007-12-26
PCT/US2008/013998 WO2009082485A1 (en) 2007-12-26 2008-12-23 Anti-c35 antibody combination therapies and methods

Publications (2)

Publication Number Publication Date
CA2710680A1 CA2710680A1 (en) 2009-07-02
CA2710680C true CA2710680C (en) 2018-10-16

Family

ID=40801516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2710680A Expired - Fee Related CA2710680C (en) 2007-12-26 2008-12-23 Anti-c35 antibody combination therapies and methods

Country Status (9)

Country Link
US (1) US8637026B2 (cg-RX-API-DMAC7.html)
EP (1) EP2237792B1 (cg-RX-API-DMAC7.html)
JP (1) JP5690593B2 (cg-RX-API-DMAC7.html)
KR (1) KR101642846B1 (cg-RX-API-DMAC7.html)
CN (1) CN101932333A (cg-RX-API-DMAC7.html)
AU (1) AU2008341050B2 (cg-RX-API-DMAC7.html)
CA (1) CA2710680C (cg-RX-API-DMAC7.html)
NZ (1) NZ586544A (cg-RX-API-DMAC7.html)
WO (1) WO2009082485A1 (cg-RX-API-DMAC7.html)

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WO2008073578A2 (en) 2006-12-08 2008-06-19 Iowa State University Research Foundation, Inc. Plant genes involved in nitrate uptake and metabolism
MX353352B (es) 2009-05-08 2018-01-10 Vaccinex Inc Anticuerpos anti-cd100 y metodos para su uso.
CN103298489A (zh) * 2010-10-29 2013-09-11 伊缪诺金公司 新型egfr结合分子及其免疫偶联物
PT2766093T (pt) 2011-10-11 2018-05-18 Vaccinex Inc Utilização de moléculas de ligação a semaforina-4d para modulação da permeabilidade da barreira hematoencefálica
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
DK3489261T3 (da) 2012-08-24 2020-12-14 Univ California Antistoffer og vacciner til anvendelse ved behandling af ror1-cancere og hæmning af metastase
BR112015010740B1 (pt) * 2012-11-13 2024-01-30 Biontech Ag Agentes para tratamento de doenças cancerosas expressando claudina
WO2014160336A1 (en) * 2013-03-13 2014-10-02 University Of Kentucky Research Foundation METHODS OF ADMINISTERING IgG1 ANTIBODIES AND METHODS OF SUPPRESSING ANGIOGENESIS
ES2782834T3 (es) 2013-06-25 2020-09-16 Vaccinex Inc Uso de moléculas inhibidoras de semaforina-4D en combinación con una terapia inmunomoduladora para inhibir el crecimiento tumoral y la metástasis
CN116286909A (zh) 2016-04-22 2023-06-23 瓦西尼斯公司 痘病毒胞外包膜病毒颗粒上的整合膜蛋白展示
JP7109007B2 (ja) 2016-06-27 2022-07-29 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア がん治療の組み合わせ
EP3494131B1 (en) 2016-08-02 2024-09-18 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
JPWO2021039592A1 (cg-RX-API-DMAC7.html) * 2019-08-29 2021-03-04
WO2021055562A1 (en) * 2019-09-18 2021-03-25 Biomarker Strategies, Llc Methods to increase the sensitivity and reversing the resistance to drugs

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Also Published As

Publication number Publication date
EP2237792B1 (en) 2017-05-24
US8637026B2 (en) 2014-01-28
JP2011509246A (ja) 2011-03-24
WO2009082485A1 (en) 2009-07-02
KR101642846B1 (ko) 2016-07-26
NZ586544A (en) 2012-07-27
AU2008341050B2 (en) 2013-10-24
KR20100095017A (ko) 2010-08-27
EP2237792A1 (en) 2010-10-13
AU2008341050A1 (en) 2009-07-02
EP2237792A4 (en) 2012-07-25
US20110008322A1 (en) 2011-01-13
CN101932333A (zh) 2010-12-29
CA2710680A1 (en) 2009-07-02
JP5690593B2 (ja) 2015-03-25

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