CA2705862C - Compositions and method for manipulating pim-1 activity in circulatory system cells - Google Patents
Compositions and method for manipulating pim-1 activity in circulatory system cells Download PDFInfo
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- CA2705862C CA2705862C CA2705862A CA2705862A CA2705862C CA 2705862 C CA2705862 C CA 2705862C CA 2705862 A CA2705862 A CA 2705862A CA 2705862 A CA2705862 A CA 2705862A CA 2705862 C CA2705862 C CA 2705862C
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/12—Dual-specificity kinases (2.7.12)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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| US61/091,698 | 2008-08-25 | ||
| PCT/US2008/083693 WO2009065080A1 (en) | 2007-11-16 | 2008-11-14 | Compositions and method for manipulating pim-1 activity in circulatory system cells |
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| ES2660492T3 (es) * | 2012-02-14 | 2018-03-22 | The Regents Of The University Of California | Administración sistémica y expresión regulada de genes paracrinos para enfermedades cardiovasculares y otras afecciones |
| ES2649156T3 (es) | 2013-01-14 | 2018-01-10 | Incyte Holdings Corporation | Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim |
| ES2941292T3 (es) | 2013-01-15 | 2023-05-19 | Incyte Holdings Corp | Tiazolecarboxamidas y compuestos de piridinecarboxamida útiles como inhibidores de PIM quinasa |
| AR097431A1 (es) | 2013-08-23 | 2016-03-16 | Incyte Corp | Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de quinasas pim |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2018232323A1 (en) | 2017-06-16 | 2018-12-20 | Avery Therapeutics, Inc. | Three dimensional tissue compositions and methods of use |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| CN108913655B (zh) * | 2018-07-16 | 2022-07-15 | 浙江大学 | 基于多能干细胞技术建立“人源性”心肌肥大模型的方法 |
| US20210386827A1 (en) * | 2018-10-15 | 2021-12-16 | Avery Therapeutics, Inc. | Cell-free compositions and methods for restoration or enhancement of tissue function |
| AU2021218411A1 (en) | 2020-02-13 | 2022-10-06 | Tenaya Therapeutics, Inc. | Gene therapy vectors for treating heart disease |
| US20230282387A1 (en) * | 2020-09-04 | 2023-09-07 | Dexerials Corporation | Conductive layered product, optical device using same, and manufacturing method for conductive layered product |
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| US20040132190A1 (en) | 1995-02-28 | 2004-07-08 | The Regents Of The University Of California | Gene therapy for myocardial ischemia |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
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| US5869037A (en) * | 1996-06-26 | 1999-02-09 | Cornell Research Foundation, Inc. | Adenoviral-mediated gene transfer to adipocytes |
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| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| US6630137B1 (en) | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
| KR100556864B1 (ko) | 1997-05-13 | 2006-03-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 렌티바이러스-기원 유전자 전달 벡터 |
| JP2000516641A (ja) | 1997-07-02 | 2000-12-12 | エスディージー インコーポレイテッド | 診断および治療用途の目標指向性リポソーム構成物 |
| ATE298371T1 (de) | 1997-09-24 | 2005-07-15 | Univ California | Nicht-primaten lentivirale vektoren und verpackungssysteme |
| CN1322137C (zh) | 1997-12-22 | 2007-06-20 | 牛津生物医学（英国）有限公司 | 基于马传染性贫血病毒(eiav)的逆转录病毒载体 |
| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| US6867348B1 (en) * | 1999-12-16 | 2005-03-15 | Xenogen Corporation | Methods and compositions for screening for angiogenesis modulating compounds |
| US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
| CA2434643C (en) * | 2001-01-18 | 2013-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for activation and inhibition of.delta.pkc |
| CA2433936A1 (en) * | 2001-01-23 | 2002-08-22 | Boston Scientific Corporation | Localized myocardial injection method for treating ischemic myocardium |
| US20030003582A1 (en) | 2001-05-08 | 2003-01-02 | Tranzyme, Inc. | Trans-viral vector mediated gene transfer to the retina |
| US7732199B2 (en) * | 2001-07-12 | 2010-06-08 | Geron Corporation | Process for making transplantable cardiomyocytes from human embryonic stem cells |
| US7671010B2 (en) | 2002-08-30 | 2010-03-02 | The Board Of Regents Of The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer |
| NZ532060A (en) | 2001-10-02 | 2005-11-25 | Inst Clayton De La Rech | Methods and compositions relating to restricted expression lentiviral vectors and their applications |
| AU2003290601A1 (en) * | 2002-11-05 | 2004-06-03 | The Brigham And Women's Hospital, Inc. | Mesenchymal stem cells and methods of use thereof |
| CN100567502C (zh) * | 2003-04-03 | 2009-12-09 | 株式会社康福来 | 药学制剂 |
| US20060246047A1 (en) * | 2003-06-24 | 2006-11-02 | Masaya Imoto | Peptide wirh apoptosis-inhibiting activity |
| US7135339B2 (en) | 2003-11-20 | 2006-11-14 | University Of Iowa Research Foundation | Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) |
| US20070077286A1 (en) | 2003-12-24 | 2007-04-05 | Tsutomu Ishihara | Drug-containing nanoparticle, process for producing the same and parenterally administered preparation from the nanoparticle |
| AU2005219413A1 (en) | 2004-03-02 | 2005-09-15 | Massachusetts Institute Of Technology | Nanocell drug delivery system |
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| CN101437938B (zh) * | 2004-11-08 | 2015-05-13 | 约翰霍普金斯大学 | 心脏干细胞 |
| CA2609937A1 (en) * | 2005-05-27 | 2006-11-30 | The Hospital For Sick Children | Modulation of the integrin linked kinase signaling pathway to promote cardiac cell proliferation and self-renewal |
| CA2616877C (en) | 2005-07-27 | 2014-01-28 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
| WO2010135401A2 (en) | 2009-05-19 | 2010-11-25 | San Diego State University Foundation | Kinase-mediated cytoprotection and enhanced cellular engraftment and persistence |
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| US20140234265A1 (en) | 2014-08-21 |
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| CA2705862A1 (en) | 2009-05-22 |
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| US8617534B2 (en) | 2013-12-31 |
| WO2009065080A1 (en) | 2009-05-22 |
| US20160324936A1 (en) | 2016-11-10 |
| JP5795670B2 (ja) | 2015-10-14 |
| JP2015007063A (ja) | 2015-01-15 |
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