CA2706357C - 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease - Google Patents

3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease Download PDF

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Publication number
CA2706357C
CA2706357C CA2706357A CA2706357A CA2706357C CA 2706357 C CA2706357 C CA 2706357C CA 2706357 A CA2706357 A CA 2706357A CA 2706357 A CA2706357 A CA 2706357A CA 2706357 C CA2706357 C CA 2706357C
Authority
CA
Canada
Prior art keywords
trimethylhydrazinium
propionate
meldonium
heart disease
ischemic heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2706357A
Other languages
English (en)
French (fr)
Other versions
CA2706357A1 (en
Inventor
Ivars Kalvins
Ilmars Stonans
Original Assignee
Grindeks JSC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40364183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2706357(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grindeks JSC filed Critical Grindeks JSC
Publication of CA2706357A1 publication Critical patent/CA2706357A1/en
Application granted granted Critical
Publication of CA2706357C publication Critical patent/CA2706357C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2706357A 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease Expired - Fee Related CA2706357C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07122359.8 2007-12-05
EP07122360 2007-12-05
EP07122359 2007-12-05
EP07122360.6 2007-12-05
PCT/EP2008/066712 WO2009071586A2 (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease

Publications (2)

Publication Number Publication Date
CA2706357A1 CA2706357A1 (en) 2009-06-11
CA2706357C true CA2706357C (en) 2013-06-11

Family

ID=40364183

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2706357A Expired - Fee Related CA2706357C (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease

Country Status (36)

Country Link
US (1) US20110028438A1 (de)
EP (1) EP2222376B1 (de)
JP (1) JP2011506285A (de)
KR (1) KR20100084687A (de)
CN (1) CN101951991A (de)
AR (1) AR069548A1 (de)
AT (1) ATE503473T1 (de)
AU (1) AU2008333263A1 (de)
BR (1) BRPI0819055A2 (de)
CA (1) CA2706357C (de)
CL (1) CL2008003552A1 (de)
CO (1) CO6280507A2 (de)
DE (1) DE602008005930D1 (de)
DK (1) DK2222376T3 (de)
DO (1) DOP2010000162A (de)
EA (1) EA016971B1 (de)
GE (1) GEP20125646B (de)
HR (1) HRP20110468T1 (de)
IL (1) IL205962A0 (de)
MA (1) MA31992B1 (de)
MX (1) MX2010006257A (de)
MY (1) MY158799A (de)
NZ (1) NZ586518A (de)
PA (1) PA8806001A1 (de)
PE (1) PE20091209A1 (de)
PL (1) PL2222376T3 (de)
PT (1) PT2222376E (de)
RS (1) RS51785B (de)
SI (1) SI2222376T1 (de)
SV (1) SV2010003585A (de)
TN (1) TN2010000249A1 (de)
TW (1) TWI391131B (de)
UA (1) UA100249C2 (de)
UY (1) UY31499A1 (de)
WO (1) WO2009071586A2 (de)
ZA (1) ZA201003640B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2702033T1 (sl) * 2011-04-27 2016-09-30 Grindeks, A Joint Stock Company Uporaba soli 3-karboksi-n-etil-n,n-dimteilpropan-1-amina pri zdravljenju bolezni srca in ožilja
RU2457198C1 (ru) * 2011-05-31 2012-07-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Производное 3-(2,2,2-триметилгидразиний)пропионата - глицинат 3-(2,2,2-триметилгидразиний)пропионат калия, обладающее противоишемической активностью
RU2467748C1 (ru) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Производное 3-(2,2,2-триметилгидразиний)пропионата - глицинат 3-(2,2,2-триметилгидразиний)пропионат калия, обладающее эндотелиопротекторной активностью

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV13280B (en) * 2003-08-04 2005-11-20 Grindeks Publiska As Sustained release salts of 3-(2,2,2-trimethylhydrazinium)propionate, a method of production and pharmaceutical compositions thereof
MXPA06000955A (es) * 2003-08-04 2006-03-30 Grindeks Jsc Sales de meldonio, metodo para su preparacion y composiciones farmaceuticas basadas en ellas.

Also Published As

Publication number Publication date
KR20100084687A (ko) 2010-07-27
WO2009071586A3 (en) 2009-09-24
EA201000739A1 (ru) 2011-02-28
PT2222376E (pt) 2011-07-01
CO6280507A2 (es) 2011-05-20
TN2010000249A1 (en) 2011-11-11
EP2222376B1 (de) 2011-03-30
DK2222376T3 (da) 2011-07-25
SI2222376T1 (sl) 2011-08-31
TWI391131B (zh) 2013-04-01
DE602008005930D1 (de) 2011-05-12
MX2010006257A (es) 2010-08-10
CL2008003552A1 (es) 2009-12-18
SV2010003585A (es) 2011-03-23
GEP20125646B (en) 2012-09-25
WO2009071586A2 (en) 2009-06-11
AR069548A1 (es) 2010-02-03
PA8806001A1 (es) 2009-08-26
AU2008333263A1 (en) 2009-06-11
RS51785B (sr) 2011-12-31
MA31992B1 (fr) 2011-01-03
CA2706357A1 (en) 2009-06-11
UY31499A1 (es) 2009-01-30
MY158799A (en) 2016-11-15
IL205962A0 (en) 2010-11-30
UA100249C2 (uk) 2012-12-10
CN101951991A (zh) 2011-01-19
EP2222376A2 (de) 2010-09-01
JP2011506285A (ja) 2011-03-03
PE20091209A1 (es) 2009-09-10
ATE503473T1 (de) 2011-04-15
ZA201003640B (en) 2011-03-30
DOP2010000162A (es) 2010-08-31
EA016971B1 (ru) 2012-08-30
TW200927092A (en) 2009-07-01
PL2222376T3 (pl) 2011-10-31
NZ586518A (en) 2012-02-24
BRPI0819055A2 (pt) 2015-05-05
US20110028438A1 (en) 2011-02-03
HRP20110468T1 (hr) 2011-08-31

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