CA2709538A1 - Pharmaceutical formulations containing tolperisone - Google Patents
Pharmaceutical formulations containing tolperisone Download PDFInfo
- Publication number
- CA2709538A1 CA2709538A1 CA2709538A CA2709538A CA2709538A1 CA 2709538 A1 CA2709538 A1 CA 2709538A1 CA 2709538 A CA2709538 A CA 2709538A CA 2709538 A CA2709538 A CA 2709538A CA 2709538 A1 CA2709538 A1 CA 2709538A1
- Authority
- CA
- Canada
- Prior art keywords
- tolperisone
- acid
- pharmaceutical formulation
- formulation according
- glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- FSKFPVLPFLJRQB-UHFFFAOYSA-N 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone Chemical compound C=1C=C(C)C=CC=1C(=O)C(C)CN1CCCCC1 FSKFPVLPFLJRQB-UHFFFAOYSA-N 0.000 title claims abstract description 113
- 229960005334 tolperisone Drugs 0.000 title claims abstract description 110
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 51
- 239000000203 mixture Substances 0.000 claims abstract description 74
- 238000009472 formulation Methods 0.000 claims abstract description 27
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 17
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims abstract description 15
- 239000002671 adjuvant Substances 0.000 claims abstract description 14
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 11
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 230000009977 dual effect Effects 0.000 claims abstract description 7
- 229920002521 macromolecule Polymers 0.000 claims abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 144
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 66
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 64
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 28
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- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 19
- 229960001680 ibuprofen Drugs 0.000 claims description 19
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 17
- 239000004480 active ingredient Substances 0.000 claims description 16
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 15
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 15
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 11
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 8
- CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzydamine Chemical compound C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 claims description 8
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- MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 claims description 4
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- 229960004420 aceclofenac Drugs 0.000 claims description 4
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- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 4
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims description 3
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- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims description 3
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- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 3
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 claims description 3
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- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0700828 | 2007-12-20 | ||
| HU0700828A HUP0700828A2 (en) | 2007-12-20 | 2007-12-20 | Transdermal pharmaceutical compositions containing tolperisone alone and in combination |
| PCT/HU2008/000153 WO2009081217A1 (en) | 2007-12-20 | 2008-12-18 | Pharmaceutical formulations containing tolperisone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2709538A1 true CA2709538A1 (en) | 2009-07-02 |
Family
ID=89987953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2709538A Abandoned CA2709538A1 (en) | 2007-12-20 | 2008-12-18 | Pharmaceutical formulations containing tolperisone |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100273746A1 (https=) |
| EP (1) | EP2231116A1 (https=) |
| JP (1) | JP2011507826A (https=) |
| CA (1) | CA2709538A1 (https=) |
| EA (1) | EA018536B1 (https=) |
| HU (1) | HUP0700828A2 (https=) |
| WO (1) | WO2009081217A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6002385B2 (ja) * | 2008-09-12 | 2016-10-05 | クリティカル ファーマシューティカルズ リミテッドＣｒｉｔｉｃａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｉｍｉｔｅｄ | 医薬組成物、医薬組成物における吸収促進剤の使用方法、及び医薬組成物の製造方法 |
| JP5739679B2 (ja) * | 2010-03-01 | 2015-06-24 | ロート製薬株式会社 | 外用組成物 |
| PE20140936A1 (es) * | 2011-05-03 | 2014-08-06 | Aponia Lab Inc | Composiciones transdermicas de ibuprofeno y metodos de uso de las mismas |
| WO2012172413A1 (en) | 2011-06-16 | 2012-12-20 | Abbott Healthcare Pvt. Ltd. | Pharmaceutical composition comprising a combination of eperisone and diclofenac and process for preparing thereof |
| KR101156054B1 (ko) * | 2011-09-05 | 2012-06-20 | 주식회사 네비팜 | 안정한 에페리손 함유 서방성 의약조성물 |
| UA119324C2 (uk) * | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
| WO2016121996A1 (ja) * | 2015-01-30 | 2016-08-04 | 株式会社メドレックス | 水性外用剤 |
| RU2711624C2 (ru) * | 2017-06-30 | 2020-01-17 | Общество с ограниченной ответственностью "ФБК" | Комбинированное средство на основе нпвс, миорелаксанта и витамина |
| TR201720293A2 (tr) * | 2017-12-13 | 2019-06-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Tolperi̇zon ve non-selekti̇f cox i̇nhi̇bi̇törü kombi̇nasyonlari |
| WO2020086046A2 (en) * | 2018-10-26 | 2020-04-30 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Topical compositions comprising tolperisone and flurbiprofen combination |
| US20220378729A1 (en) | 2019-11-06 | 2022-12-01 | Smartech Topical, Inc. | Topical formulations of cyclooxygenase inhibitors and their use |
| CN114939104B (zh) * | 2022-06-02 | 2023-10-24 | 杭州润宠归美生物科技有限公司 | 一种用于减轻猫应激的外用透皮制剂、制备方法及应用 |
| CN120919084A (zh) * | 2025-08-27 | 2025-11-11 | 广州神元辉康生物医药科技有限公司 | 一种药物组合物及其制备方法和用途 |
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| JPS6087215A (ja) * | 1983-10-19 | 1985-05-16 | Mitsui Toatsu Chem Inc | 外用薬用基材 |
| JPH0720866B2 (ja) * | 1987-05-15 | 1995-03-08 | 三生製薬株式会社 | エペリゾン又はトルペリゾン或いはそれらの塩類含有経皮適用製剤 |
| US5446070A (en) * | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5093133A (en) * | 1990-01-24 | 1992-03-03 | Mcneil-Ppc, Inc. | Method for percutaneous delivery of ibuprofen using hydroalcoholic gel |
| US5252588A (en) * | 1990-04-27 | 1993-10-12 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation |
| JPH0640917A (ja) * | 1991-06-21 | 1994-02-15 | Nichiban Co Ltd | トルペリゾン又はエペリゾン含有ハップ剤 |
| JP3525225B2 (ja) * | 1992-11-09 | 2004-05-10 | 積水化学工業株式会社 | エペリゾンまたはトルペリゾン経皮吸収テープ剤またはパッチ剤、およびその製造方法 |
| IT1265001B1 (it) * | 1993-12-16 | 1996-10-17 | Zambon Spa | Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico |
| DE69528165T2 (de) * | 1994-04-21 | 2003-05-15 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal verabreichbare grundlage und daraus hergestelltes transdermal verabreichbares arzneimittel |
| US5846620A (en) * | 1997-02-06 | 1998-12-08 | W. R. Grace & Co.-Conn. | High strength flexible film package |
| JP2000143510A (ja) * | 1998-11-16 | 2000-05-23 | Taisho Pharmaceut Co Ltd | 外用組成物 |
| WO2001052823A2 (en) * | 2000-01-20 | 2001-07-26 | Noven Pharmaceuticals, Inc. | Compositions to effect the release profile in the transdermal administration of drugs |
| US20050163831A1 (en) * | 2002-08-02 | 2005-07-28 | Hisamitsu Pharmaceutical Co., Inc. | Patch for transdermal administration |
| KR101105612B1 (ko) * | 2003-03-18 | 2012-01-18 | 히사미쓰 세이야꾸 가부시키가이샤 | 비스테로이드계 소염 진통제 함유 첩부제 |
| US20070065463A1 (en) * | 2003-06-20 | 2007-03-22 | Ronald Aung-Din | Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions |
| HUP0303313A2 (hu) * | 2003-10-09 | 2005-07-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transzdermális gyógyszerkészítmények |
| AT500144A1 (de) * | 2004-03-05 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Tolperison enthaltende, pharmazeutische zubereitung mit steuerbarer wirkstofffreisetzung zur oralen verabreichung |
| KR20070011469A (ko) * | 2004-04-13 | 2007-01-24 | 알자 코포레이션 | 펜타닐계 약제의 경피전달용 장치 및 방법 |
| AU2005267396B2 (en) * | 2004-06-24 | 2009-09-17 | Idexx Laboratories, Inc. | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
| US20060004050A1 (en) * | 2004-07-02 | 2006-01-05 | Speicher Brian T | Compositions and methods for the prevention or treatment of pain and other nervous system disorders |
| DE602005021248D1 (de) * | 2004-12-17 | 2010-06-24 | Exxonmobil Chem Patents Inc | Homogenes polymerblend und artikel daraus |
| AT505225A1 (de) * | 2007-04-26 | 2008-11-15 | Sanochemia Pharmazeutika Ag | 0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen |
-
2007
- 2007-12-20 HU HU0700828A patent/HUP0700828A2/hu unknown
-
2008
- 2008-12-18 WO PCT/HU2008/000153 patent/WO2009081217A1/en not_active Ceased
- 2008-12-18 JP JP2010538924A patent/JP2011507826A/ja active Pending
- 2008-12-18 CA CA2709538A patent/CA2709538A1/en not_active Abandoned
- 2008-12-18 EP EP08864922A patent/EP2231116A1/en not_active Withdrawn
- 2008-12-18 US US12/809,905 patent/US20100273746A1/en not_active Abandoned
- 2008-12-18 EA EA201070747A patent/EA018536B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0700828A2 (en) | 2010-01-28 |
| HU0700828D0 (en) | 2008-02-28 |
| EA201070747A1 (ru) | 2010-12-30 |
| WO2009081217A1 (en) | 2009-07-02 |
| US20100273746A1 (en) | 2010-10-28 |
| JP2011507826A (ja) | 2011-03-10 |
| EA018536B1 (ru) | 2013-08-30 |
| EP2231116A1 (en) | 2010-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20141218 |