WO2009071586A3 - 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease - Google Patents

3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease Download PDF

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Publication number
WO2009071586A3
WO2009071586A3 PCT/EP2008/066712 EP2008066712W WO2009071586A3 WO 2009071586 A3 WO2009071586 A3 WO 2009071586A3 EP 2008066712 W EP2008066712 W EP 2008066712W WO 2009071586 A3 WO2009071586 A3 WO 2009071586A3
Authority
WO
WIPO (PCT)
Prior art keywords
trimethylhydrazinium
heart disease
ischemic heart
treating ischemic
propionate salts
Prior art date
Application number
PCT/EP2008/066712
Other languages
French (fr)
Other versions
WO2009071586A2 (en
Inventor
Ivars Kalvins
Ilmars Stonans
Original Assignee
Grindeks, A Joint Stock Company
Chemco Ventures (Cyprus) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40364183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009071586(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to SI200830294T priority Critical patent/SI2222376T1/en
Priority to AT08857821T priority patent/ATE503473T1/en
Priority to EP08857821A priority patent/EP2222376B1/en
Priority to BRPI0819055 priority patent/BRPI0819055A2/en
Priority to DK08857821.6T priority patent/DK2222376T3/en
Priority to CA2706357A priority patent/CA2706357C/en
Priority to UAA201006836A priority patent/UA100249C2/en
Priority to PL08857821T priority patent/PL2222376T3/en
Priority to AU2008333263A priority patent/AU2008333263A1/en
Application filed by Grindeks, A Joint Stock Company, Chemco Ventures (Cyprus) Limited filed Critical Grindeks, A Joint Stock Company
Priority to MX2010006257A priority patent/MX2010006257A/en
Priority to JP2010536439A priority patent/JP2011506285A/en
Priority to EA201000739A priority patent/EA016971B1/en
Priority to CN200880119405XA priority patent/CN101951991A/en
Priority to NZ586518A priority patent/NZ586518A/en
Priority to US12/734,785 priority patent/US20110028438A1/en
Priority to DE602008005930T priority patent/DE602008005930D1/en
Publication of WO2009071586A2 publication Critical patent/WO2009071586A2/en
Publication of WO2009071586A3 publication Critical patent/WO2009071586A3/en
Priority to ZA2010/03640A priority patent/ZA201003640B/en
Priority to IL205962A priority patent/IL205962A0/en
Priority to TN2010000249A priority patent/TN2010000249A1/en
Priority to MA32977A priority patent/MA31992B1/en
Priority to HR20110468T priority patent/HRP20110468T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to highly effective treatment of ischemic heart disease with 3-(2,2,2-trimethylhydrazinium) propionate hydrogen fumarate, and 3-(2,2,2-trimethylhydrazinium) propionate dihydrogen phosphate.
PCT/EP2008/066712 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease WO2009071586A2 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
MX2010006257A MX2010006257A (en) 2007-12-05 2008-12-03 New medical use of 3-(2,2,2-trimethylhydrazinium) propionate salts.
JP2010536439A JP2011506285A (en) 2007-12-05 2008-12-03 3- (2,2,2-trimethylhydrazinium) propionate salt for new use in medicine
EP08857821A EP2222376B1 (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating myocardial infarction
BRPI0819055 BRPI0819055A2 (en) 2007-12-05 2008-12-03 "USE OF 3- (2,2,2-TRIMETHYLHYDRAZINE) PROPIONATE AND ITS SALTS"
DK08857821.6T DK2222376T3 (en) 2007-12-05 2008-12-03 3- (2,2,2-trimethylhydrazinium) propionate salts for the treatment of myocardial infarction
CA2706357A CA2706357C (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease
UAA201006836A UA100249C2 (en) 2007-12-05 2008-12-03 Novel medical use of 3-(2,2,2-trimethylhydrazinium) propionate salts
PL08857821T PL2222376T3 (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating myocardial infarction
AU2008333263A AU2008333263A1 (en) 2007-12-05 2008-12-03 New medical use of 3-(2,2,2-trimethylhydrazinium) propionate salts
AT08857821T ATE503473T1 (en) 2007-12-05 2008-12-03 3-(2,2,2-TRIMETHYLHYDRAZINIUM) PROPIONATE SALTS FOR THE TREATMENT OF MYOCARDIAL INFARCTION
DE602008005930T DE602008005930D1 (en) 2007-12-05 2008-12-03 3- (2,2,2-TRIMETHYLHYDRAZINIUM) PROPIONATE SALTS FOR THE TREATMENT OF THE MYOKARDIN FARCT
SI200830294T SI2222376T1 (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating myocardial infarction
NZ586518A NZ586518A (en) 2007-12-05 2008-12-03 Use of meldonium salts to treat myocardial infarction
CN200880119405XA CN101951991A (en) 2007-12-05 2008-12-03 New medical use of 3-(2,2,2-trimethylhydrazinium) propionate salts
EA201000739A EA016971B1 (en) 2007-12-05 2008-12-03 New medical use of 3-(2,2,2-trimethylhydrazinium)propionate salts
US12/734,785 US20110028438A1 (en) 2007-12-05 2008-12-03 Medical use of 3-2,2,2-trimethylhydrazinium propionate salts.
ZA2010/03640A ZA201003640B (en) 2007-12-05 2010-05-21 3-(2,2,2-trimethylhhydrazinuim) propionate salts for treating ischemic heart disease treating
IL205962A IL205962A0 (en) 2007-12-05 2010-05-25 3-(2,2,2-trimethlhydrazinium)propionate salts for treating ischemic heart disease
TN2010000249A TN2010000249A1 (en) 2007-12-05 2010-06-01 New medical use of 3-(2,2,2-trimethylhydrazinium ) propionate salts
MA32977A MA31992B1 (en) 2007-12-05 2010-07-01 New medical use of 3-salts (2,2,2-trimetylhydrazinium) propionate
HR20110468T HRP20110468T1 (en) 2007-12-05 2011-06-21 3-(2,2,2-trimethylhydrazinium) propionate salts for treating myocardial infarction

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07122359.8 2007-12-05
EP07122360 2007-12-05
EP07122359 2007-12-05
EP07122360.6 2007-12-05

Publications (2)

Publication Number Publication Date
WO2009071586A2 WO2009071586A2 (en) 2009-06-11
WO2009071586A3 true WO2009071586A3 (en) 2009-09-24

Family

ID=40364183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/066712 WO2009071586A2 (en) 2007-12-05 2008-12-03 3-(2,2,2-trimethylhydrazinium) propionate salts for treating ischemic heart disease

Country Status (36)

Country Link
US (1) US20110028438A1 (en)
EP (1) EP2222376B1 (en)
JP (1) JP2011506285A (en)
KR (1) KR20100084687A (en)
CN (1) CN101951991A (en)
AR (1) AR069548A1 (en)
AT (1) ATE503473T1 (en)
AU (1) AU2008333263A1 (en)
BR (1) BRPI0819055A2 (en)
CA (1) CA2706357C (en)
CL (1) CL2008003552A1 (en)
CO (1) CO6280507A2 (en)
DE (1) DE602008005930D1 (en)
DK (1) DK2222376T3 (en)
DO (1) DOP2010000162A (en)
EA (1) EA016971B1 (en)
GE (1) GEP20125646B (en)
HR (1) HRP20110468T1 (en)
IL (1) IL205962A0 (en)
MA (1) MA31992B1 (en)
MX (1) MX2010006257A (en)
MY (1) MY158799A (en)
NZ (1) NZ586518A (en)
PA (1) PA8806001A1 (en)
PE (1) PE20091209A1 (en)
PL (1) PL2222376T3 (en)
PT (1) PT2222376E (en)
RS (1) RS51785B (en)
SI (1) SI2222376T1 (en)
SV (1) SV2010003585A (en)
TN (1) TN2010000249A1 (en)
TW (1) TWI391131B (en)
UA (1) UA100249C2 (en)
UY (1) UY31499A1 (en)
WO (1) WO2009071586A2 (en)
ZA (1) ZA201003640B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20140777A1 (en) 2011-04-27 2014-07-20 Grindeks Jsc METHOD OF OBTAINING A PHARMACEUTICAL COMPOSITION OF 3-CARBOXI-N-ETHYL-N, N-DIMETHYLPROPAN-1-AMINIUM SALTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
RU2457198C1 (en) * 2011-05-31 2012-07-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" 3-(2,2,2-trimethylhydrazinium) propionate derivative - potassium glycinate 3-(2,2,2-trimethylhydrazinium) propionate
RU2467748C1 (en) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" 3-(2,2,2-trimethylhydrazinium) propionate derivative - 3-(2,2,2-trimethylhydrazinium) potassium propionate glycinate exhibiting endothelioprotective activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012233A1 (en) * 2003-08-04 2005-02-10 'joint Stock Company Grindeks' Meldonium salts, method of their preparation and pharmaceutical composition on their basis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV13280B (en) * 2003-08-04 2005-11-20 Grindeks Publiska As Sustained release salts of 3-(2,2,2-trimethylhydrazinium)propionate, a method of production and pharmaceutical compositions thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012233A1 (en) * 2003-08-04 2005-02-10 'joint Stock Company Grindeks' Meldonium salts, method of their preparation and pharmaceutical composition on their basis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAMBROVA M ET AL: "Mildronate: Cardioprotective action through carnitine-lowering effect", TRENDS IN CARDIOVASCULAR MEDICINE, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 12, no. 6, 1 January 2002 (2002-01-01), pages 275 - 279, XP002409968, ISSN: 1050-1738 *
SESTI CASILDE ET AL: "Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, RAVEN PRESS, NEW YORK, NY, vol. 47, no. 3, 1 March 2006 (2006-03-01), pages 493 - 499, XP008090058, ISSN: 0160-2446 *

Also Published As

Publication number Publication date
DE602008005930D1 (en) 2011-05-12
TN2010000249A1 (en) 2011-11-11
US20110028438A1 (en) 2011-02-03
PE20091209A1 (en) 2009-09-10
MY158799A (en) 2016-11-15
ATE503473T1 (en) 2011-04-15
PT2222376E (en) 2011-07-01
CO6280507A2 (en) 2011-05-20
MA31992B1 (en) 2011-01-03
EP2222376A2 (en) 2010-09-01
PL2222376T3 (en) 2011-10-31
PA8806001A1 (en) 2009-08-26
RS51785B (en) 2011-12-31
AU2008333263A1 (en) 2009-06-11
ZA201003640B (en) 2011-03-30
CN101951991A (en) 2011-01-19
NZ586518A (en) 2012-02-24
WO2009071586A2 (en) 2009-06-11
SV2010003585A (en) 2011-03-23
UY31499A1 (en) 2009-01-30
HRP20110468T1 (en) 2011-08-31
CA2706357C (en) 2013-06-11
MX2010006257A (en) 2010-08-10
EA201000739A1 (en) 2011-02-28
AR069548A1 (en) 2010-02-03
UA100249C2 (en) 2012-12-10
SI2222376T1 (en) 2011-08-31
CA2706357A1 (en) 2009-06-11
TWI391131B (en) 2013-04-01
GEP20125646B (en) 2012-09-25
KR20100084687A (en) 2010-07-27
IL205962A0 (en) 2010-11-30
TW200927092A (en) 2009-07-01
BRPI0819055A2 (en) 2015-05-05
DOP2010000162A (en) 2010-08-31
JP2011506285A (en) 2011-03-03
EA016971B1 (en) 2012-08-30
CL2008003552A1 (en) 2009-12-18
EP2222376B1 (en) 2011-03-30
DK2222376T3 (en) 2011-07-25

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