CA2706224A1 - Poulets transgeniques comprenant un gene a chaine legere d'immunoglobuline endogene inactive et procedes de production de tels poulets au moyen de cellules germinales primordialesgenetiquement modifiees - Google Patents

Poulets transgeniques comprenant un gene a chaine legere d'immunoglobuline endogene inactive et procedes de production de tels poulets au moyen de cellules germinales primordialesgenetiquement modifiees Download PDF

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Publication number
CA2706224A1
CA2706224A1 CA2706224A CA2706224A CA2706224A1 CA 2706224 A1 CA2706224 A1 CA 2706224A1 CA 2706224 A CA2706224 A CA 2706224A CA 2706224 A CA2706224 A CA 2706224A CA 2706224 A1 CA2706224 A1 CA 2706224A1
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CA
Canada
Prior art keywords
gene
cells
pgcs
chicken
transgene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2706224A
Other languages
English (en)
Inventor
Marie-Cecile Van De Lavoir
Philip Albert Leighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synageva Biopharma Corp
Original Assignee
Origen Therapeutics, Inc.
Marie-Cecile Van De Lavoir
Philip Albert Leighton
Insolvency Services Group, Inc.
Synageva Biopharma Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Origen Therapeutics, Inc., Marie-Cecile Van De Lavoir, Philip Albert Leighton, Insolvency Services Group, Inc., Synageva Biopharma Corp. filed Critical Origen Therapeutics, Inc.
Publication of CA2706224A1 publication Critical patent/CA2706224A1/fr
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/30Bird
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0393Animal model comprising a reporter system for screening tests
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2706224A 2007-08-14 2008-08-14 Poulets transgeniques comprenant un gene a chaine legere d'immunoglobuline endogene inactive et procedes de production de tels poulets au moyen de cellules germinales primordialesgenetiquement modifiees Abandoned CA2706224A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96489107P 2007-08-14 2007-08-14
US60/964,891 2007-08-14
PCT/US2008/073214 WO2009023800A1 (fr) 2007-08-14 2008-08-14 Poulets transgéniques porteurs d'un locus de gènes endogènes inactivés

Publications (1)

Publication Number Publication Date
CA2706224A1 true CA2706224A1 (fr) 2009-02-19

Family

ID=40351167

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2706224A Abandoned CA2706224A1 (fr) 2007-08-14 2008-08-14 Poulets transgeniques comprenant un gene a chaine legere d'immunoglobuline endogene inactive et procedes de production de tels poulets au moyen de cellules germinales primordialesgenetiquement modifiees

Country Status (7)

Country Link
EP (1) EP2187732A4 (fr)
JP (3) JP5760159B2 (fr)
KR (1) KR101563017B1 (fr)
CN (1) CN101868144A (fr)
AU (1) AU2008286791A1 (fr)
CA (1) CA2706224A1 (fr)
WO (1) WO2009023800A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2713712B1 (fr) 2011-05-24 2017-04-12 Crystal Bioscience Inc. Poulet transgénique comportant un gène inactivé de l'immunoglobuline
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
EP3340787A4 (fr) * 2015-08-27 2019-01-02 Crystal Bioscience Inc. Animal transgénique pour la production d'anticorps ayant une chaîne légère commune
US20200214273A1 (en) * 2017-09-19 2020-07-09 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization Genome-edited birds
CN110484549B (zh) * 2018-04-20 2023-10-03 北京大学 基因组靶向修饰方法
KR20210137499A (ko) * 2019-03-05 2021-11-17 더 스테이트 오브 이스라엘, 미니스트리 오브 애그리컬처 & 루럴 디벨로프먼트, 애그리컬처럴 리서치 오거니제이션, (에이.알.오.), 볼카니 센터 게놈-편집 조류
WO2023127903A1 (fr) * 2021-12-28 2023-07-06 国立大学法人北海道大学 Procédé de préparation d'embryon enrichi en cellules germinales primordiales
CN115120382A (zh) * 2022-05-26 2022-09-30 广东省农业科学院动物科学研究所 一种鸡生殖前体细胞移植受体的制备方法
CN115191404B (zh) * 2022-07-28 2023-04-21 四川省畜牧科学研究院 提高黄羽肉鸡后代公鸡比例的新品种选育方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1023442E (pt) * 1997-10-16 2011-02-25 Synageva Biopharma Corp Vectores compreendendo um promotor específico do magno para transgénese aviária
GB2398784B (en) * 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
WO2005007696A2 (fr) * 2003-07-15 2005-01-27 Therapeutic Human Polyclonals, Inc. Locus d'immunoglobuline humanises
AU2006210645A1 (en) * 2005-02-01 2006-08-10 Symphogen A/S Transgenic chickens

Also Published As

Publication number Publication date
EP2187732A4 (fr) 2012-11-07
KR20100088125A (ko) 2010-08-06
JP5760159B2 (ja) 2015-08-05
KR101563017B1 (ko) 2015-10-23
JP2016129519A (ja) 2016-07-21
JP2014239702A (ja) 2014-12-25
EP2187732A1 (fr) 2010-05-26
CN101868144A (zh) 2010-10-20
JP6004290B2 (ja) 2016-10-05
AU2008286791A1 (en) 2009-02-19
JP2010536346A (ja) 2010-12-02
WO2009023800A1 (fr) 2009-02-19

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EEER Examination request

Effective date: 20130404

FZDE Discontinued

Effective date: 20180628